INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2023
·
IF 8.2
Dejian Bian,Zheng Chen,Yongliang Ouyang,Shige Wang,Meitang Wang,Weichang Chen
The rapid and effective hemostasis of gastrointestinal bleeding sites remains an urgent clinical challenge. In this study, an ultrafast self-gelling, sprayable, and adhesive carboxymethyl chitosan/poly-γ-glutamic acid/oxidized dextran (CPO) powder was designed for gastric perforation hemostasis and healing. When the CPO powder was sprayed to the gastric perforation site, the CPO powder absorbed water from the blood and concentrate blood cells and clotting factors to achieve the purpose of rapid hemostasis. During the hemostasis, the CPO powder formed a hydrogel in situ through the formation of amide bonds and Schiff base bonds within 15 s, forming a physical barrier to cover the wound surface. Concurrently, the aldehyde group (-CHO) of oxidized dextran formed additional Schiff base bonds with the amino group (−NH 2 ) of the tissue, enabling the CPO powder with wound surface adhesion. Moreover, the CPO powder was shown to have excellent in vitro and in vivo antibacterial properties and it was able to promote the healing of infected wounds in a mouse model. In summary, CPO powder provides a promising idea for the rational design of gastrointestinal hemostatic agents.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
FOOD HYDROCOLLOIDS
·
2023
·
IF 10.7
Tiantian Min,Yujie Lei,Chuanxiang Cheng,Yuwan Luo,Yushan Zhang,Jin Yue
Natural biopolymers have widespread applications in active food packaging attribute to their low-cost, easy availability, environmental-friendly, and excellent processibility. Extensive attention has been paid to integrate or modify nanostructures on biopolymer substrates to endow packaging materials with satisfactory preservation effects. Herein, green γ-cyclodextrin-metal-organic frameworks (γ-CD-MOFs) were successfully integrated on chitosan-cellulose (CS-CEL) polysaccharide film through in situ growth method and encapsulated with carvacrol (CAR) for controlled release active packaging. The γ-CD-MOFs were anchored on CS-CEL film depending on the coordination of glucose units in CS-CEL and potassium ion , which significantly improved the surface area of CS-CEL film from 1.0294 m 2 /g to 43.3458 m 2 /g. Furthermore, the molecular docking and 1 H NMR spectra indicated that γ-CD-MOF has better complexing and stabilizing ability for CAR molecules than γ-CD. Additionally, the inhibition rate of this composite film against Escherichia coli , Staphylococcus aureus and Botrytis cinerea reached more than 99%. The film performed a humidity-controlled release effect on CAR and the release conformed to non-Fick diffusion. The shelf life of strawberries was extended to 7 days after treated with this film during storage. By incorporating the merits of natural biopolymers and MOFs, this novel active packaging offers great potential as a substitute for traditional packaging materials.
✓ 已验证
产品关联
DOI
高影响因子
TALANTA
·
2023
·
IF 6.1
Zeying Yang,Boyong Cao,Xiaowei An,Zhongliang Yu,Wuduo Zhao,Fangcheng Su,Guoqing Guan,Yanhao Zhang,Zhengkun Xie,Baoxian Ye
The rapid and sensitive determination of antioxidant N-(1,3-dimethylbutyl)-N′-phenyl- p -henylenediamine (6-PPD) in the environment is crucial for early intervention to prevent its adverse effects. Here, a reliable electrochemical sensor based on a N–C mediated γ-Mo 2 N nanocomposite (γ-Mo 2 N@N–C) modified carbon paste electrode (CPE) was developed and applied for selective and sensitive determination of 6-PPD. Benefiting from the superior stability and faster electron diffusion coefficient , the peak current responded to 6-PPD on the sensor linearly over a concentration range from 5 × 10 −8 mol L −1 to 1.0 × 10 −5 mol L −1 with a detection limit of 1.67 × 10 −8 mol L −1 (4.48 ng mL −1 ). Moreover, the sensor maintained good anti-interference ability in the determination of 6-PPD in soil samples from different regions in Zhengzhou City. Furthermore, the density functional theory (DFT) calculations combined with kinetics analysis proved that the enhanced basicity of the γ-Mo 2 N@N–C facilitated the deprotonation of 6-PPD, with the preferred orientation facet of (200) in γ-Mo 2 N playing a vital role in inducing the dissociation of 6-PPD, thereby improving the sensor's response. Such an electrochemical sensor, with its good stability and superior sensitivity, has the potential to be applied for real-time evaluation and monitoring of environmental pollutants .
