POLYMER SCIENCE SERIES B
·
2019
·Vol. 61
·期 5
·595-604
·
IF 0.907
Yan-Na Zhao,Lei Lin,Ji Ding-Xi,Niu Yu-Hua
Abstract A series of 4-maleimidophenol (4-HPM) modified waterborne polyurethane (MWPU) emulsions were successfully synthesized, using isophoronediisocyanate (IPDI), polycaprolactonediol (PCL, M w = 1000), 1,4-butanediol (BDO), 2,2-dimethylolpropionic acid (DMPA), trimethylolpropane (TMP) and triethylamine (TEA) as raw material. The effects of 4-HPM content on the structure, morphology and physical properties of the MWPU were characterized by Fourier transform infrared spectroscopy, dynamic light scattering, transmission electron microscope, X-ray diffraction, thermogravimetric analysis, water absorption measurement, water contact angle measurement and tensile testing. The results revealed that with 4-HPM introduced into the WPUs backbones, the crystallinity, the hardness, tensile strength, water resistance and thermal stability of MWPU films were significantly augmented. Moreover, when the content of 4-HPM was 4.0 wt %, the tensile strength of the MWPU film was up to 46.4 MPa, improved about 134.19% (measurement error ±0.001) compared with WPU (19.8 MPa). When the content of 4-HPM was 6.0 wt %, the end decomposition temperature of the film was up to 489.6°C, improved 12.6% compared with WPU (434.8°C).
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LIFE SCIENCES
·
2019
·
IF 3.448
Cheng Hu,Jiawen Ye,Licong Zhao,Xiulong Li,Yu Wang,Xinhua Liu,Lingyun Pan,Lisha You,Long Chen,Yiqun Jia,Jiaqi Zhang
Taxifolin (TAX) reportedly exerts protective and therapeutic effects in liver. Herein, the effects of TAX against acetaminophen (APAP)-induced hepatotoxicity were investigated. Pharmacodynamics, pharmacology and metabolomics analyses of TAX were assessed on C57 mice and L-02 cells. TAX was administered for 7 days, and APAP was given on the last day to establish an acute liver injury model. ALT and AST levels were determined, and liver ROS, MDA, GST, GSH and GPX1 were analysed. The expression and protein abundance of GPX1, GPS-Pi, GCLC and GCLM were assessed by PCR and western blotting, and metabolic changes in cells and serum were investigated by UPLC-Q-Orbitrap-MS. Serum ALT and AST, and liver ROS, MDA, GST, GSH and GPX1 levels confirmed the protective effects of TAX. Besides, we found Only treating with TAX decreased the expression of CYP2E1 in mice liver tissue. TAX reversed the APAP-induced decrease in cell viability in L-02 cells, and reduced cellular ROS levels. Furthermore, TAX reversed the APAP-induced decrease in antioxidant enzymes at both mRNA and protein levels. Metabolomics analysis identified metabolites mainly related to glutathione metabolism (36 in vivo and 23 in vitro ). The concentration of glutathione, oxidized glutathione, carnitine, succinic acid, pyroglutamic acid, citrulline, taurine, palmitoleic acid, phytoshingosine-1-P and sphingosine-1-P were close to normal levels after treating with TAX. These results indicate that TAX prevents APAP-induced liver injury by inhibiting APAP metabolic activation mediated by CYP450 enzymes, modulating glutathione metabolism, and expression of related antioxidative signals. These properties could be harnessed to prevent or treat hepatotoxicity.
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PubMed
高影响因子
DYES AND PIGMENTS
·
2022
·
IF 5.122
Chunfang Liu,Chunming Yuan,Guangjin Shi,Ke Jia,Jing Liu,Kun-Peng Wang,Shaojin Chen,Zhi-Qiang Hu
Chiral organic fluorescent materials have attracted broad attention for their application in various chiroptical devices. Helicenes possess special helical structure and unique optical properties , and have been utilized to develop chiral organic fluorescent materials with excellent chiroptical performance. However, the low luminescence efficiency of helicene-based chiral fluorescent materials in solid state limits their practical applications. In this work, chiral organic fluorescent emitters with helicene moiety have been developed from binaphthanol structure. These BINOL [4]helicene compounds display aggregation-enhanced emission properties, and have strong blue emission in solid state with fluorescent quantum yield up to 0.67. The DFT calculation reveals that these compounds have highly twisted molecular structures. Thus, the excellent fluorescent properties in solid state could be aroused by the highly contorted molecular structures, which could limit the π-π stacking of adjacent molecules in solid state. The enantiomers of these compounds show strong Cotton effects in circular dichroism spectra, and the molecules with 4-methoxy phenyl moiety exhibit circularly polarized luminescence properties .
