BIOORGANIC CHEMISTRY
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2017
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IF 3.231
Zhenhua Wu,Wenxia Liao,Kelin Chen,Jingfang Qin,Huang Tang
A series of 6- and 9-substituted cleistopholine derivatives has been designed, synthesized and investigated to inhibit the aggregation of acetylcholinesterase (AChE), butyrylcholinesterase (BChE) and β-myloid (A β). Results showed that these synthetic compounds had excellent AChE inhibitory activity and a significant in vitro inhibitory potency toward the self-induced A β aggregation. When SH-SY5Y cells were treated with these substituted cleistopholine derivatives during they overexpressed the Swedish mutant form of human β -amyloid precursor protein (APPsw), A β 42 secretion levels were significantly reduced. According to a parallel artificial membrane permeation assay for BBB, seven out of these sixteen synthetic compounds probably could cross the blood-brain barrier (BBB) to reach their targets in the central nervous system (CNS).
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高影响因子
JOURNAL OF MATERIALS SCIENCE
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2025
·
IF 3.9
He Xianhong,Tian Wei,Ahmed Jahangeer,Bai Zhengyu,Yang Lin
Bismuth vanadate (BiVO 4 , BVO) is an ideal photoabsorber for the photoelectrocatalytic water splitting, but its performance and photostability limit its commercial application. Therefore, enhancing the catalytic performance and stability becomes an increasingly crucial issue. In this study, we report a composite catalytic material poly (3,4-ethylenedioxythiophene, EDOT) (PEDOT)-modified β-FeOOH nanosheets loading onto the surface of BVO through the hydrolysis of Fe 3+ in BVO semiconductor film and the catalytic polymerization of EDOT form the conductive polymer. The structure facilitates the catalytic process, and when it is used in photoelectrocatalysis oxygen evolution reaction, it exhibits a photocurrent density of 3.3 mA cm −2 at 1.23 V versus standard hydrogen electrodes. Mechanistic studies show that the introduction of PEDOT-modified β-FeOOH optimized the electrode/electrolyte contact interface, adjusted the defect state, and provided catalytically active sites during the catalytic process. This study provides a feasible idea for exploring the catalytic mechanism of BVO-based photoelectrode and designing catalysts.
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APPLIED SURFACE SCIENCE
·
2024
·
IF 6.3
Zijun Sun,Zhen Li,Yi Kuang,Chunrong Su,Shuangwei Yu,Yujing Wang,Xiong He,Jinghua Liu
Severe charge recombination and poor surface water oxidation kinetics are key restrictions of BiVO 4 photoanode for efficient photoelectrochemical (PEC) water oxidation. In order to overcome this issue, we introduce Co@β-cyclodextrin (Co@β-CD) supramolecule as oxidation evolution catalyst (OEC) into BiVO 4 photoanode for the first time via a facile two-step immersion method. The optimal Co@β-CD/BiVO 4 photoanode displays a remarkable photocurrent density of 5.3 mA cm −2 at 1.23 V RHE , which is ca. 3.5 times as high as that of pristine BiVO 4 photoanode. Further analyses indicate that photogenerated holes could quickly transfer from BiVO 4 to Co sites through β-CD, thereby suppressing charge recombination. Moreover, due to the spatial confinement effect of β-CD, the dispersed Co sites in Co@β-CD are considered to possess the high catalytic activity in similar with single-atom catalyst, which accelerates the surface water oxidation kinetics. This work not only demonstrates the superiority of supramolecule/semiconductor composite photoanode, but also provides a facile preparation route for the large-scale preparation of high-performance photoanodes.
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Nanomedicine-Nanotechnology Biology and Medicine
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2024
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IF 4.2
Yuxiang Dai,Yuanping Min,Lu Zhou,Longyang Cheng,Hongbin Ni,Yang Yang,Wendi Zhou
Glioblastoma (GBM) is a central nervous system cancer with high incidence and poor survival rates . Enhancing drug penetration of the blood-brain barrier (BBB) and targeting efficacy is crucial for improving treatment outcomes. In this study, we developed a redox-sensitive targeted nano-delivery system (HCA-A2) for temozolomide (TMZ) and β-lapachone (β-Lapa). This system used hyaluronic acid (HA) as the hydrophilic group, arachidonic acid (CA) as the hydrophobic group, and angiopep-2 (A2) as the targeting group. Control systems included non-redox sensitive (HDA-A2) and non-targeting (HCA) versions. In vitro, HCA-TMZ-Lapa micelles released 100 % of their payload in a simulated tumor microenvironment within 24 h, compared to 43.97 % under normal conditions. HCA-A2 micelles, internalized via clathrin-mediated endocytosis, showed stronger cytotoxicity and better BBB penetration and cellular uptake than controls. In vivo studies demonstrated superior tumor growth inhibition with HCA-A2 micelles, indicating their potential for GBM treatment.
