Biomaterials Science
·
2020
·Vol. 8
·期 18
·5029-5046
·
IF 6.183
Yuanhang Zhou,Chuhang Zhou,Yang Zou,Yao Jin,Shidi Han,Qi Liu,Xinping Hu,Leqi Wang,Yining Ma,Yan Liu
Combination therapy has been proved to be an effective strategy to inhibit metastasis, however, its efficacy is always compromised by the poor delivery efficiency of drugs. In this study, multi pH-sensitive polymer–drug conjugate mixed micelles were fabricated by the self-assembly of PEOz-PLA-ace-Cur, a conjugate of curcumin (Cur) with poly(2-ethyl-2-oxazoline)-poly(D,L-lactide) (PEOz-PLA) through the linkage of the pH-cleavable acetal bond, and PEOz-PLA-imi-DOX, a conjugate of doxorubicin (DOX) with PEOz-PLA through the linkage of the pH-cleavable benzoic imine bond. The mixed conjugate micelles (PP-Cur/PP-DOX-Mix-PMs) with accurately and conveniently controlled mass ratio of the two drugs were demonstrated to have a small particle size (40–128 nm), high drug loading capacity and pH-dependent drug release behavior. Notably, PP-Cur5/PP-DOX1-Mix-PMs exhibited slower DOX release under physiological conditions compared with PEOz-PLA-imi-DOX micelles, resulting in deeply reduced side effects in vivo. Furthermore, the mixed conjugate micelles showed synergistically enhanced inhibition of MDA-MB-231 cell growth and metastasis evidenced by the results of in vitro anti-invasion, wound healing and anti-migration assessment, and in vivo bioluminescence imaging in nude mice, and significant reduction of the side effects of DOX compared with dual drug physically loaded polymeric micelles. Mechanistic studies demonstrated that the possible inhibitory mechanism of PP-Cur5/PP-DOX1-Mix-PMs on tumor metastasis could be assigned to their inhibition of the invasion, migration, intravasation and extravasation of tumor cells. In conclusion, the multi pH-sensitive polymer–drug conjugate mixed micelles with synergistically enhanced anti-tumor and anti-metastasis activity are potential candidates for safe and effective cancer combination therapy.
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LWT-FOOD SCIENCE AND TECHNOLOGY
·
2024
·
IF 6
Dehua Wang,Biqian Wei,Yi Zhang,Tongxin Xie,Jing Yu,Yong Xue,Biao Kong,Changhu Xue,Qingjuan Tang
Excessive salt consumption is strongly linked to the chronic diseases development, highlighting the urgent need for effective salt-reduction strategies in food products. However, reducing salt content often compromises both food preservation and flavor. In this study, we hypothesized that curcumin could enhance the flavor perception of sodium chloride while compensating for its antimicrobial effect in reduced-salt applications. To test this, we developed a curcumin/γ-cyclodextrin/sodium chloride complex (IC), using γ-cyclodextrin as a carrier, and evaluated its antimicrobial and flavor-enhancing properties. The complex's formation was confirmed through various analytical techniques. Results from electronic tongue and sensory evaluations demonstrated that the IC enhanced the perception of saltiness and imparted unique aromatic characteristics compared to standard sodium chloride. GC-IMS analysis identified key aroma contributors, such as aldehydes and alcohols. Additionally, antimicrobial tests revealed that the IC efficiently mediated the sono/photodynamic inactivation of Shewanella putrefaciens and Vibrio parahaemolyticus . In summary, the IC offers a multifunctional approach, enhancing flavor, reducing salt, and enabling antimicrobial activity, while promoting practical uses of sono/photodynamic technology in low-sodium foods.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Yulian Zhu,Chunwei Du,Fan Jiang,Wenxuan Hu,Xiuzhu Yu,Shuang-kui Du
Ultrasonic assisted acetic acid hydrolysis was applied to prepare starch nanocrystals (SNCs) from native starches with different crystalline structures (A, B, and C types). The structure properties, morphology, Pickering emulsion stability and curcumin deliver capacity of both SNCs and native starches were investigated and compared. Compared with native starches, SNCs showed smaller size and higher crystallinity. The size of SNCs varied with different crystalline types, with C-type starch exhibiting the smallest SNCs (107.4 nm), followed by A-type (113.8 nm), and B-type displaying the largest particle size (149.0 nm). SNCs-Pickering emulsion showed enhanced stability with smaller emulsion droplets, higher static stability, and denser oil/water interface. SNCs-Pickering emulsions displayed higher curcumin loading efficiency (53.53 %–61.41 %) compared with native starch-Pickering emulsions (13.93 %–19.73 %). During in vitro digestion, SNCs-Pickering emulsions proved to be more proficient in protecting and prolonging the biological activity of curcumin due to their smaller size and better interfacial properties. These findings demonstrated the potential of SNCs for application in Pickering emulsion and delivery of bioactive components.
