INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
·
2024
·Vol. 26
·期 1
·62
·
IF 4.9
Yuankun Wang,Chongli Wang,Weidong Lin,Qin Wang,Baisong Li,Cheng Chen,Ye Yuan,Francis Verpoort
α-Hydroxy ketones are a crucial class of organic compounds prevalent in natural products and pharmaceutical molecules. The CO2-promoted hydration of propargylic alcohols is an efficient method for the synthesis of α-hydroxy ketones. Herein, an ionic liquid (IL) was designed to catalyze this reaction individually under atmospheric CO2pressure, volatile organic solvents, and additives. This IL, constructed from the molybdate anion, can be recycled from industrial (NH4)2MoO4production wastewater, demonstrating its high tolerance to catalytic environments and significant potential for practical applications. To our knowledge, this is the first instance of an oxometallate-based IL catalyst being utilized for the CO2-promoted hydration of propargylic alcohols. Further mechanistic studies revealed the bifunctionality of this IL in activating both CO2and substrates.
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高影响因子
Journal of Advanced Research
·
2020
·
IF 6.992
Qinghai Meng,Yu Li,Tingting Ji,Ying Chao,Jun Li,Yu Fu,Suyun Wang,Qi Chen,Wen Chen,Fuhua Huang,Youran Wang,Qichun Zhang,Xiaoliang Wang,Huimin Bian
Introduction Excessive inflammation and the pyroptosis of vascular endothelial cells caused by estrogen deficiency is one cause of atherosclerosis in post-menopausal women. The autophagy is highly regulated by estrogen, however whether estrogen can reduce vascular endothelial cell pyroptosis through estrogen receptor-mediated activation of autophagy to improve atherosclerosis in post-menopausal stage is still unknown. Objectives To explore whether estrogen can prevent atherosclerosis by regulating estrogen receptor and subsequently activating autophagy to reduce inflammation and pyroptosis. Methods Aortic samples from pro-menopausal and post-menopausal women with ascending aortic arteriosclerosis were analyzed, and bilateral ovariectomized (OVX) female ApoE-/- mice and homocysteine (Hcy)-treated HUVECs were used to analyze the effect of estrogen supplementation therapy. Results The aortic endothelium showed a decrease in ERα expression and autophagy, but presented an increase in inflammation and pyroptosis in female post-menopausal patients. Estrogen treatment accelerated autophagy and ameliorated cell pyroptosis in the cardiac aortas of OVX ApoE-/- mice and Hcy-treated HUVECs. Estrogen had therapeutic effect on atherosclerosis and improved the symptoms associated with lipid metabolism disorders in OVX ApoE-/- mice. Inhibition and silencing of ERα led to a reduction in the autophagy promoting ability of estrogen and aggravated pyroptosis. Moreover, the inhibition of autophagy promoted pyroptosis and abolished the protective effect of estrogen, but had no influence on ERα expression. Conclusion The results of the present study demonstrated that post-menopausal women present decreased autophagy and ERα expression and excessive damage to the ascending aorta. In addition, in vitro and in vivo assay results demonstrated that estrogen prevents atherosclerosis by upregulating ERα expression and subsequently induces autophagy to reduce inflammation and pyroptosis.
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COMPOSITES SCIENCE AND TECHNOLOGY
·
2025
·
IF 9.8
Jianpeng Wu,Kexu Zhan,Junshuo Zhang,Yu Wang,Shuaishuai Sun,Shouhu Xuan,Shiyu Lin,Zimu Li,Ziyang Fan,Shuai Liu,Zhihao Hu,Xinyi Wang,Xinglong Gong
Lightweight materials with outstanding mechanical durability and heat attenuation play an indispensable role in personnel safeguard. Aerogels are excellent insulation materials while presenting low strength, posing a challenge to integrated protection. Herein, a dehydration-induced aggregation strategy is proposed to reinforce lamellar aramid nanofiber aerogels through impregnation in polyvinyl alcohol (PVA) solution followed by hot-pressing. PVA shrinkage facilitates synergistic fiber crosslinking and sheet densification in the resulting AFPA aerogels, achieving extraordinary specific tensile modulus (1143.2 MPa cm 3 g −1 ) and toughness (2557 kJ m −3 ). Both experiments and simulations demonstrate that the aggregated fibrous network extends fracture period by re-orientation and crack deflection, which enables AFPAs 220 % and 162 % greater specific puncture energy than woods and leathers. Benefiting from the lamellar porous skeleton with low PVA content, AFPAs not only prevent the invasion of heat and fire, but maintain 95 % of initial strength and robust impact dissipation after heat treatment at 300 °C. With a low thermal conductivity of 31 mW m −1 K −1 , AFPAs provide better thermal comfort from −106 to 150 °C than duck down with only 31 % of its thickness. This integrated protection system can be re-established by a solvent-mediated recycling approach, promoting their sustainable applications across fire-fighting, anti-seismic building, and aircrafts.