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PHYTOMEDICINE
·
2024
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IF 6.7
Qinwei Lu,Junlin Zhu,Linxin Teng,Cuihua Chen,Lei Bi,Weiping Chen
Background Hepatocellular carcinoma (HCC) stands out as a significant contributor of cancer-related death. Traditional Chinese Medicine (TCM) presents numerous advantages in the treatment of HCC. Britannin, a pivotal compound found in Inulae Flos, demonstrates pharmacological effects against various cancers, yet research on its specific impact on anti-hepatocellular carcinoma remains limited. Purpose This study aims to explore both the anti-hepatocellular carcinoma effects of britannin and its underlying mechanism of action. Methods MTT assay, clone formation assay and flow cytometry were utilized to detect the cell activity, proliferation ability and apoptosis of britannin against HCC cell lines. Cell migration and invasion abilities of britannin on HCC cell lines were evaluated by wound-healing assay and transwell migration and invasion assay. H22 xenografted tumor mouse model was constructed and britannin treatment was performed to observe the effect of britannin on HCC tumor. The expression levels of liver cancer biomarkers AFP, AFP-L3, APT and TGF-β were detected by Elisa, and the histopathology was observed by HE staining. Network pharmacology and molecular docking were used to predict the possible signaling pathway of anti- hepatocellular carcinoma effect of britannin. The surface plasmon resonance (SPR) experiments was used to verify the interaction between britannin and proteins. The cell kinase activity function experiment was employed to detect the effect of britannin on enzyme activity. RT-qPCR and Western-Blot were used to verify the effect of britannin on the mRNA expressions of key genes and protein levels related to GSK-3β/β-catenin pathway in hepatocellular carcinoma cells and tumor tissues in mice. Results In vitro experiments showed that britannin could inhibit the activity, proliferation, migration and invasion abilities of HCC cells, while promoting their apoptosis. In vivo experiments revealed that britannin exerted inhibitory effects on the growth of transplanted liver cancer tumors, reducing the inflammatory infiltration and the expression levels of AFP, AFP-L3, APT and TGF-β of liver cancer markers in transplanted mice. Network pharmacology and molecular docking predicted that cell adhesion factors and GSK-3β/β-catenin pathway might be the related signaling pathway and had potential docking activity with key proteins. The SPR experiments elucidated the molecular interaction between britannin and GSK-3β. Enzyme activity assays indicated that britannin could modulate the functional activity of GSK-3β kinase. RT-qPCR suggested britannin could regulate the mRNA expressions of β-catenin, GSK-3β, E-cadherin and N-Cadherin. Western-Blot further verified that britannin could significantly up-regulate the expression of GSK-3β and down-regulate the expression of p -GSK-3β and β-catenin. At the same time, the expression of E-cadherin increased and N-Cadherin decreased, thereby reducing the occurrence of EMT and inhibiting the metastasis of hepatocellular carcinoma. Conclusion In conclusion, britannin could inhibit the growth, development and metastasis of HCC, and its mechanism may be related to the regulation of GSK-3β/β-catenin signaling pathway to inhibit epithelial-mesenchymal transition of HCC.
