POLYMER
·
2014
·Vol. 55
·期 3
·840-847
·
IF 3.766
Dong Liu,Yan Li,Jianping Deng,Wantai Yang
This paper reports helix-sense-selective polymerizations (HSSPs) of achiral acetylene monomer performed in chiral micelles , by which optically active helical polymer emulsions were directly obtained. The chiral micelles were constructed by chiral emulsifiers , in which achiral acetylene underwent HSSPs in the presence of catalyst [(nbd)RhCl] 2 . The chiral emulsifiers possessed different alkyl chain lengths and different amino acid groups, and their effects on HSSPs were investigated in detail. The obtained polymer emulsions were characterized by TEM , circular dichroism and UV–vis absorption spectroscopy techniques . It is demonstrated that the polymer chains constructing the emulsions adopted helical structures of predominantly one-handed screw sense, from which the emulsions exhibited remarkable optical activity.
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INTERNATIONAL DAIRY JOURNAL
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2026
·
IF 3.1
Zi-Ying Zhao,Zi-Wei Liu,Bo-Kang Yu,Ying-Chao Qiu,Meng-Jiao Wang,Ying-Hua Zhang,Zhi-Shen Mu
STPP induces casein micelle dissociation by chelating calcium. • STPP enhanced buffering capacity and delayed acidification during fermentation. • STPP improved water holding capacity and gel strength of high-protein yogurt. • Promoted elastic gel network, enabling a clean-label protein-based stabilizer. High protein yogurt has a strong market competitiveness, but the gel structure of yogurt with higher protein content is worse than the ordinary. In this study, the effects of micellar casein dissociation induced by different concentrations of sodium tripolyphosphate (STPP) on the gel properties of casein were investigated. Increasing STPP concentration significantly reduced the turbidity of Micellar Casein Concentrate (MCC) suspensions while markedly enhancing their solubility and surface negative charge. UV–visible absorbance indicated dissociation of casein micelles upon STPP treatment. When incorporated into yogurt, samples treated with different STPP concentrations exhibited concentration-dependent acidification delay during fermentation. Moreover, STPP addition significantly improved water-holding capacity, gel strength, and textural properties of yogurt. Dynamic rheological measurements revealed that both the storage modulus (G′) and loss modulus (G″) of the STPP-treated groups were significantly higher than those of the control, confirming the formation of stronger and more elastic gel networks following STPP treatment. STPP effectively modulated the structure and functionality of casein micelles, leading to improved yogurt gel properties. These findings provide new insights into the modulation of casein micelle functionality and support the development of novel stabilizing strategies for yogurt products.
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LWT-FOOD SCIENCE AND TECHNOLOGY
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2026
·
IF 7.1
Huihui Zhang,Bingyu Zheng,Yong Wang,Ying Li
Bifunctional animal oils enable green phenolic extraction & fat stabilization. • Lecithin-mediated reverse micelles favorably localize antioxidants. • In situ reverse micelle-assisted extraction enhances the thermal stability of lard. • Lard optimizes dual recovery of lipophilic and hydrophilic antioxidants. • This solvent-free, scalable route produces clean-label, high-stability animal fats. Animal fats exhibit greater susceptibility to thermal degradation than vegetable oils, partly attributable to their lower content of endogenous minor components (e.g., natural antioxidants), which restricts their application in high-temperature food processing. This study pioneers a solvent-free strategy to stabilize animal fats (lard, beef tallow, chicken oil, and basa fish oil) via direct enrichment with rosemary antioxidants through in-situ reverse micelle-assisted extraction (IRMAE). To maximize polar polyphenol incorporation, food-grade emulsifiers were employed to tune the interfacial assembly of antioxidant-loaded reverse micelles. Among tested matrices, lard exhibited the highest extraction affinity, yielding rosmarinic acid (RA) and carnosic acid (CA) at 8.16% and 52.88%, respectively. Incorporation of lecithin further optimized the system, increasing RA concentration to 42.84 μg/g, a 5.22-fold enhancement over raw oil. Small-angle X-ray scattering (SAXS) revealed the presence of spherical nanostructures (radius ∼2 nm) consistent with reverse micelles, where the lecithin-based interfacial film is proposed to provide a robust micro-aqueous environment for sequestering polar antioxidants. Frying tests demonstrated that these nanostructure assemblies significantly inhibited increases in acid value (AV), total oxidation (TOTOX), and conjugated diene/triene (CD/CT) levels. This work proposes a clean-label approach for the long-term stabilization of traditional animal fats, integrating green extraction with advanced lipid protection strategies.
