CHINESE JOURNAL OF ANALYTICAL CHEMISTRY
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2021
·
IF 1.134
Zi-Hou LI,Kun QIAN,Akakuru Ozioma-Udochukwu,Chun-Shu PAN,Xue-Hua MA,Ying-Ying HAN,Jian-Jun ZHENG,Ping CUI,Gang WEI,Zhe-Yu SHEN,Ai-Guo WU
Accurate bioimaging of internal body tissues plays a key role in achieving precise medical diagnosis. Magnetic resonance imaging (MRI) as one of the clinically used bioimaging modalities is largely hampered by the occurrence of false-positive imaging (artifacts). The use of contrast agents has tremendously contributed to the improvement of the accuracy of MRI, however, developing a dual-responsive contrast agent that capable of effectively switching from T 2 to T 1 contrast enhancement in vivo still remains a challenge. Here, we demonstrated the synthesis of a glutathione (GSH) and H 2 O 2 dual-responsive “signal inversion” contrast agent, which mainly comprised of superparamagnetic iron oxide nanoparticles (SPION) and degradable mesoporous silica nanoparticles (DMSN). The contrast agent achieved T 2 -weighted imaging in tumor site, and enabled an efficacious switch to T 1 -weighted imaging upon the GSH- and H 2 O 2 -mediated degradation of DMSN. The characteristics of the signal transformation largely reduced the artifacts to enhance the accuracy of MRI. Interestingly, the in vivo evaluations revealed prominence of the T 2 -weighted imaging up to 2 h post-intravenous injection, which was succeeded by T 1 -weighted imaging that gradually increased with time and became dominant after 24 h. It was therefore expected that the findings shown in this work would guide the development of other contrast agents alike for more robust and accurate bioimaging by using MRI.
研究领域:
医学成像
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纳米技术
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生物医学工程
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癌症诊断
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产品关联
DOI
高影响因子
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
·
2019
·Vol. 166
·期 13
·B1138
·
IF 3.12
Zhicheng Huang,Amin Zhang,Qian Zhang,Shaojun Pan,Daxiang Cui
A novel electrochemical detection platform was constructed based on dewdrop-like platinum nanoparticles-decorated silver nanoflowers nanocomposites coated with bovine serum albumin (AgNFs-Pt@BSA), which were synthesized through replacement reaction between chloroplatinic acid and AgNFs. As expected, in final obtained AgNFs-Pt@BSA nanocomposites, the petal structures of AgNFs with broad surface areas led to a high electron conductivity; Pt nanoparticles favorably enhanced the electrocatalytic ability toward hydrogen peroxide (H2O2); bovine serum albumin (BSA) coated around AgNFs-Pt provided numerous functional groups (especially -NH2). Inspired by above characteristics, a remarkable glucose biosensor could be assembled through crosslinking glucose oxidase with AgNFs-Pt@BSA via glutaraldehyde (AgNFs-Pt@BSA/GA/GOD). The high electrochemical responses were exhibited linearly in a wide concentrate range of glucose from 1 to 14 mM with a low detection limit of 0.3 mM at a signal-to-noise ratio of 3. Furthermore, with the advantages of favorable selectivity, excellent reproducibility and durable stability, here prepared electrochemical sensor showed promising analytical performance in the detection of glucose in human serum samples. All satisfied results provided a considerable direction of advance and prospect for the clinical applications of human blood glucose detection in the coming future.
研究领域:
生物传感技术
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纳米材料科学
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分析化学
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DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2019
·
IF 8.355
Jizhi Zhou,Pei Liu,Zeyuan Liu,Jia Zhang,Xin Huang
The recovery of phosphorus (P) from wastewater has attracted substantial attention with the atrophy of global P resource. In the current work, the simultaneous recovery of P with the removal of nickel (Ni) via iron/activated carbon (Fe/AC) and hydrogen peroxide (H 2 O 2 ) form nickel-plating wastewater was achieved. The isotherm reaction showed a maximum P recovery of 99.99% with an equilibrium concentration of P of 0.12 mg/L, which was lower than the limitation of discharge regulation (China national regulation, 0.5 mg/L). The optimal conditions for P recovery were 0.25 mol/L H 2 O 2 , a Fe/AC mass ratio of 1:1, an at 60 °C, which led to the ratio of P in the form of FePO 4 in the residue to be 77%. Moreover, the Fe/AC microelectrolysis coupling to H 2 O 2 promoted Fe 2+ production from Fe 0 and improved the circulation of Fe 2+ , which improved the production of hydroxyl radicals with increasing pH and consequently enhanced oxidation efficiency of hypophosphite. The FePO 4 was found the major form of phosphate in the precipitate. The highest removal rate of nickel was 89%, which was attributed to its precipitation at high pH and adsorption on to iron hydroxides and activated carbon. Nickel purification was achieved by further coagulation as the equilibrium concentration of Ni was lower than 0.1 mg/L. Therefore, our work provides a promising approach for simultaneous recovery of P and removal of Ni from electroplating wastewater.
