JOURNAL OF SEPARATION SCIENCE
·
2022
·Vol. 45
·期 9
·1600-1609
·
IF 3.614
An Kang,Jialu Jiang,Qin Li,Xianjie Sheng,Yan Chen,Jiani Tan,Liu Li,Weixing Shen,DongXin Tang,Haibo Cheng,Dongdong Sun
Scutellaria barbata D. Don ( S. barbata ) is one of the most frequently used anticancer herb medicine in China. Mechanistic understanding of the biological activities of S. barbata is hindered by limited knowledge regarding its components and metabolic profile. In this study, ultra-high-performance liquid chromatography coupled with high resolution mass spectrometry (quadrupole time-of-flight mass spectrometry) was used to identify the chemical constituents in S. barbata and their metabolic profiles in rats. By applying cleavage rules and comparison with reference substances, 89 components were identified in S. barbata , which included 45 flavonoids, 28 diterpenoids, 10 phenolics, and 6 others. A total of 110 compounds, including 32 prototype compounds and 78 metabolites, were identified or tentatively characterized in vivo. Methylation, sulfonation, and glucuronidation were the main metabolic pathways, which could be attributed to the fact that several of the compounds in S. barbata have phenolic hydroxyl groups. This is the first systematic study on the chemical constituents and in vivo metabolic profile of S. barbata . The analytical method features a quick and comprehensive dissection of the chemical composition and metabolic profile of S. barbata and provides a basis for exploring its various biological activities.
✓ 已验证
DOI
高影响因子
Matter
·
2026
·
IF 15.7
Zhiwei Chen,Chaoyi Qiu,Zhichao Wang,Xiang Liu,Zihao Tao,Jiahe Geng,Xikun Zhang,Haoxiang Yu,Lei Yan,Peng Li,Liyuan Zhang,Ting-Feng Yi,Jie Shu,Bao-Lian Su
The practical application of sulfur-based batteries is significantly limited by sluggish reaction kinetics and structural collapse. Herein, a copper-modified sulfurized polyaniline (CuSPANI) cathode with distinctive d-p-π multi-orbital coupling is constructed through Cu heteroatom introduction. This coupling, arising from hybridization between Cu d orbitals and sulfurized polyaniline (SPANI) p/π orbitals, enables triple electronic modulation: reducing energy barriers to enhance kinetics, expanding electron delocalization to improve conductivity, and activating horizontal Cu d orbitals to strengthen structural stability. Consequently, the aqueous CuSPANI battery delivers a high reversible capacity of 834.75 mAh g s −1 at 3 C and exceptional cycling stability (61.2% capacity retention after 60,000 cycles at 15 C). Moreover, the designed flexible quasi-solid-state pouch cell achieves a 1.25 V output and maintains stable power under deformation, highlighting its potential for wearable energy storage. This work provides new insight into designing high-performance sulfurized polymers via orbital hybridization.
✓ 已验证
DOI
高影响因子
Physiological Reports
·
2026
·Vol. 14
·期 11
·e70975
·
IF 2.1
Yunxian Wang,Fenglan Chu,Yanhua Gong,Ruihong Guo,Hui Dong
Despite the ubiquitous use of monosodium glutamate (MSG) as a food additive, its specific effects on intestinal health and disease remain largely unclear. Here we found mucosal application of MSG induced an upward intestinal short-circuit current ( I sc ) in the murine ileum, which was significantly reduced by extracellular Cl − , Na + , and Ca 2+ removal. Mechanistically, MSG-induced I sc was significantly attenuated by pharmacological inhibition of key transporters (NCX, SGLT1, NKA) and secretory channels (CaCC, CFTR, IK Ca ). Furthermore, disrupting intracellular Ca 2+ homeostasis via endoplasmic reticulum (ER) chelation or blockade of IP 3 R, RyR, SOCE/CRAC, and VGCC significantly suppressed both the ileal I sc and MSG-stimulated Ca 2+ signaling in IECs. Importantly, MSG triggered a simultaneous elevation in intracellular Ca 2+ and a reduction in Na + , which were abolished by the blockers of NCX and SGLT1. In vivo, MSG-induced Ca 2+ -dependent ion transports were significantly reduced in irritable bowel syndrome with diarrhea (IBS-D) mice. Our findings indicate that MSG drives Ca 2+ -dependent intestinal ion transports through a complex network orchestrated by SGLT1 and NCX under healthy state, which is markedly attenuated in IBS-D. This study provides novel insights into the gastrointestinal impact of dietary MSG in both health and bowel disease.
