JOURNAL OF NANOBIOTECHNOLOGY
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2022
·Vol. 20
·期 1
·1-19
·
IF 9.429
Yang Yangzi,Wang Chengwei,Wang Ning,Li Jiaxin,Zhu Yingchun,Zai Jiantao,Fu Jingke,Hao Yongqiang
Background The rapid spread of infectious bacteria has brought great challenges to public health. It is imperative to explore effective and environment-friendly antibacterial modality to defeat antibiotic-resistant bacteria with high biosafety and broad-spectrum antibacterial property. Results Herein, biocompatible Cu 3 SnS 4 nanoflakes (NFs) were prepared by a facile and low-cost fabrication procedure. These Cu 3 SnS 4 NFs could be activated by visible light, leading to visible light-mediated photocatalytic generation of a myriad of reactive oxygen species (ROS). Besides, the plasmonic Cu 3 SnS 4 NFs exhibit strong near infrared (NIR) absorption and a high photothermal conversion efficiency of 55.7%. The ROS mediated cellular oxidative damage and the NIR mediated photothermal disruption of bacterial membranes collaboratively contributed to the advanced antibacterial therapy, which has been validated by the efficient eradication of both Gram-negative Escherichia coli and Gram-positive methicillin-resistant Staphylococcus aureus strains in vitro and in vivo. Meanwhile, the exogenous copper ions metabolism from the Cu 3 SnS 4 NFs facilitated the endothelial cell angiogenesis and collagen deposition, thus expediting the wound healing. Importantly, the inherent localized surface plasmon resonance effect of Cu 3 SnS 4 NFs empowered them as an active substrate for surface-enhanced Raman scattering (SERS) imaging and SERS-labeled bacteria detection. Conclusions The low cost and biocompatibility together with the solar-driven broad-spectrum photocatalytic/photothermal antibacterial property of Cu 3 SnS 4 NFs make them a candidate for sensitive bacteria detection and effective antibacterial treatment. Graphical Abstract
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Nano Convergence
·
2022
·Vol. 9
·期 1
·1-13
·
IF 10.038
Liu Jiansheng,Li Jiajia,Zhang Shu,Ding Mengbin,Yu Ningyue,Li Jingchao,Wang Xiuhui,Li Zhaohui
Infrared neural stimulation with the assistance of photothermal transducers holds great promise as a mini-invasive neural modulation modality. Optical nanoparticles with the absorption in the near-infrared (NIR) window have emerged as excellent photothermal transducers due to their good biocompatibility, surface modifiability, and tunable optical absorption. However, poor activation efficiency and limited stimulation depth are main predicaments encountered in the neural stimulation mediated by these nanoparticles. In this study, we prepared a targeted polydopamine (PDA)-coated gold (Au) nanoparticles with specific binding to thermo-sensitive ion channel as nanotransducers for second near-infrared (NIR-II) photo-stimulation of neurons in rats. The targeted Au nanoparticles were constructed via conjugation of anti-TRPV1 antibody with PEGylated PDA-coated Au nanoparticles and thus exhibited potent photothermal performance property in the second NIR (NIR-II) window and converted NIR-II light to heat to rapidly activate Ca2+ influx of neurons in vitro. Furthermore, wireless photothermal stimulation of neurons in living rat successfully evoke excitation in neurons in the targeted brain region as deep as 5 mm beneath cortex. This study thus demonstrates a remote-controlled strategy for neuromodulation using photothermal nanotransducers.
