Biomaterials Science
·
2021
·Vol. 10
·期 2
·457-466
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IF 6.843
Huiqiang Qiu,Hengtai Gong,Yuheng Bao,Hong Jiang,Weijun Tong
Inflammatory bowel disease (IBD) is related to excessive reactive oxygen species (ROS) and high expression of proinflammatory cytokines. An enzymatically active drug carrier that can simultaneously scavenge excessive ROS and deliver anti-inflammatory drugs to inhibit the production of inflammatory cytokines may lead to improved therapeutic effects. Herein, nanoparticles (NPs) that can target activated macrophages, remove ROS and release anti-inflammatory drugs are fabricated by loading budesonide (Bud) into dextran sulfate sodium (DSS)-coated hollow mesoporous manganese dioxide (hMnO2) NPs. This strategy can treat IBD better through the synergistic effect of the ROS-scavenging hMnO2 carriers and anti-inflammatory drug by blocking the amplification effect of inflammation. In addition, compared with free Bud, the drug delivery system can reduce side effects of Bud and improve its treatment outcome at the same dosage. Therefore, this study provides a new method for the design of highly effective synergistic anti-inflammatory nanomedicines.
研究领域:
药学
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纳米技术
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炎症生物学
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药物递送系统
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PubMed
高影响因子
Journal of Water Process Engineering
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2022
·
IF 7.34
Lingjie Ke,Jing Liu,Lei Sun,Fei Pan,Xiangjuan Yuan,Dongsheng Xia
In this paper, a series of copper oxide supported manganese dioxide (Cu X Mn T ) composites were prepared by the hydrothermal and deposition precipitation methods. The effects of different hydrothermal temperatures (100 °C–180 °C) and copper doping amounts (1–10 mM) on the structural and physicochemical properties of Cu X Mn T composites were systematically investigated. The BET, SEM , and XRD characterizations revealed that the Cu X Mn T composites exhibited a typical rod-like structure. Besides, with the increscent hydrothermal temperature, the BET specific surface area decreased and the crystal form of the composites changed from α-MnO 2 to β-MnO 2 . The Cu 1 Mn 180 with low specific surface area (3.277 m 2 g −1 ) exhibited the splendid catalytic ozonation activity and the oxalic acid (OA) removal rate reached 87.5% in O 3 /Cu 1 Mn 180 process compared with single ozonation (3.2%). Additionally, it was noteworthy that the excellent catalytic performance of Cu 1 Mn 180 (91.8% of OA removal rate) at pH 3.0 was resulted from the electrostatic adsorption. While, the complexation played a vital role for OA degradation at pH 6.0 and 9.0 with the OA removal efficiencies of 87.5 and 70.3% within 30 min, respectively. Furthermore, Cu 1 Mn 180 could obtain more than 90.9% of OA removal rate during multiple consecutive cycles, representing the satisfactory stability and reusability. Moreover, the multivalent Mn, the structural oxygen species, and Cu species played the key roles for OA degradation in O 3 /Cu 1 Mn 180 process at pH 6.0 via the TEM, ESR, XPS and O 2 -TPD characterizations. Overall, the results presented a promising alternative material for efficient catalytic ozonation application in water.
研究领域:
环境科学
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材料科学
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DOI
高影响因子
TALANTA
·
2018
·
IF 4.244
Maoqiang Chi,Yun Zhu,Liwei Jing,Ce Wang,Xiaofeng Lu
Recently, nanomaterials-based oxidase-like artificial enzymes have attracted much attention due to their unique catalytic efficiency, high environmental stability and low-cost. In this study, we for the first time show the application of polyaniline (PANi)-MnO 2 hybrid nanowires for oxidase mimicking. The PANi-MnO 2 hybrid nanowires are prepared via a redox reaction between PANi nanowires and KMnO 4 . The as-prepared PANi-MnO 2 hybrid nanowires exhibit an enhanced oxidase-like catalytic activity compared with individual PANi nanowires and MnO 2 alone due to the synergistic catalytic effect between the two components. Based on the above findings, we construct PANi-MnO 2 hybrid nanowires-based colorimetric assay for sensitive and selective detection of sulfite and ascorbic acid (AA). The detection limits of sulfite and AA are as low as 79 and 26 nM, respectively, which is much lower than many previous reported enzyme mimics-based colorimetric sensors. This work demonstrates a broad potential prospect of PANi-MnO 2 hybrid nanowires in biotechnology, environmental science and food safety.
