JOURNAL OF NANOBIOTECHNOLOGY
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2022
·Vol. 20
·期 1
·1-19
·
IF 9.429
Ouyang Minzhi,Ouyang Xiangnan,Peng Zefang,Liu Minghui,Xu Ganqiong,Zou Zhen,Zhang Ming,Shang Quanliang
Background A balanced endogenous level of bioavailable nitric oxide (NO) plays a key role in maintaining cardiovascular homeostasis. The bioactive NO level in the cardiomyocytes was much reduced during sepsis. However, it is clinically challenging for the NO gas therapy due to the lack of spatial and temporal release system with precise control. The purpose of this study is to design a NO-releasing biomaterial with heart-targeted capability responsive to the infectious microenvironment, thus ameliorating lipopolysaccharide (LPS)-induced cardiac dysfunction.Results The heart-targeted NO delivery and in situ releasing system, PCM-MSN@LA, was synthesized using hollow mesoporous silica nanoparticles (MSN) as the carrier, and L-arginine (LA) as the NO donor. The myocardial delivery was successfully directed to heart by specific peptide (PCM) combined with low-intensity focused ultrasound (LIFU) guidance. The myocardial system synthesized NO from the LA released from PCM-MSN@LA in the presence of increased endogenous nitric oxide synthase (NOS) activity induced by LPS. This targeted NO release in situ achieved extraordinary protective effects against LPS-challenged myocardial injury by reducing the recruitment of inflammatory cells, inhibiting oxidative stress and maintaining the mitochondria integrity. In particular, this protection was not compromised by simultaneous circulation collapse as an adverse event in the context.Conclusion sPCM-MSN@LA + LIFU exhibited extraordinary cardioprotective effects against severe sepsis in the hearts of LPS-treated animals without the side effect of NO diffusion. This technology has great potential to be served as a novel therapeutic strategy for sepsis-induced myocardial injury.
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PubMed
高影响因子
Journal of Advanced Ceramics
·
2022
·Vol. 11
·期 7
·1117-1130
·
IF 11.534
Tao Junnan,Wang Mingyuan,Liu Guiwu,Liu Qinqin,Lu Lei,Wan Neng,Tang Hua,Qiao Guanjun
Converting water into hydrogen fuel and oxidizing benzyl alcohol to benzaldehyde simultaneously under visible light illumination is of great significance, but the fast recombination of photogenerated carriers in photocatalysts seriously decreases the conversion efficiency. Herein, a novel dual-functional 0D Cd 0.5 Zn 0.5 S/2D Ti 3 C 2 hybrid was fabricated by a solvothermally in-situ generated assembling method. The Cd 0.5 Zn 0.5 S nano-spheres with a fluffy surface completely and uniformly covered the ultrathin Ti 3 C 2 nanosheets, leading to the increased Schottky barrier (SB) sites due to a large contact area, which could accelerate the electron-hole separation and improve the light utilization. The optimized Cd 0.5 Zn 0.5 S/Ti 3 C 2 hybrid simultaneously presents a hydrogen evolution rate of 5.3 mmol/(g·h) and a benzaldehyde production rate of 29.3 mmol/(g·h), which are ∼3.2 and 2 times higher than those of pristine Cd 0.5 Zn 0.5 S, respectively. Both the multiple experimental measurements and the density functional theory (DFT) calculations further demonstrate the tight connection between Cd 0.5 Zn 0.5 S and Ti 3 C 2 , formation of Schottky junction, and efficient photogenerated electron—hole separation. This paper suggests a dual-functional composite catalyst for photocatalytic hydrogen evolution and benzaldehyde production, and provides a new strategy for preventing the photogenerated electrons and holes from recombining by constructing a 0D/2D heterojunction with increased SB sites.
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高影响因子
FIBERS AND POLYMERS
·
2022
·Vol. 23
·期 10
·2740-2747
·
IF 2.347
Zheng Jiaojiao,Zhang Hong,Cao Tianyu,Zhu Yuanyuan,He Lizhong,Li Jianwei,Chen Xudong,Qu Yinhu
Superhydrophobic surfaces by creating surface roughness followed by coating with low-surface-energy fluorinated materials have been intensively developed on cotton fabrics. However, exploring superhydrophobic surfaces with non-fluorine components and further improving their attachment with cotton fabrics is still challenging. Herein, we developed a superhydrophobic surface on cotton fabric by dip coating with hexadecylamine (HDA) modified copper nanowires (Cu NWs) based on the coordination between Cu atoms and amine groups. The HDA modified Cu NWs not only created surface roughness, but also decreased the surface energy, leading to a superhydrophobic cotton fabric with water contact angle of 164 °±2.0 °. Furthermore, ultrasonic washing and tape peeling tests exhibited the Cu NWs were adhered tightly to the surface of cotton fibers, owing to the strong hydrogen bond between amine groups on HDA molecules and hydroxyl groups on cotton fibers. In addition, the superhydrophobic cotton fabric showed excellent antifouling, oil-water separation and infrared reflection properties. It is believed that this facile method provide promising industrial applications for fabricating superhydrophobic surfaces on other substrates.