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Science China-Technological Sciences
·
2022
·Vol. 65
·期 10
·2304-2316
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IF 3.903
Dai Nan,Feng Li,Zhao Li,Song Dan,Dai XingJian,Liu XiaoYing,Zhang YuXin
A one-step hydrothermal method was used to synthesize two-dimensional layered Laponite nanosheets (Laponite@diatomite) in situ on the three-dimensional biological template diatomite. The cationic dye removal ability of Laponite@diatomite with different diatomite content was studied. X-ray diffraction (XRD), scanning electron microscope (SEM), transmission electron microscope (TEM), Fourier transformed-infrared (FT-IR) spectroscopy, X-ray photoelectron spectroscopy (XPS), and N 2 adsorption-desorption technology were used to characterize synthetic materials. The effects of pH, initial concentration, dynamics, and thermodynamics behavior on the adsorption performance were further studied. La@D-0.1 had the highest adsorption efficiency, and the adsorption rate of methylene blue (MB) solution (450 mg L −1 ) reached 76.7% in the initial 5 min. At the time of adsorption equilibrium (1 h), methylene blue adsorption rate reached 86.4%. The adsorption behavior of La@D-0.1 on MB was characterized by Langumuir isotherm and with better fitting to the quasi-second-order kinetic model curve. By calculating the adsorption process’s thermodynamic parameters, we were able to illustrate that the adsorption process was exothermic. This work provides a novel idea for the synthesis of an economical and ideal, cationic dye nano-adsorbent and provides a potential application for the purification of actual dye wastewater.
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Journal of Sustainable Metallurgy
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2022
·Vol. 8
·期 2
·754-767
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IF 3.068
Zhang Lili,Yue Qiao,Yang Hongwei
The high-temperature volatilization behavior of the SnO–SiO 2 and SnO–CaO–SiO 2 slag systems was studied by simultaneous thermal analysis. The volatilization characteristics of the two systems with different SnO contents and different heating rates were discussed, and the kinetic parameters, reaction mechanism, and thermodynamic parameters of the volatilization reaction of the slag system at high temperature were calculated. The results of thermal analysis show that the volatilization of tin slag at high temperature is related to the activity of SnO and the decomposition of stannous silicate in tin slag. The slag system has obvious volatilization effect when the content of SnO is more than 60% in the SnO–SiO 2 binary slag system. When CaO is added into the binary slag system, the volatilization of slag system becomes easier. The volatilization rate decreases with increasing heating rate. The volatilization kinetic parameters and mechanism functions of the SnO–SiO 2 and SnO–CaO–SiO 2 systems were calculated by Coats–Redfern and Achar–Brindley–Sharp–Wendworth methods. It is concluded that the volatilization of tin slag at high temperature is controlled by three-dimensional diffusion mechanism. The mechanism function is Jander equation with integral form of [1 − (1 − α ) 1/3 ] 2 and the differential form of 3/2(1 − α ) 2/3 [1 − (1 − α ) 1/3 ] −1 . The rate constants of the SnO–SiO 2 and SnO–CaO–SiO 2 systems are \(k\, = \,1.36\, \times \,10^{16} \,\exp \,\left( {{{ - \,61408.61} \mathord{\left/ {\vphantom {{ - \,61408.61} T}} \right. \kern-\nulldelimiterspace} T}} \right)\) and \(k\, = \,1.61\, \times \,10^{17} \,\exp \,\left( {{{ - \,64869.66} \mathord{\left/ {\vphantom {{ - \,64869.66} T}} \right. \kern-\nulldelimiterspace} T}} \right)\) , and the isokinetic temperatures are 1174.4 and 1208.3 °C, respectively. Finally, the thermodynamic parameters of the slag system in the high-temperature volatilization process are discussed. The activation enthalpy ΔH of the SnO–SiO 2 and SnO–CaO–SiO 2 systems is 498.33 and 526.96 kJ/mol, respectively. The activation Gibbs free energy ΔG is 436.56 and 433.87 kJ/mol, and the activation entropy ΔS is 42.66 and 62.84 J/(mol K), respectively. Graphical Abstract
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Journal of Translational Medicine
·
2022
·Vol. 20
·期 1
·1-14
·
IF 8.44
Mu Shuwen,Lin Yinghong,Xu Yongjun,Wei Xianqing,Zeng Zihuan,Lin Kunzhe,Zhu Linghua,Liu Qinghong,Qi Xingfeng,Wei Liangfeng,Liang Shengxiang,Wang Shousen
