RSC Advances
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2019
·Vol. 9
·期 40
·23362-23372
·
IF 3.049
Wenbo Wang,Ning Cao,Jianwen Dong,Rabah Boukherroub,Wei Liu,Yujie Li,Haibo Cong
Carbon/carbon composite (C/C), due to its bio-inert property, is prone to cause bone consolidation defects and bacterial infections in clinical applications. Therefore, there is a great demand in practical applications to prevent implant infections and enhance its bone consolidation capability. In this study, we have developed a facile approach to construct a chitosan/hydroxyapatite composite modified layer on C/C surface by electrochemical deposition and a covalent grafting technique, and the modified layer has both the antibacterial activity of chitosan (CS) and the bioactivity of hydroxyapatite (HAP). The microstructure and chemical composition of the modified layer were analyzed using scanning electron microscopy (SEM), Fourier transform infrared (FTIR) spectroscopy, X-ray photoelectron spectroscopy (XPS) and water contact angle measurements. The biological properties of the composites were evaluated using cell culture, antimicrobial test and real-time quantitative PCR in vitro. The results showed that the CS/HAP modified C/C exhibited excellent biocompatibility, bacteriostasis and osteoinductive ability. These properties are beneficial for the potential application of the modified C/C composite as a bone tissue replacement material.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2019
·
IF 3.131
Nana He,Lili Li,Panpan Wang,Junhao Zhang,Jiaqi Chen,Jie Zhao
Herein, titanium dioxide/chitosan/poly(lactide-co-caprolactone) (TiO 2 /CS/P(LLA-CL)) composite membranes with highly efficient adsorption of copper ions (Cu(II)) in aqueous solution were developed, through a facile electrospinning method. First, TiO 2 nanoparticles were ultrasonically dispersed in CS/P(LLA-CL) solution to get a uniform suspension. Afterwards, the mixture was applied for electrospinning to generate the smooth and bead-free composite membranes. The high adsorption capability of the composite membranes on Cu(II) was mainly attributed to the combination of TiO 2 nanoparticles, CS/P(LLA-CL) matrix and nanosized membrane. Among those, the TiO 2 /CS/P(LLA-CL) composite membrane with 2% TiO 2 content demonstrated the maximum adsorption capability (˜190.5 mg g −1 ) for Cu(II) from aqueous solution. Their adsorption behaviors were well conformed to pseudo-second-order kinetic model and Langmuir isotherm model. Moreover, FTIR and XPS results confirmed the existed chelation and ion exchange between the membrane and the Cu(II) during adsorption process. Due to its simplicity, effectiveness and stability in water, this type of composite membrane may serve as a promising environmentally-friendly and non-toxic adsorbent for removal of Cu(II) in aqueous.
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POLYMER INTERNATIONAL
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2019
·Vol. 68
·期 6
·1102-1112
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IF 2.433
Cheng Liu,Liquan Yang,Liyuan Qiao,Chengde Liu,Manxia Zhang,Xigao Jian
Chitosan (CS) is a semi-natural polymer with supreme biological function, while the strong interchain hydrogen bonds cause poor water solubility and limit its broader use. To break the semi-rigid structure of CS, a kind of CS modified by adamantane (AD-CS) was successfully synthesized by amidation reaction with 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride as catalyst. The chemical structure of AD-CS was characterized by Fourier transform infrared spectroscopy and 1 H NMR. The AD substitution degree of CS is around 2%, calculated by 1 H NMR. A soft and transparent hydrogel composed of hydrogen bonds was obtained directly by simply adding a certain amount of water under mild