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高影响因子
JOURNAL OF MATERIALS SCIENCE
·
2022
·Vol. 57
·期 27
·13078-13096
·
IF 4.682
Xie Ruihang,Yuan Yexin,Sun Pengbo,Liu Zhe,Ma Jinpeng,Yang Guorui,Wang Kui,Li Ming,Shang Lei,Ao Yuhui
The preparation of bio-based epoxy resin with excellent thermal properties and flame retardant properties from green renewable resources had attracted extensive attention in recent years. Starting from the driving structural properties, the purpose of this study is to prepare multifunctional triglycidylester- diphenolic acid- bio-based epoxy (TDBE) with diphenolic acid (DPA), triglycidyl isocyanurate (TGIC), and 9,10-dihydro-9-oxa-10-phosphophenanthrene 10 oxide (DOPO) as raw materials. TDBE/DDM and bisphenol A epoxy resin curing agent (DGEBA/DDM) was prepared with 4,4 '- diaminodiphenylmethane (DDM) as curing agent. TDBE/DDM has excellent fire safety. LOI value rose from 24.5 to 42.0%, and the UL-94 test level passes V-0 level. In the cone calorimeter test, the peak heat release rate (pHRR) is decreased by 69.3%. Besides, the lap shear TDBE adhesive strength was 42.9 MPa, which increased by 62.5%. This new multifunctional bio-based flame retardant epoxy resin provides a broader application prospect for high-performance materials. Graphical Abstract
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高影响因子
npj Flexible Electronics
·
2022
·Vol. 6
·期 1
·1-14
·
IF 12.019
Tang Jie,Zhao Chao,Luo Qian,Chang Yu,Yang Zhenguo,Pan Tingrui
Emerging tactile sensing devices mimic biological functions of human mechanoreception. By introducing the feature of optical transparency, it can lead to a combined capacities of tactile and visual intelligence into single system. Yet, it is difficult to realize ultrahigh level of optical transparency and device sensitivity in single structure, for the widely used methods for sensitivity improvement, such as elevating the interfacial roughness, may further reduce the transparency. By utilizing a transparent ionic material with tunable surface topologies, as well as introducing a strategy of refractive index matching, we have proposed a transparent iontronic sensing (TIS) device based on the iontronic sensing mechanism, simultaneously offering combined high device sensitivity (83.9 kPa −1 ), with ultrahigh optical transparency (96.9%), the highest reported value in literature. Benefiting from its comprehensive performance in sensing and optical characteristics, the TIS devices hold enormous potential for the human-machine interfaces for industrial and medical applications.
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高影响因子
APPLIED PHYSICS A-MATERIALS SCIENCE & PROCESSING
·
2022
·Vol. 128
·期 9
·1-9
·
IF 2.983
Liu Fu,Wang Mingjie,Chen Yao,Gao Jianmin
When graphene is used to enhance reaction-bonded silicon carbide (RBSC), the problem of graphene being corroded by molten silicon should be considered. In this work, the polycarbosilane (PCS) was uniformly adhered to the surface of graphene nanoplatelets (GNPs) by the sol–gel method, and SiC barrier formed after pyrolysis. The structural evolution of GNPs in reaction sintering and the chemical structure of GNPs-PCS were investigated. The results showed that GNPs after siliconizing showed a porous structure, consisting of nanometer SiC particles on the surface. The ceramic yield and final pyrolysis temperature of PCS were reduced after mixing with GNPs and divinylbenzene (DVB). The SiC formed by the pyrolysis of PCS was uniformly distributed among GNPs. SiC whiskers (SiC w ) were observed in the sample of GNPs and GNPs-PCS after siliconizing. The difference and formation mechanism of SiC w in these two samples were discussed. After PCS modification and pyrolysis, GNPs survived in the loss on ignition experiment. The prepared composite powder further improved the toughness of GNPs/RBSC by 14.69%.