Background Cerebral venous sinus thrombosis (CVST) is a rare neurovascular disorder with highly variable manifestations and clinical courses. Animal models properly matched to the clinical form of CVST are necessary for elucidating the pathophysiology of the disease. In this study, we aimed to establish a rat model that accurately recapitulates the clinical features of CVST in human patients. Methods This study consisted of a clinical analysis and animal experiments. Clinical data for two centres obtained between January 2016 and May 2021 were collected and analysed retrospectively. In addition, a Sprague–Dawley rat model of CVST was established by inserting a water-swellable rubber device into the superior sagittal sinus, following which imaging, histological, haematological, and behavioural tests were used to investigate pathophysiological changes. Principal component analysis and hierarchical clustering heatmaps were used to evaluate the similarity between the animal models and human patients. Results The imaging results revealed the possibility of vasogenic oedema in animal models. Haematological analysis indicated an inflammatory and hypercoagulable state. These findings were mostly matched with the retrospective clinical data. Pathological and serological tests further revealed brain parenchymal damage related to CVST in animal models. Conclusions We successfully established a stable and reproducible rat model of CVST. The high similarity between clinical patients and animal models was verified via cluster analysis. This model may be useful for the study of CVST pathophysiology and potential therapies.
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JOURNAL OF MATERIALS RESEARCH
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2022
·Vol. 37
·期 8
·1475-1485
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IF 2.909
Xu Jiaopeng,Chen Yingbo,Cao Ming,Wang Chuanfeng,Guo Pengfei
Solar steam generation (SSG) system greatly improves the efficiency of water evaporation through heat localization, which has broad application prospects at seawater desalination and wastewater treatment. In this paper, polyamide 6-graphene oxide (PA6-GO) membrane was fabricated by nonsolvent-induced phase separation of a solution with GO-modified PA6 in formic acid. Furthermore, the PA6-GO membrane was modified by vacuum filtration of self-assembly gold nanoparticles on its surface for solar stem generation. The composite membrane obtained a light absorption rate of nearly 99.8%. Under the irradiation of 1 kW m −2 , the evaporation rate of 1.1 kg m −2 h −1 was obtained and the evaporation efficiency also reached to 75.6%. The evaporation system has the characteristics of low cost, high stability, strong acid, and alkali corrosion resistance, suggesting great potentials in seawater desalination and sewage treatment. Graphical abstract
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International Journal of Minerals Metallurgy and Materials
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2022
·Vol. 29
·期 4
·896-904
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IF 3.85
Zhang Xuefeng,Jiao Shuqiang
Metal aluminum batteries (MABs) are considered potential large-scale energy storage devices because of their high energy density, resource abundance, low cost, safety, and environmental friendliness. Given their high electrical conductivity, high theoretical specific capacity, and high discharge potential, Te is considered a potential positive electrode material for MABs. Nonetheless, the critical issues induced by the chemical and electrochemical dissolution of tellurium and subsequent chemical precipitation on bare Al negative electrodes result in poor cycle stability and low discharge capacity of Al—Te batteries. Here an efficient TiB 2 -based modified layer has been proposed to address bare Al electrodes (Al/TB). Consequently, the low-voltage hysteresis and long cycle life of the Al/TB negative electrode have been achieved. In addition, the electrochemical performance of the Al—Te battery based on the Al/TB negative electrode is dramatically improved. Furthermore, the modified separator technology is introduced to match with the as-designed Al/TB negative electrode. Therefore, the record-setting long-term cycle stability of up to 500 cycles has been achieved in the Al—Te battery. The facile strategy also opens a potential route for other high-energy density battery systems, such as Al—S and Al—Se batteries.
