Journal of Materials Chemistry B
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2020
·Vol. 8
·期 41
·9492-9501
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IF 5.344
Qi Chen,Ziliang Zheng,Xiaojing He,Shuo Rong,Yufei Qin,Xiaoyang Peng,Ruiping Zhang
Developing new strategies to enhance drug accumulation in the tumor and therapeutic efficacy is of great importance in the field of tumor therapy. Herein, a peanut-like multifunctional nanomedicine (CuS-PGH NMs) made of CuS nanoparticles encapsulated in poly(L-lysine)(PLL)/glucose oxidase (GOx)-hyaluronic acid (HA) shells has been constructed via layer-by-layer (LbL) assembly, and shows good biocompatibility and effective multi-gradient therapy. Because of the enhanced permeability and retention (EPR) effect, the CuS-PGH NMs could significantly enhance the cellular uptake by tumors overexpressing CD44 receptors, which respond to hyaluronidase (HAase)-triggered surface charge conversion. Once internalized by the tumor, GOx was the first to be exposed and could effectively deplete endogenous glucose for starvation therapy, and the excess H2O2 was then converted into highly toxic hydroxyl radicals (˙OH) via a Cu+-mediated Fenton-like reaction for chemodynamic therapy (CDT). Meanwhile, the as-obtained Cu+ ions accompanied the regenerated less-active Cu2+ ions. Interestingly, the high content of H2O2 could, in turn, accelerate Cu2+/Cu+ conversion to promote the Cu+–H2O2 reaction for enhanced chemodynamic therapy (CDT), thereby achieving efficient tumor growth suppression via synergistic starvation/CDT therapy. Subsequently, owing to the strong NIR-II absorption capability of CuS-PGH NMs, effective photothermal tumor ablation of the weakened tumor cells could be realized with the precise guidance of NIR-II PAI. This multi-gradient therapeutic strategy has been demonstrated to have excellent antitumor activity with minimal nonspecific damages, and offers a new avenue to precise tumor therapy.
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Biomaterials Science
·
2020
·Vol. 8
·期 21
·5931-5940
·
IF 6.183
Xiang Zhan,Xuan Nie,Fan Gao,Cong Zhang,Ye-Zi You,Yue Yu
Nanomedicine has attracted growing attention due to its designability and functionality, as well as its excellent pharmacokinetics with limited side effects, and recently, combined therapies have become desirable as they can obtain enhanced therapeutic efficacy by using nanomedicine. Herein, we have reported a functional drug delivery system with a dual response to temperature and reactive oxygen species to efficiently eliminate pancreatic cancer cells in a combined therapy strategy. Functional micelles with camptothecin (CPT) in the core and indocyanine green (ICG) on the surface could effectively accumulate in tumor sites through the EPR effect. The ROS in the tumor microenvironment trigger the conversion of an amino-based copolymer to a carboxy based copolymer, releasing the loaded ICG to reduce the size of the micelles with high penetration in tumor tissue. On the one hand, under 808 nm light irradiation, the micelles will produce the heat to kill tumor cells via photothermal therapy. On the other hand, the generated heat could further trigger the transition of a copolymer from a hydrophobic to a hydrophilic state, releasing the loaded CPT into the deep tumor cells to achieve chemotherapy. The in vitro and in vivo experiments revealed that this combined therapy could combat pancreatic cancer cells with an enhanced therapeutic effect.
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JOURNAL OF NANOPARTICLE RESEARCH
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2020
·Vol. 22
·期 11
·1-12
·
IF 2.132
Wang Linjuan,Zan Ling
MoS 2 -modified In 2 S 3 ( x wt.%MoS 2 -In 2 S 3 ) samples (0 ≤ x ≤ 20) were fabricated through a facile one-pot hydrothermal process. All In 2 S 3 samples modified by MoS 2 deliver an excellent Cr 6+ removal ability under visible-NIR-light-driven, and 5% MoS 2 -In 2 S 3 can reduce 20 mg/L Cr 6+ solution completely within 30 min with a trace photocatalyst concentration (0.27 mg/mL) which is 3.2-hold higher than that of single In 2 S 3 . Further investigations demonstrate that the loaded MoS 2 can not only enhance the absorption of light scope but also promote the interfacial electron transfer from In 2 S 3 to MoS 2 and then to Cr 6+ , thus greatly improving the Cr 6+ removal ability. ESR shows that the modifying of MoS 2 can accelerate the transformation of electrons from the In 2 S 3 to MoS 2 which results in that the intensity of O 2 − • significantly increased. PL, photocurrent, and EIS further identified that the modification of MoS 2 can greatly improve the charge carrier separation efficiency. The fabricated MoS 2 -In 2 S 3 samples also exhibit characteristic features such as stable and reducing Cr 6+ in the weak alkaline environment for the first time, which could always be a great challenge for wastewater purification in alkaline condition.
