POLYMER ENGINEERING AND SCIENCE
·
2018
·
IF 1.551
Tengyang Zhu,Xing Yang,Yayun Zheng,Xiaoqi He,Feifei Chen,Jujie Luo
A series of poly(amide- co -poly(propylene glycol)) (PA-PPG) random copolymers with different content of PPG were designed by polycondensation reaction. These random copolymers were blended up to 60% with commercially available Pebax 2533. The blend membranes were characterized by Fourier-transform infrared (FTIR) spectroscopy, X-ray diffraction (XRD), scanning electron microscope (SEM). Gas permeation properties of these blend membranes were investigated using five single-gases (CO 2 , H 2 , O 2 , CH 4 , and N 2 ) at different temperature of 25–55°C and 1.0 atm. The impacts of content of PA-PPG with different PPG content and operating temperature on CO 2 separation properties of Pebax/PA-PPG blend membranes were studied. The results showed that CO 2 permeability gradually increased with the increasing operating temperature, whereas CO 2 permeability gradually decreased with the increase in content of PA-PPG. CO 2 /N 2 selectivity gradually increased with the increase in content of PA-PPG. In particular, Pebax/PA-PPG (50)–60% displayed excellent CO 2 and O 2 separation properties ( P CO2 = 79.7 Barrer and P O2 = 13.6 Barrer, CO 2 /N 2 = 34.7 and O 2 /N 2 = 5.9) at 25°C and 1.0 atm. POLYM. ENG. SCI., 59:E14–E23, 2019. © 2018 Society of Plastics Engineers
✓ 已验证
产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Yu Wang,Haojie Yu,Li Wang,Lei Zhang,Jian Yang,Chenguang Ouyang,Jian Hu,Jingyi Feng,Zheng Deng,Chang Chen
Efficient glycemic control serves as the cornerstone of diabetes and its complication treatments, necessitating additional symptomatic medications or nutritional supplements tailored to various complications. However, different diseases and medications require specific treatment regimens and drug delivery methods. For instance, conventional subcutaneous insulin injections suffer from uncontrollable release rates and onset times. This study has developed a segmented microneedle array that integrates two controlled-release mechanisms within a single array. Different drugs are loaded into distinct regions, allowing for modular and simultaneous timed-release therapies. The posterior segment of the microneedle tip releases insulin via a glucose-sensitive mechanism, enabling real-time intelligent glycemic regulation and effective glycemic control for up to 43.7 h, which is nearly 8 times longer than subcutaneous injections. The anterior segment releases vitamin B9 via a sustained-release mechanism, which has potential preventive and reparative effects on diabetic neuropathy, providing a gentler and more sustained nutrient supply. The regionalized design of the microneedles significantly enhances drug delivery efficiency and the intelligent customization of drug release, especially in managing diabetic neuropathy.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
·
2025
·
IF 2.2
Yaxin Qin,Qi Dai,Zhicheng Zhang,Xiaoyan Sun,Ruolin Jiang,Xiaoyan Bao,Linjie Wu,Xin Tan,Xufang Ying,Zhiqing Ben,Qichun Wei,Min Han
Objective Boron Neutron Capture Therapy (BNCT) is a novel precision radiotherapy. The key to BNCT application lies in the effective targeting and retention of the boron-10 (10B) carrier. Among the various compounds studied in clinical settings, 4-boronophenylalanine (BPA) become the most prevalent one currently. However, challenges such as inadequate solubility and restricted tumor accumulation have affected the clinical efficacy of treatment with BPA. Therefore, there is an urgent need to prepare formulations with higher tumor uptake efficiency and increased intratumoral accumulation.Methods polyethylene glycol 400 and BPA were added to methanol and stirred until completely dissolved. The solution was then evaporated to remove methanol, yielding a pale-yellow clear liquid of the PEG400-BPA complex. This complex was then used for in vitro and in vivo experiments, and it was evaluated for inhibition effects after BNCT irradiation in GL261 cells.Results Compared to the clinically used fructose-BPA, PEG400-BPA increased the boron uptake in tumor cells nearly twice and exhibited a better tumor-to-normal tissue ratio (T/N) in the in vivo studies. Due to the BNCT efficacy with PEG400-BPA through in vitro experiments, the PEG400-BPA group also had showed significant cell-killing effects.Conclusion We discovered that PEG400 can form a complex with BPA, significantly improving its water solubility. It provides a simple, long-term stable, easily convertible, and injectable formulation method for the delivery of BPA in BNCT treatment. It also offers new insights for BPA solubilization and formulation as well as compound forms of administration of boron drugs on the delivery of boron drugs in BNCT.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