研究领域:
生物技术
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环境科学
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食品安全
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PubMed
高影响因子
TALANTA
·
2021
·
IF 6.057
Yue Hu,Yu-Cong Fan,Xiao-Hui Jiang,Li-Mei Zhou,Zheng-Jun Cheng
By simultaneously regulating the photoluminescence of alloy Au/Ag nanoclusters (NCs) and thiamine (VB1) through MnO 2 nanosheets (MnO 2 NS), a novel ratiometric fluorescent probe (RF-probe) was established for sensitively and selectively monitoring proanthocyanidins (PAs). The introduction of Ag (I) ions could enhance significantly the quantum yields (QYs, 11.1%) of AuNCs based on the synthetic method of UVI (UV irradiation) combined with MWH (microwave heating). MnO 2 NS could quench the fluorescence (FL) of Au/AgNCs mainly coming from Förster resonance energy transfer (FRET), while it could act as a nanozyme catalyst for directly catalyzing the oxidation of VB1 to produce highly fluorescent oxVB1. In the presence of PAs, MnO 2 was reduced to Mn 2+ , which caused that its quenching capacity and oxidase-like activity were vanished, thus the FL of oxVB1 and Au/AgNCs was reduced and recovered. The concentration of PAs could be monitored by the RF-probe with a linear range of 0.27–22.4 μmol L −1 and corresponding limit of detection (LOD) and limit of quantification (LOQ) were calculated to be 75.9 and 250.5 nmol L −1 . Furthermore, the RF-probe was successfully used for the determination of PAs in mineral water, PAs additive and PAs capsule with satisfactory results compared to the standard HPLC method.
研究领域:
分析化学
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食品科学
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生物化学
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PubMed
高影响因子
JOURNAL OF POWER SOURCES
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2021
·
IF 9.127
Zheng Bo,Kexin Yi,Huachao Yang,Xinzheng Guo,Zhesong Huang,Zhouwei Zheng,Jianhua Yan,Kefa Cen,Kostya (Ken) Ostrikov
Ever-increasing mass loading of transition metal oxides (TMOs) yields high pseudocapacitance in laboratory electrochemical capacitors . However, their performance based on whole electrode mass is still far from industry standards. Highly-promising solution based on loading TMOs into 3D porous electrodes causes a yet unresolved challenge to find ways to achieve ultimate energy storage by atomically precisely loading less active material. Inspired by single-atom catalysis, we propose a new “ more from less but precise ” concept of homogeneously dispersing a common MnO 2 TMO via atomic sites to maximize atom redox reaction efficiency for industry-relevant pseudocapacitance. The concept is materialized by multifunctional MXene aerogel with super-hydrophilicity and surface functional groups, which provides 3D atomic nucleation sites to homogeneously load in-situ -formed, covalently-bonded MnO 2 nanosheets . The gravimetric capacitance of MnO 2 is largely enhanced, yielding superior pseudocapacitance of >400 F/g at > 5 mg/cm 2 that is typically achieved at 10 times lower loadings. Outstanding electrode areal capacitance is achieved using 2–3 times less MnO 2 mass, demonstrating industry-relevant pseudocapacitance almost twice higher than in state-of-the-art devices. MnO 2 /MXene//MXene asymmetric supercapacitor shows practically-high energy (~50.1 Wh/kg) and power (~10.0 kW/kg) densities, among the best MnO 2 pseudocapacitors . Capacitive-mechanism-controlled redox reactions, rarely achievable in diffusion-controlled porous pseudocapacitive electrodes, are revealed.