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ACS Applied Materials & Interfaces
·
2020
·
IF 8.758
Tao Wang,Gang Lian,Liping Huang,Fei Zhu,Deliang Cui,Qilong Wang,Qingbo Meng,Ching-Ping Wong
Perovskite single-crystal (SC) or quasi-single-crystal (QSC) films are promising candidates for excellent performance of photoelectric devices. However, it is still a great challenge to fabricate large-area continuous SC or QSC films with proper thickness. Herein, we propose a pressure-assisted high-temperature solvent-engineer (PTS) strategy to grow large-area continuous MAPbI3 QSC films with uniformly thin thickness and orientation. Dramatic grain growth (∼100 μm in the lateral dimension) and adequate boundary fusion are realized in them, vastly eliminating the grain boundaries. Thus, remarkable diminution of the trap density (ntrap: 7.43 × 1011 cm–3) determines a long carrier lifetime (τ2: 1.7 μs) and superior photoelectric performance of MAPbI3-based lateral photodetectors; for instance, an ultrahigh on/off ratio (>2.4 × 106, 2 V), great stability, fast response (283/306 μs), and high detectivity (1.41 × 1013) are achieved. The combination properties and performance of the QSC films surpass most of the reported MAPbI3. This effective approach in growing perovskite QSC films points out a novel way for perovskite-based optoelectronic devices with superior performance.
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JOURNAL OF MATERIALS SCIENCE
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2020
·Vol. 55
·期 18
·7843-7856
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IF 3.553
Chen Pei-Ling,Shi Qun-Ying,Chen Tian,Wang Ping,Liu Yun,Liu Li-Han
Due to the low background and deep tissue penetration of near-infrared light, near-infrared fluorescence (NIRF) probes have received much attention in recent years. Cell membrane targeting probes can be used in in vitro and in vivo for living cell imaging, disease diagnosis and tumor targeted therapy. However, most of the currently available cell membrane probes are blue or green emissive fluorophores, NIRF probes are relatively rare. Herein, we designed and prepared a NIRF chimeric peptide probe named C 16 -CARK, which could target the tumor cell membrane with longtime retention (more than 4 h). Moreover, the C 16 -CARK can heat and disrupt the cell membrane upon high irradiation dose, revealing its dual roles as a cell membrane imaging probe and a photothermal agent. This kind of near-infrared fluorescence probe with cell membrane targeting and retention property provides a well design paradigm for the field of cancer imaging and treatment.
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Advanced Fiber Materials
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2020
·Vol. 2
·期 3
·150-160
·
IF 0
Yang Shuangping,Macharia Daniel K.,Ahmed Sharjeel,Zhu Bo,Zhong Qiuping,Wang Haifeng,Chen Zhigang
Rapid NIR light detection and/or writing has drawn much attention, but their practical applications have been limited by obtaining such NIR photodetectors. To address this problem, we have developed a simple and versatile strategy to prepare a non-woven fabric photodetector. The blue non-woven fabric photodetector has been prepared by coating photo-thermochromic ink (including crystal violet lactone (CVL) as the thermo-sensitive dye, polypyrrole (PPy) nanospheres as the photothermal component and hydroxyethyl cellulose (HEC) as the polymer matrix) on white non-woven fabric. When the blue fabric photodetector is irradiated by NIR (808-nm as model, 0.75 W cm −2 ) laser, the discoloration occurs in 35 s, and higher laser intensity confers more rapid discoloration. This discoloration results from the photothermal effect of PPy which confers the elevation of temperature (> 50 °C) and then converts CVL to its leuco form (colorless). When the laser is turned off, the temperature drops to below the transition temperature (< 43 °C), and then CVL reverts to its initial blue color. Moreover, different figures and images can be easily printed on the fabric photodetector by 808 nm laser, and then they can be erased automatically under ambient conditions, with excellent cycling stability. Therefore, this fabric photodetector may act as a new platform for rapid NIR light detection and writing.