conditions. Rheological measurements were carried out to research the mechanism of hydrogel formation by measuring the influence of different additives and conditions on the AD-CS hydrogel. Reinforced hydrogels were prepared by freezing and thawing. The mechanical strength and self-healing property of reinforced and pristine hydrogels were assessed with an oscillatory rheometer. The modulus of the reinforced hydrogel was obviously enhanced without much loss of self-healing property. Other properties such as adhesion, injectability and temperature response were also studied. These injectable and self-healing hydrogels show potential value in medical care. Additionally, this is a new method to design CS hydrogels with their original interchain hydrogen bonds. © 2019 Society of Chemical Industry
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ACS Biomaterials Science & Engineering
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2019
·
IF 4.511
Xiang Li,Hua-Mo Yin,Kai Su,Guang-Sen Zheng,Chao-Ying Mao,Wei Liu,Peng Wang,Zhen Zhang,Jia-Zhuang Xu,Zhong-Ming Li,Gui-Qing Liao
Surface function has an importance for the bioactivity of porous polymeric scaffolds. The goal of the present study is to immobilize highly bioactive chitosan (CS) onto the surface of porous composite scaffolds to accelerate bone regeneration. Porous poly(ε-caprolactone) (PCL)/bioactive glass (BG) composite scaffolds with strong anchor of CS were fabricated via mussel-inspired polydopamine (PDA) coating as a bridging layer. In vitro cell culture showed that firm immobilization of CS onto the composite scaffolds significantly enhanced protein adsorption, cell adhesion, and osteogenic differentiation compared to CS-decorated scaffolds via physical adsorption. In vivo assessments demonstrated that covalent immobilization of CS onto the surface of scaffolds obviously promoted cranial bone regeneration in comparison with the counterparts with physical adsorption of CS. The proposed method offers a feasible and effective means to fabricate artificial bioactive scaffolds for bone tissue engineering application.
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MICROCHIMICA ACTA
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2019
·Vol. 186
·期 6
·1-12
·
IF 5.479
Yang Xing,Niu Xiaohui,Mo Zunli,Guo Ruibin,Liu Nijuan,Zhao Pan,Liu Zhenyu
A composite was prepared from graphene functionalized with 3,4,9,10-perylene tetracarboxylic acid and chitosan (rGO-PTCA-chitosan) by a chemical method. It involves non-covalent functionalization of rGO with PTCA followed by amidation reaction with chitosan. Scanning electron microscopy, Fourier transform infrared spectroscopy, X-ray photoelectron spectroscopy and electrochemical methods were used to characterize the composites. By combining the chiral features of chitosan and the excellent electrochemical behaviors of rGO-PTCA, a graphene-based material with enantioselectivity was constructed for electrochemical chiral recognition of tryptophan (Trp) enantiomers. A glassy carbon electrode (GCE) modified with rGO-PTCA-chitosan had a higher recognition capability for L-Trp than for D-Trp. Best operated at a working voltage near 0.78 V (vs. SCE), the enantioselectivity coefficient is 3.0. The sensor has a linear response in the 1 mM to 10 mM Trp concentration range and a 1.2 μM detection limit (at S/ N = 3) for L-Trp, and of 3.0 μM to D-Trp. The sensor was successfully used to detect Trp enantiomers in real samples, and a recognition mechanism is presented.
Schematic presentation of a composoie prepared by graphene functionalized with 3,4,9,10-perylene tetracarboxylic acid and chitosan (rGO-PTCA-chitosan) via a chemical method. It involves non-covalent functionalization of rGO with PTCA followed by amidation reaction with chitosan and voltammetric determination of tryptophan enantiomers.