研究领域:
材料科学
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电化学
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高影响因子
WATER RESEARCH
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2023
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IF 12.8
Mingyue Ma,Zhenxiong Ye,Jie Zhang,Youbin Wang,Shunyan Ning,Xiangbiao Yin,Toyohisa Fujita,Yanliang Chen,Hanyu Wu,Xinpeng Wang
To address the imperative need for efficient removal of uranium-containing wastewater and mitigate radioactive contamination risks associated with nuclear energy, the development of materials with high removal efficiency and facile separation is crucial. This study designed and synthesised MnO 2 @chitosan (CTS) composite aerogel beads by in-situ growing δ-MnO 2 on porous CTS aerogel beads. This approach not only mitigates the agglomeration of MnO 2 nanospheres but also significantly enhances the porous structure and surface area of MnO 2 @CTS. These cost-effective and eco-friendly millimeter-scale spherical aerogels exhibited convenient separation properties after adsorption. These characteristics help mitigate the risk of equipment seam blockage and secondary pollution that are often associated with powdered adsorbents. Additionally, MnO 2 @CTS exhibited remarkable mechanical strength (stress approximately 0.55 MPa at 60 % strain), enabling rapid separation and easy regeneration while maintaining high adsorption performance even after five cycles. Significantly, MnO 2 @CTS exhibited a maximum adsorption capacity of 410.7 mg/g at pH 6 and 298 K, surpassing reported values for most CTS/MnO 2 -based adsorbents. The chemisorption process of U(VI) on MnO 2 @CTS followed the pseudo-second-order kinetic and Dubinin-Radushkevish models. X-ray photoelectron spectroscopy analysis further confirmed the reduction of U(VI) to U(V/IV). These findings highlight the substantial potential of MnO 2 @CTS aerogel beads for U(VI) removal from aqueous solutions, positioning them as a promising solution for addressing U(VI) contamination in wastewater.
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高影响因子
GREEN CHEMISTRY
·
2023
·
IF 9.8
Shihao Su,Guojun Lv,Xuyang Zou,Jiangzhang Wang,Chaoyi Zhou,Yan Chen,Jialing Shen,Yangbin Shen,Zhongmin Liu
In the cyclic alkene epoxidation reactions using molecular oxygen as oxidant, aldehyde is generally added as co-oxidant to assist transition metal catalyst to activate the oxygen molecule, oxidizing cyclic alkene and producing the corresponding epoxide; however, the added aldehyde would be converted into byproduct carboxylic acid. Herein, we report the room-temperature tandem conversion of cyclic alkenes into 1,2-diols through the application of byproduct carboxylic acid as a catalyst for epoxide hydration reaction, realizing effective utilization of the byproduct and saving energy consumption. Four kinds of nanosized MnO2 specimens, including α-, β-, δ-, and γ-MnO2, were hydrothermally synthesized and applied as heterogeneous catalysts for the room-temperature tandem conversion of cyclohexene into 1,2-cyclohexanediol using molecular oxygen as oxidant and isobutyraldehyde as co-oxidant. The characterization results demonstrated that the obtained β-MnO2 sample had the maximum Mn4+/Mn3+ ratio of 1.42 and the minimum Oads/OLatt ratio of 0.34, consistent with its least oxygen vacancies evidenced by EPR measurement. Accordingly, the β-MnO2 sample revealed the quickest alkene epoxidation reaction rate and could achieve a 99.2% cyclohexene conversion within 1 h, and meanwhile, a 73.6% 1,2-cycloheanediol yield could be attained within 24 h. A plausible mechanism for the tandem conversion of cyclohexene into 1,2-cyclohexanediol over the β-MnO2 heterogeneous catalyst was proposed and further verified by quenching experiments and DFT calculations. Furthermore, the synthesized β-MnO2 catalyst sample could be reused more than ten times, and meanwhile, the tandem conversion way could be expanded to most of the cyclic alkene substrates, which demonstrated that the β-MnO2 catalyst was an active and stable heterogeneous catalyst for tandem conversion of cyclic alkenes into 1,2-diols.