EUROPEAN POLYMER JOURNAL
·
2024
·
IF 5.8
Zhixia Gong,Tiaozhen Yu,Zhi Cai,Ying Yi,Jingli Zhang,Weiquan Cai,Yihua Yin,Guanghua He,Yaqi Xiao,Peiyu Xu,Huiyi Wu,Sihui Lin
Photoactivated pesticides with high activity, environmental friendliness, and no drug resistance represent the direction of pesticide development. However, poor photostability and lack of targeting ability greatly restrict their practical application. Herein, a novel amphiphilic photoactivated polymeric propesticide was synthesized by conjugation of mPEG with the photo/enzyme-labile o-nitrobenzyl ester group followed by grafting protoporphyrin IX (PpIX), which could self-assemble into photo/esterase responsive polymer micelles in aqueous solutions for a controlled release of PpIX. The fluorescence quenching caused by the aggregation of PpIX into hydrophobic core could enhance its photostability. UV/esterase stimulation could trigger the release of PpIX and restore its photodynamic activity. Compared to a single stimulus, dual stimulation could trigger more PpIX release and resulting in higher photodynamic activity and antibacterial effect. In addition, light exposure also showed little influence on the photodynamic activity and antibacterial effect of the system due to enhanced photostability. Compared with PpIX, the nanosystem exhibited higher wettability and retention ability on plant leaves and could resist rainwater washout. Weed control experiment also demonstrated that the system’s control effect on barnyard grass. Therefore, this study provides new ideas for promoting the application of photoactivated pesticides in the field of plant protection.
✓ 已验证
产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
·
2025
·
IF 8.3
Xinkuai He,Genfa Zeng,Jingjing Yang,Yiren Li,Luye Wu
The electrochemical reduction behavior in the preparation of Ni–Mo alloy catalysts using benzyl alcohol (BA) and ethylene glycol (EG) mixed solvents is studied via CV. These studies indicate that the mechanism of Ni–Mo co-deposition corresponds to a typical induced co-deposition mechanism, in which Ni 2+ can facilitate the Mo 6+ reduction while Mo 6+ can suppress the Ni 2+ reduction in the mixed solvents. SEM micrographs reveal that these Ni–Mo alloy catalysts exhibit dense structures composed of 'hillock'-shaped granules, and the size of these granules can be tuned by adjusting the Mo content. XRD pattern reveals that the Ni–Mo catalysts present a nanocrystalline structure with an average crystallite size of 48.7 nm. The experimental data demonstrate that increasing the Mo content in the Ni–Mo alloy catalyst from 5.36 to 11.62 wt% significantly enhances the HER performance. Particularly, the catalyst containing 11.62 wt% Mo demonstrates superior catalytic efficiency in 1 M KOH, requiring an overpotential of merely 58 mV to reach a current density of 10 mA cm −2 .
✓ 已验证
产品关联
DOI
高影响因子
Science China-Technological Sciences
·
2021
·Vol. 64
·期 6
·1285-1294
·
IF 3.572
Rong Yan,Zhang Zhen,He ChaoLiang,Chen XueSi
The response of extracellular matrix (ECM) to dynamic cell signals is of great significance for the regulation of cell behavior. In the present study, we prepared a type of matrix metalloproteinase (MMP)-sensitive degradable hydrogels (MSDHs) via the catalyst-free o -phthalaldehyde (OPA)/amine cross-linking reaction between o -phthalaldehyde-grafted four-arm poly(ethylene glycol) (4aPEG-OPA) and an MMP-sensitive degradable peptide. The gelation rates and storage moduli of MSDHs and the MMP-insensitive hydrogels (MIHs) based on an MMP-insensitive scramble peptide were comparable and dependent on the concentrations of precursor polymers. MSDHs were degradable while MIHs were stable in the presence of proteinase in vitro . The degradation of MSDHs was obviously faster than that of MIHs after subcutaneous injection into rats. In addition, both types of poly(ethylene glycol)/peptide hydrogels displayed excellent cytocompatibility in vitro , and showed good histocompatibility in vivo in the subcutaneous layer of rats. Furthermore, the proliferation of several MMP-expressing cell lines including MDA-MB-231 cells within MSDHs was obviously faster than that in MIHs, indicating the influence of metabolism-mediated scaffold degradation on the cell proliferation. This study provides a new biocompatible and biodegradable 3D cell culture interactive platform for regulation of cell behavior.