✓ 已验证
DOI
PubMed
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2026
·
IF 5.4
Tingquan Zhang,Yang Han,Fengqin Zhang,Chang Yang,Yuan Hu,Qingmei Wang
Designed ordered Pt 1 Co 1 nanocrystals anchored on N-doped carbon with optimized Pt/Co ratio for bifunctional ORR and MOR. • Achieved superior ORR performance: mass activity of 0.734 mA/μg Pt and specific activity of 1.725 mA/cm 2 , outperforming Pt/C by 4.2 and 6.2 times, respectively. • Revealed the synergy of ordered structure and metal-support interaction (SMSI) for electronic modulation (downshifted Pt d-band) and geometric stabilization. • Provided a universal design principle for high-performance Pt-based bifunctional electrocatalysts via structural ordering and support engineering. The practical deployment of fuel cells (FCs) faces significant obstacles stemming from the surface poisoning of electrocatalysts by carbonaceous intermediates (primarily CO) and the intrinsically sluggish reaction kinetics of the oxygen reduction reaction (ORR) at the cathode. Herein, we report the synthesis of ordered PtCo nanocrystals anchored on a nitrogen-doped carbon (NC) support with precisely controlled atomic ratios. The incorporation of Co atoms into the Pt lattice induces a downshift of the Pt d -band center, substantially weakening the adsorption strength of CO and other oxygen intermediates on the catalyst surface. In the CO stripping experiment, the CO oxidation peak potential of Pt 1 Co 1 NCs was observed at 0.587 V, which is 137 mV lower than that of 20% commercial Pt/C (0.724 V). This significant negative shift directly confirms the enhanced CO tolerance of the Pt₁Co₁ NCs catalyst. Furthermore, the Pt 1 Co 1 NCs catalyst demonstrated significantly enhanced bifunctional activity. Specifically, it delivered mass activities (MA) of 0.734 mA/μg Pt for the ORR and 0.932 mA/μg Pt for the MOR, outperforming commercial Pt/C by factors of 4.2 and 3.7, respectively. Download: Download high-res image (324KB) Download: Download full-size image
✓ 已验证
DOI
高影响因子
CHEMICAL ENGINEERING COMMUNICATIONS
·
2026
·
IF 2
Tongyang Wang,Rupeng Bu,Jun Han,Zhengping Wang
d-ribose, a key molecule in energy metabolism with wide applications in pharmaceuticals and functional foods, requires optimized crystallization for industrial production, where solubility is a critical thermodynamic parameter. Existing studies have limitations: narrow temperature ranges for solubility data (20–40 K) and insufficient understanding of how solvents affect solubility mechanisms. This study combines experimental and computational approaches: it measures d-ribose solubility in methanol, ethanol, 2-propanol, and 1-butanol across 293.15–333.15 K, analyzes the data, characterizes crystals formed in ethanol, and explores molecular interactions. Results show solubility follows the order: methanol > ethanol > 2-propanol > 1-butanol, increasing with temperature. Solubility differences correlate with solvent polarity, driven by hydrogen bonding interactions. Ethanol is identified as the optimal crystallization solvent due to moderate solubility, significant temperature sensitivity, and low toxicity. This work provides essential thermodynamic data and molecular insights for optimizing d-ribose production processes, while establishing a predictive framework for understanding functional sugar dissolution in alcoholic solvents.