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高影响因子
CHEMOSPHERE
·
2023
·
IF 8.8
Nan Li,Fan Chen,Shunkai Xu,Shumin Zhu,Lingjun Bu,Lin Deng,Zhou Shi,Shiqing Zhou
Previous studies have found that pre-oxidation of manganese salts such as potassium permanganate and potassium manganate can remove algae in water, while existing problems such as excessive oxidation and appearance of chromaticity. In this study, our objective was to induce a Fenton-like reaction by activating sodium percarbonate (SPC) with divalent manganese (Mn(II)) to pre-oxidize algae-contaminated water. The optimal dosage of Mn(II)/SPC was determined by assessing the zeta potential of the algae and the residual Mn(II) in the solution. Moreover, we conducted a characterization of the cells post-reaction and assessed the levels of dissolved organic carbon (DOC). The disinfection by-products (DBPs) (sodium hypochlorite disinfection)of the algae-containing water subsequent to Mn(II)/SPC treatment were measured. Experiments show that Mn(II)/SPC pre-oxidation at optimal dosage acquired 88% removal of algae and less damage to the cell membrane. Moreover, the Mn(II) acted not only as a catalyst but also formed MnO 2 which adsorbed onto the cell surface and facilitated sedimentation. Furthermore, this technology exhibits the capability to effectively manage algal organic matters present in water, thereby mitigating the formation of nitrogen-containing DBPs. These results highlight the potential of Mn(II)/SPC treatment for treating water contaminated with algae, thus ensuring the safety and quality of water resources.
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高影响因子
CHEMOSPHERE
·
2020
·
IF 5.778
Jian Cheng,Doudou Wang,Baohua Wang,Han Ning,Ying Zhang,Yuchao Li,Jiutao An,Peiling Gao
The α-MnO 2 , β-MnO 2 and γ-MnO 2 samples were prepared by the hydrothermal method and were used for the degradation of ciprofloxacin (CIP) wastewater in a combined DBD-catalytic process. The physical and chemical properties of the samples were systematically studied by several analytical techniques including BET, XRD, SEM, HRTEM, XPS, and H 2 -TPR. The combination of DBD with α-MnO 2 showed the highest CIP degradation efficiency, and the efficiency could reach 93.1% after 50 min, which was 10.8% and 18.1% higher, respectively, than those of β-MnO 2 and γ-MnO 2 catalysts in the plasma-catalytic system. According to the model of response surface methodology , the contribution of key experimental parameters on the CIP degradation decreased in the order: peak voltage > air flow rate > initial concentration > initial pH. The optimum operating parameters were peak voltage 17 kV, air flow rate 2.5 L min −1 , an initial concentration 5 mg L −1 and an initial pH 6.9. The quenching experiments of active species showed that OH and O 2 − were critical to the CIP degradation. The generated O 3 might be adsorbed by the α-MnO 2 catalyst and resulted in more OH generation. The intermediate products of CIP degradation in DBD+α-MnO 2 system were analyzed by LC-MS, and three possible degradation pathways were proposed. This research provides an insight into the use of the crystallographic structures in discharge plasma system for antibiotics in water.
研究领域:
环境科学
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化学工程
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PubMed
高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
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2020
·
IF 4.65
Mingliang Ma,Yuying Yang,Yan Chen,Yong Ma,Ping Lyu,Aiqi Cui,Weibo Huang,Zhe Zhang,Yanzheng Li,Feiyan Si
The flower-like Fe 3 O 4 /SiO 2 /MnO 2 /BiOBr-Bi magnetic composite photocatalyst was prepared in this work. The combination of BiOBr and Bi metal with flower-like MnO 2 constituted a heterojunction structure, which increased the specific surface area of the photocatalyst and promoted the separation of photo-generated carriers, resulting in the enhanced catalytic performance. The morphologies and the compositions of the photocatalyst were characterized in detail. Under simulated light, the degradation of organic dye methylene blue (MB) was used to research the photocatalytic activity. In the case of 15 mg photocatalyst, it was found that the photocatalytic degradation efficiency to the MB solution was 95.23% within 150 min. Moreover, the degradation rate of MB could still reach 81.11% after four cycles. The design of flower-like composites with magnetic core-shell structure provided a new method for fabricating photocatalysts having excellent catalytic performance and cyclic stability.
