COLLOIDS AND SURFACES B-BIOINTERFACES
·
2020
·
IF 4.389
Ying Yang,Shuxin Wang,Yinlong Zhou,Xueyan Wang,Xuan Liu,Anjian Xie,Yuhua Shen,Manzhou Zhu
Theranostics including imaging and therapy has become an advanced trend for cancer treatment. It is of great significance to develop new theranostics agent for precision medicine research. In this regard, structurally precise metal nanoclusters (NCs) with ultra-small diameter and potential theranostic functions are no doubt to be a priority. In this study, we firstly investigated the photothermal and photodynamic properties of structurally precise oil-soluble bimetallic NCs (Pt 1 Ag 28 ) and tactfully solubilize them into the hydrophobic inner cavity of biodegradable amphiphilic chitosan derivative (ACD) micelles via hydrophobic interaction. Positively charged Pt 1 Ag 28 @ACD with suitable particle size (∼60 nm) could not only realize effectively passive targeted delivery, but also be easily uptaken by negatively charged cancer cells for increasing targeting effect. Further, the aggregation induced emission fluorescence imaging (AIE FI)-guided enhanced photothermal/photodynamic therapy (PTT/PDT) on tumor is finally nicely achieved by the micelle solubilization of ACD micelles to Pt 1 Ag 28 NCs, which were demonstrated by in vitro and in vivo experimental results. This theranostic platform overcomes the difficulty of lipophilic NCs entering water-phase organisms, provides enlightenment for the universal study of the interaction mechanism between organisms and oil-soluble NCs at the atomic level in future precision medicine research.
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DOI
高影响因子
ACS Applied Materials & Interfaces
·
2019
·
IF 8.456
Huamin Wang,Haodi Wu,Yeming Xian,Guangda Niu,Weinan Yuan,Huanyong Li,Hang Yin,Peng Liu,Yi Long,Wenzhe Li,Jiandong Fan
CsxFA1–xPbI3 single crystals are expected to provide more excitement in optoelectronic applications, including photodetector, laser, light-emitting diode, etc. Herein, we aim to gain an in-depth understanding of the growth mechanisms of perovskite single crystal with various morphologies in view of microscopic dynamics by the combination of component, structure, and solvent engineering. A sequence of CsxFA1–xPbI3 (0 ≤ x ≤ 0.14) perovskite single crystals with a dodecahedron morphology and tunable aspect ratio can be obtained by means of a solution-processed uniform-cooling approach. The optimized Cs0.1FA0.9PbI3 single crystals prepared in γ-butyrolactone mixed with dimethyl sulfoxide are theoretically and experimentally demonstrated to have superior performances, e.g., extremely higher long-term stability, lower trap density, and higher mobility. The broadband absorption, i.e., 300–910 nm, enables its application in near-infrared detection (880 nm), and the corresponding detector demonstrates higher responsivity at different light intensities and a fast photocurrent response (τ1 = 11 μs, τ2 = 10 μs). Equally important, we also explore the application of optimized Cs0.1FA0.9PbI3 single crystals with a tunable aspect ratio in an X-ray detector and the extremely high sensitivity (2772.1 μC Gyair–1 cm–2 under a bias of 150 V) demonstrates their good potential for radiation detection.