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2026
·
IF 9.6
Jinghao Zhao,Baoqin Hao,Wei Tan,Jing Chen,Yan Meng,Lin Han,Xinhao Qu,Xin Li
Constructing vanadium oxide/metal selenide heterostructure is a promising strategy to enhance the reaction kinetics and structural stability for high-performance sodium-ion batteries (SIBs) anode. However, achieving a uniform and robust heterointerface remains challenging due to the multivalent state transformation of the V and the thermodynamic stability difference between V O and V Se bonds. Herein, we design and synthesize the V 2 O 3 /Fe 3 Se 4 @C heterostructure via a facile liquid-phase reaction followed by a seleniziation method. The unique coordination environment in a ferric vanadate and the reduction potentials difference between Fe and V cations promote the formation of a well-defined heterointerface. Density functional theory calculations confirm the formation of a built-in electric field at the heterointerface, thereby accelerating the reaction kinetics. The electric field originates from the orbital hybridization, which promotes the formation of a robust Se V O bonding configuration. Meanwhile, the carbon coating maintains structural integrity by suppressing volume expansion during cycling. These synergistic effects effectively enhance the overall structural stability of the material. Thus, the prepared V 2 O 3 /Fe 3 Se 4 @C anode exhibits exceptional electrochemical performance, delivering a high specific capacity of 378.2 mAh g −1 at 0.5 A g −1 and 308.9 mAh g −1 at 8 A g −1 , and retaining a specific capacity of 313.8 mAh g −1 after 2500 cycles at 5 A g −1 . This work establishes a new electron orbital modulation strategy for exploring high-performance vanadium oxide-based anode materials for SIBs.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2026
·
IF 4.8
Haoyu Zheng,Zhen Sun,Jianjun Liu,Su-an Xu,Jiadan Xue,Yong Du
A graphene-enhanced double-D metamaterial sensor exhibits electric-dipole scattering. • The maximum refractive index sensitivity of the optimized sensor reaches 204 GHz/RIU. • The graphene-coated sensor responds measurably at the lowest tested level of 1 μM. • The double-D electric-dipole sensor enables trace glucose detection using THz-FDS. Terahertz metamaterial sensors provide an efficient platform for highly sensitive biochemical detection. Herein, a graphene-enhanced terahertz metamaterial sensor was developed and coupled with a terahertz frequency-domain spectroscopy (THz-FDS) system for trace-level detection of glucose. A metamaterial sensor comprising a double-D-shaped split-ring aluminum resonator was fabricated, which exhibited a pronounced resonance at 0.951 THz under transverse-electric (TE)-polarized terahertz incidence. Multipole decomposition, together with electric-field, magnetic-field, and surface-current analyses, showed that the resonance is dominated by the electric dipole (ED). The ED channel accounts for approximately 98.59% of the summed isolated multipolar scattering power, whereas the toroidal dipole (TD) and magnetic quadrupole (MQ) provide only minor contributions. After structural optimization, CST simulations of bulk refractive-index variation yielded a sensitivity of 204 GHz/RIU, characterizing the simulated index-sensing performance of the resonator. To achieve high-precision detection of trace-level glucose, monolayer graphene was transferred onto the metamaterial surface using a wet transfer method. Experimental measurements showed a measurable response at the lowest tested concentration of 1 μM for the graphene-coated sensor, whereas the bare sensor showed a clear concentration-dependent response primarily in the millimolar range. Although the resonance amplitude varied nonmonotonically with concentration, the resonance-frequency shift increased monotonically and yielded a log-concentration calibration with R 2 = 0.932. Controlled paired simulations separated the contributions of graphene Fermi-level modulation and conventional dielectric loading. At an analyte thickness of 40 μm, the graphene-associated shift was +182.609 GHz, whereas dielectric loading produced redshifts of −245.081 GHz at E f = 0 and −247.997 GHz at E f = −120 meV. The interaction residual was −2.916 GHz, or 1.60% of the graphene contribution, indicating that the two effects are approximately additive under full loading. This work demonstrates that graphene-enhanced terahertz metamaterials can serve as highly sensitive sensing platforms for trace substance detection and provides both a physical strategy and experimental basis for developing high-performance terahertz biosensors involving interactions with low-dimensional materials. Download: Download high-res image (148KB) Download: Download full-size image
