JOURNAL OF MATERIALS SCIENCE
·
2023
·Vol. 58
·期 7
·3066-3077
·
IF 4.5
Liu Xiang,He Zhanglong,Li Tao,Wang Xiaodong,Zhao Chen,Liu Shan,Liu Yuling,Fan Zheqiong,He Hao
MnO 2 is a promising catalyst for oxygen reduction and metal–air batteries due to the natural abundance, low cost and nontoxicity. Improving its activity is an important challenge for its large-scale commercialization. Defect engineering and heteroatom doping are the most effective means and can be easily operated through plasma treatment at different atmospheres. In this work, defects on MnO 2 are manufactured via rapid plasma treatment at Ar atmosphere while both defects and N-doping are simultaneously fabricated at N 2 atmosphere. N–MnO 2 exhibits a greatly enhanced ORR activity with a half-wave potential of 0.84 V, a limiting current density of 6.7 mA cm −2 and the number of transferred electrons of 3.9. In neutral Mg-air battery, N–MnO 2 -based battery exhibits a max power density of 124.3 mW cm −2 at a current density of 255.4 mA cm −2 and excellent stability under different working condition. These superior performances of N–MnO 2 to Ar–MnO 2 and pristine α -MnO 2 demonstrate that the defects and N-doping by plasma treatment at N 2 atmosphere significantly enhance the oxygen reduction activity. This work reveals the relationship between microstructure and oxygen reduction reaction and supplies a new idea for the developing economical and efficient oxygen reduction reaction catalysts for metal–air batteries. Graphical
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ACS Applied Materials & Interfaces
·
2023
·
IF 9.5
Xin-Yang Yue,Jing Zhang,Dong Chen,Xue-Jiao Xu,Hai-Tao Wu,Yong-Ning Zhou,Zheng Liang
Spatial hindrance of lithium polysulfide (LiPS) diffusion by inserting a barrier interlayer has been deemed as an effective strategy to restrict the shuttle effect in lithium–sulfur batteries (LSBs). However, the extra interlayer without reversible capacity production inevitably reduces the actual energy density of the battery. Herein, a freestanding α-MoO3 nanobelt interlayer with the decoration of TiN nanoparticles and carbon nanotubes (denoted as MCT) is established. To investigate the capacity compensation effect of the MCT during cell operations, X-ray absorption near-edge spectrometry is conducted. It is revealed that MoO3 can sustain a reversible Li intercalation/deintercalation in a voltage range of 1.8–2.8 V, providing 180 mAh g–1 of extra capacity for compensating sulfur cathode. In addition, the adsorption of the lithiated α-MoO3 toward LiPSs is further evaluated. By matching a high-loading sulfur cathode (3.0 mg cm–2), a superior capacity of 713.3 mAh g–1 can be retained after 100 cycles under the MCT assistance.
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RSC Advances
·
2026
·
IF 6.1
Baoliang Lv,Wei Zhang,Guohua Zhang,Guofu Zhang,Miao Zhang,Shoufeng Xue,Huixiang Wang
The epoxidation of long-chain α-olefins is an effective strategy for optimizing synthetic oil products and expanding their high-value-added derivatives. Tungsten trioxide (WO 3 ) is a promising catalyst for this reaction, yet pure WO 3 suffers from low specific surface area and a high density of Brønsted acid sites (B acid), resulting in poor activity and selectivity. Herein, graphene oxide (GO) was employed as a support to anchor WO 3 via an in situ growth strategy. Leveraging the strong interaction between the oxygen-containing functional groups of GO and the acidic hydroxyl groups of WO 3 , we achieved both high dispersion and effective reduction of B acid sites on WO 3 , successfully fabricating a high-performance WO 3 /GO catalyst. In the epoxidation of 1-octene, the WO 3 /GO catalyst exhibited excellent performance, specifically, its catalytic activity for producing 1,2-epoxyoctane increased from 7.9 mmol g WO 3 −1 h −1 (pure WO 3 ) to 20.3 mmol g WO 3 −1 h −1 , representing a 2.6-fold enhancement in catalytic efficiency. The catalyst also exhibited excellent performance towards other long-chain α-olefins. This study provides a simple, efficient, and dual-benefit strategy for the structural modification of WO 3 -based catalysts, offering a promising approach for designing low-acid, highly dispersed metal oxide catalysts for the efficient conversion of long-chain α-olefins. In situ anchoring of WO 3 onto GO enables high dispersion and reduced B acidity, boosting 1-octene epoxidation activity by 2.6 times.