✓ 已验证
DOI
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2025
·
IF 9.7
Anqi Zhao,Wei Zhou,Xin Wang,Zhongjie Song,Nannan Zhang,Huan Zhang,Xinyu Gu,Jiawei Qiang,Zhengying Wu,Yong Wang,Yukou Du
Strong electronic interactions at the heterojunction interfaces of heterostructured catalysts can effectively regulate the electronic structure, optimize the adsorption of reactants and intermediates, and enhance the electrooxidation of alcohols. Due to this unique structural advantage, heterostructured catalysts are widely utilized as anode catalysts for alcohol fuel cells. However, the controlled synthesis of ternary metal heterostructures remains a significant challenge. In this study, we successfully synthesized Pt-PdPtFe ternary metal hetero-nanosheets (HNSs) using a seed-mediated method. The synergistic effects of the three metals, along with the strain effect at the heterojunction interface, contribute to the enhanced alcohol oxidation performance of Pt-PdPtFe HNSs compared to commercial Pd/C and numerous previously reported advanced catalysts. The mass activities for ethylene glycol oxidation reaction (EGOR) and glycerol oxidation reaction (GOR) are 9.77 A mg Pd+Pt −1 and 6.04 A mg Pd+Pt −1 , respectively. Furthermore, CO stripping tests and durability tests indicate that Pt-PdPtFe HNSs exhibit excellent anti-poisoning ability and cyclic stability. This research presents a viable strategy for the controlled synthesis of ternary metal heterostructures, while also offering valuable insights into the rational design of high-performance electrocatalysts.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
FOOD HYDROCOLLOIDS
·
2025
·
IF 12.4
Yue Niu,Lulu Fu,Kaijie Liu,Huiqing Liu,Dan Zhang,Aoran Wang,Hongxiang Xie,Zhi Fan,Minjie Guo,Bowen Cheng
The irreversible aggregation of nanocellulose during drying poses severe limitations to its practical applications. In this study, we developed a novel oven-drying system for cellulose nanocrystals (CNCs) using polyethylene glycol dimethyl ether (PD) as a capping agent. The incorporation of only 10 wt% PD (relative to dried CNC mass) into the CNC suspension effectively inhibited the formation of irreversible hydrogen bonds during drying, significantly enhancing both the redispersion rate and redispersion stability of dried CNCs. The redispersed CNC suspension fully restored the nanostructure and physicochemical properties identical to those of the original CNC suspension. The dried CNCs incorporated with PD (CNC PD ) not only retained its original crystal structure and crystallinity but also achieved higher thermal stability compared to original CNCs. Furthermore, CNC PD exhibited excellent redispersion in strongly polar aprotic solvents such as THF and DMSO, facilitating subsequent chemical modifications. In the modification process, PD can be regarded as a co-solvent without affecting the chemical modification of CNCs. After that, PD was conveniently removable through a simple water rinsing step. These results demonstrate PD's exceptional efficacy as a capping agent for preventing CNCs aggregation, thereby enabling convenient storage and application of CNCs in dried solid form.
✓ 已验证
产品关联
DOI
高影响因子
MOLECULES
·
2020
·Vol. 25
·期 3
·759
·
IF 3.267
Bo Wang,Haiyan Tian,Dong Xiang
Coconut oil-in-water emulsions were prepared using three polysaccharides:Dendrobium officinalepolysaccharide (DOP), propylene glycol alginate (PGA), gum arabic (GA) and their polysaccharide complexes as emulsifiers. The effects of the ratio of the compounded polysaccharides on their apparent viscosity and interfacial activity were explored in this study. The average particle size, zeta potential, microstructure, rheological properties, and physical stability of the emulsions prepared with different compound-polysaccharides were studied. The results showed that mainly DOP contributed to the apparent viscosity of the compound-polysaccharide, while the interfacial activity and zeta potential were mainly influenced by PGA or GA. Emulsions prepared with compound-polysaccharides exhibited smaller average particle sizes, and microscopic observations showed smaller droplets and less droplet aggregation. In addition, the stability analysis of emulsions by a dispersion analyzer LUMiSizer showed that the emulsion prepared by compounding polysaccharides had better physical stability. Finally, all of the above experimental results showed that the emulsions prepared by PGA:DOP = 2:8 (total concentration = 1.5 wt%) and 2.0% GA + 1.5% DOP were the most stable.Keywords:Dendrobium officinalepolysaccharides;propylene glycol alginate;gum arabic;coconut oil-in-water emulsion
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF PHARMACY AND PHARMACOLOGY
