EMBO Molecular Medicine
·
2026
·Vol. 18
·期 5
·1679
·
IF 7.9
Yufei Wu,Xiaomei Yang,Yu Bai,Chenze Li,Peng Wang,Qing Xu,Hui Li,Xiaoli Rao,Yangkai Xu,Jie Chen,Huanhuan Cao,Qi Zhang,Mingming Zhao,Rui Zhan,Xue Fan,Yuedong Hou,Jie Liu,Hong S Lu,Tianyun Wang,Wei Dong Gao,Linzhang Huang,Han Xiao,Lingyun Zu,Alan Daugherty,Mingguo Xu,Lemin Zheng
Cardiac microvascular endothelial cells (CMECs) dysfunction is a well-recognized mediator of heart failure with preserved ejection fraction (HFpEF), but the underlying mechanism remains unclear. Here we find that scavenger receptor class B type I (SR-B1) is predominantly expressed in CMECs and decreased significantly in HFpEF. Endothelial-specific SR-B1 deficiency exacerbates cardiac pathological remodeling and diastolic dysfunction in HFpEF, which can be prevented by endothelial SR-B1 reconstitution through adeno-associated virus serotype 1 (AAV1)-mediated delivery in endothelial-specific SR-B1-deficient mice. Single-cardiac-endothelial-cell transcriptomics and lineage-tracing system reveal that inflammatory CMECs subcluster activation is responsible for the deteriorating HFpEF progression induced by endothelial SR-B1 loss, rather than endothelial-to-mesenchymal transition. Mechanistically, SR-B1 loss drives increased CXCL10 secretion, which orchestrates CMECs activation and CXCR3-positive T-cell cardiotropism to promote diastolic dysfunction—a process associated with endothelial IRF1 activation. Most importantly, the SR-B1-CXCL10-CXCR3 axis is activated in human HFpEF cardiac tissue, and the elevated CXCL10 level in plasma is independently associated with a higher HFpEF prevalence. This study uncovers that activation of the SR-B1–CXCL10-CXCR3 axis in CMECs aggravates HFpEF pathogenesis through the accumulation of CXCR3-positive T-cells in hearts. This study demonstrates that SR-B1 deficiency in cardiac microvascular endothelial cells (CMECs) exacerbates heart failure with preserved ejection fraction (HFpEF) by driving the CXCL10-CXCR3 signaling, thereby linking inflammatory CMEC activation to CXCR3 + T-cell recruitment. This study demonstrates that SR-B1 deficiency in cardiac microvascular endothelial cells (CMECs) exacerbates heart failure with preserved ejection fraction (HFpEF) by driving the CXCL10-CXCR3 signaling, thereby linking inflammatory CMEC activation to CXCR3 + T-cell recruitment.
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CHEMICAL ENGINEERING JOURNAL
·
2026
·
IF 12.5
Yueyang Li,Jingde Luan,Haibin Yan,Yu Zhang,Qingyu Chi,Wengang Liu,Jian Liu,Zheng Yan
Integrating dual functional sites in the crystal lattice is a promising strategy to fabricate novel hetero nuclear-hetero polar dual-atom catalyst. However, the synergy between the dual active sites is governed by the local coordination environment, shaped by doping configuration of hetero atoms in the crystal lattice. Herein, engineering cobalt–iodine dual-site on anatase-TiO2 (Co-I-a-TiO2) was conducted by coupling in-situ cross-linking-assisted hydrothermal synthesis with electrostatic self-assembly. The optimal Co-I-a-TiO2 exhibits a H2 production rate of 20.8 mmol g−1 h−1, approximately 8.32 fold higher than that of pristine a-TiO2. Experimental and theoretical analysis reveal that the Co3+-for-Ti4+ substitution and vacancy-doped I ions in the lattice alter the electron density distribution, establishing a built-in electric field oriented from bulk to surface in the near-surface region. This redistribution empowers Co atom to function as an electron-rich center and I atom as a proton-trapping site. These findings emphasize the importance of constructing asymmetric coordination via anion-cation dual-site modification to promote photogenerated charge separation, as well as the enhanced probability of electron-proton binding.