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JOURNAL OF BIOSCIENCE AND BIOENGINEERING
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2022
·
IF 3.185
Qihao Zhang,Xiaohui Yang,Lin Lin,Shuhong Wu,Ping Wang,Wei Wei,Dongzhi Wei
Melanin has an increasing market demand in cosmetics, food, medicine as well as aerospace due to its unique properties. Heterologous expression of 4-hydroxyphenylpyruvate dioxygenase (HPPD) from the melanin-producing strain Streptomyces fungicidicus NW-EN1 in Escherichia coli shortened the fermentation cycle of melanin. HPPD catalyzed 4-hydrophenylpyruvate (HPP) to form homologous acid (HGA) and finally form melanin. The purified melanin had the highest absorption peak at 460 nm. Fourier transform infrared spectroscopy and scanning electron microscope scanning showed that the pigment had universal characteristic peaks. The presence of HGA, a predictor of pyomelanin, was identified by high-performance liquid chromatography analysis. The recombinant E. coli produced 804.4 ± 5.9 mg/L pyomelanin within 48 h. Metal ions had a great influence on the production of pyomelanin. Pyomelanin was stable in response to light intensity and had a protective effect against bacteria under UV irradiation. Meanwhile, we utilized the chromogenic effect after whole-cell catalysis to reflect the inhibition of the HPPD inhibitors (mesotrione and isoxaflutole) on HPPD by observing the color change. As a rapid method to test the action of inhibitors, this method is expected to be useful for the development of HPPD-inhibiting herbicides.
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PubMed
高影响因子
BIOORGANIC & MEDICINAL CHEMISTRY
·
2013
·
IF 2.903
Jianzhang Wu,Yali Zhang,Yuepiao Cai,Jian Wang,Bixia Weng,Qinqin Tang,Xiangjian Chen,Zheer Pan,Guang Liang,Shulin Yang
We previously reported the design and discovery of three series of 5-carbon linker-containing mono-carbonyl analogs of curcumin (MCACs) as excellent anti-inflammatory agents. In continuation of our ongoing research, we designed and synthesized the fourth series of MCACs, whose central linker is a piperid-4-one. Their inhibitory effects against IL-6 production were evaluated in lipopolysaccharide (LPS)-stimulated macrophages. Among them, compounds F8 , F29 , F33 , F35 , and F36 exhibited the IC 50 values under 5 μM. The structure–activity relationship was discussed. Mechanistically, F35 and F36 dose-dependently prevented LPS-induced NF-κB and ERK activation. Finally, pretreatment with F35 and F36 significantly protected the C57B/L6 mice from LPS-induced septic death. Together, these data present a series of new analogs of curcumin as promising anti-inflammatory agents.
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PubMed
高影响因子
APPLIED CATALYSIS A-GENERAL
·
2023
·
IF 5.5
Shuang Wang,Cheng Li,Rujie Shang,Huihui Zhang,Kehui Qi,Yao Yao,Chunyan Yu,Qing Liu,Guorui Li,Shitao Yu,Lu Li
Producing vanillin from lignin model compounds in an elegant and efficient manner is a focus of chemical utilization in lignocellulosic biomass. The facile synthesis of a cobalt-palladium bimetallic alloy anchored on activated carbon (Co-Pd/C), which excels in the selective oxidation of the lignin model compound 4-methylguaiacol to vanillin, is reported here. The characterization results of Co-Pd/C indicate that the catalysts enhance the catalytic efficiency by forming a cobalt-palladium alloy to modulate the number of d-band cavities and influence the O 2 adsorption. Meanwhile, the synergistic effect between the alloys causes the Co-Pd/C catalyst exhibits good activity and stability in cycling experiments. A series of controlled experiments offer insight into the mechanism of catalytic generation of vanillin from 4-methylguaiacol. This work opens a new opportunity for achieving the valuable aromatic products from lignin.