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高影响因子
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2024
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IF 3.8
Yining Chen,Qinxin Jing,Ying Zhang,Xinghan Wu,Zhongxiang Bai,Nianhua Dan,Zhengjun Li,Yuwen Li,Yunbing Wang
Diabetic wound usually accompanied by adverse factors such as hyperglycemia, oxidative stress damage, and inflammatory response is a typical refractory chronic wound. An insufficient regulation of the wound microenvironment is the limiting factor of diabetic wound healing. A drug-loaded micelle is a potential material for the treatment of diabetic wounds. Herein, an injectable, self-healable, and multiresponsive hydrogel (hydrogel@MIC&bFGF) was developed for the integrated diabetic wound therapy by a facile double-injection strategy. Meanwhile, the anti-inflammatory acetyl-11-keto-β-boswellic acid (AKBA) from a medicinal plant loaded in the hyaluronic acid-based micelles (MIC@AKBA) was encapsulated in the hydrogel along with basic fibroblast growth factor (bFGF). Hydrogel@MIC&bFGF had integrated rheology properties, antioxidant properties, and multiresponse abilities that realized the sustained release of AKBA and bFGF to treat inflammation and promote wound healing in response to glucose, reactive oxygen species, and an acidic environment. In vitro and in vivo experiments substantiated that hydrogel@MIC&bFGF showed the desired therapeutic effects for the treatment of full-thickness skin defects in diabetic rats, which promoted wound healing by reducing inflammation and oxidative stress while accelerating angiogenesis. This study provides a potential strategy for drug-loaded hydrogels for diabetic wound treatment.
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高影响因子
METABOLIC BRAIN DISEASE
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2025
·Vol. 40
·期 5
·1-14
·
IF 3.5
Zhao Hexiang,Yang Ping,Zhang Mou,Zheng Wenshu,Qi Renli,Zhu Xiaofeng,Li Jinghui,Li Shipeng
Reperfusion, while essential for restoring blood supply, paradoxically exacerbates neuronal damage through cerebral ischemia-reperfusion injury (CIRI). This study aimed to develop a reactive oxygen species (ROS)-responsive drug delivery system (DDS) loaded with edaravone (EDA) to enhance targeted therapy for CIRI. The stimuli-responsive DDS was synthesized using dextran (DEX) as the biocompatible carrier and benzeneboronic acid pinacol ester (BAPE) as the ROS-sensitive moiety. The physicochemical characteristics of the DEX-BAPE/EDA (DB/EDA) micelles were systematically evaluated. In vitro studies assessed the anti-inflammatory, antioxidant, and anti-apoptotic effects of DB/EDA. Moreover, the neuroprotective efficacy of DB/EDA in vivo was analyzed via behavioral tests, infarct volume measurement, ELISA assays of inflammatory cytokines and OS markers, and Western blot analysis of Nrf2-related pathways. Pharmacokinetics and biosafety were analyzed through plasma profiling and H&E staining. DB/EDA exhibited high stability, efficient drug encapsulation, and ROS-responsive drug release. Cellular uptake studies confirmed enhanced internalization of DB/EDA micelles in BV2 cells. In the oxygen-glucose deprivation/reoxygenation (OGD/R) model, DB/EDA significantly suppressed TNF-α, IL-1β, IL-6, and MDA, restored SOD levels, and attenuated apoptosis. In the middle cerebral artery occlusion/reperfusion (MCAO/R) mice, DB/EDA administration effectively improves cognition and mitigates neuronal damage. Mechanistically, DB/EDA activated the Nrf2/HO-1 pathway, amplifying antioxidant and anti-inflammatory responses. Pharmacokinetic analysis revealed prolonged circulation and increased brain accumulation, and histopathological analysis demonstrated the safety profile of DB/EDA. The ROS-responsive DB/EDA nano-micelles provided targeted EDA delivery to ischemic brain regions, alleviating CIRI via Nrf2 activation, suggesting that DB/EDA is a promising strategy for CIRI treatment. Graphical abstract
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产品关联
DOI
PubMed
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2018
·
IF 2.829
Yue Zhang,Caili Dai,Yao Qian,Xiqun Fan,Jianfeng Jiang,Yining Wu,Xuepeng Wu,Yongping Huang,Mingwei Zhao
A novel nanoparticle-enhanced VES fracturing system was proposed based on the conventional viscoelastic surfactant (VES) fracturing fluid composed of cetyltrimethylammonium bromide (CTAB) and sodium salicylate (NaSal). Hydrophilic silica nanoparticles were used as the addition agent in this system for enhancing properties of VES fracturing fluid. The formation of wormlike micelles by CTAB and NaSal was investigated by cryogenic transmission electron microscopy (cryo-TEM). Rheological properties of the nanoparticle-enhanced VES fracturing system were discussed in detail. With the addition of nanoparticles, the nanoparticle-enhanced VES fracturing system has higher viscosity and viscoelasticity than conventional VES fracturing fluid without nanoparticles. Constant shearing and variable shearing measurements showed the shear-resistant and restoration properties of nanoparticle-enhanced VES fracturing system. This enhancement was due to the formation of newly micelle-nanoparticle junctions and a mechanism was proposed. Formation dynamic filtration damage (DFD) measurement was conducted to study damage effects of the nanoparticle-enhanced VES fracturing system on the core. In addition, cores before and after DFD were characterized by scanning electron microscopy (SEM), showing the formation of nano-filter cake. The contact angle of water on the core surface decreased after DFD, showing stronger hydrophilicity . This work could further develop the application of nanotechnology and colloid on reservoir fracturing system.