研究领域:
环境科学
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化学工程
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DOI
高影响因子
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
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2021
·Vol. 32
·期 2
·2061-2074
·
IF 2.478
Wang Xule,Song Jimei,Lu Yun,Zhu Wanrong,Hu Gang
In this work, a series of Z-scheme Ag/Ag 2 WO 4 /g-C 3 N 4 (AAC) photocatalysts were successfully constructed by the deposition–precipitation method at room temperature. The phase, structure, morphology and optical property of the as-prepared photocatalysts were well characterized. Interestingly, all AAC exhibited prominent photocatalytic activity for Rhodamine B (RhB) degradation under visible light illumination. Especially, AAC-3 possessed the higher RhB degradation rate ( k = 0.1855 min −1 ). More remarkably, when H 2 O 2 (1 mL 0.0977 mol/L) was dissolved into reaction system, the degradation rate of RhB was further improved ( k = 0.7899 min −1 ), which could be mainly attributed to the high separation rate of photogenic carriers and more active species. Meanwhile, a feasible photocatalytic reaction mechanism was proposed and discussed in detail.
研究领域:
材料科学
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环境科学
·
化学
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产品关联
DOI
高影响因子
Chinese Journal of Natural Medicines
·
2021
·
IF 3
Di ZHANG,Bing YANG,Shi-Quan CHANG,Sheng-Suo MA,Jian-Xin SUN,Lin YI,Xing LI,Hui-Mei SHI,Bei JING,Ya-Chun ZHENG,Chun-Lan ZHANG,Feng-Guo CHEN,Guo-Ping ZHAO
This study was to investigate the protective effect of paeoniflorin (PF) on hydrogen peroxide-induced injury. Firstly, “SMILES” of PF was searched in Pubchem and further was used for reverse molecular docking in Swiss Target Prediction database to obtain potential targets. Injury-related molecules were obtained from GeenCards database, and the predicted targets of PF for injury treatment were selected by Wayne diagram. For mechanism analysis, the protein-protein interactions were constructed by String, and the KEGG analysis was conducted in Webgestalt. Then, cell viability and cytotoxicity assay were established by CCK8 assay. Also, the experimental cells were allocated to control, model (200 μmol·L −1 H 2 O 2 ), SB203580 10 μmol·L −1 (200 μmol·L −1 H 2 O 2 + SB203580 10 μmol·L −1 ), PF 50 μmol·L −1 (200 μmol·L −1 H 2 O 2 + PF 50 μmol·L −1 ), and PF 100 μmol·L −1 (200 μmol·L −1 H 2 O 2 + PF 100 μmol·L −1 ) groups. We measured the intracellular ROS, Hoechst 33258 staining, cell apoptosis, the levels of Bcl-xl, Bcl-2, Caspase-3, Cleaved-caspase3, Cleaved-caspase7, TRPA1, TRPV1, and the phosphorylation expression of p38MAPK. There are 96 potential targets that may be associated with PF for injury treatment. Then, we chose the “Inflammatory mediator regulation of TRP channels” pathway for the experimental verification from the first 10 KEGG pathway. In experimental verification, H 2 O 2 decreased the cell viability moderately ( P < 0.05), and 100 μmol·L −1 PF increased the cell viability significantly ( P < 0.05). Depending on the difference of intracellular ROS fluorescence intensity, PF inhibited H 2 O 2 -induced reactive oxygen species production in Schwann cells. In Hoechst 33258 staining, PF reversed the condensed chromatin and apoptotic nuclei following H 2 O 2 treatment. Moreover, Flow cytometry results showed that PF could substantially inhibit H 2 O 2 induced apoptosis ( P < 0.05). Pretreatment with PF obviously reduced the levels of Caspase3, Cleaved-caspase3, Cleaved-caspase7, TRPA1, TRPV1, and the phosphorylation expression of p38MAPK after H 2 O 2 treatment ( P < 0.05), increased the levels of Bcl-2, and Bcl-xl ( P < 0.05). PF inhibited Schwann cell injury and apoptosis induced by hydrogen peroxide, which mechanism was linked to the inhibition of phosphorylation of p38MAPK.
