CHEMICAL ENGINEERING SCIENCE
·
2025
·
IF 4.3
Xiaoting Feng,Chenlu Liu,Kunkun Ren,Xinglei Zhao,Longjie Liu,Keming Zhang,Xiaohe Tian,Qingnan Wang,Xiangyu Liu,Yueyangchao Yu,Tianhe Gu,Shaofei Wang
The urgent need for efficient CO 2 capture technologies to mitigate climate change has driven the advancement of membrane-based separation systems. We report a mixed matrix membrane design through the in-situ growth of a ZIF-8 gel network within a Pebax-1657 matrix. By tuning the solvent ratio and concentration of modulator, ZIF-8 gel rather than particles are formed within the polymer, establishing a three-dimensional interconnected MOF network that ensures homogeneous filler dispersion and creates continuous gas transport nanochannels. The optimized membrane achieves a remarkable CO 2 permeability of 183.9 Barrer and a CO 2 /N 2 selectivity of 73.3, surpassing the 2008 Robeson upper bound. These values represent 190.4 % and 34.9 % enhancements in permeability and selectivity, compared to the pristine polymer. The membrane also demonstrates robust operational stability and maintains > 95 % of its initial performance over 60 days. This work offers a promising solution to creating continuous channels in CO 2 separation membranes.
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高影响因子
Biomaterials Science
·
2025
·
IF 5.7
Min Sun,Jinke Cao,Yang Zou,Haiyan Ju,Yonggang Lv
During tendon injury repair, deficiency of basic fibroblast growth factor (bFGF) is a critical factor leading to unsatisfactory repair results. This study aims to prepare bFGF-loaded zeolite imidazole framework-8 (ZIF-8) nanocrystals using one-pot synthesis method. Subsequently, a bilayer nanofibrous membrane incorporating these drug-loaded nanocrystals was fabricated through electrospinning technology. The potential of this composite nanofibrous membrane to facilitate the continuous release of bFGF at the site of tendon injury was evaluated, with the aim of enhancing the quality of tendon repair. The efficacy of the nanofibrous membrane in promoting tendon differentiation, preventing tendon adhesion, and facilitating tendon repair was assessed through both in vitro and in vivo experiments. At the site of tendon injury, the degradation of ZIF-8 in an acidic microenvironment resulted in the release of bFGF and Zn2+, which contribute to the enhancement of tendon repair. ZIF-8 nanocrystals, achieving an encapsulation efficiency of 50.13% ± 1.42%. Following a continuous release period exceeding 40 days, the cumulative in vitro release rate was determined to be 35.02% ± 4.27%. The incorporation of ZIF-8 nanocrystals into a nanofibrous membrane demonstrated the ability to effectively preserve the bioactivity of bFGF while enabling sustained sustained release at the site of tendon injury, thereby facilitating tendon repair. The findings offer novel insights into the treatment of tendon injuries and provide significant theoretical guidance for the tendon repair process.
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PubMed
高影响因子
Journal of Environmental Chemical Engineering
·
2025
·
IF 7.2
Pin Hou,Jiaqi Yan,Xiaoyu Yang,Ridha Djellabi,Xinrui Ge,Xinyu Sun,Jianli Jia,Jianbing Wang
Metal-organic framework (MOF)-derived carbon-based electrodes have demonstrated outstanding capacitive deionization (CDI) performance, owing to their special structures and configurations. Developing novel low-cost controllable protocols to obtain highly efficient Nitrogen-doped carbon-derived MOFs is the most challenging factor to transfer widely the application of these materials at real world. This work aims to develop a low-cost one-step growth route to produce N-doped carbon (NGZC) utilizing N-doped graphene quantum dots (N-GQDs) and zeolitic imidazolate frameworks-8 (ZIF-8) as starting substrates. The surface chemistry, morphology and CDI performance of the as-synthesized NGZC electrode were investigated, compared with conventional materials. The authors found that the introduction of N-doped graphene quantum dots dramatically enhances the mesopore volume (0.742 cm 3 /g) and pyrrolic-N ratio (19.21 %) for NGZC. These improvements effectively shorten the electron and sodium ion transport paths which in turn facilitate the pseudocapacitive activity and charge transfer in NGZC. The specific capacitance and salt adsorption capacity were found to be 283.16 F/g and 17.86 mg/g, respectively, demonstrating superior values than commonly used electrodes. NGZC shows a high stability over 30 adsorption-desorption cycles with a capacity retention of 90 %. DFT results further demonstrate the pseudocapacitive superiority of pyrrolic-N to reinforce the Na + capture. This finding provides new insights into the design of an economical and controllable N-doped carbon electrode for efficient CDI desalination.