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CARBOHYDRATE POLYMERS
·
2019
·
IF 6.044
Hao Zhang,Liang Peng,Anwei Chen,Cui Shang,Ming Lei,Kai He,Si Luo,Jihai Shao,Qingru Zeng
Chitosan-stabilized FeS magnetic (MC-FeS) composites were successfully prepared to address the easily oxidization of FeS and enhance Cr(VI) removal from water. Results showed that the MC-FeS composites enhanced the Cr(VI) removal capacity as compared to bare FeS. Further investigation using X-ray photoelectron spectroscopy showed that FeOOH, S 8 , Cr 2 O 3 , Cr 2 S 3 , and a Fe(III)-Cr(III) complex were apparently introduced by Cr(VI), Fe(II), and S(−II), respectively. The sorption kinetics could be interpreted using a pseudo-second-order kinetic model, whereas the isotherms were simulated using the Redlich‒Peterson isotherm model indicating Cr(VI) removal by MC-FeS composites was a hybrid chemical reaction‒sorption process. In addition, the MC-FeS composite presented high stability against aging and performed well in a long-term reaction system and typical natural water environment. The effective performance of MC-FeS composites shows their great potential in wastewater remediation contaminated by heavy metals.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2019
·
IF 4.784
Ze-yu Qin,Xi-Wen Jia,Qian Liu,Bao-hua Kong,Hao Wang
In this study, Chitosan/pullulan composite nanofiber fast dissolving oral films (FDOFs) were prepared via electrospinning technology. The ratio of chitosan/pullulan (C/P) had an influence on solution property and nanofiber morphology, with the increase of chitosan, viscosity and conductivity of solutions increased, the morphology obtained by scanning electron microscopy indicated that the diameter of nanofibers decreased initially then increased. The Fourier transform infrared spectra indicated hydrogen bond interactions between chitosan and pullulan molecules. X-ray diffraction analysis proved that electrospinning process decreased the crystallinity of materials. Thermal analysis showed that melting point, degradation temperature and glass transition temperature increased with the addition of chitosan content in the FDOF. Water solubility test proved that the FDOF can dissolve in water completely within 60 s. Finally, in order to prove its practicability in future, a model drug of aspirin was encapsulated in the FDOF successfully.
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CHEMOSPHERE
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2018
·
IF 4.427
Xue Xue Liang,A.M. Omer,Zhao-hong Hu,Yang–guang Wang,Di Yu,Xiao-kun Ouyang
In this study, we prepared a magnetic composite based on amine-functionalized chitosan (aminochitosan; AmCS) and Fe 3 O 4 to remove diclofenac sodium (DS) from water. The fabricated AmCS@Fe 3 O 4 composite was characterized using Fourier-transform infrared spectroscopy, transmission electron microscopy , scanning electron microscopy, vibrating sample magnetometry, X-ray diffraction, and thermogravimetric analysis . Furthermore, we investigated the influence of pH, initial DS concentration, and adsorbent dosage on the adsorption of DS. Through thermodynamic analysis, we found that the data corresponded with the Langmuir adsorption isotherm model. The maximum adsorption capacity reached 469.48 mg g −1 , and the adsorption process followed the pseudo-second-order kinetic model. Finally, the AmCS@Fe 3 O 4 composite retained good adsorption characteristics after four consecutive cycles, with removal efficiency exceeding 70%. Therefore, the developed adsorbent could be used for efficient adsorptive removal of trace drugs and personal care products from water bodies.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2019
·
IF 4.784
Menglu Xu,Sajid Asghar,Shuang Dai,Yajing Wang,Shanshan Feng,Liang Jin,Feng Shao,Yanyu Xiao
The combination of controlled release technology and targeted drug delivery has become a promising strategy for cancer therapy. In this study, cell-nanoparticle hybrid vector was constructed using mesenchymal stem cells as the targeting cellular carrier and biotinylated chitosan polymer nanoparticles as the drug depot. Drug-loaded nanoparticles (hydrodynamic size =377.0 ± 14.6 nm and zeta potential = 9.6 ± 1.9 mV) were prepared by encapsulating hydrophobic model drug curcumin into biotinylated chitosan polymer. The biotin-modified nanoparticles were anchored on biotinylated mesenchymal stem cells surface by biotin-avidin binding, achieving an upload of 54.73 ± 3.95 pg/cell. The anchorage of nanoparticles on mesenchymal stem cells had no effect on their viability and homing property. Biotin-avidin binding lasted over 48 h, which could be sufficient for cell-directed tumor-tropic delivery. The in vitro and in vivo anti-tumor results advocate that cell-nanoparticle hybrid vector could prove beneficial in pulmonary melanoma metastasis therapy.