研究领域:
神经生物学
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药理学
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分子生物学
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产品关联
DOI
PubMed
高影响因子
RSC Advances
·
2017
·Vol. 7
·期 54
·34182-34191
·
IF 3.108
Cunzhi Zhang,Jingjing Su,Hongxiang Zhu,Jianhua Xiong,Xinliang Liu,Dongxue Li,Yangmei Chen,Yunhua Li
A new biosorbent (PEI/SA-MCCMV) with abundant amino and carboxyl groups was prepared by grafting polyethylenimine (PEI) onto carboxylated microcrystalline cellulose (SA-MCCMV), which was obtained through grafting succinic anhydride (SA) on pretreated microcrystalline cellulose (MCCMV) with microwave-H2O2. It was confirmed by Fourier transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), X-ray photoelectron microscopy (XPS) and thermogravimetric (TG) that the amino and carboxyl groups were introduced onto the microcrystalline cellulose, and the amino and carboxyl groups content were 2.61 mmol g−1 and 4.64 mmol g−1, respectively. The effects of the contact time and pH on heavy metal ion uptake were investigated. The adsorption kinetic data was described well with the pseudo-second-order model (R2 > 0.99) and the adsorption isotherms were well fitted by the Freundlich isotherm model, demonstrating that chemisorption was the rate-controlling factor for heavy metal ion adsorption on the PEI/SA-MCCMV biosorbent. Furthermore, the remarkable adsorption capacity (217.3 and 357.1 mg g−1 for Cd(II) and Pb(II), respectively) obtained from the Langmuir isotherm indicated that this biomass adsorbent has a promising application in water treatment.
研究领域:
环境科学
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材料科学
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产品关联
DOI
高影响因子
JOURNAL OF MATERIALS SCIENCE
·
2018
·Vol. 53
·期 20
·14063-14074
·
IF 2.993
Zhou Junyi,Tang Qiuju,Zhong Jiaxing,Lei Zhentao,Luo Haipeng,Tong Zaizai,Jiang Guohua,Liu Xiangdong
Herein, glucose and H 2 O 2 stimuli-responsive vesicles are constructed based on host–guest interaction between a diblock copolymer,
poly(ethylene glycol)- b -poly[3-acrylamidophenylboronic acid- co -4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl acrylate], (PEG- b -P(PBA- co -PBEM), BCP for short) and α-cyclodextrin.
In the presence of glucose, the vesicles are transformed to giant swollen spherical micelles because of the formation of a negatively charged tetravalent form between phenylboronic acid and glucose. On the other hand, the vesicles are totally disassembled when they are exposed to H 2 O 2 , which is due to the H 2 O 2 -mediated degradation of the pendant phenylboronic acid pinacol ester. The glucose and H 2 O 2 stimuli-responsive vesicles are then applied in the controlled release of water-soluble anticancer drug, doxorubicin hydrochloride (DOX). Upon external stimuli, the DOX displays a faster release rate than that without stimuli. Moreover, the polymeric vesicles show an excellent cytocompatibility toward MCF-7 cells, and the drug-loaded vesicles exhibit a lower cytotoxicity than free drug toward cancer cells. The drug-loaded vesicles can be taken up by MCF-7 cells and further release the DOX in cancer cells due to the high glucose and H 2 O 2 concentration in tumor cells, while they have negligible effect on normal cells, which may be important for applications in the therapy of cancers as a controlled-release drug carrier.