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PubMed
高影响因子
Nanomaterials
·
2026
·Vol. 16
·期 4
·250
·
IF 4.8
Yingxing Yang,Yihan Zheng,Mengyao Zhao,Xiaomei Yu,Songjie Li,Jinyou Zheng
As a renewable energy source, solar energy holds significant potential for addressing future energy and environmental challenges. Concurrently, hydrogen (H2), as a clean and renewable energy carrier, has garnered substantial attention. Photoelectrocatalytic water splitting to produce H2represents an emerging green technology for converting solar energy into hydrogen energy, which has been highly valued by researchers. The key to advancing this technology lies in identifying photoelectrode materials with high catalytic activity and stability. In this study, dendritic α-Fe was synthesized via electrodeposition at the optimal potential of −1.4 V vs. Ag/AgCl for 300 s, and the photoelectrocatalytic performance of α-Fe2O3@Fe was enhanced through partial oxidation annealing at 300 °C for 6 h. This approach effectively addressed the issue of the short carrier transport distance in α-Fe2O3. The resulting partially oxidized α-Fe2O3@Fe(300 °C, 6 h) exhibited a photocurrent density of 281.1 μA/cm2at +0.55 V vs. Ag/AgCl, which was 2.23 times higher than that of the fully oxidized dendritic α-Fe2O3(500 °C, 2 h) (125.8 μA/cm2). The influence of deposition potential on photoelectrocatalytic performance was systematically explored, and the optimal deposition potential was identified. Additionally, surface modification with 0.15 wt% Pt (ultra-low loading) was employed to further improve the photocatalytic stability of α-Fe2O3(500 °C, 2 h). After continuous operation for 2 h, the photocurrent of the surface-modified sample decreased by only 6.5%, indicating a substantial enhancement in stability.
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ACS Synthetic Biology
·
2026
·
IF 3.9
Haiquan Yang,Lingling Chen,Wei Shen,Yuanyuan Xia,Li Zhou,Xianzhong Chen
(−)-α-bisabolol, a valuable sesquiterpene with anti-inflammatory and antibacterial properties, was sustainably produced via de novo high-titer biosynthesis in Candida tropicalis using engineered cell factories. To minimize resource-intensive extraction methods, we employed green metabolic engineering strategies, including an optimized Scaffold-Mediated Assembly Regulation Tool for coexpressing MrBBS and ERG20 genes, enhancing (−)-α-bisabolol titer 3.24-fold over the control strain. A novel Linker- and Scaffold-Mediated Assembly Regulation Tool further improved pathway efficiency by coordinating eight key acetyl-CoA/mevalonate pathway genes, achieving a 5.23-fold increase. Sustainable strain optimization included knockout of the competing gene DPP1 (yielding 261.2 mg•L–1) and the peroxisomal surface display of Cat2 and ERG10 (290.1 mg•L–1). Additional deletions of genes ADH1 and GPD1 reduced metabolic waste, boosting the titer 2.46-fold. A low-energy two-stage temperature control strategy further improved the titer to 1108.2 mg•L–1, while fed-batch fermentation in a 5 L fermenter─optimized for minimal energy and substrate input─achieved a record titer of 36.9 g•L–1. This study demonstrated a green, scalable biosynthesis platform for (−)-α-bisabolol, reducing reliance on petrochemical or plant-extraction routes, and provided a sustainable blueprint for terpenoid production in nonconventional yeasts.
