Nanomaterials
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2019
·Vol. 9
·期 4
·548
·
IF 4.034
Weihao Zhao,Lin Wang,Chengjie Pei,Cong Wei,Hui You,Jindong Zhang,Hai Li
Recently, graphene oxide nanoscroll (GONS) has attracted much attention due to its excellent properties. Encapsulation of nanomaterials in GONS can greatly enhance its performance while ion encapsulation is still unexplored. Herein, various ions including hydronium ion (H3O+), Fe3+, Au3+, and Zn2+were encapsulated in GONSs by molecular combing acidic graphene oxide (GO) solution. No GONS was obtained when the pH of the GO solution was greater than 9. A few GONSs without encapsulated ion were obtained at the pH of 5–8. When the pH decreased from 5 to 0.15, high-density GONSs with encapsulated ions were formed and the average height of GONS was increased from ~50 to ~190 nm. These results could be attributed to the varied repulsion between carboxylic acid groups located at the edges of GO nanosheets. Encapsulated metal ions were converted to nanoparticles in GONS after high-temperature annealing. The resistance-type device based on reduced GONS (rGONS) mesh with encapsulated H3O+showed good response for applied pressure from 600 to 8700 Pa, which manifested much better performance compared with that of a device based on rGONS mesh without H3O+.Keywords:graphene oxide nanoscroll;pH value;ion encapsulation;mesh structure;pressure sensing
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Frontiers in Pharmacology
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2019
·
IF 3.845
Yang Yihua,Wang Zhe,Peng Ying,Ding Jinsong,Zhou Wenhu
Micelles are highly attractive nano-drug delivery systems for targeted cancer therapy. While they have been demonstrated to significantly alleviate the side-effects of their cargo drugs, the therapy outcomes are usually suboptimal partially due to ineffective drug release and endosome entrapment. Stimulus-responsive nanoparticles have allowed controlled drug release in a smart fashion, and we want to use this concept to design novel micelles. Herein, we reported pH-sensitive paclitaxel (PTX)-loaded poly (ethylene glycol)-phenylhydrazone-dilaurate (PEG-BHyd-dC12) micelles (PEG-BHyd-dC12/PTX). The micelles were spherical, with an average particle size of ∼135 nm and a uniform size distribution. The pH-responsive properties of the micelles were certified by both colloidal stability and drug release profile, where the particle size was strikingly increased accompanied by faster drug release as pH decreased from 7.4 to 5.5. As a result, the micelles exhibited much stronger cytotoxicity than the pH-insensitive counterpart micelles against various types of cancer cells due to the hydrolysis of the building block polymers and subsequent rapid PTX release. Overall, these results demonstrate that the PEG-BHyd-dC12 micelle is a promising drug delivery system for cancer therapy.
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ORGANIC & BIOMOLECULAR CHEMISTRY
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2019
·Vol. 17
·期 15
·3853-3860
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IF 3.49
Leixia Mei,Keming Xu,Ziran Zhai,Suyun He,Tingting Zhu,Wenying Zhong
Drug incorporation in hydrogels often brings undesirable effects on the stability or mechanical properties of the system. To address this problem, we report the design and synthesis of a RGD-derived peptide conjugate (1-RGDH) for its co-assembly with a commonly used chemotherapeutic drug, doxorubicin (DOX), that formed electrostatic interactions with the 1-RGDH peptide and reinforced the supramolecular network of nanofibers within the matrix of the hydrogel. The hybrid hydrogel demonstrated excellent viscoelastic and shear-thinning properties that greatly facilitated the development of injectable drug delivery systems. Furthermore, it demonstrated a unique pH responsive release of DOX under weakly acidic conditions, paving ways for the controlled release of drug cargos in a typical tumor microenvironment with mild acidity. Finally, the DOX-incorporated hydrogel exhibited a superior anti-tumor efficacy in non-small-cell lung cancer cells A549 compared to the aqueous solution of free DOX, with an integrin receptor-mediated endocytosis pathway revealed for the cellular uptake of DOX-incorporated nanofibers.