✓ 已验证
DOI
高影响因子
JOURNAL OF PHYSICS AND CHEMISTRY OF SOLIDS
·
2026
·
IF 5.9
WenYu Yan,Hao Yi,ZhongKe Luo,Fei Qi,XinFeng Li,Chao Wang
Constructing MoSe 2 @Ni 3 Se 2 heterostructures optimized active site distribution and charge transport. • Three-dimensional nanostructure achieved high specific surface area and outstanding mechanical stability. • Synergistic Mn/Co/Se regulation optimizes adsorption behavior of reaction intermediates. • Theoretical calculations reveal d-p orbital hybridization as the electronic-scale mechanism for high activity. • Demonstrates highly efficient bifunctional full water splitting activity (1.57 V@10 mA cm −2 ). This paper reports an MCS-MoSe 2 @Ni 3 Se 2 /NF composite electrocatalyst with remarkable performance advantages, achieving breakthroughs in full hydrolysis performance through ingenious structural design and interfacial engineering. The catalyst first constructs MoSe 2 @Ni 3 Se 2 nanosheet arrays on a nickel foam substrate, followed by Mn–Co–Se introduction via electrodeposition for interfacial modification. This forms a unique spherical structure that substantially exposes active sites and optimizes electron transport pathways, significantly enhancing reaction kinetics. Under alkaline conditions, this material exhibits outstanding bifunctional catalytic activity: HER achieves 10 mA cm −2 at just 103 mV overpotential, while OER requires only 263 mV. Notably, when assembled as an integrated water electrolysis cell with simultaneous anode and cathode functions, it drives a current density of 10 mA cm −2 at a low voltage of 1.57 V and operates stably for over 50 h. Density functional theory calculations further reveal that its outstanding performance stems from the precise regulation of the material's d-orbital electronic structure by Mn–Co–Se. This creates a strong, broad d-p orbital hybridization region near the Fermi level, achieving an ideal balance between high conductivity and catalytic activity, thereby optimizing the reaction pathway. This work provides crucial material systems and theoretical insights for designing efficient, stable bifunctional water electrolysis catalysts. The MCS-MoSe 2 @Ni 3 Se 2 /NF structure engineered through interface design enhances water electrolysis performance by optimizing electron transfer pathways and regulating d orbitals. Download: Download high-res image (318KB) Download: Download full-size image
✓ 已验证
DOI
高影响因子
FOOD MICROBIOLOGY
·
2026
·
IF 5.4
Jian Chen,Shiya Guo,Huan Li,Shigenobu Koseki,Jianhao Zhang,Xiaowei Sheng,Yanbo Wang
Dielectric barrier discharge (DBD) cold plasma combined with d -tryptophan ( d -Trp) exhibited a pronounced synergistic inactivation effect against Shewanella baltica , a dominant spoilage bacterium in aquatic products, and the underlying reactive oxygen species (ROS)-mediated mechanism was elucidated. 40 s combined treatment (DBD + d -Trp) achieved a 7.31 log CFU/mL reduction, markedly exceeding the 1.3 log reduction obtained with DBD treatment alone. Physicochemical analysis showed elevated hydrogen peroxide and nitrite levels accompanied by decreased pH in the synergistic system. Electron paramagnetic resonance and radical scavenging assays revealed that d -Trp selectively enhanced singlet oxygen ( 1 O 2 ) generation while suppressing hydroxyl radicals and superoxide anions, thereby reshaping the ROS profile compared to DBD treatment alone. Severe cellular damage was observed by scanning electron microscopy, and increased alkaline phosphatase release, potassium leakage, and membrane depolarization confirmed disruption of the cell envelope integrity. Elevated intracellular ROS accumulation and dysregulation of antioxidant enzyme activity indicated aggravated oxidative stress leading to bacterial death. The synergistic inactivation effect was further validated in fish juice, demonstrating superior efficacy compared to individual treatments. These findings demonstrate that d -Trp potentiates plasma inactivation through selective modulation of ROS composition and provide a mechanistic foundation for developing targeted control strategies against specific spoilage bacteria in aquatic products.