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BioNanoScience
·
2026
·Vol. 16
·期 9
·592
·
IF 4
Yan Qi,Wang Shiyu,Gao Qian,Wang Jian,Xiong Ni,Zhu Yue,Chen Tianyu,Cheng Yuhang,Li Jiafen,Cao Jie,Ying Xue,Ming Xin,Wu Min
Systemic chemotherapy remains the most frequent treatment for triple-negative breast cancer (TNBC) because the tumors do not express any of the three surface receptors targeted by selected treatments. A more selective alternative may be delivering drugs such as the well established anti-tumor drug as well as mitochondrial toxin doxorubicin to mitochondria in tumor cells by carriers containing TNBC surface proteins and delocalized lipophilic cations such as berberine derivatives that can target TNBC tumors and mitochondria, respectively. Once they enter tumor cells, the drug-loaded carriers will target to the mitochondria and inactivate them in the presence of cations. Here we synthesized amphiphilic 9- O -cetyl-berberine, which retained the anti-tumor activity of berberine, through a method involving microwave irradiation, then allowed the molecules to co-assemble spontaneously with doxorubicin into micelles. The micelles were coated with membranes derived from erythrocytes and the TNBC cell line MDA-MB-231 to shield their cytotoxic and hemolytic positive charge. The resulting nanovesicles showed good stability in the short term and good safety, and synergistically inhibited proliferation and migration of TNBC cells by reducing mitochondrial membrane potential and promoting the generation of reactive oxygen species and activating apoptotic signaling. These results establish the potential of this system to co-deliver doxorubicin and delocalized lipophilic cations to treat TNBC.
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MICROCHEMICAL JOURNAL
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2026
·
IF 5.2
Jiahui Lin,Yujie Gao,Fengna Xi
Hard-soft organic–inorganic hybrid interface is constructed by confining surfactant micelles in silica nanochannels. • Surfactant micelles enable triple enrichment of emitter, co-reactant and analyte for signal amplification. • Local concentration of both luminol and dissolved oxygen is enhanced to boost ECL of the luminol/DO system. • Micelle-mediated analyte enrichment allows highly sensitive detection of morin with a low detection limit. • Micellar confinement in nanochannels confers strong interference resistance for analysis in complex matrices. Enhancing the microconcentration of electrochemiluminescence (ECL) emitters and co-reactants at the electrode interface is a potent strategy for ECL signal amplification, while analyte enrichment further improves detection sensitivity. In this work, a hard-soft organic–inorganic hybrid interface incorporating silica nanochannels and surfactant micelles (SM) was developed to achieve triple enrichment of the emitter (luminol), co-reactant (dissolved oxygen-DO), and analyte (antioxidant morin, Mor), resulting in a significant enhancement of ECL and highly sensitive detection. A vertically-ordered mesoporous silica film (VMSF) embedded with cetyltrimethylammonium bromide (CTAB) micelles was fabricated on an affordable and readily accessible indium tin oxide (ITO) electrode via a simple electrochemical-assisted self-assembly (EASA) method. The micelles efficiently concentrate both luminol and DO, leading to a remarkable increase in the ECL signal of the luminol/DO system. Due to the micellar confinement within the VMSF nanochannels, the sensor displayed remarkable resistance to interference. Combined with enhanced ECL and SM-mediated analyte enrichment, sensitive detection of Mor was achieved. Under optimal conditions, the detection range for Mor was from 1 pg/mL to 1 μg/mL, with a detection limit as low as 0.18 pg/mL. This work not only offers an efficient strategy to enhance the ECL of luminol/DO system but also introduces a novel approach for the development of high-performance ECL sensors for trace analysis in complex samples. Download: Download high-res image (170KB) Download: Download full-size image