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BRITISH JOURNAL OF NUTRITION
·
2015
·Vol. 114
·期 6
·866-872
·
IF 3.453
Xihong Zhou,Jingqing Chen,Weiche Wu,Xinxia Wang,Yizhen Wang
n-3 Long-chain PUFA up-regulate intestinal lipid metabolism. However, whether these metabolic effects of PUFA on intestine are mediated by AMP-activated protein kinase (AMPK) remains to be elucidated. To determine the effects of α-linolenic acid (ALA) on intestinal fatty acid (FA) metabolism and whether these effects were affected by AMPK deletion, mice deficient in the catalytic subunit of AMPKα1 or AMPKα2 and wild-type (WT) mice were fed either a high-fat diet (HF) or HF supplemented with ALA (HF-A). The results showed that ALA supplementation decreased serum TAG content in WT mice. ALA also increased mRNA expression of genes (carnitine palmitoyltransferase 1a, acyl-CoA oxidase 1, medium-chain acyl-CoA dehydrogenase, cytochrome P450 4A10 and pyruvate dehydrogenase kinase isoenzyme 4a) involved in intestinal lipid oxidation and mRNA expression of TAG synthesis-related genes (monoacylglycerol O-acyltransferase 2, diacylglycerol O-acyltransferases 1 and 2) in WT mice. Consistent with these, expression levels of phosphorylated AMPKα1 and AMPKα2 were also increased in WT mice after ALA addition. However, in the absence of either AMPKα1 or AMPKα2, ALA supplementation failed to increase intestinal lipid oxidation. In addition, no significant effects of either diet (HF and HF-A) or genotype (WT, AMPKα1–/– and AMPKα2–/–) on FA uptake in the intestine and faecal TAG output were observed. Our results suggest that AMPK is indispensable for the effects of ALA on intestinal lipid oxidation.
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NANO
·
2022
·
IF 1.438
Canguo Li,Qiying Zhu,Meng Jiang,Huiqin Chang,Liguo Zhao,Ling Kong,Zhiwei Chen,Jun Wang,Hongyun Tian
Cow milk is an important source of protein, but it is also a food that can cause allergies. In this research, a novel photoelectrochemical immunosensor based on CdWO 4 –CdS type-II heterojunction was constructed for the detection of allergen α -lactalbumin ( α -Lac) in milk. CdWO 4 –CdS heterojunction was synthesized by one-step hydrothermal method. Compared with pure CdWO 4 , the CdWO 4 –CdS heterojunction significantly improved the photocurrent intensity. The polydopamine (PDA) was used as a crosslinking agent to couple basis materials and biomolecules. Ascorbic acid was used as an efficient electron donor to eliminate the photo-generated holes and inhibit the recombination of photo-generated electrons and holes. Under the optimum experimental conditions, the photocurrent intensity reduced linearly with the logarithm of α -Lac concentration ranging from 0.001 ng ⋅ mL − 1 to 10 ng ⋅ mL − 1 and the limit of detection was 0.17 pg ⋅ mL − 1 . The constructed photoelectrochemical immunosensor exhibited excellent stability, selectivity and reproducibility, which provided a novel ideal for sensitive detection of α -Lac and shed light on monitoring of other allergenic proteins in foods.
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Food & Function
·
2025
·
IF 5.4
Hailing Song,Yun Ma,qian Du,Zeyuan Deng,Yalun Zou,Yadong Miao,Jing Li,Liufeng Zheng
Methionine-containing cyclolinopeptide ([1–9-NαC]-linusorb B2, CLB) and α-linolenic acid (ALA), two anti-inflammatory flaxseed constituents, were investigated for their combined vascular benefits. CLB-enriched orbitides were prepared for long-term high-fat diet (HFD)-fed mouse studies, while high-purity CLB monomer (>97%) was isolated via preparative chromatography for acute in vivo and cell-based assays. Structural confirmation and purity validation were achieved via mass spectrometry and liquid chromatography. CLB-enriched orbitides co-administered with ALA in HFD-fed mice reduced body weight gain, serum trimethylamine N-oxide (TMAO), dyslipidemia, and vascular inflammation, histologically confirmed by reduced pro-inflammatory mediators and endothelial repair. Purified CLB combined with ALA further demonstrated efficacy in alleviating TMAO-induced acute vascular inflammation in mice. Mechanistically, CLB enhanced ALA metabolism by upregulating key enzymes (lipoxygenases and cytochrome P450) and directly binding to their catalytic pockets. Combined effect loss upon enzyme inhibition confirmed ALA metabolic modulation as the key mechanism. These findings highlight CLB's role in amplifying ALA's efficacy to combat vascular inflammation.