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高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2019
·
IF 3.131
Feng Su,Peng Yun,Chenglong Li,Rongye Li,Laishun Xi,Yuandou Wang,Yangsheng Chen,Suming Li
A series of poly(2-ethyl-2-oxazoline)-poly(L-lactide) (PEOz-PLA) diblock copolymers were synthesized by ring-opening polymerization of l -lactide using a monohydroxy terminated PEOz-OH macro-initiator in the presence of stannous octoate as catalyst. The resulting diblock copolymers were characterized by 1 H nuclear magnetic resonance and gel permeation chromatography . Self-assembled micelles were prepared using the co-solvent evaporation method in water and in phosphate buffered saline (PBS) at pH 7.4, 6.5 and 5.0. The resulting micelles exhibit different morphologies, such as spherical micelles and worm-like micelles depending on the hydrophilic/hydrophobic balance. Spherical micelles were exclusively observed for PEOz-PLA copolymers with short PLA blocks, whereas co-existence of worm-like and spherical micelles was observed for copolymers with long PLA blocks. The micelle size increases with decreasing pH due to the electrostatic repulsion between PEOz chains resulting from ionization of the tertiary amide groups along PEOz chains. A hydrophobic anti-tumor drug, paclitaxel , was entrapped in PEOz-PLA micelles. High loading efficiency up to 86.7% was obtained for copolymers with long PLA blocks. Drug release was performed in PBS at different pH values. During the 30-day release period, faster release was obtained for copolymers with shorter PLA blocks than for copolymers with longer PLA blocks, at acidic pH than at pH 7.4. It is thus concluded that pH-responsive PEOz-PLA copolymer micellss could be promising as carrier of anti-tumor drugs.
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高影响因子
Materials Science & Engineering C-Materials for Biological Applications
·
2014
·
IF 2.736
Minming Wu,Kai Guo,Hongwei Dong,Rong Zeng,Mei Tu,Jianhao Zhao
Novel biomimetic amphiphilic chitosan derivative, deoxycholic acid–phosphorylcholine–chitosan conjugate (DCA–PCCs) was synthesized based on the combination of Atherton–Todd reaction for coupling phosphorylcholine (PC) and carbodiimide coupling reaction for linking deoxycholic acid (DCA) to chitosan. The chemical structure of DCA–PCCs was characterized by 1 H and 31 P nuclear magnetic resonance (NMR). The self-assembly of DCA–PCCs in water was analyzed by fluorescence measurements, dynamic laser light-scattering (DLS), zeta potential and transmission electron microscopy (TEM) technologies. The results confirmed that the amphiphilic DCA–PCCs can self-assemble to form nanosized spherical micelles with biomimetic PC shell. In vitro biological evaluation revealed that DCA–PCCs micelles had low toxicity against NIH/3T3 mouse embryonic fibroblasts as well as good hemocompatibility. Using quercetin as a hydrophobic model drug, drug loading and release study suggested that biomimetic DCA–PCCs micelles could be used as a promising nanocarrier avoiding unfavorable biological response for hydrophobic drug delivery applications.