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MATERIALS AND MANUFACTURING PROCESSES
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2019
·
IF 3.35
Chunyu Wang,Yuhuan Bu,Shenglai Guo,Zhuang Cai,Baojiang Sun,Guangquan Li,Zhonghou Shen
pH-sensitive water and oil dual-absorption material (WODAM) has been successfully synthesized through microemulsion polymerization. Firstly, microemulsions prepared with monomers were analyzed by pseudo-ternary phase diagram. In addition, conductivities of microemulsions were tested to identify microemulsion types. Meanwhile, the factors that affected microemulsion types were analyzed. Then WODAMs were prepared, and the chemical structure was characterized using Fourier transform infrared (FTIR) spectroscopy. Liquid absorption tests indicated that both monomer ratio and microstructure of WODAMs had influences on their water absorption rate (WAR) and oil absorption rate (OAR). In addition, pH sensitivity tests showed that WODAM absorbed much water in neutral and weak alkaline solutions, but little water in strong alkaline solutions. What’s more, liquid absorption tests in cement slurry filtrate (CSF) showed that WODAM was applied to oil well cement. This paper prepared a new self-healing agent, and is of great significance to realize self-healing cement in complex downhole condition.
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PROGRESS IN ORGANIC COATINGS
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2019
·
IF 3.42
Bingyang Lu,Dan Luo,Ansha Zhao,Haohao Wang,Yuancong Zhao,Manfred F. Maitz,Ping Yang,Nan Huang
Environmentally responsive polymer films have received much attention, but the stability of such films and the sensitivity of the response still have to be improved. The preparation of responsive films for low pH changes still faces challenges. In this study, catechol groups were used to functionalize chitosan and hyaluronic acid for mussel-inspired, catechol based adhesion. The modified chitosan and the modified hyaluronic acid were deposited in a layer-by-layer manner. The chemical properties of the compounds and surface properties of the coatings were characterized by UV, IR, scanning electron microscopy and water contact angles. The assembly and stability of the film were investigated in situ using quartz crystal microbalance (QCM-D). The film had improved stability compared to the native polymers and it showed reversible pH-dependent swelling and shrinkage. The film was loaded with a drug and placed in PBS solutions of different pH for several days, and the amount of drug released by the drug-loaded film was different under different pH environments. This provides ideas for the intelligent application in materials science and biology, and has broad prospects in drug delivery systems and tissue engineering.
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FOOD HYDROCOLLOIDS
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2019
·
IF 5.839
Yun He,Shishuai Wang,Jing Li,Hongshan Liang,Xianlin Wei,Dengfeng Peng,Zhengqiang Jiang,Bin Li
The objective of this study was to investigate the interaction between tannic acid (TA) and konjac glucomannan (KGM) with different molecular weight at different pHs,temperatures and urea concentration. The different molecular weight of KGM without change in primary structure were obtained by ultrasonic treatment. Turbidity titration showed that TA/KGM complexes could form at lower pH. The dynamic light scattering (DLS) and transmission electron microscopy (TEM) results indicated that the TA/KGM complexes assembled into large and uniform colloidal particles and would lead to precipitate with the increase of TA/KGM weight ratio. Isothermal titration calorimetry (ITC) results further revealed two-step binding behavior: the first stage corresponded to soluble complex formation, while the second stage represented aggregation between complexes. When the molecular increased, the transition of TA/KGM mass ratio between stage 1 and stage 2 changed from 3.5 to 3.0. KGM of higher molecular weight needed to bind more TA to move to the next stage. When the pH was 7 at 25 °C, the pH was 3.8 at 40 °C or urea addition, the ITC signal was completely abolished, the formation of complexes between KGM and TA was shown to be highly dependent on pH, temperature, urea concentration, suggesting the main driving force of TA-KGM complexes formation was hydrogen bond.