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Small
·
2025
·
IF 12.1
Xiaohang Yang,Zhiqiang Sun,Panxin Wang,Qi Wang,Qiong Li,Xingbo Bian
Soil salinity is a critical abiotic stressor that disrupts plant growth by impairing redox balance, membrane stability, and metabolic coordination. While nanomaterials have emerged as promising abiotic stress modulators, the influence of nanoscale architecture on multi-level plant responses remains insufficiently understood. Here, we report the design and application of pinwheel-like α-Fe 2 O 3 @Ag nanohybrids, engineered through controlled hydrolysis, ball milling, and high-temperature calcination, to reprogram salt stress responses across physiological and molecular scales. These hybrids exhibit hierarchical anisotropic structures that promote leaf adhesion, cellular uptake, and redox interface activity. Integrated multi-omics analyses reveal that α-Fe 2 O 3 @Ag enhances stress tolerance by modulating antioxidant defense, preserving photosynthetic efficiency, and rebalancing osmotic and hormonal pathways. At the molecular level, the nanohybrids induce transcriptomic and metabolomic rewiring across key axes, including unsaturated fatty acid metabolism, sulfur assimilation, hormone signaling (ABA and JA), and protein turnover. This study presents a structure-function-response framework linking nanomaterial morphology to biological outcomes, and highlights the potential of hybrid nanoregulators as versatile tools for enhancing crop resilience under environmental stress. The findings offer conceptual and practical advances for developing next-generation nano-enabled strategies in sustainable agriculture.
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JOURNAL OF INVESTIGATIVE DERMATOLOGY
·
2021
·
IF 8.551
Yingjie Shen,Zhongxin Zhu,Weitao Cong,Mengying Jiang,Jianan Wang,Xixi Chen,Nan Wang,Ying Yu,Yetong Dong,Zhili Liu,Jia Sun,Wenjie Gong,Siyi Zhang,Kwonseop Kim,Litai Jin
Skin wound healing is a complex process involving intricate molecular mechanisms that remain unknown. Restoration of homeostasis after wounding requires the remodeling function of fibroblasts. In this study, we show that phosphorylation of α-catenin S641 was upregulated in fibroblasts during wounding, which accelerated their proliferation and migration to restore the skin barrier. At the wound edge, phosphorylated α-catenin S641 stabilized IκBα and thereby impaired the expression of NF-κB target genes to promote proliferation and migration of fibroblasts. Mechanically, phosphorylated α-catenin S641 blocked K48-linked polyubiquitination and proteasomal degradation of IκBα. Moreover, we also showed that EGF/EGFR/CK2α functioned as key upstream signaling of α-catenin by phosphorylating α-catenin at S641. Wound repair was significantly disrupted in the skin of mice in which α-catenin phosphorylation and CK2α kinase activity were perturbed in fibroblasts. These findings provide insights into the molecular control of fibroblast proliferation and migration in response to wounding and identify potential targets for the treatment of defective wound repair.
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FUEL
·
2025
·
IF 7.5
Junjie Liu,Jianmin Wu,Qiwen Sun,Jiancheng Wang,Yan Sun,Hengxuan Zhang
The high-viscosity poly-alpha-olefin was prepared from Fischer-Tropsch mixed α-olefins (FTO) polymerization under [EBIZrCl 2 /Al( i Bu) 3 /[Ph 3 C] + [B(C 6 F 5 ) 4 ] - system (EBI = rac -C 2 H 4 (1-Ind) 2 ), and its mechanism was investigated by in situ UV–Vis, 1 H NMR and ESI-MS. The results show that the kinematic viscosity at 100°C (KV 100 ), viscosity index (VI) and yield of product reach to 306.3 cSt, 244 and 81.12 % under optimum reaction condition, respectively. Through adjusting temperature to 20°C, in situ UV–Vis, 1 H NMR and ESI-MS are conducted to monitor the formation of origin species (EBIZr( i Bu) 2 + ), active species (EBIZr-σ-y n + (y = nonenyl, decenyl and undecenyl, n ≥ 1)), reactivated species and dormant species (EBIZr-η 3 -(1-R-C m H m+1 ) + (R = n-propyl and m = 6 or 7 or 8)). The simultaneous generation of active and dormant species is observed, and the reaction process is described as [FTO] + [catalyst] → [active species] + [dormant species]. This reaction fitting curve also conforms to the Boltzmann (R 2 ≥ 0.993). The effect of different types of olefins on catalytic evolution and product properties is investigated. The existence of multiple α-olefins inhibits the formation of the second inactivate species found in 1-decene polymerization. However, the multiple isomeric olefins further enhance the possibility of dormant species generation, because of the promotion of β-H concentration in catalytic system, leading to the higher activation energy (19.597kJ/mol) than pure 1-decene (10.949kJ/mol). Based on those findings, a possible mechanism in ansa-zirconocene catalyzed to prepare high-viscosity poly-alpha-olefin from Fischer-Tropsch mixed α-olefins is proposed.