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Journal of Functional Foods
·
2026
·
IF 3.9
Lin Zhang,Zi-Li Chen,Ding-Tao Wu,Qin Yuan,Shengpeng Wang,Mei-Lin Feng,Yi-Chen Hu,Mao-Ling Tan,Jing-Wei Huang,Liang Zou,Ya-Nan Cao
Tartary buckwheat leaf is a promising sustainable source of rhamnogalacturonan-I-rich pectic polysaccharides (TBP) with marked in vitro immunostimulatory activity. However, their in vivo efficacy and structure-activity relationships remain unknown. Here, we investigated TBP fractions differing in esterification degree, molecular mass, and branching in a murine immunosuppression model. All TBP fractions attenuated immunosuppression, an effect associated with modulating gut microbial homeostasis, enhancing levels of short-chain fatty acids (SCFAs), reinforcing gut barrier integrity, and improving systemic immune markers. Structural modifications augmented bioactivity; low-esterified TBP-D and low-molecular-mass, low-branching TBP-F outperformed native TBP. TBP-F had the strongest effects, significantly improving immune organ indices, cytokines, immunoglobulins, SCFAs, and tight-junction proteins. Microbiota analysis revealed that all TBPs enriched Muribaculaceae and decreased dysbiosis-associated taxa, with TBP-F most strongly suppressing detrimental bacteria. These results imply that TBPs with lower molecular mass, less branching, or reduced esterification possess superior immunostimulatory potency, supporting their development as immune-enhancing functional foods.
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JOURNAL OF LUMINESCENCE
·
2019
·
IF 2.961
Yanchun Yang,Song Wei,Xiaojiao Kang,O. Tegus,Daocheng Pan
Employing the short-chain C 4 H 9 NH 3 X (X = Cl, Br, I) compound as the unique capping agent, highly quality CH 3 NH 3 PbX 3 (X = Cl, Br, I) perovskite quantum dots can be synthesized at room temperature in the open air, which possess high photoluminescence quantum yields and tunable emission in the range of 440–660 nm. Besides, C 4 H 9 NH 3 Br can also improve the morphology of CH 3 NH 3 PbBr 3 thin films by spin-coating the N, N -dimerthylformamide solution of CH 3 NH 3 Br, C 4 H 9 NH 3 Br and PbBr 2 , making the thin film dense and compact, and improving its optical properties .
研究领域:
材料科学
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纳米科技
·
光电功能材料
·
半导体物理
·
凝聚态物理
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ACS Applied Nano Materials
·
2023
·
IF 5.9
Lei Zhong,Weisong Li,Guoning Li,Zhaoyu Feng,Chunjian Xu
I-deficient nanoplatelet bismuth oxyiodide (BiOI) microflowers were successfully synthesized via a one-pot solvothermal method using NaOH. Results demonstrated that OH– played a key role in regulating the morphology, pore structure, and energy band structure of the prepared samples. As the volume of NaOH increased, the size of the BiOI microflowers gradually decreased, and the specific surface area and pore volume increased, providing more accessible active sites for photocatalytic reactions. Additionally, some iodine atoms in B-7 (i.e., 7 mL of a 1.0 M NaOH solution was added during the synthesis process) were replaced by hydroxide ions, affording B-7 with slight defects. The loss of iodine atoms shifted the valence band maximum (VBM) from 1.372 eV for the pristine BiOI (B-0) to 1.596 eV for I-deficient BiOI (B-7). The lowered VBM provides more oxidative holes, which is favorable for the oxidation reaction. The photocatalytic activities of the prepared samples were evaluated via the photodegradation of various organic pollutants, such as methyl orange, Rhodamine B, and phenol, under visible light. Owing to the higher surface area and pore volume, lower VBM, and presence of surface defects, B-7 exhibited the highest degradation efficiency among all of the samples.
