AIP Advances
·
2023
·Vol. 13
·期 11
·
IF 1.6
Liu Jinhua,Zhu Guoren,Liu Yuanan,Wang Xiaohui
The combined treatment method integrated photothermal therapy (PTT) with chemotherapy is extremely promising owing to the synergistic therapeutic effect as compared to single PTT or chemotherapy. To facilitate more novel and facile photothermal-chemotherapy drugs as well as promote controllable combination therapy, we have developed a mild and facile method to fabricate polymer polypyrrole (PPy)-doxorubicin (DOX) nanoparticles (NPs) as pH-responsive drug nanocarriers for synergistic photothermal-chemotherapy. In the nanoplatform, poly-L-lysine (PLL)-modified PPy serves as the photothermal material, and (DOX) molecules are adopted as the chemotherapy agent. Based on the cross-linking reaction of glutaraldehyde, DOX molecules are flexibly and efficiently assembled on the surface of PLL-modified PPy NPs. The obtained PPy-DOX NPs possess high photothermal effect, superior loading capacity of DOX, and controlled drug release behavior. The combination photothermal-chemotherapy based on PPy-DOX NPs has significantly enhanced the antitumor therapy effect. In general, the designed PPy-DOX NPs may be a potential drug delivery nanoplatform for cancer combination therapy.
✓ 已验证
产品关联
DOI
高影响因子
ACS Applied Bio Materials
·
2023
·
IF 4.7
Lingli Jin,Fengjiao Chen,Xianwu Chen,Shun Zhang,Zhenjiang Liang,Lingling Zhao,Hui Tan
Thrombolytic therapy for ischemic stroke still has several limitations, such as a narrow therapeutic time window and adverse effects. Therapeutic hypothermia is a neuroprotective strategy for stroke. In this study, we developed pH/temperature dual-responsive protein–polymer conjugates (PEG–uPA–PEG–PPG–PEG) by modifying a urokinase-type plasminogen activator (uPA) with polyethylene glycol (PEG) and poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol) (PEG–PPG–PEG, a thermosensitive polymer) via pH-sensitive imine bonds and disulfide bonds, respectively. At 37 °C and pH 7.4 (normothermia and physiological pH), PEG–uPA–PEG–PPG–PEG exhibits antiprotease hydrolysis and masked bioactivity of uPA due to the protective effect of the polymer segments wrapped around the protein surface. However, at 33 °C and pH 6.0 (hypothermia and pH at the thrombotic site), uPA loses the protective effect and recovers its bioactivity due to PEG dissociation and PEG–PPG–PEG stretching. The masked bioactivity of uPA at normothermia and physiological pH could reduce the risk of acute hemorrhage complication, and the recovery of protein activity at acidic pH and 33 °C is of great significance for thrombolytic therapy at mild hypothermia. Thus, PEG–uPA–PEG–PPG–PEG provides promising potential for therapeutic hypothermia in ischemic stroke.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
·
2023
·
IF 6.2
Lijing Wang,Tianyi Yang,Xiangyu Xu,Guangya Zhang,Yunming Liu,Amin Ju,Gang Zhou,Bo Feng,Guangbo Che,Zhao Zhao
As a wastewater treatment technology, the activity of advanced oxidation process (AOPs) is strongly dependent on pH value. Herein, considering the low activity of AOPs under alkaline conditions, the acid organic ligand (nitrilotriacetic acid, NTA) was chosen to design Co-NTA metal-organic catalyst for efficient photo-Fenton reaction at full pH range. The experimental results indicate the acid ligands in Co-NTA offers more·OH that can achieve high activity under alkaline conditions. To further enhance the electron injection ability and redox cycles of Co(II)/Co(III), Ferrocene (Fc) nanoparticles was introduced to form bimetallic organic catalyst Fc-Co-NTA. The mechanism study indicates that the synergistic effect between Co-NTA and Fc promotes the activation of potassium persulfate and improves the stability of the catalyst under extreme pH conditions, while the π-π interaction between TC and Fc-Co-NTA can improve the electron injection capability and accelerate the production of·OH/SO 4 •- , so as to accelerate the redox cycles of Fe(II)/Fe(III) and Co(II)/Co(III), bringing about prolonged carrier lifetime and better photocatalytic activity. The possible degradation pathway of TC was investigated by Fukui function and LC-MS. A machine learning model is used to optimize the synthesis and photocatalytic parameters of Fc-Co-NTA. This study provides a new design idea to prepare highly efficient and stable photo-Fenton advanced oxidation technology at full pH range.