✓ 已验证
产品关联
DOI
PubMed
高影响因子
FITOTERAPIA
·
2023
·
IF 3.4
Nan Zhang,Junwei Zhang,Weiqi Cui,Deqiao Wu,Jingxian Zhang,Bo Wei,Lingbo Qu,Xia Xu
Artemisia argyi H.Lév. & Vaniot, a traditional Chinese medicine with a history spanning over two millennia, has been extensively used in folk medicine to treat dysmenorrhea, uterine bleeding and inflammation. Recent studies have demonstrated that the essential oil extracted from Artemisia argyi H.Lév. & Vaniot, known as AAEO, exhibits significant anti-tumor properties against liver and lung cancers. There is a scarcity of research on the potential impact of AAEO on pancreatic cancer (PC) cells. In this study, UPLC-MS/MS-based metabolomics method was established to evaluate the effect of AAEO on the proliferation of PC cells. The differential compounds included 5-oxoproline, glutamate, γ-glutamylcysteine, glutathione, arachidonic acid, adrenal acid and linoleic acid were detected by metabolomics, enriching in the γ-glutamyl cycle and polyunsaturated fatty acid metabolism, which were closely related to ferroptosis. Meanwhile, AAEO dramatically increased the levels of intracellular iron ion via up-regulation of TFR1, augmented reactive oxygen species and malondialdehyde in a dose-dependent manner by down-regulation of γ-glutamyl cycle through decreasing expressions of SLC7A11. Additionally, β-caryophyllene oxide, one of the main components of AAEO, could covalently bind to Cys in SW1990 cells to form a conjugate Cpo-Cys, resulting in the inhibition of glutathione synthesis. Importantly, the ferroptosis inhibitor deferoxamine significantly blocked the inhibitory effect of AAEO on SW1990 cells. Meanwhile, β-caryophyllene oxide, dihydro-β-ionone and α-bisabolol had strong binding force with GPX4, SLC7A11 and TFR1, respectively. These findings showed that AAEO induced ferroptosis via regulation of γ-glutamyl cycle by SLC7A11 and iron disorders by TFR1. Our study discovered AAEO as a potential therapeutic approach to induce ferroptosis to prevent or treat PC.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
BIOCHEMICAL ENGINEERING JOURNAL
·
2023
·
IF 3.9
Juanjuan Ding,Wenyan Ba,Shengping You,Wei Qi,Rongxin Su
γ-aminobutyric acid (GABA) is an important inhibitory neurotransmitter in the brain with many physiological functions. Therefore, this work establishes an efficient biosynthesis process to achieve the high production of food-grade GABA. Firstly, we adopted a directional colorimetric screening method and then obtained the strain Lactobacillus brevis ( Lb. brevis) CGMCC 24975 with 22.61 g/L GABA in shake flasks, much higher than Lb. brevis ATCC 367 (3.07 g/L) due to its more efficient and stable expression of its glutamate decarboxylase (GAD) system. After exploring the effects of optimal fermentation conditions and oxygen on GABA production, we found that anaerobic fermentation could increase GABA production by up-regulating gad operon expression and activating GADase. Finally, we developed an oil-sealed anaerobic fermentation process with 157.90 g/L GABA in a 5 L bioreactor, which was 6.98-fold of that in shake flasks. This work includes a complete process from screening GABA-producing strains to developing efficient fermentation processes, laying the foundation for producing food-safe GABA.