研究领域:
生物材料
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药学
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肿瘤学
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产品关联
DOI
高影响因子
CELLULAR AND MOLECULAR NEUROBIOLOGY
·
2016
·Vol. 36
·期 8
·1365-1375
·
IF 2.328
Lin Xuemei,Wu Songdi,Wang Qing,Shi Yaling,Liu Guozheng,Zhi Jin,Wang Fang
Neuronal oxidative stress (OS) injury has been proven to be associated with many neurodegenerative diseases, and thus, antioxidation treatment is an effective method for treating these diseases. Saikosaponin-D (SSD) is a sapogenin extracted from Bupleurum falcatum and has been shown to have many pharmacological activities. The main purpose of this study was to investigate whether and how SSD protects PC12 cells from H 2 O 2 -induced apoptosis. The non-toxic level of SSD significantly mitigated the H 2 O 2 -induced decrease in cell viability, reduced the apoptosis rate, improved the nuclear morphology, and reduced caspase-3 activation and poly ADP-ribose polymerase (PARP) cleavage. Additionally, exogenous H 2 O 2 -induced apoptosis by damaging the intracellular antioxidation system. SSD significantly slowed the H 2 O 2 -induced release of malonic dialdehyde (MDA) and lactate dehydrogenase and increased the activity of superoxide dismutase (SOD) and the total antioxidant capacity, thereby reducing apoptosis. More importantly, SSD effectively blocked H 2 O 2 -induced phosphorylation of extracellular-regulated kinase (ERK), c-Jun N-terminal kinase (JNK), and p38 mitogen-activated protein kinase (p38MAPK), and specific inhibitors of ERK, JNK, and p38-reduced OS injury and apoptosis, suggesting that SSD reduces OS injury and apoptosis via MAPK signalling pathways. Finally, we confirmed that SSD significantly reduced H 2 O 2 -induced reactive oxygen species (ROS) accumulation, and the ROS inhibitor blocked the apoptosis caused by MAPK activation and cellular oxidative damage. In short, our study confirmed that SSD reduces H 2 O 2 -induced PC12 cell apoptosis by removing ROS and blocking MAPK-dependent oxidative damage.
研究领域:
神经科学
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药理学
·
细胞生物学
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分子生物学
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产品关联
DOI
PubMed
高影响因子
Nano Research
·
2017
·Vol. 10
·期 7
·2482-2494
·
IF 7.354
Cui Shiqiang,Li Li,Ding Yaping,Zhang Jiangjiang,Wu Qingsheng,Hu Zongqian
Uniform, ordered mesoporous ZnCo 2 O 4 (meso-ZnCo 2 O 4 ) nanospheres were successfully synthesized using a sacrificing template method. The meso-ZnCo 2 O 4 nanospheres were used for the first time for H 2 O 2 biosensing and in glucose biofuel cells (GBFCs) as an enzyme mimic. The meso-ZnCo 2 O 4 nanospheres not only exhibited excellent catalytic performance in the H 2 O 2 sensor, achieving a high sensitivity (658.92 μA·mM –1 ·cm –2 ) and low detection limit (0.3 nM at signal-to-noise ratio (S/N) = 3), but also performed as an excellent cathode material in GBFCs, resulting in an open circuit voltage of 0.83 V, maximum power density of 0.32 mW·cm –2 , and limiting current density of 1.32 mA·cm –2 . The preeminent catalytic abilities to H 2 O 2 and glucose may be associated with the large specific surface area of the mesoporous structure in addition to the intrinsic catalytic activity of ZnCo 2 O 4 . These significant findings provide a successful basis for developing methods for the supersensitive detection of H 2 O 2 and enriching catalytic materials for biofuel cells.
研究领域:
材料科学
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生物传感
·
能源科学
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产品关联
DOI
高影响因子
WATER AIR AND SOIL POLLUTION
·
2017
·Vol. 228
·期 9
·1-11
·
IF 1.702
Feng Weihua,Zhang Lanxin,Fang Jianzhang,Lu Shaoyou,Wu Shuxing,Chen Yi,Fang Zhanqiang
Graphitic carbon nitride (g-C 3 N 4 ) is a photocatalyst with wide application in removal of organic pollutants. In this study, we designed a porous g-C 3 N 4 (p-g-C 3 N 4 )/8-quinolinolato iron(III) (Q 3 Fe)/H 2 O 2 system to enhance the organic pollutant removal efficiency by combining photocatalysis and Fenton interaction under neutral condition. The p-g-C 3 N 4 was prepared through a two-step thermal oxidation reaction. Afterwards, Q 3 Fe-coupled p-g-C 3 N 4 was prepared by an impregnating method. The 2,4-dichlorophenol (2,4-DCP) photodegradation ratio and decomposition rate of the p-g-C 3 N 4 /Q 3 Fe/H 2 O 2 system are approximately 5 and 18 times as high as those of individual p-g-C 3 N 4 system, respectively. Besides, its degradation rate is 4.3 times as high as that in the p-g-C 3 N 4 /H 2 O 2 system. Meanwhile, Q 3 Fe/g-C 3 N 4 also exhibits higher activity than individual p-g-C 3 N 4 in 2,4-DCP photo-decomposing. On the basis of the results of the radical trapping experiments and the Fe(II) concentration in different systems, the synergistic effect between photocatalysis and Fenton reaction is vital for the efficient pollutant degradation. The coupled system combining p-g-C 3 N 4 with Q 3 Fe and H 2 O 2 shows potential for efficient treatment of recalcitrant organic pollutants. The combined system in this work indicated a new idea for the decomposition of organic pollutants.