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NEUROTOXICITY RESEARCH
·
2022
·Vol. 40
·期 2
·596-604
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IF 3.978
Wang Fei,Li Wu-lin,Shen Li-juan,Jiang Ting-ting,Xia Jian-jun,You Da-li,Hu Shan-you,Wang Li,Wu Xiao
Intracerebral hemorrhage (ICH) is the deadliest type of stroke. Oxidative stress was considered to play an important role in ICH-induced secondary injury. Crocin, the main compound isolated from Crocus sativus L., possesses a potential anti-oxidative function in many types of diseases including ICH. In the current study, the protective role of crocin in ICH-induced brain injury was investigated in the ICH model. The ICH-induced brain edema and neurological deficits were analyzed by brain edema measurement and neurological testing. The superoxide dismutase (SOD) and glutathione peroxidase (GSH-px) activity and the content of malondialdehyde (MDA) were assessed by a total superoxide dismutase assay kit. The expressions of ferroptosis-related genes were verified by quantitative real-time PCR (qPCR) and western blotting. The ICH-induced brain edema and neurological deficits were significantly decreased after treatment with crocin. Moreover, the SOD and GSH-px activities were obviously increased in the ICH with crocin-treated group compared with the ICH group, while the content of MDA was markedly decreased after treatment with crocin. Crocin inhibited ferroptosis of neuron cells, as evidenced by increased Fe 2+ concentration and the expression of GPX4, FTH1, and SLC7A11. Mechanistically, crocin treatment increased the expression and nuclear translocation of Nrf2. Our data suggest that crocin alleviates intracerebral hemorrhage–induced neuronal ferroptosis by facilitating Nrf2 nuclear translocation.
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JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
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2022
·Vol. 33
·期 13
·9830-9844
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IF 2.779
Liu Gu,Wang Weichao,Wang Liuying,Ge Chaoqun,Wang Wenhao,Wang Long,Xu Kejun,Chen Mengzhou
La 0.8 Sr 0.2 MnO 3 (LSMO) powder was prepared using the sol–gel method and treated at different annealing temperatures ( AT ), and the effects of AT on the crystal structure, oxygen vacancies, magnetic, electromagnetic, and microwave absorption properties of LSMO were investigated. Our results showed that with increased AT , the lattice constant and average grain size increased while the density of oxygen vacancies gradually decreased. The bond angle of Mn–O–Mn and saturation magnetization also increased gradually when AT ≤ 1373 K, and decreased slightly when AT = 1473 K. The increase of mole ratio of Mn 4+ and grain size growth also contributed to the significant improvement in electrical conductivity of LSMO, while the decreases polarization of the material weakened its dielectric properties. When the frequency range was 2–18 GHz, and AT = 1173 K, LSMO exhibited the maximum effective bandwidth, which was 4.7 GHz (13.1–17.8 GHz) when the thickness was 1.62 mm. A minimum reflection loss ( RL ) of − 21.4 dB was reached at 15.8 GHz. Furthermore, when T = 973 K, LSMO exhibited excellent low-frequency absorption properties. When the thickness was 2.2 mm, the effective bandwidth in the X-band was 3.2 GHz (8.65–11.85 GHz) and RL was − 46.3 dB at 10.4 GHz. This indicated that the annealing temperature was the key parameter for determine the effective working frequency band of LSMO. As a result, this work provides a reference for regulating the electromagnetic properties of LSMO, which is necessary to meet the microwave absorption requirements in different occasions.