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MOLECULES
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2019
·Vol. 24
·期 16
·2923
·
IF 3.06
Piaopiao Chen,Iqra Ilyas,Su He,Yichen Xing,Zhigang Jin,Chaobiao Huang
Polymer dots (Pdots) represent newly developed semiconductor polymer nanoparticles and exhibit excellent characteristics as fluorescent probes. To improve the sensitivity and biocompatibility of Pdots ratiometric pH biosensors, we synthesized 3 types of water-soluble Pdots: Pdots-PF, Pdots-PP, and Pdots-PPF by different combinations of fluorescent dyes poly(9,9-dioctylfluorenyl-2,7-diyl) (PFO), poly[(9,9-dioctyl-fluorenyl-2,7-diyl)-co-(1,4-benzo-{2,1′,3}-thiadazole)] (PFBT), and fluorescein isothiocyanate (FITC). We found that Pdots-PPF exhibits optimal performance on pH sensing. PFO and FITC in Pdots-PPF produce pH-insensitive (λ = 439 nm) and pH-sensitive (λ = 517 nm) fluorescence respectively upon a single excitation at 380 nm wavelength, which enables Pdots-PPF ratiometric pH sensing ability. Förster resonance energy transfer (FRET) together with the use of PFBT amplify the FITC signal, which enables Pdots-PPF robust sensitivity to pH. The emission intensity ratio (I517/I439) of Pdots-PPF changes linearly as a function of pH within the range of pH 3.0 to 8.0. Pdots-PPF also possesses desirable reversibility and stability in pH measurement. More importantly, Pdots-PPF was successfully used for cell imaging in Hela cells, exhibiting effective cellular uptake and low cytotoxicity. Our study suggests the promising potential of Pdots-PPF as an in vivo biomarker.Keywords:Pdots;semiconductor polymer;FRET;pH sensing;cell imaging
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JOURNAL OF APPLIED POLYMER SCIENCE
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2019
·Vol. 137
·期 18
·48640
·
IF 2.188
Song Gao,Gang Wei,Qiang Liu,Qinze Liu,Tingting Gao,Jinshui Yao
Lignosulfonate-based polycatecholamine (PCEA-LS) was synthesized by a two-stage approach involving Mannich and catechol–amine reactions, and it was directly used to adsorb Congo red (CR) from the pH-unadjusted aqueous solution. PCEA-LS was characterized using scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FT-IR), thermogravimetric analysis (TGA), and X-ray photoelectron spectroscopy (XPS). Various factors affecting on removal of CR by PCEA-LS were investigated in depth, including contact time, adsorbent dosage, and initial concentration of CR and adsorption temperature. The adsorption kinetics, isotherm, and thermodynamics of PCEA-LS for CR were explored in detail, and then its adsorption mechanism was systematically elucidated. Results indicated that the removal process of CR followed the pseudo-second-order kinetic model, and the isotherm data fitted the Langmuir model well. The maximum adsorption capacity reached 972.6 mg g −1 at 30°C in the pH-unadjusted (pH = 6.25) solution possibly due to the hydrogen bond, π–π stacking, and electrostatic interaction between PCEA-LS and CR. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2020 , 137 , 48640.
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MICROCHEMICAL JOURNAL
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2019
·
IF 3.206
Xu Chen,Jianliang Bai,Yusha Ma,Guojun Yuan,Jing Mei,Lu Zhang,Lili Ren
Recently, carbon dots (CDs) with long wavelength (i.e., orange and red-light) are gradually critical in the bioimaging and biomedical fields. In this paper, a simple one-pot hydrothermal method for preparing bright orange N-doped carbon dots (N-CDs) from p -phenylenediamine has been developed. The resulting N-CDs with abundant surface functional groups show strong orange fluorescence, certain water solubility property and obvious fluorescence quenching to Fe 3+ ions and pH. What's more, the fluorescence of the N-CDs displays a consequent color variation with the increasing concentration of Fe 3+ and pH. In short, N-CDs can be considered as an efficient and multifunctional fluorescent sensor for monitoring pH and Fe 3+ because of their prominent biocompatibility and low toxicity characteristics.