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Polymers
·
2019
·Vol. 11
·期 9
·1418
·
IF 3.164
Wei Li,Kewang Zheng,Hujian Chen,Shirong Feng,Wei Wang,Caiqin Qin
The combined effects of nano titanium dioxide (TiO2-N) and clove oil (CO) on the physico-chemical, biological and structural properties of chitosan (CH)/starch (ST) films were investigated by using a solvent casting method. Results indicated that the incorporation of TiO2-N could improve the compactness of the film, increase the tensile strength (TS) and antioxidant activity, and decrease the water vapour permeability (WVP). As may be expected, the incorporation of CO into the film matrix decreased TS but increased the hydrophobicity as well as water vapour barrier antimicrobial and antioxidant properties. Fourier-transform infrared spectroscopy (FTIR) data supported intermolecular interactions between TiO2-N, CO and the film matrix. Use of a scanning electron microscope (SEM) showed that TiO2-N and CO were well dispersed and emulsified in the film network. Thermogravimetric (TG) and derivative thermogravimetric (DTG) curves demonstrated that TiO2-N and CO were well embedded in the film matrix, hence this blend film system could provide new formulation options for food packaging materials in the future.Keywords:chitosan;starch;nano titanium dioxide;clove essential oil;edible film
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Materials
·
2018
·Vol. 11
·期 8
·1403
·
IF 2.467
Jie Li,Bing Xie,Kai Xia,Yingchun Li,Jing Han,Chunmao Zhao
Nano titanium dioxide (TiO2) with photocatalytic activity was firstly modified by diethanolamine, and it was then doped with broad spectrum antibacterial silver (Ag) by in situ method. Further, both Ag doped TiO2-chitosan (STC) and TiO2-chitosan (TC) composites were prepared by the inverse emulsion cross-linking reaction. The antibacterial activities of STC composites were studied and their antibacterial mechanisms under visible light were investigated. The results show that in situ doping and inverse emulsion method led to good dispersion of Ag and TiO2nanoparticles on the cross-linked chitosan microsphere. The STC with regular particle size of 1–10 μm exhibited excellent antibacterial activity againstE. coli,P. aeruginosaandS. aureusunder visible light. It is believed that STC with particle size of 1–10 μm has large specific surface area to contact with bacterial cell wall. The increased antibacterial activity was attributed to the enhancement of both electron-hole separations at the surface of nano-TiO2by the silver ions under the visible light, and the synergetic and sustained release of strong oxidizing hydroxyl radicals of nano-TiO2, together with silver ions against bacteria. Thus, STC composites have great potential applications as antibacterial agents in the water treatment field.Keywords:cross-linked chitosan;silver;titanium dioxide;photocatalytic antibacterial
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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
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2018
·
IF 3.412
Lingli Deng,Maierhaba Taxipalati,Aiping Zhang,Fei Que,Hewen Wei,Fengqin Feng,Hui Zhang
In this study, chitosan/poly(ethylene oxide) (PEO)/lauric arginate (LAE) composite nanofibrous films were fabricated via electrospinning. The addition of LAE did not change the physical properties of chitosan/PEO in acetic aqueous solutions, but increased the fluorescent intensity of chitosan by electrostatic interactions, resulting in uniform and bead-free nanofibers with an average diameter of 150 nm. The Fourier transform infrared spectra and thermal analysis indicated that the LAE molecules were homogeneously dispersed within the chitosan/PEO nanofibers. The formation of electrostatic and hydrogen bonding interactions induced by the LAE addition changed the inter- and intramolecular interactions between PEO and chitosan and further affected the mobility of the polymer molecules, leading to the increased crystallinity and decreased melting point. The hydrophilicity of the nanofibrous films was significantly increased by the incorporation of LAE, as indicated by the decreasing water contact angle from 39° to 10°. Meanwhile, the chitosan/PEO/LAE nanofibrous films showed LAE concentration dependent antimicrobial activity against Escherichia coli and Staphylococcus aureus, suggesting enhanced antimicrobial activity. The fluorescent staining experiments demonstrated that the antimicrobial mechanism of the nanofibrous films was cell membrane damage.
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