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高影响因子
Soft Matter
·
2012
·Vol. 8
·期 14
·3856-3863
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IF 4.39
Hua-Neng Xu,Shu-Feng Ma,Wei Chen
The effect of β-cyclodextrin (β-CD) on the aggregation behavior of a nonionic surfactant, Triton X-114 ((1,1,3,3-tetramethylbutyl)phenyl-polyethylene glycol), in aqueous solutions has been studied as a function of temperature by means of turbidity, dynamic light scattering (DLS), transmission electron microscopy (TEM), and rheo-small angle light scattering (rheo-SALS). The Triton X-114 (TX-114) solutions possess unique structural variations and display special aggregate transitions upon β-CD addition. In contrast to the reported aggregate disruption effect of β-CD for dilute nonionic surfactant solutions, aggregate growth is found in the aqueous TX-114 solutions of 93 mM upon β-CD addition. The micelle to vesicle transition induced by β-CD addition, which can greatly influence the turbidity and the viscosity of the solutions, is quantified by the characteristic length and aspect ratio of the aggregates. The characteristic length and aspect ratio of the aggregates change significantly after β-CD addition. It shows that aggregate growth may occur in nonionic surfactant–CD systems, as well as the reported ionic surfactant–CD systems. It is proposed that the CD–CD H-bonds create intermicelle interactions and promote aggregation of the CD/surfactant complexes, resulting in the formation of micrometer-scale phase-separated droplets.
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Journal of Materials Chemistry A
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2024
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IF 10.7
Yuhui Huang,Yehan Tao,Qingqing Wang,Jian Du,Jinwen Hu,Jie Lu,Yanna Lv,Haisong Wang
To develop an industrial zeolite-based catalyst for efficient furfural production, the acidity, pore structure, and electronic properties of H-β zeolite were modulated by synergistic deatomization and atomic implantation treatments. The dealumination effectively decreased the intrinsic aluminum-related Lewis and Brosted acid sites, thus decreasing the occurrence of unwanted side reactions. Meanwhile, the removed skeleton aluminum can create voids for the following atomic implantation of introducing higher valent-state niobium species, which would provide new kinds of catalytic active sites, increase the average pore size by distorting the zeolite skeleton, and enhance the interaction with reactant molecules by acting as more electron deficient centers. In a single-phase water/γ-valerolactone reaction system, the optimum catalyst can efficiently convert both xylan and xylose with a conversion of 100 % at a medium temperature of 130 ℃ within 3 hours. Compared with the furfural yield over untreated H-β (12.7%), the yield over deAlβ/Nb(20%) catalyst was greatly enhanced by 54% with xylose as raw material. The catalyst can be recovered by simple cleaning and thermal regeneration and then reused. The proposed post-treatment strategy could maintain the integrity of the zeolite structure, ensure uniform and stable metal dispersion under harsh conditions, manage the complexity and cost of the preparation process, and most importantly, optimize the catalytic performance. Addressing these issues is essential for improving the efficiency and practical application of industrial zeolite catalysts by this general approach and benefiting industrial furfural production.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2024
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IF 7.7
Zhongyu Shi,Xiasen Wei,Yunfan Wei,Zheyi Zhang,Sibao Wan,Haiyan Gao,Zhen Qin
A novel glycoside hydrolase (GH) family 16 multi-domain β-1,3-1,4-glucanase (FsGlc16A) from Fibrobacter sp. UWP2 was identified, heterogeneously expressed, and its enzymatic properties, protein structure and application potential were characterized. Enzymological characterization showed that FsGlc16A performed the optimal catalytic activity at pH 4.5 and 50 °C with a specific activity of 3263 U/mg. FsGlc16A exhibited the substrate specificity towards oat β-glucan, barley β-glucan and lichenan, and in addition, it hydrolyzed oat β-glucan and lichenan into different β-glucooligosaccharides with polymerization degrees of 3–4, which further illustrated that it belonged to the endo-type β-1,3-1,4-glucanase. FsGlc16A was classified in subfamily25 of GH16. A ‘PXSSSS’ repeats domain was identified at the C-terminus of FsGlc16A, which was distinct from the typical GH family 16 β-1,3-1,4-glucanases. Removing the ‘PXSSSS’ repeats domain affected the binding of the substrate to FsGlc16A and reduced the enzyme activity. FsGlc16A displayed good potential for the applications, which hydrolyzed oat bran into β-glucooligosaccharides, and reduced filtration time (18.89 %) and viscosity (3.64 %) in the saccharification process. This study investigated the enzymatic properties and domain function of FsGlc16A, providing new ideas and insights into the study of β-1,3-1,4-glucanase.