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BIORESOURCE TECHNOLOGY
·
2025
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IF 9
Weiqi Zhang,Xin Kong,Linlin Bo,Delin Yin,Zhichun Zhang,Xiaojun Fan,Hongping Chen,Jin Yuan
Zeolitic imidazolate framework-8 (ZIF-8) has been widely employed for carbon dioxide (CO 2 ) and methane (CH 4 ) separation, and CO 2 adsorption and storage owing to its high porosity and tunable pore structure. However, its potential to enhance CO 2 -to-CH 4 conversion by grasping CO 2 in hydrogenotrophic methanogenic systems, thereby increasing CH 4 percentage in biogas, remains unexplored. This study synthesized ZIF-8 material and applied it in a biological biogas upgrading system. The results indicated that the CO 2 -to-CH 4 conversion rate was maximized in the system with 0.75 g/L of ZIF-8 added. Over a single reaction cycle (5 days), the CH 4 proportion increased from 60 % to 97 %. Furthermore, in continuous operation over three reaction cycles, the ultimate CH 4 proportion in this reactor consistently exceeded 95 %, meeting the standards of biomethane. The pathway analysis revealed that the ZIF-8 introducing could increase abundance of hydrogenotrophic methanogens and facilitated the transition of metabolic pathway from acetotrophic to hydrogenotrophic methanogenesis.
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PubMed
高影响因子
Theranostics
·
2020
·
IF 8.579
Chao Fang,Dong Cen,Yifan Wang,Yongjun Wu,Xiujun Cai,Xiang Li,Gaorong Han
Abnormal tumor microenvironment, such as hypoxia, interstitial hypertension and low pH, leads to unexpected resistance for current tumor treatment. The development of versatile drug delivery systems which present responsive characteristics to tumor microenvironment (TME) has been extensively carried out, but remains challenging. In this study, zeolitic imidazolate framework-8 (ZIF-8) coated ZnS nanoparticles have been designed and prepared for co-delivery of ICG/TPZ molecules, denoted as ZSZIT, for H 2 S-amplified synergistic therapy. Methods: The ZSZ nanoparticles were characterized using SEM, TEM and XRD. The in vitro viabilities of cancer cells cultured with ZSZIT under normoxia/hypoxia conditions were evaluated by cell counting kit-8 (CCK-8) assay. In addition, in vivo anti-tumor effect was also performed using male Balb/c nude mice as animal model. Results: ZSZIT shows cascade PDT and hypoxia-activated chemotherapeutic effect under an 808nm NIR irradiation. Meanwhile, ZSZIT degrades under tumor acidic environment, and H 2 S produced by ZnS cores could inhibit the expression of catalase, which subsequently favors the hypoxia and antitumor effect of TPZ drug. Both in vitro and in vivo studies demonstrate the H 2 S-sensitized synergistic antitumor effect based on cascade PDT/chemotherapy. Conclusion: This cascade H 2 S-sensitized synergistic nanoplatform has enabled more effective and lasting anticancer treatment.
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高影响因子
Surfaces and Interfaces
·
2025
·
IF 6.3
Aminov Nail,Huan Liu,Decheng Meng,Liran Zhu,Xiaohan Guo,Cong Li,Hao Yu,Zilian Yu,Huanjun Li
In the frontier of drug delivery research, the amalgamation of nanotechnology with 3D printing presents a transformative avenue for patient-centric therapies. This study presents the development of insulin/GOx-loaded Zeolitic Imidazolate Framework-8 (ZIF-8) microneedles, utilizing the unique properties of Metal-Organic Frameworks (MOFs) and advanced 3D printing techniques to enhance transdermal drug delivery systems. A key innovation lies in the use of a Polymerizable Deep Eutectic Solvent (PDES)-based ink for digital light processing (DLP) 3D printing, enabling accelerated photopolymerization and precise fabrication of microneedles. The PDES formulation, consisting of Betaine, Methacrylic Acid (MAA), 2-Hydroxyethyl Methacrylate (HEMA), Polyethylene Glycol Diacrylate (PEGDA), and the photoinitiator trimethylolpropane triacrylate (T-POL), was specifically designed to exploit hydrogen bonding interactions, thereby enhancing polymerization efficiency and structural integrity. The insulin/GOx-loaded ZIF-8 microneedles demonstrated responsive and controlled drug release, with notable sensitivity to glucose and pH changes, making them particularly suitable for diabetic applications. In vitro and in vivo results confirmed the superior drug encapsulation, stability, and release kinetics of the microneedles, showcasing their potential for effective and sustained transdermal delivery of insulin. This work establishes a new paradigm in the synthesis of multifunctional microneedles through the integration of MOFs and PDES for DLP 3D printing. The findings highlight the capability of this approach to address current challenges in drug delivery, offering a scalable, biocompatible, and responsive platform for advanced therapeutic applications.