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SEPARATION AND PURIFICATION TECHNOLOGY
·
2025
·
IF 9
Song Xue,Yu Xu,Sihui Ding,Haoxiang Meng,Xiaodong Sun,Qi Zhang
Two hydrophobic (deep) eutectic solvents (H(D)ESs), menthol:octanoic acid (Men:OctA) and menthol:trioctylphosphine oxide (Men:TOPO), were prepared, characterized, and then employed for the first time in combination with sulfobutylether-β-cyclodextrin (SBE-β-CD) for chiral separations in capillary electrokinetic chromatography (EKC). The “H(D)ES + SBE-β-CD” dual pseudo-stationary phase (PSP) systems yielded not only enhanced enantioselectivities, but also accelerated migrations of primaquine and chlorpheniramine, two drugs that cannot be resolved using the single SBE-β-CD system. The enhancement originated from the combined effects of stereoselective complexation and hydrophobic partitioning involving the H(D)ES phase, which moved faster than the anionic CD phase under the separation conditions. The best results in terms of enantioresolution and migration time were obtained using a 20 mM phosphate buffer (pH 7.0) containing 2.0 % SBE-β-CD and 0.2 % Men:OctA at an applied voltage of 15 kV. We further compared the chiral EKC performance of the H(D)ESs with a series of conventional PSPs, including three micelles (Tween-20, Brij-35, SDS) and three ionic liquids (ILs). The results showed that none of these modifiers could achieve comparable EKC performance, suggesting that in certain cases, H(D)ESs could be a superior alternative to traditional modifiers for chiral EKC separations.
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MOLECULES
·
2022
·Vol. 27
·期 8
·2419
·
IF 4.927
Xiao-Ling Wang,Wen-Zheng Zhao,Jia-Ze Fan,Le-Chen Jia,Ya-Nan Lu,Ling-Hui Zeng,Yuan-Yuan Lv,Xiao-Yi Sun
Tumor penetration and the accumulation of nanomedicines are crucial challenges in solid tumor therapy. By taking advantage of the MSC tumor-tropic property, we developed a mesenchymal stem cell (MSC)-based drug delivery system in which paclitaxel (PTX)-encapsulating hyaluronic acid-poly (D,L-lactide-co-glycolide) polymeric micelles (PTX/HA-PLGA micelles) were loaded for glioma therapy. The results indicated that CD44 overexpressed on the surface of both MSCs and tumor cells not only improved PTX/HA-PLGA micelle loading in MSCs, but also promoted the drug transfer between MSCs and adjacent cancer cells. It was hypothesized that CD44-mediated transcytosis played a crucial role and allowed deep glioma penetration depending on sequential intra–intercellular delivery via endocytosis–exocytosis. MSC-micelles were able to infiltrate from normal brain parenchyma towards contralateral tumors and led to the eradication of glioma. The survival of orthotopic glioma-bearing rats was significantly extended. In conclusion, the MSC-based delivery of HA-PLGA micelles is a potential strategy for tumor-targeting drug delivery.Keywords:mesenchymal stem cells;hyaluronic acid;poly (lactide-co-glycolide);orthotopic glioma;tumor penetration
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ACS Biomaterials Science & Engineering
·
2021
·
IF 4.749
Chuhang Zhou,Xinping Hu,Qi Liu,Leqi Wang,Yuanhang Zhou,Yao Jin,Yining Ma,Yan Liu