✓ 已验证
产品关联
DOI
高影响因子
REACTIVE & FUNCTIONAL POLYMERS
·
2020
·
IF 3.333
Xiaojing Zhang,Yang Meng,Weiwei Shen,Jingcheng Dou,Ruixue Liu,Qingxian Jin,Shaoming Fang
Injectable polysaccharide-based hydrogels are widely employed as drug delivery and tissue engineering materials due to the promising biocompatibility and biodegradability , while the mechanical property of polysaccharide hydrogels still requires to be enhanced much for further applications. In the present work, a family of injectable nanocomposite hydrogels were prepared for the first time through the Schiff base reaction between cationic octa (γ-chloroammoniumpropyl) silsesquioxane (OCAPS), chitosan (CS), and oxidized hydroxypropyl cellulose (HPC). It was found that OCAPS dispersed well in the hydrogels and inhibited the crystallization of CS and HPC, and the resulted nanocomposite hydrogels response pH values by reversible sol-gel transitions, namely as the pH value was less than 4.2, the hydrogels were low viscous solutions; while gelled again in mild and basic conditions. The gelation time of the hydrogels shrank from 80 to 49 s, and the swelling ratio increases from 3.7 to 6.6, along with the increase of OCAPS feed ratio gradually. The incorporation of OCAPS into the system also enhanced the mechanical property of the hydrogels. Compared with the controllable hydrogel without OCAPS, which failed to remain a certain shape for a long time, the nanocomposite hydrogels exhibited an outstanding compression property, and 68.4% of stain, 4.1 kPa of modulus, 97.9 kPa of strength when 40.0 wt% OCAPS was loaded. The rheological investigations suggested that the hydrogels possessed a very stable network, hence a self-healing property. Moreover, the result of Bovine serum albumin (BSA) load and release experiments demonstrated much improved drug load efficiency and cumulative drug release percentage of the nanocomposite hydrogels; the in-vitro degradation and cytotoxicity tests exhibited perfect biodegradability and biocompatibility of the hydrogels. All of these results demonstrate that the OCAPS and polysaccharides based hydrogels endow sound applications in drug carrier and tissue engineering materials.
✓ 已验证
产品关联
DOI
高影响因子
NANOTECHNOLOGY
·
2016
·Vol. 27
·期 31
·315104
·
IF 3.573
Lei Tan,Tao Wu,Zhao-Wen Tang,Jian-Yun Xiao,Ren-Xi Zhuo,Bin Shi,Chuan-Jun Liu
In this paper, a biocompatible and water-soluble fluorescent fullerene (C60-TEG-COOH) coated mesoporous silica nanoparticle (MSN) was successfully fabricated for pH-sensitive drug release and fluorescent cell imaging. The MSN was first reacted with 3-aminopropyltriethoxysilane to obtain an amino-modified MSN, and then the water-soluble C60 with a carboxyl group was used to cover the surface of the MSN through electrostatic interaction with the amino group in PBS solution (pH = 7.4). The release of doxorubicin hydrochloride (DOX) could be triggered under a mild acidic environment (lysosome, pH = 5.0) due to the protonation of C60-TEG-COO−, which induced the dissociation of the C60-TEG-COOH modified MSN (MSN@C60). Furthermore, the uptake of nanoparticles by cells could be tracked because of the green fluorescent property of the C60-modified MSN. In an in vitro study, the prepared materials showed excellent biocompatibility and the DOX-loaded nanocarrier exhibited efficient anticancer ability. This work offered a simple method for designing a simultaneous pH-responsive drug delivery and bioimaging system.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
FOOD HYDROCOLLOIDS
·
2023
·
IF 10.7
Ying-Ying Chen,Qiang-Ming Li,Li-Hua Pan,Jian-Ping Luo,Xue-Ying Li,Xue-Qiang Zha
Naringenin (Nar) is an important natural flavonoid compound with multiple health functions, but stability issues and poor solubility greatly limit its bioavailability. To enhance the water-solubility, chemical stability and bioavailability of Nar, quinoa protein isolate (QPI)-Nar and pH-shifted QPI (PQPI)-Nar nanoparticles were constructed in this study. The results of ultraviolet–visible and fluorescence spectra showed there existed the interactions between QPI or PQPI and Nar, with stronger interaction between PQPI and Nar. Thermodynamic analysis indicated the molecular interactions between QPI or PQPI and Nar were mainly driven by hydrogen bonds. Circular dichroism (CD) and surface hydrophobicity results revealed that the binding of Nar changed the secondary structures and reduced surface hydrophobicity of QPI and PQPI. The measured DLS, LC and EE results suggested that PQPI-Nar nanoparticles formed a more stable system with higher encapsulation capacity. Additionally, PQPI-Nar nanoparticles exhibited higher antioxidant activity , superior slow-release property and biocompatibility, as well as better thermal and ultraviolet stability than QPI-Nar nanoparticles. These results indicated that PQPI-Nar nanoparticles could effectively improve the bioavailability of Nar. This study may provide a theoretical basis for the promising application of PQPI-Nar nanoparticle delivery systems in the food industry.