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高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
·
2023
·
IF 6.2
Zhen-Fei Tian,Jing-Xuan Pei,Xiang Yu,Yi-Bo Sun,Lei Yang
4-Aminothiophenol (4-ATP, a toxic pesticide intermediate) residues in waste water endanger water ecology and human health. Therefore, the development of reliable surface-enhanced Raman scattering (SERS) substrate is a promising strategy for monitoring and preventing 4-ATP pollution. In this work, a core-shell structured Ag@ZnS hybrid, consisting of Ag nano-core and ZnS nano-shell, was fabricated and employed as a SERS substrate to detect 4-ATP. Owing to the specific core-shell structure, epy as-prepared Ag@ZnS substrate is stable against oxidation and spontaneous agglomeration of Ag NPs, enjoying good stability and uniform hot spots. Moreover, the formation of heterostructure between Ag-core and ZnS-shell offered a remarkable chemical enhancement for the Raman signals. The optimized Ag@ZnS substrate showed high sensitivity for rhodamine 6 G (R6G, 10 −9 M) and methylene blue (10 −8 M) probes, as well as 4-ATP (10 −8 M) target analyte. Likewise, the superior reproducibility (RSD<5.50 %, n = 16) and good stability (79.5 % of initial strength after 28 days) for 4-ATP makes this substrate a good candidate for actual determination of trace 4-ATP. This work proposes a strategy to fabricate a reliable SERS substrate with high sensitivity and superior reproducibility, and the designed Ag@ZnS substrate may be applicable to monitor 4-ATP residues in wastewater.
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高影响因子
JOURNAL OF SUPERCRITICAL FLUIDS
·
2023
·
IF 3.9
Yulan Qian,Ye Yuan,Junyang Zhu,Jinglong Li,Chengqi Jiao,Xiaoqing Xiong
In this study, three N ,4-dialkyl-substituted 1,8-naphthalimide fluorescent dyes (NPBA, NPHA, and NPOA) were synthesized in supercritical carbon dioxide (scCO 2 ) by reacting 4-bromo-1,8-naphthalic anhydride with three amines ( n -butylamine, n -hexylamine, and n -octylamine). The optimal reaction conditions and highest yields of these dyes were obtained. The yield of NPHA was 92% ± 0.57% using an organic solvent-free synthetic method. The results also indicate that the reaction time was gradually shortened by elongating the alkyl chain in the amines, and the required reaction pressure was 12 MPa or lower. Additionally, the dyeing of polyester fabrics with these three dyes was investigated using scCO 2 . The optimal dyeing time and temperature for NPBA were 70 min and 150 ℃, but they decreased at 10 gradients with the addition of two carbon atoms to the alkyl chain in the amines. The optimal dyeing pressure increased from 20 MPa to 24 MPa.
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高影响因子
JOURNAL OF MOLECULAR LIQUIDS
·
2023
·
IF 6
Zixuan Xue,Pengrui Zhang,Qian Zhang,Chaochi Huang,Ciming Wang,Lianjing Mao,Xiaolong Zhou,Huiqun Ju,Jinhe Sun,Fei Shao,Xingwu Zou,Bo Li,Mixiang Qi,Yongzhong Jia,Yan Jing
This paper reported a novel chelating agent and a green precipitation-extraction separation strategy for lithium isotope enrichment. 1-Hydroxy-4-(p-toluidino) anthraquinone and anisole were used as chelating agent and diluent, respectively. Three phases including organic phase, aqueous phase and precipitation could be preparated. The experiment indicated that excess sodium hydroxide was helpful to promote the single-stage precipitation rate and equilibrium time. The isotope result indicated that 6 Li was concentrated in the aqueous phase and 7 Li was concentrated in precipitation phase. The maximum single-stage lithium isotope speration factor reached to 1.013 ± 0.001. By doing thermodynamic analysis of the reaction, the free energy change (ΔG), enthalpy change (ΔH) and entropy change(ΔS) of the separation process were −8.97 J mol −1 , −21.37 J mol −1 and −0.0438 J mol −1 K −1 at 283 K. The results of DFT simulation and wave function analysis indicated that a lithium ion combined with a chelating agent anion formed a stable six-member ring between two oxygen, which was more stable than sodium ions combined with chelating agent anions (the Gibbs free energy of the lithium ions reaction was more negative). As interaction analysis result showed, the Li-O bond in complex interaction was significantly stronger than the Li-O bond interaction in aqueous phase, which was the theroy that led to the enrichment of 7 Li in organic phase. In the activated carbon treatment experiment, it was found that part of lithium chelator solved in aqueous phase, which resulted in that the lithium abundance of aqueous phase hardly changed. In order to increase the abundance of 6 Li in aqueous phase, it is necessary to add adjuvant to reduce the water solubility of lithium chelate. Overall, an economical and environmental-friendly precipitation method with a certain application prospect for lithium isotope separation was proposed, and the direction of improving the separation performance was pointed out in this paper.