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高影响因子
Discover Applied Sciences
·
2025
·Vol. 7
·期 7
·728
·
IF 0
Lan Tian,Ding Xiaofan,Xiao Songtao,Yuan Zhongwei,Yan Taihong,Chen Qi,Li Tianchi,Zheng Weifang
Developing effective iodine capture technologies is critical for both nuclear safety and environmental protection. This study investigates the iodine adsorption properties of ZIF-8, a metal–organic framework (MOF). ZIF-8 samples with varying particle sizes (∼50 nm, 90 nm, 150 nm, and 8 μm) were synthesized and tested for iodine vapor adsorption at 80 °C. Iodine uptake continuously increased with time, reaching ~ 3500 mg/g after 24 h without reaching equilibrium, with no significant dependence on particle size. Structural changes in ZIF-8 were observed, as iodine accumulation led to the breakdown of the framework into an amorphous gel-like substance, representing a previously unreported phase transformation. SEM and XRD characterization confirmed the collapse of the crystalline structure after iodine loading. These results indicate that iodine adsorption in ZIF-8 involves strong chemisorption in addition to physical uptake, causing irreversible framework transformations. This work highlights the influence of particle size and provides important insights for using ZIF-8 in effective radioactive iodine capture.
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CERAMICS INTERNATIONAL
·
2025
·
IF 5.6
Hongtao Wang,Yuanchao Xie,Yang Liu,Yaodan Zhang,Jianan Ma,Jiaqi Yang
The enhanced sensitivity and selectivity of NO 2 gas sensors are crucial for atmospheric environmental monitoring. In this study, a novel NO 2 gas sensor based on small-sized ZIF-8/In 2 O 3 core-shell nanocube has been developed through a simple solvothermal method along with in situ modification. The ZIF-8 coating significantly increased the specific surface area of the In 2 O 3 nanocubes from 60.64 m 2 /g to 140.84 m 2 /g, while also boosting the adsorption of oxygen ions on the surface. Gas-sensing tests revealed that the ZIF-8/In 2 O 3 composites exhibited a response of 56.3 to 1 ppm of NO 2 , with an exceptionally low detection limit of 1 ppb. Notably, the sensor demonstrated outstanding selectivity for NO 2 over other potential interfering gases. The remarkable NO 2 sensing performance of the ZIF-8/In 2 O 3 composites can be attributed to the grain boundary effects in the In 2 O 3 nanocubes (with side lengths of approximately 40–50 nm), as well as the sensitizing and filtering effects of the ZIF-8 layer. This work holds significant promise for the rapid detection of low-concentration NO 2 gases in various applications.
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JOURNAL OF MATERIALS SCIENCE
·
2025
·
IF 3.9
Xiong Yujie,Li Guo,Feng Dunfeng,Lao An,Wu Hanqi,Chen Jiabin,Nie Yanyan,Zhang Weizhen,Zheng Zheng
Microcystin-LR (MC-LR), a cyanotoxin frequently generated during algal blooms, has drawn significant attention owing to its widespread occurrence and severe toxic effects. The development of efficient methodologies for removing MC-LR is essential to address the challenges posed by eutrophication-related pollution. In this study, we synthesized three porous carbon materials derived from zeolitic imidazolate framework-8 (ZIF-8) at varying carbonization temperatures and systematically evaluated their adsorption efficiency for MC-LR removal. The experimental data indicated that the saturation capacities of MC-LR adsorption on ZIF-8, CZIF-700, CZIF-950, and CZIF-1200 were 3.10, 3.98, 35.97, and 13.53 mg g −1 , respectively. Remarkably, CZIF-950 exhibited both the highest adsorption capacity and the fastest equilibrium time (< 5 min), outperforming all other adsorbents by a significant margin. Furthermore, adsorption isotherm and kinetic analyses revealed that the adsorption process aligned with the Langmuir model and followed the pseudo-second-order kinetics. Material characterization revealed that CZIF-950 achieves highly efficient MC-LR removal through synergistic adsorption mechanisms involving electrostatic interactions, hydrogen bonding, hydrophobic effects, and π-π stacking, facilitated by its optimal pore structure, large specific surface area, and unique structural characteristics. Our study provides valuable insights into the design of advanced metal–organic framework-derived adsorbents for the efficient removal of MC-LR and other environmental contaminants. Graphical abstract
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高影响因子
ACS Applied Nano Materials
·
2025
·
IF 5.5
Lingling Li,Zihao Lv,Hao Jiang,Xiaoxian Zhao,Lan Wu,Xiuming Cao,Helan Xu,Qufu Wei,Qingqing Wang
A pH-responsive bacterial cellulose (BC)-based composite nanofiber membrane functionalized with rose bengal (RB)-encapsulated ZIF-8 (BC/RB@ZIF-8) was developed via in situ growth for the targeted therapy of bacterial stomatitis. The BC film enhanced the photodynamic effect, addressing the challenges of photosensitizer aggregation-induced quenching and its reuse. The BC/RB@ZIF-8 nanofiber membrane demonstrated sustained photodynamic activity, maintaining a stable singlet oxygen (1O2) quantum yield under continuous 130 min irradiation. The nanofiber membrane exhibited robust mechanical properties, including a tensile strength greater than 33 MPa, high water absorption capacity (916.61 ± 4.7%), and optimal moisture vapor transmission rate (40.56 ± 1.37 g/m2·h), meeting the key requirements for oral wound dressings. In acidic infection microenvironments, ZIF-8 degradation facilitated the synchronized release of Zn2+ and RB, leading to dual-mode antibacterial action: (1) the continuous release of Zn2+ from ZIF-8 disrupts bacterial cell membranes through electrostatic interactions; and (2) ROS generation via Type I (•OH) and Type II (1O2) pathways, resulting in irreversible damage to bacterial cell membranes and components. This synergistic mechanism led to a 99.99% eradication of S. aureus and MRSA under acidic conditions, outperforming conventional therapies. Cytocompatibility and hemocompatibility were confirmed in accordance with ISO 10993 standards. The BC/RB@ZIF-8 nanofiber membrane represents a significant advancement in pH-responsive antibacterial materials, offering a promising alternative to antibiotic-based treatments for biofilm-infected oral wounds.