✓ 已验证
DOI
高影响因子
ACS Food Science & Technology
·
2023
·
IF 2.3
Xiaxi Pan,Guixin Chen,Ting Xu,Lingyue Kong,Xinying Li,Defu Li,Changdao Mu,Zhilang Xu,Liming Ge
The development of packaging films with food preservation and monitoring functions is of great significance and applications. Herein, gelatin was combined with rosmarinic acid (RosA) and blueberry anthocyanin extract (BAE) to fabricate RosA-gelatin/BAE (RGA) films with pH-responsiveness and long-term antioxidant and antibacterial activities. The films have better surface hydrophobicity and antiswelling performance than that of pure gelatin film. The films show good ductility and the elongation at break of the films can be easily adjusted in the range of 1.01–292.19% by adjusting the content of BAE. The films can block ultraviolet light, scavenge the ABTS+ radical, and kill bacteria almost 100%. Significantly, the films showed good pH/NH3 responsiveness as an obvious color change. Comparing with polyethylene film, there was a reduction of around 60.8% in the release of volatile base nitrogen compounds from crucian in storage using RGA5. Overall, these films may be useful for food preservation and real-time quality monitoring.
✓ 已验证
产品关联
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2023
·
IF 9.5
Lihua Li,Zefeng Lin,Xingyi Xu,Wanshun Wang,Hu Chen,Zhibin Feng,Zhongmin Yang,Jianhua Hao
Nanozymes have brought enormous opportunities for disease theranostics. Here, a self-enhanced catalytic nanocrystal based on a bismuth–manganese core–shell nanoflower containing glucose oxide (GOx), termed BDS-GOx@MnOx, was designed for 4T1 tumor theranostics in vitro and in vivo. The BDS-GOx@MnOx nanozymes enable enhanced starvation treatment (ST) and chemotherapy (CDT) with high efficacy and exhibit sensitive tumor microenvironment (TME) responsive character for tumor therapy as well as for tumor-enhanced computer tomography (CT) and magnetic resonance (MR) diagnostic imaging. The characters and mechanism of the BDS-GOx@MnOx nanozymes have also been systematically studied and revealed.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2023
·
IF 8.2
Xu Enyu,Liu Xinbo,Chen Xuelian,Chen Huimin,Chen Yin,Chen Yan
In this study, hollow mesoporous silica (HMSN) was created to facilitate drug distribution using the hard template method. The oxidized hyaluronic acid (oxiHA) was coated on the carrier surface by the Schiff base reaction, producing the pH-responsive nanoparticles HMSNs-DOX-oxiHA targeted by CD44 and preventing drug leakage from mesopores. The prepared nanoparticles had a size of 151.79 ± 13.52 nm and a surface potential of −8.42 ± 0.48 mV. The rich mesoporous structure and internal cavity of HMSNs-NH 2 achieved the effective encapsulation and loading rates of doxorubicin (DOX) at 76.84 ± 0.24 % and 18.73 ± 0.05 %, respectively. Owing to the pH sensitivity of imine bonds, HMSNs-DOX-oxiHA has a good pH response and release performance. The in vitro experiments showed that the nanoparticles were not cytotoxic and could enhance HCT-116 uptake efficiency by hyaluronic acid/CD44 receptor-mediated endocytosis , effectively inhibiting tumor cell proliferation and reducing toxic side effects on normal cells. In summary, the polysaccharide-based nano-drug delivery system constructed in this experiment not only has the basic response properties of a carrier but also introduces the bioactive advantages of natural polysaccharides.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
FOOD CHEMISTRY
·
2023
·
IF 8.8
Qianjin Li,Meng Wang,Yu Jin,Yongling Lu,Shuqing Xiong,Mengdi Wang,Jianhong Xu,Chenhong Wei,Jianlin Li