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高影响因子
Biomass Conversion and Biorefinery
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2022
·
IF 4.05
Xi Xi,Sun Daolai,An Hualiang,Zhao Xinqiang,Wang Yanji
The self-condensation of levulinic acid was studied using cesium silicotungstate (Cs x H 4-x SiW 12 O 40 ) catalyst without solvent. The Cs x H 4-x SiW 12 O 40 catalyst was characterized by FT-IR, Raman, XRD, NH 3 -TPD, N 2 adsorption–desorption, SEM, and ICP. The results showed that the structure of Keggin was well retained in all samples of Cs x H 4-x SiW 12 O 40 catalyst. With a decrease of Cs content, the acid strength of Cs x H 4-x SiW 12 O 40 catalyst decreased, and thus the yield of cyclic C 10 products decreased accordingly, while that of linear C 10 products increased. The effect of reaction conditions on levulinic acid self-condensation was studied using Cs 2.5 H 1.5 SiW 12 O 40 (H 2 SO 4 ) catalyst. Under the conditions of catalyst amount of 15 wt.%, reaction temperature of 130 °C, and reaction time of 6 h, the conversion of levulinic acid was 53.8%, and the total selectivity of C 10 products were 83.1%. Through spectroscopic characterization and DFT calculation, the possible structures of C 10 products of levulinic acid aldol self-condensation were deduced. The results showed that levulinic acid condensed in two different paths to form two intermediates, 4-hydroxy-4-methyl-6-oxononanedioic acid and 3-acetyl-4-hydroxy-4-methylheptanedioic acid. The two intermediates were then subjected, respectively, to lactonization and intramolecular dehydration to three cyclic C 10 products: 5-(2-methyl-5-oxotetrahydrofuran-2-yl)-4-oxopentanoic acid, 3-(2-methyl-5-oxotetrahydrofuran-2-yl)-4-oxopentanoic acid, and 3-(3-acetyl-2-methyl-5-oxotetrahydrofuran-2-yl) propanoic acid, and to obtain the linear C 10 product, (E)-4-methyl-6-oxonon-4-enedioic acid.
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高影响因子
COLLOID AND POLYMER SCIENCE
·
2022
·Vol. 300
·期 10
·1113-1127
·
IF 2.434
Fang Xiya,Shi Yan,Yan Chunfu,Wang Honggen,Hui Jia
In this paper, gradient and block polycarboxylate ether superplasticizers (PCEs) composed of allyl alcohol polyoxyethylene ether macromonomer and acrylic acid were synthesized via aqueous reversible addition-fragmentation chain transfer (RAFT) polymerization. The molecular structure of PCEs was characterized by 1 H nuclear magnetic resonance (NMR), Fourier transform infrared (FT-IR) spectroscopy, and size exclusion chromatography (SEC), and the fluidity of cement paste and the influence of SO 4 2− on the dispersibility of PCEs were investigated in detail. The experimental results show that the molecular weight and polydispersity of the obtained PCEs were well controlled by the RAFT process. Compared with the PCEs prepared by conventional free radical polymerization, the gradient PCEs synthesized by RAFT polymerization exhibited excellent dispersion capability. The range of molecular weights and acid-ether ratios of the gradient PCEs for high fluidity of cement paste was much wider. Furthermore, PCEs with gradient structure also showed excellent sulfate resistance. In contrast, PCEs with block architecture exhibited the lowest flowability. Based on these findings, the relationship between dispersibility of PCEs and their chemical structures was illustrated.
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高影响因子
Nature Communications
·
2022
·Vol. 13
·期 1
·1-13
·
IF 17.694
Xiao Kui,Zhang Niyuan,Li Feifei,Hou Dayong,Zhai Xiaoyi,Xu Wanhai,Wang Gelin,Wang Hao,Zhao Liang
Medicinal applications of gold complexes have recently attracted attention due to their innovative antitumor mechanisms. In this work, two hypercoordinated carbon-centered gold clusters PAA4 and PAA5 are quantitatively synthesized by an intramolecular 6- exo - dig cyclization of polymetalated precursors. The on-bench and in vitro experimental studies demonstrate that the characteristic hypercarbon-tetragold(I) multi-center bonding in PAA4 and PAA5 not only guarantees their stability under common physiological conditions, but also facilitates a glutathione (GSH)-triggered prompt and synergetic release of active Au(I) ions in the GSH-overexpressed and acidic microenvironment of human bladder cancer EJ cells. The instantly massive release of coordination unsaturated Au(I) ions causes the efficient inhibition of thioredoxin reductases and then induces a rapid pro-oxidant response, consequently causing the occurrence of accelerated ferroptosis of EJ cells. As a result, these hypercarbon-centered gold(I) cluster prodrugs show high cytotoxicity to bladder cancer cell lines and thus exhibit a significant inhibition effect towards bladder tumors in vivo. Correlation of the synergetic domino dissociation of carbon-polymetal multi-center bonding in metal clusters with the accelerated ferroptosis of cancer cells provides a strategy for metallo-prodrugs and opens a broader prospect for the biological application of metal cluster compounds.