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NEW JOURNAL OF CHEMISTRY
·
2020
·Vol. 44
·期 26
·10902-10910
·
IF 3.288
Zhongying Wu,Pin Cheng,Weiguang Zhao,Jianglin Fang,Tianchi Xu,Dongzhong Chen
Liquid crystalline elastomers (LCEs) combine the ordering character of a liquid crystal and the elasticity of a polymer network. The development of fully light-driven LCE-based soft actuators with good reshapeability and recyclability is in high demand. In this work, we prepared SWCNT/LCE composite films through the introduction of allyl sulfide-based dynamic covalent crosslinks in the LCE matrix and the well-dispersed filler single-walled carbon nanotubes (SWCNTs) with a strong photothermal effect. The SWCNT/LCE composite films were facilely fabricated with reorientation and remouldable capabilities regulated by 405 nm visible light. The monodomain composite films demonstrated multimode actuations of contraction, bending, curling, stretching recovery, and even shape memory driven by 808 nm near-infrared (NIR) light. Moreover, the monodomain spiral ribbon or stretching flat strip and the original polydomain composite film can be readily transformed into each other, and reshaped through easily achievable fabrication conditions. Therefore, the well-prepared SWCNT/LCE composite films with exchangeable covalent crosslinks showed promise as candidates for the development of multimode NIR photomechanical soft actuators with fully light-driven controllability and good remouldability.
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ACS Sustainable Chemistry & Engineering
·
2020
·
IF 7.632
Yumei Qin,Zhaoyang Ding,Wenwei Guo,Xiaolu Guo,Cheng Hou,Bang-Ping Jiang,Chun-Guang Liu,Xing-Can Shen
The utilization of diffusive solar energy through photocatalytic processes has received tremendous attention. Herein, a full-solar-spectrum photocatalyst with strong near-infrared (NIR) photoactivity, which is based on the synergy of oxygen vacancies (OVs) and doped boron that is cointegrated into zirconia (B@ZrO2–OV), is designed in this work. The doped photocatalyst is prepared via a controlled one-step NaBH4 reduction from white ZrO2. Density functional theory (DFT) calculations reveal that simultaneously introduced OVs and boron dopants on ZrO2 induced a narrow band gap (4.78 eV) and achieved charge separation (work function of 4.12 eV), thus confirming its excellent photocatalytic activity in the degradation of rhodamine B under NIR irradiation. In contrast, oxygen-deficient ZrO2 and white ZrO2 were inactive under NIR light. Therefore, this synergistic strategy provides an efficient way to use the narrow band gap of a classic semiconductor zirconia as a highly efficient catalyst for full-solar-spectrum-driven photocatalysis.
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BIOMATERIALS
·
2019
·
IF 10.273
Meng Lyu,Daoming Zhu,Yanhong Duo,Yang Li,Hong Quan
Hypoxic tumor microenvironment leads to resistance or failure of radiotherapy (RT). As a non-invasive therapy, photothermal therapy (PTT) can improve the tumor hypoxic microenvironment in addition to directly killing tumor cells. PTT combined with RT (thermoradiotherapy) becomes an emerging treatment. Multi-functional nanoparticles used for hypoxia-resistant thermoradiotherapy in the second near-infrared (NIR-II) biological windows (1000–1700 nm) are urgently needed to be developed. Here, a facil method synthesis of ultra-small cysteamine (Cys)-coated FePd bimetallic nanodots (NDs) is reported. These NDs can not only produce effective hyperthermia (35.4%) when irradiated in the NIR-II region (1064 nm) but also have an enhanced radiation effect due to i) Hypoxic improvement in tumor tissues by photothermal treatment in the NIR-II Biological Windows can greatly enhance the sensitivity of tumor cells to radiotherapy ii) The ability of NDs to deposit radiation energy in tumors has further enhanced the sensitivity of tumor cells to radiotherapy. Meanwhile, NDs was a contrast agent for tri-modal imaging including computed tomography (CT)/magnetic resonance imaging (MRI)/photoacoustic imaging (PAI) in vitro and in vivo . Both in vitro and in vivo tests demonstrated good biocompatibility and excellent stability of NDs, indicating great potential for clinical applications.