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高影响因子
SENSORS
·
2025
·Vol. 25
·期 24
·7462
·
IF 3.5
Yuanyue Lu,Yong Mei,Yingying Gu,Ye Tao,Yuhan Yang,Jiao Yu,Yang Zhang,Lin Liu,Xin Li
An electrochemical immunosensor was fabricated to identify CA15-3, a biomarker for breast cancer (BC). A composite sensor substrate made of “zeolitic imidazolate framework-8” (ZIF-8) and “reduced graphene oxide” (rGO) was chosen and its conductivity was further improved by the addition of chitosan (CS)-doped gold nanoparticles (AuNPs). The CS@AuNPs are able to conjugate with antibodies via the strong Au-S interaction, which offers multiple active sites for antibody immobilization and enhances the sensor performance. This immunosensor is capable of ultrasensitive detection of CA15-3 by specific antigen–antibody –interactions. In healthy people, normal serum CA15-3 is up to 25 U/mL. Under optimized experimental conditions, the alteration in the signal intensity measured by the sensor was related to the CA15-3 activity. The quantitative relationship was linear over 0.001–400 U/mL with a limit of detection (LOD) of 0.0031 U/mL at a “signal-to-noise ratio” (S/N) of 3 and a “correlation coefficient” (r2) of 0.9983. The developed immunosensor showed great accuracy, stability, and selectivity, and was able to detect CA15-3 in human serum samples. These results validate its potential as a reliable analytical platform for BC diagnosis and early clinical screening.
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高影响因子
DESALINATION
·
2025
·
IF 9.8
Jialu Li,Zhonghao Xu,Yangdong He,Sheng Shi,Sihan Ye,Liyun Zhang,Lan Ma,Jian Zhen Ou,Hao Yu
Integrating metal-organic-frameworks (MOFs) into graphene oxide (GO) membranes offers a pathway toward stable and highly selective nanofiltration, yet conventional blending or precursor-diffusion-driven in situ growth compromise structural integrity and is prohibitively slow (∼36 h). Here, we report an electric-field-driven strategy that induces electrophoretic migration of Zn 2+ and 2-methylimidazole precursors, enabling ultrafast (<60 s) synthesis of ZIF-8 within the internal pores of ethylenediamine (EDA)-crosslinked GO-based membranes intercalated by arched graphene (WG). Growth is directed preferentially into high-permeability channels, sequentially plugging dominant and subdominant pores at a rate 2160 times faster than diffusion. This selective pore filling suppresses ZIF-8 overgrowth and minimizes structural disruption, while enhancing rejection performance. The resulting membrane exhibits exceptional dye rejection of 87.11 % (MB), 99.45 % (EBT), 97.39 % (CV), 99.21 % (CR), and 99.37 % (TB), surpassing pristine GO (36.90–91.07 %) and slightly outperforming diffusion-grown counterparts. Meanwhile, the intrinsic 0.7 nm pores of ZIF-8 permit nearly complete salt permeation (rejection <2.73 %), yielding practical dye/salt selectivity >8. Amine-functionalized ZIF-8 further promotes crosslinking, imparting remarkable stability: wet/dry interlayer spacing variation <1 Å and strong resistance to acid/base exposure, hydraulic flushing, and ultrasonication. This electric-field-guided, sub-nanopore engineering strategy thus establishes a generalizable platform for precision separation membranes using diverse substrates and porous framework.
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