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DOI
高影响因子
JOURNAL OF CHROMATOGRAPHY A
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2018
·
IF 3.716
Chengxin Wu,Wei Wang,Feifei Quan,Pengfei Chen,Jiali Qian,Lei Zhou,Qiaosheng Pu
Curcuminoids, the major bioactive constituents of traditional medicine known as turmeric, have exhibited extensive therapeutic benefits. Excited by violet-blue light, curcuminoids can emit native fluorescence, making them possible to be detected with high sensitivity and specificity by laser-induced native fluorescence (LINF). Here, a commercial 445 nm laser diode was used as an excitation source to construct a confocal laser-induced fluorescence (LIF) detector and then a complete capillary electrophoresis (CE) system coupled with LIF detection was established. With three major curcuminoids, curcumin, demethoxy curcumin (DMC) and bisdemethoxy curcumin (BDMC) as target analytes, a micellar electrokinetic chromatography (MEKC) method was proposed using mixed micelles consisting of Triton X-100 and SDS to sensitize the native fluorescence of curcuminoids and enhance their separation efficiency. Fluorescence spectra revealed that the mixed micelles induced fluorescence synergism could enhance the signals of three curcuminoids by 77-, 57-, and 47-fold for curcumin, DMC, and BDMC. After systematic investigation, the optimal separation buffer for curcuminoids was chosen as follows: 20 mM Triton X-100, 20 mM SDS, 30% (v/v) methanol in 10 mM borax solution at pH 10.0. Under these conditions, a baseline separation of three curcuminoids was achieved within 10 min and the detection limits were found to be 4.1, 2.6, and 0.4 ng/mL for curcumin, DMC, and BDMC, respectively. Furthermore, the developed MEKC-LINF method was validated in terms of precision, linearity, accuracy and successfully applied for the determination of three curcuminoids in turmeric, medicinal turmeric liniment, curry seasoning, and human urine samples.
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DOI
高影响因子
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
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2015
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IF 2.353
Meiduo Zhang,Dehua Li,Yi He,Guang Wang
An amphiphilic naphthopyran derivative (DSNP) with negative-charged di-sulfatoethoxy was first designed and synthesized. DSNP was used to prepare the LBL self-assembly films with cationic quaternized poly(4-vinylpyridine) (P4VPQ). The multilayer assembly process was monitored via UV–Vis spectra and the DSNP displayed a significant slow fading rate in film. In addition, DSNP was also used as the light-responsive group to fabricate light-responsive micelles with polyethylene glycol–triethylamine bromide (PEG–NEt 3 ). The photoisomerization of naphthopyran moieties can rapidly and reversibly tune the disassembly and re-assembly of the micelles. The changes of fluorescent spectra of Nile Red (NR) in water solution of polymeric micelles demonstrated that the polymeric micelle can be used as nanocarriers to encapsulate, release and re-encapsulate guest solutes on demand controlling of light irradiation. The results indicate that the amphiphilic naphthopyran can be used in both optical-switches and biomedical area for drug delivery.
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高影响因子
MACROMOLECULAR BIOSCIENCE
·
2016
·Vol. 17
·期 4
·1600262
·
IF 3.68
Qin Yun,Si Song Wang,Shan Xu,Jin Ping Yang,Juan Fan,Ling Lin Yang,Yue Chen,Shao Zhi Fu,Jing Bo Wu
Colorectal peritoneal carcinomatosis (CRPC) is a common systemic metastasis of intra-abdominal cancers. Intraperitoneal chemotherapy against CRPC is at present the preferred treatment. The aim of this study is to develop a novel hydrogel drug delivery system through the combination of 5-fluorouracil (5-FU) loaded polymeric micelles and cisplatin (DDP) in biodegradable thermosensitive chitosan (CS) hydrogel. The prepared CS hydrogel drug is a free-flowing solution at room temperature and forms a stationary gel at body temperature. Therefore, a CRPC mouse model is established to investigate the antitumor activity of CS hydrogel drug system. The results suggest that intraperitoneal administration of CS hydrogel drug can inhibit tumor growth and metastasis, and prolong survival time compared with other groups, thus improving the chemotherapeutic effect. Ki-67 immunohistochemical analysis reveals that tumors in the CS hydrogel drug group has lower cell proliferation in contrast to other groups ( P < 0.001). Furthermore, hematoxylin-eosin staining of liver and lung tissue indicates that the CS hydrogel drug has also a certain inhibitory effect on colorectal cancer metastasis to the liver and lung. Hence, the work highlights the potential clinical applications of the CS hydrogel drug.