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FIRE TECHNOLOGY
·
2022
·Vol. 58
·期 4
·2077-2091
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IF 3.605
Nabipour Hafezeh,Shi Hu,Wang Xin,Hu Xiangming,Song Lei,Hu Yuan
Wildfires have been recognized as a natural incident in some forests, however, fire season is now more severe and extensive, even in tropical rainforests in which fire could have damaging impacts. A hydrogel is a 3-D polymeric structure encompassing cross-linked and hydrophilic macromolecules. In comparison with water, hydrogels have shown some superiorities in terms of water-binding, cooling, and sealing, which make them be applied in forest fire prevention programs for improving fire-extinguishing performance. In this study, an environmentally friendly phosphorus-modified methylcellulose/silica hybrid hydrogel was prepared based on the modified methylcellulose by 9,10-dihydro-9-oxa-10-phosphaphenanthrene-10-oxide–itaconic acid (DOPO-ITA) and silica nanoparticles. In the fire prevention experiments, the grass treated with the methylcellulose@DOPO-ITA@silica hybrid hydrogel shows self-extinguishing behavior, whereas those treated with ordinary water or methylcellulose hydrogel can be easily ignited after one week. In the firefighting experiments, the methylcellulose@DOPO-ITA@silica hybrid hydrogel displays a much shorter extinguishing time and lower consumption volume than ordinary water and the methylcellulose@DOPO-ITA hydrogel. This work presents an environmentally friendly, non-toxic, and biodegradable cellulose-based hybrid hydrogel for the fire prevention and firefighting of wildfires.
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CHEMICAL RESEARCH IN CHINESE UNIVERSITIES
·
2022
·Vol. 38
·期 3
·823-828
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IF 2.726
Hao Zhimin,Liu Dapeng,Ge Huaiyun,Zuo Xintao,Feng Xilan,Shao Mingzhe,Yu Haohan,Yuan Guobao,Zhang Yu
Molybdenum doping is an effective way to improve the oxygen evolution reaction(OER) properties of catalysts, which can efficiently improve the electronic conductivity, mass transport process, and intrinsic activity of transition metal oxides or hydroxides, especially for those multi-component oxides with more abundant active sites. Herein, we have prepared a quaternary FeCoMoCu metal oxide on Cu foam(FeCoMoCuO x @Cu) as an efficient OER catalyst. As expected, FeCoMoCuO x @Cu could exhibit a low overpotential(252 mV at the current density of 10 mA/cm 2 ) and exceptional stability(10000 cycles of CV scans or constant electrolysis for 48 h).
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BMC Complementary Medicine and Therapies
·
2022
·Vol. 22
·期 1
·1-10
·
IF 2.838
Deng Jiuhong,Zheng Chao,Hua Zhou,Ci Haideng,Wang Guiying,Chen Lijing
Background Diosmin has been reported to treat diabetes, but its role in diabetic nephropathy (DN) remains unclear. This research investigated the mechanism by which diosmin alleviated high glucose (HG)-induced HK-2 cell injury.Methods First, we used CCK-8 to detect the effect of 0.1, 1, or 10 μg/mL diosmin on the viability of HK-2 cells treated with normal glucose or HG. Next, we used flow cytometry, automatic biochemical analyzer, ELISA, immunofluorescence, and colorimetric assay kit to examine the apoptosis, oxidative stress, inflammatory factors, and Caspase-3 expression in HK-2 cells. Thereafter, we used the western blot and qRT-PCR to examine the expression of the endoplasmic reticulum stress-, oxidative stress-, inflammation-, apoptosis-, and autophagy, and PI3K/AKT pathway-related factors.Results Diosmin was non-cytotoxic to normal HK-2 cells and enhanced the HK-2 cell viability suppressed by HG. Meanwhile, diosmin restrained apoptosis, the contents of MDA, pro-inflammatory factors, and Caspase-3 but intensified the contents of SOD and CAT induced by HG. We further confirmed that diosmin blunted oxidative stress-, inflammation-, apoptosis-, and autophagy-related factors expression induced by HG via restraining the CHOP and GRP78 expressions. Further, we also discovered that PTEN level was restrained and the ratios of p-PI3K/PI3K and p-AKT/AKT were enhanced in HK-2 cells induced by HG, which was reversed by co-treatment of HG and diosmin.Conclusion sOur study manifested that diosmin alleviated the HG-mediated endoplasmic reticulum stress injury in HK-2 cells via restraining the PI3K/AKT pathway.
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