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FOOD CHEMISTRY
·
2024
·
IF 8.5
Shen Long,Meng-Jie Yu,Ran Feng,Han Tao,Bao Zhang
In this study, a novel dextrin-based micelle (OSAD-SH), dual-modified with octenyl succinic anhydride (OSA) and cysteamine, has been developed to address the acid instability issues of micelles modified only by OSA and designed for curcumin delivery. The chemical structure of OSAD-SH was characterized and the physical properties of the micelles were evaluated. Results displayed that OSAD-SH micelles exhibit strong self-assembly properties, appearing as spheres with diameters ranging from 92.41 to 194.20 nm. Blank micelles with good dilution resistance, acid, thermal, and ionic strength stability. The curcumin encapsulated by the micelles is in an amorphous state. In vitro release experiments demonstrated that curcumin released from OSAD-SH micelles exhibits intestinal targeting. The Ritger-Peppas model effectively predicted the release behavior of curcumin, indicating that the release mechanism follows super case-II transport. The OSAD-SH micelle could be a promising nanocarrier for improving the physicochemical properties of curcumin in food fields.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Han Gao,Ni Chen,Luyi Sun,Dandan Sheng,Yuting Zhong,Mingru Huang,Chengxuan Yu,Xing Yang,Yuefeng Hao,Shiyi Chen,Zhengzhong Shao,Jun Chen
Artificial graft serves as the primary grafts used in the clinical management of sports-related injuries . Until now, optimizing its graft-host integration remains a great challenge due to the excessive inflammatory response during the inflammatory phase, coupled with an absence of tissue-inductive capacity during the regeneration phase. Here, a multi-layered regenerated silk fibroin (RSF) coating loaded with curcumin (Cur) and Zn 2+ on the surface of the PET grafts (Cur@Zn 2+ @PET) was designed and fabricated for providing time-matched regulation specifically tailored to address issues arising at both inflammatory and regeneration phases, respectively. The release of Cur and Zn 2+ from the Cur@Zn 2+ @PET followed a time-programmed pattern in vitro. Specifically, cellular assays revealed that Cur@Zn 2+ @PET initially released Cur during the inflammatory phase, thereby markedly inhibit the expression of inflammatory cytokines TNF-a and IL-1β. Meanwhile, a significant release of Zn 2+ was major part during the regeneration phase, serving to induce the osteogenic differentiation of rBMSC. Furthermore, rat model of anterior cruciate ligament reconstruction (ACLR) showed that through time-programmed drug release, Cur@Zn 2+ @PET could suppress the formation of fibrous interface (FI) caused by inflammatory response, combined with significant new bone (NB) formation during regeneration phase. Consequently, the implementation of the Cur@Zn 2+ @PET characterized by its time-programmed release patterns hold considerable promise for improving graft-host integration for sports-related injuries.
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FOOD HYDROCOLLOIDS
·
2025
·
IF 12.4
Tingting Yang,Xinming Zhang,Feifei Wang,Liming Zhang,Dawei Yu,Xueying Zhang,Guanghua Xia,Jiamei Wang
Cold plasma (CP) modification, combined with nanotechnology, has demonstrated significant potential for enhancing the performance of bio-based packaging films. In this study, zein-curcumin-quercetin-chondroitin sulfate nanoparticles (ZCQC NPs) were incorporated into a chitosan film and modified by CP (0, 10, 30, 50 kV) to enhance the physicochemical properties, bioactivity, and preservation ability of the chitosan-based film. Fourier transforms infrared spectrometer (FT-IR) and X-ray diffraction (XRD) analyses confirmed the presence of hydrogen bonding and electrostatic interactions between the NPs and chitosan, as well as their good compatibility. Thermogravimetric analysis revealed that CP treatment synergistically enhanced the thermal stability of NPs-incorporated composite films. The incorporation of CP and NPs enhanced the film's mechanical strength, hydrophobicity, and barrier performance synergistically. Among them, the CP-C-NPs 30 kV film exhibited lower water vapor permeability (1.33 ± 0.15 g/m·d) and oxygen permeability (4.16 ± 0.27 × 10 −6 g/m·d·Pa), along with excellent antioxidant and antibacterial properties. More importantly, the CP-C-NPs 30 kV film significantly reduced the total viable count (13.64 % compared to the control) and the degree of lipid oxidation (TBARS value decreased by 42.86 %) in packaged fish, extending the shelf life at 4 °C to 8 days, which was twice that of ordinary packaging film. This study not only reveals the synergistic enhancement mechanism of CP modification on the performance of active packaging materials but also provides new strategies for developing efficient food preservation materials.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Cunshi Zhao,Lili Song,Yuanxun You,Yi Yang,Dong Wang,Zefang Xiao,Yanjun Xie,Qingbo Wang,Yonggui Wang