·
2013
·Vol. 66
·期 4
·557-563
·
IF 2.033
Zhang Zhaoliang,Xu Lu,Chen Hao,Li Xingyi
ObjectivesAllograft rejection is the major cause of corneal graft failure. To inhibit corneal allograft rejection, rapamycin as a novel immunosuppressive agent has been discovered. However, the high water insolubility and low bioavailability of rapamycin has strongly hindered its application in the clinical setting. In this paper, we attempted to develop a novel rapamycin nano-formulation using poly(ε-caprolactone)-poly(ethylene glycol)-poly(ε-caprolactone) (PCEC) nanoparticles as carrier by an emulsion evaporation method for potential application in corneal transplantation.MethodsThe solubility of rapamycin in the nano-formulation was determined and in-vitro release studies were performed. The developed rapamycin-loaded PCEC nanoparticles were further characterized by dynamic light scattering, transmission electron microscopy, X-ray diffraction and differential scanning calorimetery. Toxicity studies were performed in eye-related cell lines.Key findingsThe rapamycin in nano-formulation exhibited ∼103-fold increased solubility as compared with native rapamycin. According to the results of the in-vitro cytotoxicity assay, the developed PCEC nanoparticles did not exhibit any apparent cytotoxicity against various eye-related cell lines with PCEC nanoparticle concentrations in the range of 0.05–10 mg/ml. In-vitro release study showed that the release of rapamycin was sustained from PCEC nanoparticles over a period of 48 h.ConclusionsAll the results suggested that the developed rapamycin-loaded PCEC nanoparticles might be suitable for immunosuppression in corneal transplantation by instillation administration.
✓ 已验证
DOI
高影响因子
IRANIAN POLYMER JOURNAL
·
2018
·Vol. 28
·期 1
·39-49
·
IF 1.278
Yang Zhouxiaoshuang,Zou Hu,Liu Hui,Xu Wenshuang,Zhang Lulu
To compare the synthesis and drug release of random and block copolymers, random and block copolymerizations of oligo(ethylene glycol)methyl ether methacrylate (OEGMA) and 1′-(2-methacryloxyethyl)-3′,3′-dimethyl-6-nitrospiro-(2H-1-benzopyran-2,2′-indoline) (SPMA) were carried out by atom transfer radical polymerization. The 1 H NMR and GPC results indicated the targeted random and block copolymers were successfully synthesized. Critical micelle concentrations of random and block copolymers were determined as 0.0178 mg/mL and 0.0265 mg/mL, and the micelle aggregation numbers of the random and block copolymers were calculated as approximately 17 and 13, respectively, indicating that more molecular chains were required to form a stable polymeric micelle for a random than its block copolymer. A lower critical solution temperature of 37 °C, the human body temperature, was obtained for two copolymer samples, suggesting that they might have potential application in the biomedical field. During the self-assembly, the morphology of block copolymer micelles was more regular than that of random copolymer, and both copolymers exhibited the exchange of hydrophilic and hydrophobic segments called as “Schizophrenic” behavior under UV light irradiation at 50 °C. With doxorubicin as a model molecule in drug release control, heating and ultraviolet light irradiation could accelerate the drug release process to some extent, indicating the potential application of the resulting random and block copolymers in drug release and bioengineering.
✓ 已验证
DOI
高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
·
2017
·
IF 3.133
Yiyong Zhang,Kun Li,He Li,Yunhui Wang,Yueying Peng,Shuangshuang Lin,Bing Joe Hwang,Jinbao Zhao
Lithium sulfur batteries have been widely studied because of their high energy density . However, their commercialization has been impeded by several problems, such as the poor conductivity of the active material sulfur and its discharge products, the volume expansion and the shuttle effect caused by the polysulfide intermediates dissolving in organic electrolytes. To address these problems well, we have constructed high sulfur content spherical sulfur-carbon nanotube-polyethylene glycol-nickel nitrate hydroxide (SCNT-PEG-NNH) composite material by using a simple ball-milling method. The conductivity of the composite material gets improvement due to the spherical conductive frame constructed by CNT, while the shuttle effect of polysulfides is well inhibited by the wrapping of the PEG and the fixation of NNH. The results of electrochemical tests have shown that the performance of cathode made by the SCNT-PEG-NNH composite material is greatly improved. Therefore, the SCNT-PEG-NNH composite material can be a promising cathode material for lithium sulfur batteries.
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）