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ACS Applied Bio Materials
·
2019
·
IF 0
Yao Huang,Junqing Huang,Mingyang Jiang,Songjun Zeng
Gaseous therapy based on nitric oxide (NO) has emerged as a potential tumor therapy route. However, the development of a NO generator with precisely controlled NO releasing in the target site is still facing enormous challenges. Herein, a typical NO delivery platform by integrating the hollow structured polydopamine (PDA) coated Bi2S3 nanohybrids (denoted as H-Bi2S3@PDA) with a heat-sensitive S-nitrosothiol (RSNO) molecule was explored for near-infrared (NIR) light-responsive on-demand NO-releasing and synergetic gas/photothermal combination therapy of tumors. The designed H-Bi2S3@PDA nanocomposites hold high photothermal conversion efficiency of 46.13% under irradiation of a NIR laser, leading to NIR light-triggered controllable generation of NO gas via breaking the S–NO bonds of the heat-sensitive RSNO molecules. More importantly, synergistic gas/photothermal therapy of the tumor was also achieved, which presented remarkable inhibition growth and ablation of tumors. These findings provide the opportunity to design a NIR light-activated NO generator with a combination of photothermal materials and heat-sensitive molecules for integrative gas/photothermal therapy in deep tumors.
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SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2019
·
IF 2.931
Aiqing Feng,Yongmei Jia,Liping Huang,Lin Wang,Guohua Zhou,Sheng Wang,Peilian Liu
Near-Infrared “turn on” type fluorescent probes are attractive and promising in the fields of chemical sensing and bioimaging. Here, a new dicyanomethylene-4H-pyran derivative (DCM-Si) NIR fluorescent probe was designed and synthesized for specific lighting up F − in living cells and bodies. Si O bond was used as F − trigger, and the release of fluorophore (DCM-NH 2 ) occurred after substituent reaction and subsequent 1,6-elimination. This NIR probe displayed high sensitivity and selectivity for the sensing of F − , and the detection limit was calculated to be as low as 157 nM. Moreover, the “off-on” fluorescent signal changes can be realized by adding F − in living cells and zebrafish embryos.
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JOURNAL OF NANOBIOTECHNOLOGY
·
2023
·Vol. 21
·期 1
·1-23
·
IF 10.2
Mu Zhixiang,Jin Ting,Chu Tengda,Lu Hongyang,Chen Yuanqi,Li Sisi,Zeng BaiRui,Huang Chen,Lei Kezheng,Cai Xiaojun,Deng Hui,Hu Rongdang
Bacterial infection in skin and soft tissue has emerged as a critical concern. Overreliance on antibiotic therapy has led to numerous challenges, including the emergence of multidrug-resistant bacteria and adverse drug reactions. It is imperative to develop non-antibiotic treatment strategies that not only exhibit potent antibacterial properties but also promote rapid wound healing and demonstrate biocompatibility. Herein, a novel multimodal synergistic antibacterial system (SNO-CS@MoS 2 ) was developed. This system employs easily surface-modified thin-layer MoS 2 as photothermal agents and loaded with S-nitrosothiol-modified chitosan (SNO-CS) via electrostatic interactions, thus realizing the combination of NO gas therapy and photothermal therapy (PTT). Furthermore, this surface modification renders SNO-CS@MoS 2 highly stable and capable of binding with bacteria. Through PTT’s thermal energy, SNO-CS@MoS 2 rapidly generates massive NO, collaborating with PTT to achieve antibacterial effects. This synergistic therapy can swiftly disrupt the bacterial membrane, causing protein leakage and ATP synthesis function damage, ultimately eliminating bacteria. Notably, after effectively eliminating all bacteria, the residual SNO-CS@MoS 2 can create trace NO to promote fibroblast migration, proliferation, and vascular regeneration, thereby accelerating wound healing. This study concluded that SNO-CS@MoS 2 , a novel multifunctional nanomaterial with outstanding antibacterial characteristics and potential to promote wound healing, has promising applications in infected soft tissue wound treatment.
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