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OPTICAL MATERIALS
·
2023
·
IF 3.9
Shun Lu,Kegui Li,Ruojing Zhen,Maling Xiang,Xiaoyan Gan,Liling Guo,Hanxing Liu
Recently, perovskite solar cells (PSCs) basing on quasi-two-dimensional (quasi-2D) perovskites with hydrophobic bulky organic cations have received a lot of interests owing to their superior moisture stability. While quasi-2D perovskites have achieved great success in planar p-i-n PSCs, their application in planar n-i-p devices and the corresponding efficiencies lag far behind. In our work, (FPEA) 2 (MA) 4 Pb 5 I 16 perovskite films with high crystallinity , compact and smooth surface were deposited on electron transport layer with NH 4 SCN as an additive. Formamidinium (FA + ) were then incorporated into the FPEA based perovskite films to partially replace methylammonium (MA + ), and effects of FA + on the film's vertical orientation, light absorption capacity, carrier lifetime, defect density and electron mobility were studied. It was found that when molar ratio of FA/MA = 0.5/9.5, the film had the highest vertical orientation, enhanced light absorption, less carrier recombination loss. The obtained (FPEA) 2 (FA 0.05 MA 0.95 ) 4 Pb 5 I 16 based n-i-p PSCs gave a maximum efficiency of 12.17% under standard illumination, retaining 83% of the initial efficiency after stored in air environment (25–30 °C) with 40 ± 5% RH for 1080 h. The results demonstrate an efficient approach to prepare high-quality quasi-2D perovskite films in a n-i-p structure as well as improved device efficiency and stability.
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FOOD CONTROL
·
2023
·
IF 6
Chenfei Han,Yu Xiao,Zhenjiang Liu,Daolin Du,Ming Li
To improve the performance of aptasensor, the coupling of novel material and strategy had been the hottest research with the promising prospects. In this study, a cascade amplifying aptasensor (CA-aptasensor), which had coupled the DNase I-assisted cyclic enzyme digestion and AgNPs@gel-enhanced fluorescence, had reflected the desired performance for positively correlated detecting OTA . For this purpose, the GO@PVP was used to adsorb and quench the free FAM-Apt, while the complex of OTA and FAM-Apt was digested by the DNase I. The released OTA allowed the free FAM-Apt to separate from the GO@PVP cyclically, thus the OTA level was amplified preliminarily. The AgNPs@gel could combine with the released FAM to form the metal enhanced fluorescence (MEF) effect, resulting in the cascade signal amplification. The OTA was detected at pg mL −1 level with an ultrasensitive LOD of 3.33 pg mL −1 and IC 50 of 13.6 pg mL −1 , which improved 90-fold and 728-fold than that of ELASA for same aptamer. The CA-aptasensor indicated high specificity, reliability and practicability. Meanwhile, the CA-aptasensor exhibited more highlights, including the efficient homogeneous system, low background signal and standardized aptamer recognizer. This study might provide a new approach for improving the performance of aptasensor, which could also guide the signaling cascade and positively correlated detection for other risk factors.
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SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2022
·
IF 4.831
Xiaozong Dou,Zhenhong Jia,Hongyan Zhang,Chu Chen,Ling Zhang,Jianping Man,Weiyuan Gu
A high-performance fluorescent probe 2,5-dimercapto-1,3,4-thiadiazole copper nanoparticles (DMTD-CuNPs) was synthesized by hydrothermal method based on monovalent copper (Cu(I)) and 2,5-dimercapto-1,3,4-thiadiazole (DMTD), and it can effectively detect cysteine (Cys) in plasma. Experiments show that DMTD can reduces band gap of Cu(I) in DMTD-CuNPs, promote charge transfer transition from DMTD to Cu(I) and significantly enhance fluorescence intensity of DMTD-CuNPs at 515 nm. The large Stokes shift of DMTD-CuNPs is 315 nm, which can reduce the self-quenching of probe fluorescence and improves detection accuracy of the probe. In the presence of Cys, fluorescence of DMTD-CuNPs at 515 nm is significantly quenched because Cys reacts with Cu(I) in DMTD-CuNPs through Cu-S bond to form reduced charge transfer, which can be successfully used for the detection of Cys. Linear range and detection limit for Cys detection are 25–65 µM and 50 nM, respectively. Furthermore, feasibility of detecting Cys in plasma using DMTD-CuNPs probe was evaluated by standard addition method, and the absolute recovery is 96–99%. Such a DMTD-CuNPs probe shows high sensitivity, good selectivity and low detection limit for Cys, which is expected to be used for the practical analysis of Cys in plasma.