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高影响因子
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2026
·Vol. 37
·期 10
·761
·
IF 3.2
Wang Yongyuan,Li Xuyin,Xu Chaoyong,Cao Jianchun
Expanding the stable voltage window and specific capacitance of supercapacitor electrode materials remains a key scientific challenge due to the low energy density of supercapacitors. In this study, starting from the problem of low specific capacitance caused by the limited electron transfer rate due to the low conductivity of MnO 2 , a simple and economical hydrothermal method was used to doping different contents of Nb 5+ ions, which replaced some Mn 4+ ions in the α-MnO 2 lattice, thereby causing certain changes in the charge density and band structure of α-MnO 2 , and effectively improving its conductivity. In addition, Nb 5+ -doped α-MnO 2 effectively alters its morphology and surface area, providing a large surface area for ion and electron transport. The optimized Nb-MnO 2 electrode has a voltage window widened from 0.8 V to 1.2 V in a 1 M Na 2 SO 4 electrolyte, with a specific capacitance of 587 F/g with in the 1.2 V wide voltage window, while the undoped MnO 2 has a specific capacitance of only 131 F/g. A 2 V asymmetric supercapacitor is constructed with activated carbon AC as the negative electrode, providing a high energy density of 57 Wh/kg at a power density of 1010 W/kg in a 3 M KOH electrolyte. In addition, at a current density of 5 A/g, the capacitance retention rate of 84.85% was maintained after 5000 charge–discharge cycles. This work is a valuable foundation for the future exploration of wide voltage window and high-performance aqueous electrolyte asymmetric supercapacitors.
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CHEMICAL ENGINEERING SCIENCE
·
2026
·
IF 5.1
Kehui Qi,Peng Lu,Xuehui Zhang,Yuxiang Liu,Yue Liu,Lu Li
Single-atom catalysts (SACs) are highly regarded for their high atomic efficiency and outstanding catalytic performance. However, the stable anchoring of single atoms and the precise regulation of their multiple valence states are still challenges. To address this challenge, a structurally stable and valence-tunable multivalent zinc single-atom catalyst was successfully synthesized according to a thermodynamically-driven lattice substitution strategy. Experimental and theoretical analyses indicate that zinc single atoms precisely occupy a pair of adjacent Cu + vacancies in the Cu 2 O lattice with a spacing of approximately 2.9 Å, forming Zn-O-Cu units. This structure establishes an electron transport channel mediated by oxygen bridges, facilitating strong electron coupling between the 3d orbitals of Zn and Cu. This strong coupling results in the formation of a stable multivalent Zn δ+ (0＜δ < 2) state, which is identified as the primary origin of the catalyst’s high activity. Benefiting from the unique electronic synergistic effect of the Zn-O-Cu units and the resulting promotion of oxygen vacancy formation, this catalyst enables carboxylic acid molecules to be adsorbed and activated in a bridging mode. Through this adsorption configuration, the α-C–C bond becomes polarized and significantly weakened, setting the stage for its selective cleavage. The Zn δ+ -O-Cu catalyst showed remarkable catalytic performance in the selective cleavage of the α-C–C bond in fatty acids for alkane production, achieving up to 96.89% n-C n-1 alkane selectivity. Furthermore, the Zn δ+ -O-Cu catalyst demonstrated excellent versatility across fatty acids with varying carbon chain lengths. These results demonstrate the significant promise of this strategy not only for advancing the practical utilization of biomass feedstock with high fatty acid (FA) content, but also for establishing an efficient and novel pathway toward long-chain alkane production.
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FOOD HYDROCOLLOIDS
·
2026
·
IF 13.8
Xine Huang,Yizhou Xiang,Xiaoning Zhu,Chenjuan Zeng,Liang Zou,Lei Wang,Changling Wu,Xingquan Liu,Zisheng Luo,Li Li
The thermal sensitivity of α-amylase inhibitors (α-AL) from white kidney beans (WKB) poses a significant challenge in the food industry. This issue can be effectively addressed through stabilization strategies based on polysaccharides. In this study, iota-carrageenan (ι-CG) was chosen as a stabilizing agent owing to its high charge density and flexible chain structure. A chelation-based approach utilizing ι-CG was developed, and both the formation mechanism of the resulting complex and its effect on the thermal stability of α-amylase inhibitors from white kidney beans (α-AL-WKB) were thoroughly investigated. Multi-scale characterization demonstrated that the complexation at pH 6.0 and a mass ratio of α-AL-WKB to ι-CG of 2:1 effectively suppressed the thermal aggregation of α-AL-WKB, with only a minor decrease in activity from 7864.19 ± 239.90 U to 6094.88 ± 88.27 U. The compact structure of the complex was primarily stabilized through hydrogen bonding and electrostatic interactions. Surface plasmon resonance (SPR) analysis further confirmed a moderate binding affinity between the α-AL-WKB/ι-CG complex and α-amylase, with the equilibrium dissociation constants (KD) value of 4.01 × 10 −8 M before heating and 5.59 × 10 −8 M after thermal treatment. In simulated in vitro digestion assays, the complexation significantly lowered the digestibility of gelatinized corn starch, reducing rapidly digestible starch (RDS) by 27.74% ± 0.58% and increasing the resistant starch (RS) by 54.35% ± 0.27%. These findings demonstrate a promising strategy for enhancing the thermal stability of α-AL-WKB and provide a basis for developing low-glycemic-index functional foods.