✓ 已验证
DOI
高影响因子
Surfaces and Interfaces
·
2026
·
IF 6
Lihuan Feng,Yulin Wang,Hao He,Chunyu Li,Peng Chen,Qiang Liu,Xing’an Dong,Wenjie He,Jiazhen Liao,Wendong Zhang
Solar-driven photocatalytic CO 2 reduction provides a sustainable pathway for carbon-neutral fuel production, yet its efficiency is fundamentally limited by the chemical inertness of linear CO 2 and inefficient utilization of photogenerated charge carriers. Effective activation of CO 2 requires electron injection into its antibonding π* orbitals, a process that is poorly matched with conventional oxide photocatalysts. Herein, we construct chemically defined Ti-O-Fe interfacial bonds in TiO 2 /Fe 2 O 3 heterojunctions to establish a directional d→π* electron-transfer channel for CO 2 activation. The optimized TiO 2 /Fe 2 O 3 photocatalyst, synthesized via a one-step hydrothermal method, exhibits broadened visible-light absorption and delivers a CO formation rate of 17.56 μmol·g −1 ·h −1 , over three times higher than that of pristine TiO 2 . Spectroscopic analyses and density functional theory calculations reveal that interfacial electron transfer shifts Fe 3d states toward the Fermi level, enabling strong hybridization with the CO 2 π* orbitals and significantly lowering the free-energy barrier for *COOH formation. This bond-mediated electronic coupling not only suppresses charge recombination but also directs photogenerated electrons toward the CO 2 activation pathway. These results demonstrate that interfacial d-band engineering through chemically specific oxide–oxide bonds provide a powerful strategy to program elementary reaction steps in solar-driven CO 2 reduction beyond conventional band-alignment design.
✓ 已验证
DOI
高影响因子
ACS ES&T Water
·
2026
·
IF 4.5
Ziwen Cheng,Han Zhao,Zhenxiang Sun,Kexin Yin,Qinyan Yue,Weiyan Yin,Baoyu Gao,Yue Gao
Mass transfer limitations in Co-based heterogeneous peroxymonosulfate (PMS) activation systems were effectively mitigated via electronic structure modulation. Nitrogen doping introduces electron-withdrawing effects into Co/NC catalysts, which shifts the Co d-band center upward and optimizes orbital hybridization between the Co 3d and O 2p orbitals. This electronic configuration lowers the antibonding state occupancy in the Co-PMS complex, thereby facilitating PMS adsorption and activation. The engineered Co/NC catalyst completely degrades sulfamethoxazole within 3 min (rate constant: 2.3 min–1), demonstrating enhanced interfacial electron transfer kinetics. Its robust performance is maintained in complex aqueous matrices containing Cl–, NO3–, H2PO4–, and SO42– anions. Moreover, effective pollutant removal persists for over 240 min in a continuous-flow membrane reactor, confirming the practical applicability. This orbital-level design strategy advances cobalt-based PMS activation systems by synergistically optimizing the mass transfer and electronic interactions.
✓ 已验证
产品关联
DOI
高影响因子
ENZYME AND MICROBIAL TECHNOLOGY
·
2026
·
IF 3.9
Zhicen Liu,Caiyun Wang,Junjian Wu,Ming Chen,Yue Zhang
This study developed a highly efficient immobilized phospholipase D (PLD) system using a magnetic chitosan-based carrier with the natural crosslinking agent genipin (Fe 3 O 4 @CS-Gnp-PLD). Systematic characterization confirmed successful PLD immobilization, with chitosan's abundant amino and hydroxyl groups providing stable binding sites that enhanced both enzyme loading and stability. In the sodium deoxycholate-based mixed micelle system, the Fe 3 O 4 @CS-Gnp-PLD achieved an 8.05-fold higher phosphatidylserine (PS) conversion rate than free PLD, owing to enhanced substrate solubility and improved enzyme accessibility. The immobilized enzyme demonstrated exceptional operational stability, retaining 80% activity after 6 reuse cycles and 72% activity after 12 days of storage at 4 °C. This integrated platform, combining chitosan-based enzyme immobilization with a mixed micelle system, offers an efficient, stable, and recyclable approach for sustainable PS biomanufacturing.
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）