研究领域:
环境科学
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材料科学
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产品关联
DOI
高影响因子
Journal of Materials Chemistry B
·
2017
·Vol. 5
·期 41
·8200-8208
·
IF 4.543
Bin Xu,Guohua Jiang,Weijiang Yu,Depeng Liu,Yang Zhang,Junyi Zhou,Shiqing Sun,Yongkun Liu
A glucose-mediated insulin delivery system would be highly satisfactory for diabetes diagnosis dependent on the concentration of blood glucose in the body. Herein, a novel microneedle (MN) delivery device integrated with insulin-loaded and H2O2-responsive mesoporous silica nanoparticles (MSNs) was designed to achieve fast and painless administration. The MSNs were obtained by the modification by 4-(imidazoyl carbamate)phenylboronic acid pinacol ester (ICBE) and following a host–guest complexation between ICBE and α-cyclodextrin (α-CD). A drug and a glucose-responsive factor, namely insulin and glucose oxidase (GOx), were encapsulated into the MSNs. GOx in the MSNs could convert glucose to gluconic acid and generate hydrogen peroxide (H2O2). The phenylboronic ester on the surface of the MSNs could be oxidized in the presence of H2O2, which resulted in the destruction of host–guest complexation, leading to the disassembly of the drug-loaded MSNs and subsequent release of the preloaded insulin. After transdermal administration to diabetic rats, an effective hypoglycemic effect was obtained by detection over time compared with that of subcutaneous injection. This work suggests that the as-prepared glucose-mediated and H2O2-responsive MN systems have promising applications in diabetes treatment.
研究领域:
纳米技术
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药学
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生物医学工程
·
糖尿病治疗
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Materials Science & Engineering C-Materials for Biological Applications
·
2021
·
IF 7.328
Minhui Gong,Jiayu Xiao,Huan Li,Luo Hai,Ke Yang,Junqin Li,Zefeng Wang,Le Deng,Dinggeng He
Chemodynamic therapy (CDT) involving the highly toxic hydroxyl radical ( OH) has exhibited tremendous potentiality in combating bacterial infection. However, its antibacterial efficacy is still unsatisfactory due to the insufficient H 2 O 2 levels and near neutral pH at infection site. Herein, a glucose-fueled and H 2 O 2 -self-supplying OH nanogenerator (pFe 3 O 4 @GOx) based on cascade catalytic reactions is developed by immobilizing glucose oxidase (GOx) on the surface of PAA-coated Fe 3 O 4 (pFe 3 O 4 ). Magnetic pFe 3 O 4 can act as a horseradish peroxidase-like nanozyme, catalyzing the decomposition of H 2 O 2 into OH under acidic conditions for CDT. The immobilized GOx can continuously convert non-toxic glucose into gluconic acid and H 2 O 2 , and the former improves the catalytic activity of pFe 3 O 4 nanozymes by decreasing pH value. The self-supplying H 2 O 2 molecules effectively enhance the OH generation, resulting in the high antibacterial efficacy. In vitro studies demonstrate that the pFe 3 O 4 @GOx conducts well in reducing pH value and improving H 2 O 2 level for self-enhanced CDT. Moreover, the cascade catalytic reaction of pFe 3 O 4 and GOx effectively avoids strong toxicity caused by directly adding high concentrations of H 2 O 2 for CDT. It is worth mentioning that the pFe 3 O 4 @GOx performs highly efficient in vivo CDT of bacteria-infected wound via the localized long-term magnetic retention at infection site and causes minimal toxicity to normal tissues at therapeutic doses. Therefore, the developed glucose-fueled OH nanogenerators are a potential nano-antibacterial agent for the treatment of wound infections.
研究领域:
纳米技术
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生物医学工程
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药学
·
传染病学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）