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PubMed
高影响因子
SURFACE AND INTERFACE ANALYSIS
·
2015
·Vol. 47
·期 4
·491-497
·
IF 1.245
Kailong Cui,Xingzhong Yuan,Ting Sun,Huajun Huang,Xin Peng,Yongqiang Zhang,Guangming Zeng,Lihuan Fu
Compared with synthetic surfactants (cetyltrimethyl ammonium bromide, sodium bis(2-ethylhexyl) sulfosuccinate and Tween-80), the properties of the aqueous core as well as the microenvironment behavior were investigated in water-in-oil microemulsions, which are formed by water and biosurfactant rhamnolipid (RL) in the solvent of isooctane/n-hexanol (1:1, v/v ). Besides, as a typical substrate of lignocellulose, guaiacol was used to detect the laccase activity in reversed micelles (RMs). The results were eventually confirmed that RL-based RM system has higher solubilization ability, more friendly environmental compatibility and milder reaction microenvironment than the others. In this study, triangle phase diagram of surfactant/n-hexanol/isooctane/water was constructed to analyze the variation of phase behavior between each RM system. For the RL-based RM system, the effect of the molar ratio of water to surfactant ( ω 0 ) on enzyme hydrolytic activity was also determined to be shown as a bell-shaped curve and presented a maximum at ω 0 = 19; the O―H stretching vibrations of water in aqueous core was also studied by analyzing the IR spectrum over the region of 3050–3750 cm − 1 . Moreover, kinetic studies showed that the catalytic efficiency of the laccase in RL-based RM system was lower than in aqueous solution. Nevertheless, the RM system obtained the highest hydrolysis rate at RL concentration of 1.0CMC, which is 0.055 mM. Copyright © 2015 John Wiley & Sons, Ltd.
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高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
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2016
·
IF 3.299
Jian Long,Lin Li,Yueming Jin,Hao Sun,Yunhai Zheng,Senlin Tian
Surfactant-enhanced remediation is a powerful technology for soil clean-up. However, some drawbacks, such as its high cost and the secondary contamination caused by flushing agents, have hampered this technology and its commercial application has been largely limited to North American and European countries. The aim of this work is to introduce a novel reversible solubilization system composed of the photoresponsive surfactant 4-butylazobenzene-4′-(oxyethyl)trimethylammonium bromide (AZTMA) and the commercial non-ionic surfactant Tween80 for the solubilization of organic contaminants. The solubilization behavior of the AZTMA/Tween80 surfactant system toward polycyclic aromatic hydrocarbons (PAHs) has been studied. Critical micelle concentration (CMC) values indicate that the mixed system has a synergism in mixed micelle formation, and that the interaction parameter ( β ) is −2.85 when the mole ratio is 2:8. AZTMA is also predicted to be low biologic toxicity by the CMC and surface tension. The synergistic effect on molar solubilization ratio (MSR) and micelle-phase/aqueous-phase partition coefficient K mc values is related to the composition and concentration of the mixed system and follows the order pyrene > phenanthrene > acenaphthene, and these parameters are much higher than those for the single surfactants. After irradiation with UV light, more than 65% of the PAHs could be separated from the mixed micelles , and the cumulative release efficiencies of selected PAHs are consistent with the results of solubilization experiments. All of these features demonstrate that mixed AZTMA/Tween80 should be preferable to single surfactants for soil remediation, avoiding the issues associated with chemical flushing agents and decreasing remediation costs.
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高影响因子
危险品化学品经营许可证（带存储）