Polylactic acid (PLA), as a biodegradable material, is considered an ideal alternative to petroleum-based plastics. The intrinsic mechanical fragility and lack of multifunctional characteristics significantly constrain its practical utilization in advanced applications. This study designed and prepared a ternary PLA composite material with uniform surface and enhanced functionality by uniformly dispersing esterified CNC (E n CNC) Curcumin (Cur) hybrid nanostructures in the polymer matrix. The synergistic interaction between the E n CNC and Cur significantly enhanced their interfacial compatibility with the PLA matrix, leading to uniform dispersion and significantly improved flexibility. The flexibility of resulting E n CNC_Cur_PLA composite films was significantly improved, with elongation at break increased to 64.42 %, representing a 628.59 % increase compared to pure PLA. The addition of EnCNC increased the bioavailability of Cur and demonstrated multifunctional effects, including controlled release of Cur in ethanol, enhanced antioxidant activity (80.6 % DPPH clearance) and antibacterial activity (over 99 % against Escherichia coli, 87.7 % against Staphylococcus aureus ). Overall, these results highlight a simple and effective strategy to fabricate multifunctional, sustainable bio-based films with improved mechanical performance and biological activity, suitable for advanced food packaging applications.
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Food Bioscience
·
2025
·
IF 5.9
Sirui Ni,Weiyun Zheng,Qiuyue Men,Xiaomeng Ren,Shuang Song,Chunqing Ai
Curcumin (Cur) is renowned for its antioxidant and anti-inflammatory properties; however, its application faces many challenges, including poor bioavailability and low solubility. Alginate (SA) gel system is a promising platform for the delivery of Cur, but its efficacy remains limited and requires further improvement. In this study, Cur/oil was encapsulated into water-in-oil nanoemulsions, which were subsequently incorporated into SA microparticles modified with chitosan (CS) or inulin (IN) to fabricate four types of microparticles: Cur/SA, Cur/SAIN, Cur/SACS, and Cur/Mix. Their characteristics were analyzed, including particle size and morphology, and their stability and release properties were assessed using in vitro models. It demonstrated that the incorporation of IN and CS slightly improved the encapsulation efficiency and stability of SA-based microparticles in simulated human upper digestive tract conditions. The in vitro results further indicated that the incorporation of IN and CS enhanced the release of Cur from SA microparticles in simulated intestinal conditions through pH- and biodegradation-dependent mechanisms. Moreover, Cur/Mix exhibited a longer residence time in the small intestine and colon compared to the other microparticles. The four microparticles exerted distinct effects on the composition of gut microbiota, with Cur/Mix enhancing microbiota richness and diversity. Furthermore, these microparticles altered microbiota metabolite profile, particularly amino acid metabolism, with Cur/Mix exhibiting a more pronounced effect on arginine biosynthesis. This study suggests that incorporating IN and CS into SA microparticles not only improves their physicochemical properties but also achieves a synergistic effect between Cur and polysaccharides.
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DRUG DELIVERY
·
2017
·
IF 6.402
Cihui Tian,Sajid Asghar,Yifan Wu,Daddy Kambere Amerigos,Zhipeng Chen,Mei Zhang,Lining Yin,Lin Huang,Qineng Ping,Yanyu Xiao
The application of orally administered nanoparticles in the circulation system is limited by the secretion and shedding of intestinal tract mucous layer. In order to enhance mucoadhesion and mucus penetration of curcumin (Cur)-loaded nanostructured lipid carrier (NLC) after oral administration, a new multifunctional conjugate, N-acetyl-L-cysteine-polyethylene glycol (100)-monostearate (NAPG), was synthesized. Functionalized nanocarriers (Cur-NAPG-NLC) modified by different amounts of NAPG (the amounts of NAPG were 20, 50, and 100 mg) were prepared and investigated for in vitro and in vivo behavior. Mean particle sizes of 89–141 nm with negative zeta potential (−15 to −11 mV) and high encapsulation efficiency (EE, >90%) possessing spherical and stable nanocarriers were observed. Sustained drug release was also observed for the NAPG-NLC. In situ intestinal perfusion studies showed that with increasing the amount of NAPG increase absorption of Cur. In vivo oral pharmacokinetic evaluation suggested that the bioavailability of Cur in rats was proportional to the degree of functionalization of NLCs with NAPG. AUC0–t of Cur-NAPG100-NLC was improved by 499.45 and 116.89 folds as compared to that of Cur solution and unmodified Cur-NLC, respectively. In conclusion, NAPG modified NLC could be a promising drug delivery system for improving oral performance of BCS class IV drugs.