Cancer-associated fibroblasts (CAFs) were believed to establish a tight physical barrier and a dense scaffold for tumor cells to make them maintain immunosuppression and drug resistance, strongly hindering nanoparticles to penetrate into the core of tumor tissues and limiting the performance of tumor cell-targeted nanoparticles. Here, we fabricated the substrate Z-Gly-Pro of fibroblast activation protein α (FAPα) and folic acid-codecorated pH-responsive polymeric micelles (dual ligand-modified PEOz-PLA polymeric micelles, DL-PP-PMs) that possessed nanodrill and tumor cell-targeted functions based on Z-Gly-pro-conjugated poly(2-ethyl-2-oxazoline)-poly(D,l-lactide) (ZGP-PEOz-PLA), folic acid (FA)-conjugated PEOz-PLA (FA-PEOz-PLA), and PEOz-PLA for cancer therapy. The micelles with about 40 nm particle size and a narrow distribution exhibited favorable pH-activated endo/lysosome escape induced by their pH responsibility. In addition, the enhancement of in vitro cellular uptake and cytotoxicity to folate receptors or FAPα-positive cells for doxorubicin (DOX)/DL-PP-PMs compared with DOX/PP-PMs evidenced the dual target ability of DOX/DL-PP-PMs, which was further supported by in vivo biodistribution results. As expected, in the human oral epidermal carcinoma (KB) cells xenograft nude mice model, the remarkable enhancement of antitumor efficacy for DOX/DL-PP-PMs with low toxicity was observed compared with DOX/FA-PP-PMs and DOX/ZGP-PP-PMs. The possible mechanism was elucidated to be the dismantling of the stromal barrier by nanodrill-like DOX/DL-PP-PMs via the deletion of CAFs evidenced by the downregulation of α-SMA and inhibition of their functions proved by the decrease in the microvascular density labeled with CD31 and the reduction in the extracellular matrix detected by the collagen content, thereby promoting tumor penetration and enhancing their uptake by tumor cells. The present research offered an alternative approach integrating anticancer and antifibrosis effects in one delivery system to enhance the delivery efficiency and therapeutic efficacy of anticancer drugs.
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DESALINATION
·
2021
·
IF 9.501
Yang Li,Tian-Hui Chen,Chun-Yang Yu,Tao Wu,Xue-Ting Zhao,Jie-Feng Pan,Li-Fen Liu
The integrity and uniformity of polyamide (PA) layer have a great influence on the separation performance of thin-film composite (TFC) polyamide reverse osmosis (RO) membrane. In this work, three kinds of micelles including the neutral macromolecule Pluronic F127 (PF127), anionic surfactant sodium dodecyl sulfate (SDS) and the PF127/SDS mixed micelles (PSMM), were proposed to be introduced in the aqueous phase to regulate the interfacial polymerization (IP) process with the purpose of constructing a more integrated and uniform PA separation layer of the RO membrane for seawater desalination . Compared to the single PF127 and SDS, the PSMM-1 (0.05 wt% PF127/0.05 wt% SDS) in the aqueous solution exhibited special advantages including unique three-dimensional (3D) spherical structure, lower solution viscosity and water-Isopar G interface tension (IFT), which sped up m -phenylenediamine (MPD) to homogeneously diffuse to the water-Isopar G interface and further regulated the interfacial polymerization reaction between MPD and trimesoyl chloride (TMC). Ultimately, the regulated RO membrane via PSMM-1 had more uniform PA layer and thus exhibited better comprehensive separation performances including higher salt rejection (more than 99.5%) and ideal water flux (about 35 L·m −2 ·h −1 ). This study provides a facile method of PA microstructure adjustment via micelles to fabricate higher-performance TFC RO membrane for seawater desalination.