Here, fluorescent artificial antibodies for sensing ovalbumin in food were synthesized by molecular imprinting technique in a microfluidic reactor. A phenylboronic acid-functionalized silane was employed as the functional monomer to enable the polymer has pH-responsive property. Fluorescent molecularly imprinted polymers (FMIPs) could be produced continuously in a short time. Both fluorescein isothiocyanate (FITC) and rhodamine B isothiocyanate (RB)-based FMIPs can specifically recognize the target ovalbumin, particularly FITC-based FMIP, giving an imprinting factor of 2.5 and cross-reactivity factors of 2.7 (ovotransferrin), 2.8 (β-lactoglobulin) and 3.4 (bovine serum albumin), and was applied for the detection of ovalbumin in milk powder with recovery rates of 93–110%; moreover, the FMIP can be reused at least four times. Such FMIPs have promising future in replacing the fluorophore-labelled antibodies to fabricate fluorescent sensing devices or establish immunoassay methods, which have extra merits of low-cost, high stability and recyclability, easy to carry and store at ambient environments.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2023
·
IF 15.1
Jieming Huang,Yuanwu Liu,Lirong Wang,Zhipeng Hou,Zhang Zhang,Xiaoming Zhang,Junming Liu
Hydrogen energy can be a promising alternative to fossil energy and can be applied to address the global energy challenge. However, the large overpotential and limited operation in the single electrolyte for hydrogen evolution reaction (HER) greatly hinder its practical applications. Herein, an efficient HER electrocatalyst demonstrated as MoO 2 -Mo 2 C-NC (NC is nitrogen-doped carbon) heterostructure applied in a wide pH, was in-situ constructed on carbon cloth (CC) by controlling coupling interactions of multicomponents. The strong coupling interactions in the heterostructure triggered the strain effect to induce C atoms to absorb H and promoted the establishment of a distinct synergy effect between Mo and C atoms, resulting in further electron configuration regulation. Besides, C defects and O vacancies of catalyst developed a rich H 3 O + environment in alkaline media, improving H-seizure of active sites. As expected, MoO 2 -Mo 2 C-NC@CC-950 °C achieved 10 mA·cm −2 only with 72 mV in 0.5 M H 2 SO 4 , 206 mV in 1 M phosphate buffer solution (PBS) and 79 mV in 1 M KOH, respectively, corresponding to the Tafel slopes of 56.42, 133.42 and 59.7 mV∙dec -1 . In addition, stability test in 1 M KOH performed at 100 mA∙cm −2 for 120 h exhibited ultrahigh durability in HER. The high-performance was attributed to the synergy of Mo and C atoms and the key roles of C defects and O vacancies, which were verified by the density functional theory (DFT) calculations. This work presents fresh possibilities for multicomponent modification and mechanism exploration in HER electrocatalysts.
✓ 已验证
产品关联
DOI
高影响因子
POLYMER
·
2023
·
IF 4.6
Ke Wang,Liru An,Ganghui Lu,Jialu Zhang,Zilong Wang,Meiyu Si,Guiyan Liu,Yongfei Zeng
A series of novel thermo/pH/CO 2 -triple responsive homopolymers were synthesized by reversible addition-fragmentation chain transfer (RAFT) polymerization. These homopolymers contain ethoxy groups , and the end substituents are pyrrolidine , piperidine , N -methylpiperazine, morpholine and thiomorpholine , respectively. The effects of different heterocyclic substituents on the responsiveness of temperature, pH and CO 2 were studied. For temperature-response, it was found that the lower critical solution temperature (LCST)-type cloud point (CP) temperature decreased as the number of carbon atoms increases, while the solubility of the polymers changed greatly with the introduction of oxygen, nitrogen and sulfur atoms. And the CP of the polymers can be adjusted by molecular weight , concentration and salt. Furthermore, some of these polymers present upper critical solution temperature (UCST) behavior in alcohols. For pH-response, the initial pH of the polymer solution is different, their critical pH changed accordingly, and is affected by temperature; in addition, changing the pH of solution can also affect the CP. For CO 2 -response, all of the polymers were completely soluble after pumping with CO 2 , and their LCST behavior recovered after N 2 was pumped in, but there was a gap with the initial CP. The study of these properties reveals the influence of different heterocyclic substituents on the responsiveness of polymers, which is of great significance for understanding the stimulation response properties of polymers and provides ideas for the design of new stimuli-responsive polymers.
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）