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PubMed
高影响因子
Biomass Conversion and Biorefinery
·
2022
·
IF 4.05
Li Zhengsheng,Shao Shanshan,Hu Xinggang,Li Xiaohua,Cai Yixi
The catalytic conversion of renewable biomass-derived aldehydes and ketones to aviation fuels is very attractive for sustainable development. We provided insight into the production of aviation fuel from typical biomass carbonyl platform compounds (furfural, acetone, butanone, and butyraldehyde) by aldol condensation followed with hydrodeoxygenation over bifunctional catalyst Ni/Mg–Al-O/AC, focusing on the mechanism of condensation reaction. It was found that high temperature is not only conducive to aggravate the depth of aldehyde ketone condensation reaction, further convert dimer to trimer, but also promote its self-condensation. The optimal condensation temperature of aldehydes and ketones under this idea was 170 °C, the carbon number range of the jet fuel intermediates was C7–C14, and the yield of condensates reached 79.23%. In order to explore the mechanism in the aldol condensation of aldehydes and ketones, the evolution law of typical products was studied by controlling the reaction time, and seven main condensation pathways were proposed. The ratios of aldehyde/ketone in the reactant and the ratios of each component within the aldehyde and ketone were adjusted, and it was found that the reaction priority of chain aldehydes is the highest in this reaction system, and the reaction priority of small-molecule ketones with low carbon number is higher than that of high carbon number ketones. The presence of long-chain groups in the hydrogenated oil increased the density of jet fuel, and it has a higher calorific value, which are very promising as aviation fuels or additives of aviation bio-fuels.
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高影响因子
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
·
2022
·Vol. 414
·期 20
·6247-6257
·
IF 4.478
Li Tingting,Deng Donglian,Tan Dongdong,Chen Siqi,Ji Yibing,Li Ruijun
Covalent organic frameworks (COFs) with uniform porosity, good stability, and desired biocompatibility can function as carriers of immobilized enzymes. However, the obstructed pores or partially obstructed pores have hindered their applicability after loading enzymes. In this study, the hierarchical COFs were prepared as an ideal support to immobilize glucose oxidase (GOD) and obtain GOD@COF. The hierarchical porosity and porous structures of COFs provided sufficient sites to immobilize GOD and increased the rate of diffusion of substrate and product. Moreover, N,Fe-doped carbon dots (N,Fe-CDs) with peroxidase-like activity were introduced to combine with GOD@COF to construct an enzyme-mediated cascade reaction, which is the basis of the sensor GOD@COF/N,Fe-CDs. The sensor has been successfully built and applied to detect glucose. The limit of detection was 0.59 μM for determining glucose with the proposed fluorescence sensor. The practicability was illustrated by detecting glucose in human serum and saliva samples with satisfactory recoveries. The proposed sensor provided a novel strategy that introduced COF-immobilized enzymes for cascade reactions in biosensing and clinical diagnosis. Graphical abstract
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高影响因子
JOURNAL OF SOL-GEL SCIENCE AND TECHNOLOGY
·
2022
·Vol. 103
·期 3
·890-897
·
IF 2.606
Tian Zhennan,Wu Taiqi,Hu Rong,Yu Junsheng,Cheng Jiang,Li Lu
In this study, a ZnO-Fe 2 O 3 thin film was designed as electron transport layer for organic solar cells (OSCs). The preparation strategy was based on the spin coating of aqueous sol–gel precursor. The result showed that composite ZnO-Fe 2 O 3 -based OSCs had higher power conversion efficiency than pure ZnO-based OSCs. To explain this result, morphology, optical and physical properties of ZnO-Fe 2 O 3 were investigated to analyze the relation between structure of interface layer and performance of OSCs. It was demonstrated that composite ZnO-Fe 2 O 3 layer had denser structure and lower surface roughness than pure ZnO layer. Thus, it showed a good contact with the active layer. Furthermore, 3.3% Fe 2 O 3 could reduce the W F and E g of ZnO, and greatly enhanced electron mobility from the acceptor (IT-4F) phase to the ZnO/ITO electrode. Meanwhile, ZnO-Fe 2 O 3 layer showed a low reflectivity that allowed more photons to entrance the active layer for utilization. Hence, the higher short-circuit current and power conversion efficiency were achieved in ZnO-Fe 2 O 3 -based OSCs.
Graphical abstract
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高影响因子
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