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JOURNAL OF MATERIALS SCIENCE
·
2023
·Vol. 58
·期 7
·3066-3077
·
IF 4.5
Liu Xiang,He Zhanglong,Li Tao,Wang Xiaodong,Zhao Chen,Liu Shan,Liu Yuling,Fan Zheqiong,He Hao
MnO 2 is a promising catalyst for oxygen reduction and metal–air batteries due to the natural abundance, low cost and nontoxicity. Improving its activity is an important challenge for its large-scale commercialization. Defect engineering and heteroatom doping are the most effective means and can be easily operated through plasma treatment at different atmospheres. In this work, defects on MnO 2 are manufactured via rapid plasma treatment at Ar atmosphere while both defects and N-doping are simultaneously fabricated at N 2 atmosphere. N–MnO 2 exhibits a greatly enhanced ORR activity with a half-wave potential of 0.84 V, a limiting current density of 6.7 mA cm −2 and the number of transferred electrons of 3.9. In neutral Mg-air battery, N–MnO 2 -based battery exhibits a max power density of 124.3 mW cm −2 at a current density of 255.4 mA cm −2 and excellent stability under different working condition. These superior performances of N–MnO 2 to Ar–MnO 2 and pristine α -MnO 2 demonstrate that the defects and N-doping by plasma treatment at N 2 atmosphere significantly enhance the oxygen reduction activity. This work reveals the relationship between microstructure and oxygen reduction reaction and supplies a new idea for the developing economical and efficient oxygen reduction reaction catalysts for metal–air batteries. Graphical
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RSC Advances
·
2016
·Vol. 6
·期 56
·51247-51256
·
IF 3.289
Chuanping Gao,Ga Zhang,Tingmei Wang,Qihua Wang
The formation of a tribo-film on the counterface plays an important role on the tribological performances of polymer subjected to mixed and boundary lubrication conditions. However, when freshwater is used as a lubricant, the formation of a tribo-film usually is hindered. In order to overcome this disadvantage, PEEK/α-FeOOH nanocomposites were developed and their tribological performances were studied under water lubrication conditions in the present work. It was demonstrated that the inclusion of α-FeOOH nanoparticles (NPs) into the PEEK matrix improves significantly the tribological performance of the matrix. The nanostructures and properties of the tribo-films formed on the steel counterface were comprehensively studied. It was identified that the addition of α-FeOOH NPs promotes the formation of a lubricating tribo-film which covers the entire counterface. Based on the investigations on tribo-films, we deem that the α-FeOOH NPs act as precursors for the dehydration reaction promoting the formation of a tribo-film which consists of α-Fe2O3 and transferred PEEK. It is assumed that the enhanced tribological performance is related to the possibly high load-bearing capability and “easy-to-shear” characteristic of the tribo-film.
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APPLIED SURFACE SCIENCE
·
2019
·
IF 5.155
Yang Sun,Qiang Xie,Yangyang Zhu,Lu Wang,Qiang Sun,Lijuan Wang
In order to achieve high recovery for low concentration NO 2 gas detection, the α-6T OTFT gas sensors were fabricated by inducing growth method. The effect of interface inducing layer and active layer thickness on the sensor performance was studied. It was found that the p -6P inducing layer improved the surface properties of SiO 2 substrates and the α-6T films were manipulated to favorable film formation on p -6P interface layer. The α-6T crystal grains can be fused well and the large-area continuous crystal films were obtained. By the thickness modulation of α-6T active films, the sensors can achieve the detection to the low concentration of 1 ppm to NO 2 gas and exhibit the rapid recovery of 28 s. And the sensitivity was as high as 998% / ppm and the responsivity was up to 2645% for 1 ppm NO 2 gas. The formation of ultra-thin films on surface substrates is an effective method, which can induce the growth of organic semiconductor films and obtain the high-property devices.
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