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Advanced Science
·
2024
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IF 14.3
Yichang Quan,Engui Wang,Han Ouyang,Lingling Xu,Lu Jiang,Lijing Teng,Jiaxuan Li,Lin Luo,Xujie Wu,Zhu Zeng,Zhou Li,Qiang Zheng
Triboelectric nanogenerators (TENGs) are highly promising as implantable, degradable energy sources and self-powered sensors. However, the degradable triboelectric materials are often limited in terms of contact electrification and mechanical properties. Here, a bio-macromolecule-assisted toughening strategy for PVA aerogel-based triboelectric materials is proposed. By introducing β-lactoglobulin fibrils (BF) into the PVA aerogel network, the material's mechanical properties while preserving its swelling resistance is significantly enhanced. Compared to pure PVA porous film, the BF-PVA porous film exhibits an eightfold increase in fracture strength (from 1.92 to 15.48 J) and a fourfold increase in flexibility (from 10.956 to 39.36 MPa). Additionally, the electrical output of BF-PVA in triboelectric performance tests increased nearly fivefold (from 45 to 203 V). Leveraging these enhanced properties, a biodegradable TENG (bi-TENG) for implantable muscle activity sensing is developed, achieving real-time monitoring of neuromuscular processes. This innovation holds significant potential for advancing implantable medical devices and promoting new applications in bio-integrated electronics.
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高影响因子
JOURNAL OF FLUORESCENCE
·
2015
·Vol. 25
·期 5
·1397-1402
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IF 1.927
Cao Yujuan,Wei Jiongling,Wu Wei,Wang Song,Hu Xiaogang,Yu Ying
In the present work, the CdTe quantum dots were covalently conjugated with permethylated- β -cyclodextrin (OMe- β -CD) using 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride as cross-linking reagent. The obtained functional quantum dots (OMe- β -CD/QDs) showed highly luminescent, water solubility and photostability as well as good inclusion ability to malachite green. A sensitive fluorescence method was developed for the analysis of malachite green in different samples. The good linearity was 2.0 × 10 −7 –1.0 × 10 −5 mol/L and the limit of detect was 1.7 × 10 −8 mol/L. The recoveries for three environmental water samples were 92.0–108.2 % with relative standard deviation (RSD) of 0.24–1.87 %, while the recovery for the fish sample was 94.3 % with RSD of 1.04 %. The results showed that the present method was sensitive and convenient to determine malachite green in complex samples.
The analytical mechanism of OMe-β-CD/QDs and its linear response to MG
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高影响因子
JOURNAL OF MATERIALS RESEARCH
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2015
·Vol. 30
·期 21
·3201-3210
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IF 1.647
Wenping Guo,Zhongli Lei
Herein, we present a method for introducing β-cyclodextrin (β-CD) and Ferrocene (Fc) into the main chain of poly(acrylic acid) (PAA) to fabricate a novel supramolecular polymer, which was investigated by Fourier transform infrared spectroscopy and 1H Nuclear Magnetic Resonance (1H NMR). This polymer can self-assemble into interesting nanoparticles in aqueous solution. The redox-responsive Fc–CD host–guest interactions endow these nanoparticles with unique self-degradable and self-healable features under redox potential control. This redox behavior of the supramolecular polymer would open up an approach for redox-controlled biological materials with great application potential.
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INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2017
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IF 2.843
Peng Liu,Ni Yuan,Wei Xiong,Hanyu Wu,Duoqiang Pan,Wangsuo Wu
β-Zeolite was synthesized and modified with ethylenediamine (EDA). The synthesized materials were characterized and used for the removal of nickel(II) from aqueous solutions. The influences of the pH, contact time, and temperature on nickel(II) adsorption onto synthesized β-zeolite and β-zeolite modified with ethylenediamine (β-zeolite–EDA) were studied by a batch technique, and X-ray photoelectron spectroscopy was employed to analyze the experimental data and identify the formation of coordination bonds between the adsorbents and nickel(II). The dynamic process showed that the adsorption of nickel(II) onto β-zeolite and β-zeolite–EDA matched the pseudo-second-order kinetics model, and the adsorption of nickel(II) was significantly dependent on the pH values. Through simulation of the adsorption isotherms by the Langmuir, Freundlich, and Dubinin–Radushkevich models, it could be seen that the adsorption patterns of nickel(II) onto β-zeolite and β-zeolite–EDA were mainly controlled by surface complexation and the adsorption processes were endothermic and spontaneous. The modification of β-zeolite–EDA improved the adsorption capacity of nickel(II) significantly; this shows a novel material for the removal of nickel(II) from the water environment for industrialized application.
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