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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2026
·
IF 6.7
Ying-Xin Zhao,Ke-Tian Zhu,Yu-Xuan Tong,Qi-Qian Wang,Jin-Long Li
Abstract Di-2-ethylhexyl phthalate (DEHP) accumulates in the food chain, threatening human and animal health. However, how DEHP induces neurotoxicity by interfering with microglia has not been fully revealed. Our research aims to explore the effects of DEHP on microglia and identify relevant targets that cause neurotoxicity. The results indicated that DEHP damaged neurons, leading to swelling, demyelination, and abnormal autophagy. Inhibition of autophagy resulted in α-Syn misfolding, characterized by an increase in dimers with increasing additive concentrations (P = 0.0096). Dimer formation was promoted by the addition of additives, which increased the electrostatic force, along with interactions between Glu106, Gly51, and Val66. Transmitted from neurons to microglia (Pearson r2 = 0.889), pathological aggregates under DEHP exposure induced microglial M1 subtype switching. This study elucidated a novel mechanism by which DEHP damages the nerves of birds and provided a therapeutic target for the neurotoxic disease risk caused by the transmission of plastic additives through the food chain.
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ANALYTICA CHIMICA ACTA
·
2026
·
IF 6.1
Li Jiang,Luna Shen,Shuting Fang,Fangyuan Sun,Guizhong Xin,Lifang Liu,Jiayi Zheng
An integrated multi-level analytical framework was developed to characterize glutamine metabolic remodeling associated with RA-ILD. • Multi-matrix metabolomics revealed compartment-specific redistribution of glutamine-related amino acids. • [α- 15 N] glutamine tracing in vitro identified intracellular fibrotic redirection toward serine/glycine biosynthesis. • CTSs modulated intestinal transporters and suppressed the ATF4-associated serine/glycine program. Background Rheumatoid arthritis-associated interstitial lung disease (RA-ILD) is a severe complication with limited therapeutic options, characterized by destructive joint lesions and pulmonary fibrosis involving excessive collagen deposition. Glutamine metabolism supplies precursors for collagen-related amino acid biosynthesis, which drives the fibrotic remodeling process, but its cross-organ redistribution and pathway-specific utilization remain difficult to resolve using conventional metabolomic readouts. An analytical strategy capable of integrating quantitative multi-matrix profiling with isotope-resolved nitrogen tracing is therefore needed to characterize alterations in glutamine-related amino acid metabolism associated with RA-ILD and its pharmacological modulation. Results We established a complementary analytical framework in which 3-trimethylsilyl-1-propanaminium chloride (TSPC) derivatization-assisted UPLC-QqQ-MS/MS targeted metabolomics and intestinal amino acid transporter profiling were applied to an RA-ILD rat model, while [α- 15 N] glutamine tracing was independently performed in a TGF-β1-induced fibrotic cell model to examine pathway-specific glutamine nitrogen utilization. The validated method enabled sensitive quantification of glutamine-related amino acids in serum, lung tissue, and cells. In RA-ILD rats, cross-matrix profiling revealed a compartment-dependent disturbance of glutamine-related amino acid distribution, characterized by pulmonary accumulation coupled with altered circulating availability. Clematis triterpenoid saponins (CTSs) partially normalized this metabolic imbalance and were associated with coordinated regulation of intestinal glutamine transporters. Stable-isotope tracing in a fibrotic cell model further showed preferential incorporation of glutamine-derived nitrogen into the serine-glycine axis, which was supported by increased expression of ATF4-associated serine-glycine biosynthetic enzymes in lung tissue. CTSs treatment attenuated the corresponding lung transcriptional alterations. Significance Together, in vivo multi-matrix metabolomics characterized systemic glutamine-related metabolic redistribution and its response to CTSs in RA-ILD, whereas complementary in vitro isotope tracing provided pathway-level evidence for preferential glutamine-derived nitrogen utilization through the serine-glycine axis under fibrotic stimulation. Such a complementary framework also provides a transferable analytical strategy for investigating cross-organ diseases and multi-level interventions of traditional Chinese medicines. Download: Download high-res image (371KB) Download: Download full-size image