✓ 已验证
产品关联
DOI
高影响因子
FOOD CHEMISTRY
·
2023
·
IF 8.8
Zonghan Wang,Deyang Li,Xiaoyang Liu,Min Zhang,Pengfei Chu,Beiwei Zhu,Donghong Liu,Dayong Zhou
Epigallocatechin-3-gallate (EGCG) exhibits excellent cross-linking effects of myofibrillar proteins, it is prone to self-aggregation, causing excessive cross-linking and moisture loss of gels, which limits its application as a food additive in surimi products. Here, through combination γ-cyclodextrin and EGCG into one inclusion complex, we achieved proper usage of EGCG in shrimp surimi products: elevating both water holding capability and texture properties (hardness, chewiness and resilience). Moreover, the mechanism behind excellent performance was elucidated: as texture modifiers, the complexes improved gel network integrity through intermolecular interactions and moderated disulfide bonds; and as water retainer agents, the complexes promoted transformation of nitrogen in proteins towards the form of protonated amino, facilitating the occurrence of hydration. Furthermore, the inclusion complexes brought a higher phenolic retention within products in contrast with direct addition of EGCG. This work may propose novel insights for the usage of polyphenols as additives in surimi-based products.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Molecular Catalysis
·
2023
·
IF 4.6
Shiwei Feng,Chengping Zhang,Hengdao Quan
As an environmentally friendly cleaning agent, Z -1-chloro-3,3,3-trifluoropropene (HCFO-1233zd( Z )) can realize industrial production by the isomerization of HCFO-1233zd( E ). Herein, various isomerization catalysts with different structures, compositions and acid properties were prepared through the fluorination of γ-Al 2 O 3 with CHF 3 by controlling the activation conditions. For the first time, the catalysts for HCFO-1233zd( E ) isomerization were systematically studied by XRD, N 2 physisorption, XPS, SEM, MAS NMR spectroscopy, NH 3 -TPD and py-IR. The active site of this reaction was revealed and the catalyst deactivation mechanism was proposed. It turned out that HCFO-1233zd( E ) isomerization prefers to occur at Lewis acid sites with moderate density and strength. The amorphous particles composed of γ-Al 2 O 3 , Al 2 O 3 (F) and α-AlF 3 ( R 3 ¯ c ) at 450 °C exhibit highly catalytic activity for HCFO-1233zd( E ) isomerization. After 100 h evaluation, it was found that residual γ-Al 2 O 3 can be fluorinated by HCFO-1233zd( E ) to form needle-like structures which could induce the amorphous Al 2 O 3 (F) particles to reorganize and give cubic structures, where the Lewis acid properties were enhanced, leading to catalyst deactivation.
✓ 已验证
产品关联
DOI
高影响因子
CHINESE JOURNAL OF CHEMICAL ENGINEERING
·
2019
·
IF 1.911
Weiquan Cai,Junlin Zhuo,Jimin Fang,Zhichao Yang
A series of nanorod-like porous Pd/γ-Al 2 O 3 catalysts with controllable textural properties and enhanced catalytic performance in 2-ethyl-9,10-anthraquinone (eAQ) hydrogenation for H 2 O 2 preparation were successfully prepared via a facile sol–gel method using aluminum isopropoxide as aluminum precursor and eAQ as structure directing agent, sequential calcination and impregnation process with Na 2 PdCl 4 solution. The physicochemical properties of the catalysts obtained with different addition amounts of eAQ were comparatively characterized by XRD, TG–DSC, BET, TEM, CO-TPR, H 2 -TPR and H 2 –O 2 titration. The results show that addition of eAQ can not only effectively control the textural properties (surface area, pore volume and average pore size) of the catalysts, but also lower their reduction temperature of active metal. Importantly, the catalyst obtained with an addition amount of 4 wt% eAQ shows the highest hydrogenation efficiency of 10.28 g·L −1 , which is 37.3% higher than 7.49 g·L −1 of the catalyst obtained without eAQ.
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY
·
2019
·Vol. 94
·期 7
·2355-2363
·
IF 2.659
Hui-Fang Ren,Dan Zhu,Ji-Fan Li,Chun-Ling Liu,Rong-Zhen Yang,Wen-Sheng Dong
BACKGROUND The chemical catalytic conversion of carbohydrates into γ-valerolactone (GVL) is a sustainable alternative to the petrochemical process starting from the depleting fossil resources. Direct conversion of carbohydrates (fructose, glucose, starch and cellulose) into GVL was achieved via the combined heteropoly acid based SO 3 H-functionalized ionic liquid (HAIL) and supported ruthenium (Ru) catalyst system in one pot and in water media. RESULTS A 63% GVL yield (based on fructose) was obtained under the catalysis of 1-methyl-3-(3-sulfopropylimidazolium)silicotungstate ([MIMPS] 4 SiW) and Ru/ZrO 2 at 180 °C, first in 0.1 MPa nitrogen (N 2 ) for 3 h (dehydration), and then in 4 MPa hydrogen (H 2 ) for 10 h (hydrogenation). Under the same reaction conditions, the GVL yields from glucose, starch and cellulose were 68%, 60% and 60%, respectively. The recyclability of the catalytic system consisting of [MIMPS] 4 SiW and Ru/ZrO 2 was investigated in four runs. The activity for [MIMPS] 4 SiW did not change after use. Partial deactivation of Ru/ZrO 2 was observed, which was ascribed to the severe carbon deposition. CONCLUSIONS In the present method, HAIL and Ru/ZrO 2 catalysts were loaded together. No separation and/or neutralization step reported in the literature was needed and only an atmosphere change (from N 2 to H 2 ) step was involved. Therefore, we provide a promising method for efficient conversion of carbohydrates into GVL. © 2019 Society of Chemical Industry