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JOURNAL OF MOLECULAR LIQUIDS
·
2021
·
IF 6.165
Wenfeng Yan,Junmao Li,Wei Long,Yulin Feng,Mingzhen He,Weifeng Zhu,Meiying Liu,Hui Ouyang,Xiaoyong Zhang,Yen Wei
In this paper, a simple method that relied on direct chain transfer free radical polymerization was reported to synthesize MSNs based polymeric composites (named as MCM-41-SH-poly (PEGMA- co -VPA)) using poly (ethylene glycol) monomethyl ether (PEGMA) and 4-vinyl phenylboric acid (VPA) as monomers. The utilization of MCM-41-SH-poly (PEGMA- co -VPA) to load and delivery curcumin (CUR) was also evaluated in detail. The structure, properties, drug loading and release behaviors were evidenced by various characterization techniques. The results from biological studies have shown that CUR can be effectively loaded on MCM-41-SH-poly (PEGMA- co -VPA) with high drug loading rate through formation of borate bond between CUR and VPA. More importantly, resultant drug-loading complexes displayed excellent water dispersibility and CUR could be released from complexes with pH responsiveness. Taken together, we have developed a simple method for surface modification MCM-41 and resultant composites could display improved properties for intracellular controlled drug delivery applications.
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CURRENT ORGANIC SYNTHESIS
·
2023
·Vol. 20
·期 8
·821-837
·
IF 1.8
Bhandari Shashikant V.,Kuthe Pranali,Patil Shital Manoj,Nagras Om,Sarkate Aniket Pardip
Introduction: Cancer is the major cause of death globally. Cancer can be treated with naturally occurring Curcumin nuclei. Curcumin has a wide range of biological actions, including anti-inflammatory and anti-cancer properties. Even though it is an effective medicinal entity, it has
some limitations such as instability at physiological pH and a weak pharmacokinetic profile due to the β-diketone moiety present in it. To overcome this drawback, research was carried out on monoketone moieties in curcumin, popularly known as mono-carbonyl curcumin. Objective: The
present review focuses on different synthetic schemes and Mono-carbonyl curcumin derivative's Structure-Activity Relationship (SAR) as a cytotoxic inhibitory anticancer agent. The various synthetic schemes published by researchers were compiled. Methods: Findings of different researchers
working on mono-carbonyl curcumin as an anticancer have been reviewed, analyzed and the outcomes were summarized. Results: The combination of all of these approaches serves as a one-stop solution for mono-carbonyl curcumin synthesis. The important groups on different positions of mono-carbonyl
curcumin were discovered by a SAR study focused on cytotoxicity, which could be useful in the designing of its derivatives. Conclusion: Based on our examination of the literature, we believe that this review will help researchers design and develop powerful mono-carbonyl curcumin derivatives
that can be proven essential for anticancer activity.
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INTERNATIONAL DAIRY JOURNAL
·
2025
·
IF 3.4
Qianqian Ding,Jiuxiu Shi,Mengjiao Lv,Ling Li,Danli Wang,Tinglan Yuan,Gongshuai Song,Jinyan Gong
Protein-based complexes are critical for enhancing food functionality, particularly owing to the synergistic effects of ternary covalent complexes containing proteins, polysaccharides, and polyphenols. This study investigated the formation mechanism, structural characteristics, and functional properties of ternary covalent complexes composed of β-lactoglobulin (β-Lg), hyaluronic acid (HA), and three dicaffeoylquinic acid (DCQA) isomers (3,5-DCQA, 3,4-DCQA, and 4,5-DCQA); the complexes were prepared using different addition sequences. These complexes exhibited reduced surface hydrophobicity, altered secondary structures, and enhanced thermal stability. They showed significantly better antioxidant activities and emulsifying properties in comparison with native β-Lg. The protein-polysaccharide-polyphenol sequence yielded more stable and compact structures with higher polyphenol binding capacity. Subsequently, the protein-polysaccharide-polyphenol complexes were used to encapsulate curcumin (Cur), and it yielded encapsulation efficiencies up to 76.14 % (β-Lg-HA-3,4-DCQA-Cur), which was significantly higher than the encapsulation efficiency of native β-Lg-Cur (36.35 %). These complexes also improved the physical stability and antioxidant activity of Cur under adverse conditions. These findings highlight the critical roles of the addition sequence and polyphenol structure in modulating the functionality of protein-based complexes, and offer promising strategies for enhancing the delivery of bioactive compounds in food applications.
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