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COLLOIDS AND SURFACES B-BIOINTERFACES
·
2021
·
IF 5.268
Yufeng Zhang,Yanliang Dong,Junhui Zhou,Wenjun Huang,Yidi Wu,Shuyue Zhao,Yongli Shi,Suping Bai,Chunhui Li,Yuanyu Huang,Anjie Dong
Optimal combination of hydrophobic-hydrophilic balance, proton buffering and electrostatic interaction is the key issue for designing polycations as efficient gene vectors and antibacterial agents . Herein, we screened a series of pH-sensitive quaternary ammonium-based amphiphilic triblock copolymers , mPEG 2k -P(DPA a /DMA b )-PQA c (TDDE-x), which had different pKa values and proton buffering capacities. Significantly, we found that both the highest siRNA intracellular delivery efficiency and the strongest antibacterial capacity occurred on TDDE-3 micelles with the segment structure of mPEG 2k -P(DPA 50 /DMA 56 )-PQA 55 . The TDDE-3/siRNA complex achieved 67% silencing efficiency on H9C2 cells (N/P = 5, 50 nM siRNA), higher than the advanced commercial transfection reagents RNAiMAX (58%) and Lipo2000 (30%). Moreover, TDDE-3 micelles showed quite low MICs of 32 μg/mL and 8 μg/mL against E. coli and S. aureus , respectively. Further studies on the structure-function relationship indicated that TDDE-3 micelles could mediate robust endosome escape and siRNA cytosolic release, and strong bacterial cell membrane-destabilizing function. Undoubtedly, this work reveals the possibility for double optimization of siRNA intracellular delivery efficiency and antibacterial activity of amphiphilic polycations by reasonable structure design, which is significant for low-cost development and clinical translation of efficient multifunctional polycations.
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JOURNAL OF PHARMACY AND PHARMACOLOGY
·
2021
·Vol. 73
·期 10
·1405-1417
·
IF 3.765
Cai Songjin,Xie Xin,Yuan Qinglan,Ding Jian,Meng Lijia,Li Junzhi,He Ming,Li Weidong,Yu Jingmou
ObjectivesThe study was to construct reduction-responsive chondroitin sulfate A (CSA)-conjugated TOS (CST) micelles with disulfide bond linkage, which was used for controlled doxorubicin (DOX) release and improved drug efficacy in vivo.MethodsCST and non-responsive CSA-conjugated TOS (CAT) were synthesized, and the chemical structure was confirmed by Fourier transform infrared (FTIR) spectroscopy, proton nuclear magnetic resonance (1H NMR) spectroscopy, fluorescence spectrophotometer and dynamic light scattering. Antitumour drug DOX was physically encapsulated into CST and CSA by dialysis method. Cell uptake of DOX-based formulations was investigated by confocal laser scanning microscopy. In vitro cytotoxicity was studied in A549 and AGS cells. Furthermore, antitumour activity was evaluated in A549-bearing mice.Key findingsCST and CAT can form self-assembled micelles, and have low value of critical micelle concentration. Notably, DOX-containing CST (D-CST) micelles demonstrated reduction-triggered drug release in glutathione-containing media. Further, reduction-responsive uptake of D-CST was observed in A549 cells. In addition, D-CST induced stronger cytotoxicity (P < 0.05) than DOX-loaded CAT (D-CAT) against A549 and AGS cells. Moreover, D-CST exhibited significantly stronger antitumour activity in A549-bearing nude mice than doxorubicin hydrochloride and D-CAT.ConclusionsThe reduction-responsive CST micelles enhanced the DOX effect at tumour site and controlled drug release.
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INTERNATIONAL JOURNAL OF PHARMACEUTICS
·
2021
·
IF 5.875
Wenjing Su,Nikolay E. Polyakov,Wenhao Xu,Weike Su
This research aimed to overcome the current challenges in the application of natural carotenoid antioxidants, such as their complex preparation processes, low bioavailability and poor drug stability. Herein, a mechanochemical method was used to prepare an inclusion complex (IC) that self-assembles into micelles in aqueous solution and achieves solid-phase loading of astaxanthin (AST). The NMR analysis, thermodynamics study, particle size analysis and electron microscopy image results showed that AST, hydroxypropyl β-cyclodextrin (HPβ-CD) and glyceryl monostearate (GMS) formed self-assembled micelles and maintained good stability in aqueous solution. The antioxidant performance experiments showed that the formation of IC increases free radical scavenging activity. The pharmacokinetic studies showed that the bioavailability of the astaxanthin inclusion complex increased 4-fold. The tissue distribution experiments showed that the astaxanthin inclusion complex targets the liver to exert its antioxidant effects. The proposed method uses an innovative preparation technology to produce an efficient drug delivery system without solvents, and it exerts powerful antioxidant activity against astaxanthin.
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