✓ 已验证
产品关联
DOI
高影响因子
RESEARCH ON CHEMICAL INTERMEDIATES
·
2018
·Vol. 44
·期 9
·5439-5453
·
IF 1.674
Huang Feng,Li Wenzhi,Zhang Tingwei,Li Dawei,Liu Qiyu,Zhu Xifeng,Ma Longlong
A carbonaceous solid acid catalyst with high strong-acid density was synthesized by facile functionalization of a biomass-derived mesoporous carbon with benzenesulfonic acid. The catalyst was characterized by using Fourier transform infrared spectroscopy, elemental analysis, X-ray photoelectron spectroscopy, transmission electron microscopy, and N 2 adsorption–desorption. The carbonaceous solid catalyst containing Brønsted acid sites was used for the production of 5-hydroxymethylfurfural (HMF) from hexoses such as fructose, glucose, and cellulose in γ-valerolactone (GVL)-H 2 O mixture. By reaction at 130 °C for 20 min using fructose as a feedstock, an HMF yield 78.1% was achieved. The catalytic performance of the catalyst in conversion of fructose into HMF hardly changed over seven cycles, demonstrating that the catalyst had excellent recyclability. The yields of HMF derived from glucose and cellulose reached 33.2 and 22.5%, respectively, whereas those of total furans were 42.1 and 33.7%, respectively. The proposed reaction system was promising in transforming biomass-based carbohydrates into fine chemicals, given the use of green functionalization methods, the utilization of sustainable biomass-derived carbon precursor and solvents, catalyst with high acid density, and the availability of high HMF yield.
✓ 已验证
产品关联
DOI
高影响因子
GREEN CHEMISTRY
·
2019
·Vol. 21
·期 16
·4499-4511
·
IF 9.405
Yuewen Shao,Kai Sun,Qingyin Li,Qianhe Liu,Shu Zhang,Qing Liu,Guangzhi Hu,Xun Hu
γ-Valerolactone (GVL) and 1,4-pentanediol (1,4-PDO) are value-added chemicals that can be produced from levulinic acid/ester via hydrogenation coupled with acid/base-catalyzed reactions. In this study, we demonstrate that the Cu-based catalysts produced via the hydrotalcite precursors with tunable distribution of acidic and basic sites could, according to the requirement of the target products, effectively tune the production of GVL or to 1,4-PDO from levulinic acid/ester. The abundant Brønsted acid sites over the CuAl catalyst suppressed the opening of the ring of GVL, achieving a higher GVL selectivity while inhibiting 1,4-PDO formation. The introduction of Mg species to the catalyst significantly increased the abundance of the basic sites on the surface of the catalyst, which was essential for the selective conversion of GVL to 1,4-PDO via the opening of the ring structure of GVL, the rate-determining step in the conversion from levulinic acid/ester to 1,4-PDO. In addition, the CuMgAl catalyst showed a much superior catalytic stability to the CuMg or CuAl catalyst due to the more stable crystal structure, the more developed porous structure, the higher dispersion of the Cu species and the higher capability to suppress the growth of metallic Cu species under hydrothermal conditions.
✓ 已验证
产品关联
DOI
高影响因子
Molecular Catalysis
·
2017
·
IF 0
Ruiying Wang,Jianjia Wang,Huimin Zi,Yongmei Xia,Haijun Wang,Xiang Liu
Zr(IV)-salphen-MCM-41 was prepared by immobilizing a zirconium(IV) Schiff base complex onto the surface of MCM-41. The structural properties of the heterogeneous catalysts were characterized by FT-IR, UV, TG, XRD, SEM, TEM, BET, EDX, CO 2 -TPD, NH 3 -TPD and ICP-OES. Studies on the catalytic properties of the immobilized Zr(IV)-Schiff base complexes were performed using the reduction and cyclization of ethyl levulinate (EL) to γ-valerolactone (GVL) with isopropanol as the hydrogen source. Various reaction parameters, such as temperature, reaction time, solvent and catalyst loading were carefully investigated. The optimal conditions (GVL yield up to 90%) involved the utilization of Zr(Salphen)-MCM-41 as the catalyst in isopropanol. The key to heightened reaction performance was the incorporation of the phenolate and aniline groups in the ligands of bound to Zr. This increased the basicity of the catalyst, which subsequently enhances the efficiency of the transfer hydrogenation reported herein. Meanwhile, the immobilized catalyst can be easily separated and efficiently recycled at least five times without significant loss of activity. Finally, we proposed a plausible reaction mechanism based on experimental and characterization data.
✓ 已验证
产品关联
DOI
危险品化学品经营许可证（带存储）