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Advanced Healthcare Materials
·
2026
·
IF 11
Xinxing Shuai,Yimeng Cai,Yuan Wang,Yi Zhao,Xiaoyu Yang,Piaoye Ming,Yuhan Li,Denghao Huang,Shuanglin Peng,Qian Wang,Ning Kang,Guoqiang Xu,Leixiao Yu,Quan Yuan
Oral mucosal lesions present significant therapeutic challenges due to the complex oral environment and the limitations of conventional biomaterials in clinical application. Herein, a self-gelling supramolecular powder composed of polyethyleneimine (PEI), poly (acrylic acid) (PAA), and α-lipoic acid (LA) is developed for oral ulcer management. Upon contact with saliva, the powder rapidly absorbs water and undergoes instantaneous self-gelation (<5 s), forming a physically cross-linked hydrogel that exhibits robust wet adhesion to oral mucosal tissues. The incorporation of LA enhances the mechanical integrity of the network without increasing swelling, while enabling sustained LA release that imparts intrinsic anti-inflammatory bioactivity. In a murine oral ulcer model, the optimized PEI/PAA/1%LA formulation accelerates wound healing, reduces pain-associated behaviors, and suppresses local expression of IL-1β and TNF-α. Mechanistically, transcriptomic analysis reveals that LA exerts its anti-inflammatory effects through comprehensive suppression of both classical and noncanonical NF-κB signaling pathways, downregulating Nfkb1, Nfkb2, and downstream inflammatory cytokines. By integrating durable wet adhesion with controlled therapeutic delivery, this supramolecular system offers a clinically translatable strategy for oral mucosal regeneration that addresses both biological healing requirements and patient comfort.
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LANGMUIR
·
2026
·
IF 4.4
Ting Xu,Baoxin Yang,Ranran Guo,Linling Yu,Xiaoyan Dong,Yan Sun
Bacillus thermocatenulatus lipase 2 (BTL2) is a highly versatile enzyme for catalyzing the hydrolysis and synthesis of various esters, but the practical application of the enzyme is limited by its poor operational stability and difficulty in recovery. To address these limitations, we have herein proposed a dual fusion strategy that combines the chaperone-like protein α-synuclein (αS) at the C-terminus and silica-binding peptide (SiBP) at the N-terminus, making a fusion enzyme (SiBP-BTL2-αS) for enhanced enzymatic performance and site-specific immobilization on mesoporous silica nanoparticles (MSNs) for repeated use. The catalytic activity of the enzymes was evaluated using a colorimetric p-nitrophenyl palmitate (pNPP) assay at 30 °C in 50 mM HEPES buffer (pH 8.0), and relative activity was expressed as the ratio to the wild-type BTL2. It was found that free SiBP-BTL2-αS showed a 1.8-fold higher activity than BTL2 due to the chaperone effect of αS, and immobilization on MSNs brought out a further 1.4-fold increase in activity at an enzyme loading of 194 mg/g. Thus, SiBP-BTL2-αS@MSNs presented 3.3-fold higher activity than BTL2. Moreover, SiBP-BTL2-αS@MSNs exhibited significantly improved thermostability and broad pH tolerance over the free counterpart and BTL2. In repeated uses, SiBP-BTL2-αS@MSNs retained 82.1% of its initial activity after seven consecutive reaction cycles. In the synthesis of vitamin E succinate, SiBP-BTL2-αS@MSNs showed 32% and 78% higher yields over SiBP-BTL2-αS and BTL2, respectively, verifying the superiority of SiBP-BTL2-αS@MSNs in enzymatic catalysis. This work not only offers a highly efficient, robust, and recyclable enzyme preparation, but also provides a promising way to design immobilized lipase with hyperactivation behavior.
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