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Journal of the Taiwan Institute of Chemical Engineers
·
2019
·
IF 3.834
Xiaohong Ji,Wei Wang,Weihua Li,Xia Zhao,Ang Liu,Xin Wang,Xiaoying Zhang,Weijie Fan,Yanli Wang,Zhaoxia Lu,Shuan Liu,Hao Shi
pH-responsible self-healing core-shell electrospun nanofibers encapsulating oleic acid (OA) and benzotriazole (BTA) corrosion inhibitors were synthesized and added into a coating material for the corrosion protection of carbon steels. The shell of electrospun nanofibers were poly(vinyl alcohol) (PVA), and the healing agents OA and BTA were used as core materials to reseal a damaged region. The average nanofiber diameters was 350 nm, and the surface is smooth, without any bead structure. OA plays a critical role on corrosion inhibitor in 3.5% alkaline sodium chloride solution and the maximum inhibition efficiency was 86.0% after 10 days immersion. BTA works in 3.5% acidic sodium chloride solution and the maximum inhibition efficiency was 83.4% after 5 days immersion. The anti-corrosion and self-healing capability of core-shell coating were evaluated through scanning electron microscopy, transmission electron microscopy, confocal laser fluorescence microscopy, Fourier transform infrared spectroscopy, electrochemical measurement technology, thermo gravimetric analysis, and material test system rack. Results showed that core-shell spinning fibers with corrosion inhibitors at different concentrations were prepared successfully. The core-shell fibers released the inhibitors to form an OA protective film and a BTA passivation film on the exposed metal surface. Electrochemical measurement monitored specifically the self-healing properties of the coating. These result potentially have important value for the design and research of self-healing materials in the future.
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JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
·
2018
·Vol. 18
·期 7
·4464-4470
·
IF 1.354
Ji Fan,Zhang Kun,Li Jie,Gu Yuanliang,Zhao Jinshun,Zhang Jianfeng
Cancer chemotherapy has limitations such as nonselective distribution of drugs, detrimental side effects on normal tissues; here we reported a smart pH and magnetic sensitive drug delivery system (DDS) based on PEGylated Fe3O4 superparamagnetic nanoparticles. The
citric-coated Fe3O4 (CIO) nanoparticles were firstly synthesized and further functionalized by biocompatible poly(ethylene glycol) bis(carboxymethyl ether) (COOH-PEG-COOH), thus PEGylated CIO (GCIO) nanoparticles were obtained. Doxorubicin (DOX) was conjugated as a model
drug to the nanoparticles via hydrazone bond. The roughly sphere GCIO nanoparticles were comparatively strong magnetism with high drug loading capability (~89%) in relatively uniform size. Drug release study revealed that the GCIO-DOX performed pH-responsive drug-release properties. MTT assay
demonstrated that GCIO nanoparticles possessed low cytotoxicity and good physiological stability. Further, cell viability results indicated that the GCIO-DOX showed effective cytotoxicity only a bit lower than free DOX. All obtained data indicated that the combined pH-responsive and magnetic
multifunction drug delivery system can has excellent potential applications in cancer therapy.
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SENSORS AND ACTUATORS B-CHEMICAL
·
2018
·
IF 5.667
Yuan Chen,Tongming Chen,Xiaoju Wu,Guowei Yang
As delafossite type of metal oxide materials, CuMnO 2 nanoflakes show great promise for optoelectronics applications due to their excellent optical, electric and multiferroic properties. Here, we for the first time demonstrate that CuMnO 2 nanoflakes possess intrinsic activity of mimicking enzymes of peroxidase, oxidase and catalase . Through modulating the pH value, CuMnO 2 nanoflakes can catalyze the reduction of oxygen (O 2 ) and hydrogen peroxide (H 2 O 2 ) at acidic environment, and the decomposition of H 2 O 2 to produce O 2 at alkaline pH. The mechanism of their peroxidase-like activity has been proposed as the generation of hydroxyl radical ( OH). Based on the colorimetric reaction of CuMnO 2 nanoflakes and the hindrance of the peroxidase-like activity in the presence of H 2 O 2 and l -cysteine, a simple platform for l -cysteine detection with low detection limit of 11.26 μM has been developed. Compared with other bimetallic oxides, CuMnO 2 nanoflakes exhibit higher sensitivity and lower detection limit towards l -cysteine. Surprisingly, the proposed method for l -cysteine estimation can also be used in milk samples. These findings pave the way for further investigation about the catalytic activity of CuMnO 2 nanoflakes and make them a promising candidate for biomedical applications.
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