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SENSORS AND ACTUATORS B-CHEMICAL
·
2022
·
IF 9.221
Ziwen Tao,Guotao Yi,Chao Zeng,Qianfen Zhuang,Yong Wang
Silver ion (Ag + ) is one of the most toxic and dangerous heavy metal pollutants. Therefore, finding a simple, sensitive and selective approach to detect Ag + is very urgent for environmental protection and risk reduction to human health. In this work, water-soluble red-emitting micellized phosphorescent silver nanoclusters (Ag 29 @Na micelles) with a large stokes shift of 380 nm are prepared and used as sensitive and selective phosphorescent probes to realize the rapid and simple detection of Ag + . Upon adding Ag + , the phosphorescence of Ag 29 @Na micelles is quenching, and the phosphorescence quenching ratio is linearly proportional to the Ag + concentration over the range from 1 nM to 100 nM with the detection limit of 0.8 nM ( S / N = 3). The Ag 29 @Na micelles exhibit high selectivity for Ag + over other potentially interfering metal ions . The quenching mechanism of Ag 29 @Na micelles by Ag + is studied in details using various analytical characterizations including UV–vis absorption spectroscopy, photoluminescence lifetime, X-ray photoelectron spectroscopy, transmission electron microscopy , and zeta potential , and the results denote that the aggregation between Ag 29 @Na micelles and Ag + is responsible for the phosphorescence quenching. The Ag 29 @Na micelles-based phosphorescence probes are successfully applied to detect Ag + in lake water samples with good recoveries of 98 %−108 %.
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Biomedicines
·
2023
·Vol. 11
·期 7
·2030
·
IF 4.7
Jie Zhao,Geng Tian,Haibin Qu
The continuous twin-screw wet granulation (TSWG) process was investigated and optimized with prediction-oriented I-optimal designs. The I-optimal designs can not only obtain a precise estimation of the parameters that describe the effect of five input process parameters, including the screw speed, liquid-to-solid (L/S) ratio, TSWG feed rate, and numbers of the 30° and 60° mixing elements, on the granule quality in a TSWG process, but it can also provide a prediction of the response to determine the optimum operating conditions. Based on the constraints of the desired granule properties, a design space for the TSWG was determined, and the ranges of the operating parameters were defined. An acceptable degree of prediction was confirmed through validation experiments, demonstrating the reliability and effectiveness of using the I-optimal design method to study the TSWG process. The I-optimal design method can accelerate the screening and optimization of the TSWG process.Keywords:twin-screw wet granulation (TSWG);I-optimal design;continuous manufacturing;process understanding;design space
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FUEL PROCESSING TECHNOLOGY
·
2023
·
IF 7.5
Qiang Le,Zan Liu,Zhilin Cheng
In this work, a novel core-shell nanostructured coaxial nanofiber membranes (CFMs) were successfully produced by the coaxial electrospinning . The structure and composition of CFMs were probed by a series of characterizations. The results demonstrated that the CFMs were comprised of the versatile core-shell structure nanofibers, therein Cu(I)/UIO-66 scattered in the shell layer and HNTs dispersed in the core layer. As applied in the selective adsorption desulfurization , the Cu(I)/UIO-66 embedded on the surface of the nanofiber undertook the adsorption active sites, while HNTs in core layer served as enhancing the mechanical performance of PAN nanofibers. The CFMs had the superior adsorption performance in the batch adsorption (maximum:40.14 mg·g −1 ) and fixed-bed adsorption (maximum: 47.43 mg·g −1 ) capacities for benzothiophene (BT) from fuel oil, respectively. Furthermore, due to having the robust mechanical performance, the CFMs exhibited the preferable recycling adsorption and mechanical stability . The adsorption mechanism of BT molecules on CFMs was explored by the kinetics, isotherms and thermodynamic models , indicating the existence of the synergistic effect of physical adsorption and chemical adsorption.
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Foods
·
2021
·Vol. 10
·期 12
·2896
·
IF 4.35
Liangliang Zhu,Hongshun Hao,Chao Ding,Hanwei Gan,Shuting Jiang,Gongliang Zhang,Jingran Bi,Shuang Yan,Hongman Hou
To achieve the rapid detection ofListeria monocytogenes, this study used aptamers for the original identification and built a photoelectrochemical aptamer sensor using exonuclease-assisted amplification. Tungsten trioxide (WO3) was used as a photosensitive material, was modified with gold nanoparticles to immobilize complementary DNA, and amplified the signal by means of the sensitization effect of CdTe quantum dots and the shearing effect of Exonuclease I (Exo I) to achieve high-sensitivity detection. This strategy had a detection limit of 45 CFU/mL in the concentration range of 1.3 × 101–1.3 × 107CFU/mL. The construction strategy provides a new way to detectListeria monocytogenes.Keywords:photoelectrochemical detection;aptamer;Listeria monocytogenes;quantum dots;exonuclease I
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