研究领域:
材料科学
·
环境科学
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DOI
高影响因子
ACS Applied Materials & Interfaces
·
2018
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IF 8.097
Ting Xiao,Jian Sun,Jiahui Zhao,Shuang Wang,Guoyong Liu,Xiurong Yang
As an essential and universal hydrolase, alkaline phosphatase (ALP) has been identified as a crucial indicator of various diseases. Herein, we, for the first time, expanded the application of fluorescent polydopamine (F-PDA) nanoparticles to nanoquencher-based biosensing system, as well as discovered the reversible quenching effect of manganese dioxide (MnO2) nanosheets on the fluorescence of F-PDA nanoparticles and intensively confirmed the quenching mechanism of Förster resonance energy transfer by using transmission electron microscopy, UV–vis, Fourier transform infrared spectroscopy, and fluorescence lifetime experiments. By means of the ALP-triggered generation of ascorbic acid (AA) from the substrate ascorbic acid 2-phosphate, the AA-triggered reduction of MnO2 nanosheets to Mn2+, as well as the clear quenching mechanism of F-PDA nanoparticles by MnO2 nanosheets, we have developed a label-free, low-cost, visual, and facile synthetic fluorescent biosensor for convenient assay of ALP activity. The fluorescent bioassay shows a good linear relationship from 1 to 80 mU/mL (R2 = 0.999), with a low detection limit of 0.34 mU/mL, and the excellent applicability in human serum samples demonstrates potential applications in clinical diagnosis and biomedical research.
研究领域:
生物化学
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纳米医学
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临床诊断
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DOI
PubMed
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
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2017
·
IF 5.401
Su-Juan Li,Jing-Chao Zhang,Juan Li,Hong-Yuan Yang,Jing-Jing Meng,Bing Zhang
In this paper, a 3D sandwich structured hybrid of gold nanoparticles (AuNPs) decorated MnO 2 /graphene (GP)-carbon nanotubes (CNTs) was prepared via three steps, and the resultant AuNPs/MnO 2 /GP-CNTs hybrids was characterized by field-emission scanning electron microscopy (FESEM), transmission electron microscopy (TEM), energy-dispersive X-ray spectroscopy (EDX) detector and X-ray diffraction (XRD) spectrum, respectively. In this structure, the peeled GP nanosheets from CNTs work as linkers with CNTs to form 3D scaffold for facilitating fast electron conduction. The MnO 2 nanoparticles well distributed on the GP-CNTs scaffold have excellent electrocatalytic activities towards H 2 O 2 , serving as active materials for fabricating electrochemical H 2 O 2 sensors. AuNPs ( < 10 nm) uniformly distributed on the MnO 2 surface not only further enhance the electric conductivity, but also provide a second active material for sensing H 2 O 2. As a result, taking full advantage of the synergistic effect among AuNPs, MnO 2 and GP-CNTs scaffold, the as-prepared AuNPs/MnO 2 /GP-CNTs hybrids showed excellent electrocatalytic activity towards H 2 O 2 with ultrahigh detection sensitivity of 452 μA mM −1 cm −2 and low detection limit of 0.1 μM (S/N = 3). In addition, the prepared H 2 O 2 sensor was applied for the determination of real samples with satisfactory results, indicating that the prepared sensors are promising in practical application.
研究领域:
材料科学
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生物医学工程
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电化学
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高影响因子
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