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高影响因子
Surfaces and Interfaces
·
2023
·
IF 6.2
Hao Yang,Yi Liu,Hidetoshi Saitoh,Hao Chen,Hua Li
Biofouling is a stepwise accumulation process involving participation of various molecules and marine organisms. To tackle this complex threat, development of efficient long-term antifouling coatings yet keeps elusive. Here we report a newly constructed coating with both antifouling activity and low surface energy. The special surface structure formed by silica spheres and fluorosilanes offers the coating superhydrophobicity. Capsaicin-mimicking N-(4-hydroxy-3-methoxy-benzyl)-acrylamide (HMBA) powder is synthesized via the Friedel-Crafts reaction and is used as the antifoulant additives in the coating. By the synergistic effect of surface superhydrophobicity and the dispersed antifoulant, the multilayered HMBA-silica coating effectively inhibits the adhesion of alginate, bovine serum albumin and Chlorella , their adhesion rate on the HS-3 coating is 11.9 %, 8.7 % and 3.3 % respectively. The HS-3 coating kills 96.6 % gram-negative bacteria E. coli and 99.9 % gram-positive bacteria S. aureus. Furthermore, the HMBA-silica coating significantly mitigates by its superhydrophobicity the corrosion of artificial seawater, its corrosion current density has decreased by 4 orders of magnitude compared to bare 316 L plate. In a 90 days real seawater immersion experiment, the coating shows excellent anti-fouling and anti-corrosion properties. The fabrication route of the HMBA-silica coating using the synthesized broad-spectrum antifoulant HMBA and hydrophobic silica would give insight into developing new antifouling materials for marine applications.
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高影响因子
CHEMICAL PHYSICS LETTERS
·
2023
·
IF 2.8
Kaili Liang,Yang Liu,Lishuang Hu,Jiashun Liang,Tiancheng Lv,Yanping Wang,Shuangqi Hu
Micron-sized zirconium (μZr) is a viable alternative fuel source for high-energy propellants. To explore the combustion performance of Zr-containing DAP-4-based composites, DAP-4/Zr and F/DAP-4/Zr composites were designed. The results showed that the optimized composite had high combustion performance. When DAP-4/Zr was 54:46, the sample had the highest combustion heat and the fastest flame spreading velocity. The combustion time of F/DAP-4/Zr became longer after adding F 2602 , and the flame spread was the fastest when F/DAP-4/Zr was 10:48.6:41.4. The results indicate that the introduction of μZr as a fuel in DAP-4 can improve the material's energy density and combustion characteristics.
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高影响因子
Journal of Materials Chemistry C
·
2023
·Vol. 11
·期 38
·13106-13112
·
IF 6.4
Mingquan Guo,Jiangnan Shu,Dexin Du,Yisha Wang,Hua Cui
Potential resolved electrochemiluminescence (ECL) nanoluminophores are very important for precise analysis and simultaneous determination of multiple targets. Designing ideal potential resolved ECL nanoluminophores, generating multiple high efficiency ECL emissions without overlap and interference of potential and wavelength, is a challenging subject. Herein, we developed a new nanoluminophore, meso-tetra (4-carboxyphenyl) porphine (TCPP)-functionalized chitosan/Ru(bpy)32+/SiO2 (CRuSiO2) (TCPP@CRuSiO2), with cathode and anode ECL emissions by modifying TCPP on the surface of CRuSiO2 nanoluminophores. The TCPP@CRuSiO2 nanoluminophores presented a uniform sphere morphology (∼50 nm). They exhibited two ECL emissions of 695 nm and 610 nm at −1.20 V and 1.15 V, respectively, by using K2S2O8 and tripropylamine (TPrA) as coreactants. Subsequently, the relevant ECL mechanisms are proposed. In the negative potential range, sulfate radicals (SO4˙−) reacted with TCPP−, generated by the electro-reduction of S2O42− and TCPP, to form the excited state TCPP*, resulting in ECL-1. In the positive potential range, Ru(bpy)33+ and TPrA˙, obtained by electro-oxidation of Ru(bpy)32+ and TPrA, reacted with each other to produce the excited state Ru(bpy)32+*, leading to ECL-2. The synthesized TCPP@CRuSiO2 possesses not only potential and wavelength resolved ECL emissions, but also the advantages of easy synthesis, high ECL efficiency, good stability, and easy film formation on the electrode surface. This work enriches ECL nanoluminophores, which are of important application potential in precise analysis and multiplex analysis.
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