Antioxidants
·
2025
·Vol. 14
·期 4
·468
·
IF 6.6
Xin Zhang,Shuang Han,Zhu Zeng,Jie Dai,Yi Jia
Selenium-binding protein 1 (SELENBP1) has been implicated in cancer development, neurological disorders, tissue injury, metabolic regulation, and cell differentiation. Sepsis is characterized prominently by immunological dysregulation and severe organ damage. However, whether SELENBP1 improves sepsis by regulating immune cell activity remains unknown. Here, we detected an elevation of SELENBP1 levels in the blood of sepsis patients and in the livers of septic mice. Significantly, SELENBP1 knockout (KO) prolonged survival in septic mice. This phenomenon was accompanied by decreased liver damage, reduced inflammation levels, and an increased regulatory T cell/T helper 17 cell (Treg/Th17) ratio in the spleen. Additionally, SELENBP1 deficiency induced a redox imbalance and inhibited dendritic cell (DC) maturation, resulting in a tolerogenic DC (tolDC) phenotype and an increase in the Treg/Th17 ratio. Furthermore, SELENBP1-KO mature DCs (mDCs) alleviated liver injury by increasing the Treg/Th17 ratio in the spleen, thus improving the survival of septic mice. These findings indicate that SELENBP1 is involved in sepsis by regulating DC immune activity, which might provide a potential way for sepsis treatment.
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高影响因子
ACS Nano
·
2025
·
IF 16
Hairui Huang,Hanyu Wu,Yizhou Zhang,Xunda Feng
Molecular-scale adsorption, catalysis, and separation demand nanoporous materials with high permeability, extensive surface areas, and pronounced nanoconfined effects. Fabricating polymeric particles with 3-D interwoven pores of ∼1 nm potentially addresses these needs. However, significant challenges remain in controlling their pore interconnectivity, uniformity, and achieving faceted particle shapes. Herein we present facile fabrication of polyhedral particles possessing interpenetrating 1 nm pores by suspension polymerization of double-gyroid (DG) liquid crystalline droplets. Mechanical stirring of the disordered phase at elevated temperatures, followed by undercooling, leads to the emulsification of DG droplets, as confirmed by synchrotron small-angle X-ray scattering (SAXS). UV-induced cross-linking of the DG droplets preserves the ordered network of 1 nm pores, as characterized by SAXS and microscopy. Intriguingly, due to the elasticity induced by the Ia3̅d periodicities, these particles adopt polyhedral shapes to avoid the elastic energy penalty associated with conventional sphericity. We demonstrate that these faceted particles, featuring 1 nm pores and efficient packing, enable rapid, size-exclusive adsorption and nanoconfined degradation of organic pollutants, driven by their 3-D permeability, high surface area, and enhanced nanoconfinement effects.
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JOURNAL OF MEMBRANE SCIENCE
·
2025
·
IF 9
Wei Chen,Pengfei Wang,Weike Jia,Huidan Zeng
Membrane-based pervaporation process is the most time- and energy-saving method for the separation of xylene isomers. However, developing easily prepared membrane with a high separation factor still remains a significant challenge. Herein, the silicalite-1/polyvinyl alcohol (PVA) mixed matrix membrane (MMM) (SPMMM) with enhanced xylene isomers pervaporation separation performance was successfully fabricated via solution scraping method. The compactness and compatibility of the SPMMM were effectively tuned by optimizing the zeolite content and selecting appropriate cross-linker. Results showed that the SPMMM with 40 % zeolite content, cross-linked with fumaric acid (SPMMM-Fu), exhibited the densest and most continuous membrane structure, the lowest swelling degree and the best xylene compatibility. Pervaporation experiments demonstrated that the SPMMM-Fu exhibited superior xylene isomers selective separation performance compared to the templated-silicalite-1/α-Al 2 O 3 membrane. For the SPMMM-Fu, the maximum separation factor was achieved in binary xylene isomer solutions containing 10 % p-X. The total permeate fluxes in the aforementioned binary p-X/o-X and p-X/m-X isomer solutions were about 43.20 g m −2 h −1 and 34.66 g m −2 h −1 , respectively. The corresponding separation factors of p-X/o-X and p-X/m-X were about 34.65 and 39.73, respectively. The third-stage separation experiment demonstrated that the SPMMM-Fu could produce p-X with a purity ≥99.7 % from binary p-X/o-X isomer solutions. Long-term and variable-temperature pervaporation experiments suggested the SPMMM-Fu had excellent structural stability. Furthermore, reproducibility tests conducted on multiple batches of the SPMMM indicated that the SPMMM-Fu could be produced stably. The scalable experiment demonstrated that our strategy could produce large-area SPMMM-Fu (25 × 40 cm 2 ), exhibiting separation performance similar to that of small membrane coupons. This work presented a potentially low-cost and scalable approach for producing highly dense SPMMM with exceptional xylene compatibility, enabling efficient pervaporation separation of xylene isomers from their mixtures.
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International Journal of Nanomedicine
·
2023
·
IF 8
Xiaofeng Chen,Yu Liu,Leiying Miao,Yangyang Wang,Shuangshuang Ren,Xuebin Yang,Yong Hu,Weibin Sun
Periodontitis is a major cause for tooth loss, which affects about 15% of the adult population. Cementum regeneration has been the crux of constructing the periodontal complex. Cementum protein 1 (CEMP1) is a cementum-specific protein that can induce cementogenic differentiation. In this study, poly(ethylene glycol) (PEG)-stabilized amorphous calcium phosphate (ACP) nanoparticles were prepared by wet-chemical method and then loaded with recombinant human CEMP1 (rhCEMP1) for controlled release. An electrospun multiphasic scaffold constituted of poly(ε-caprolactone) (PCL), type I collagen (COL), and rhCEMP1/ACP was fabricated. The effects of rhCEMP1/ACP/PCL/COL scaffold on the attachment proliferation, osteogenic, and cementogenic differentiations of human periodontal ligament cells, (PDLCs) were systematically investigated. A critical size defect rat model was introduced to evaluate the effect of tissue regeneration of the scaffolds in vivo. The results showed that PEG-stabilized ACP nanoparticles formed a core-shell structure with sustained release of rhCEMP1 for up to 4 weeks. rhCEMP1/ACP/PCL/COL scaffold could suppress PDLCs proliferation behavior and upregulate the expression of cementoblastic markers including CEMP1 and cementum attachment protein while downregulating osteoblastic markers including osteocalcin and osteopontin when it was cocultured with PDLCs in vitro for 7 days. Histology analysis of cementum after being implanted with the scaffold in rats for 8 weeks showed that there was cementum-like tissue formation but little bone formation. These results indicated the potential of using electrospun multiphasic scaffolds for controlled release of rhCEMP1 for promoting cementum regeneration in reconstruction of the periodontal complex.
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高影响因子
MACROMOLECULES
·
2021
·
IF 5.985
Hanyu Wu,Fengxian Xu,Guanzhen Gao,Xunda Feng
Polymerization of bicontinuous cubic (Q) liquid crystals (LCs) can be utilized to produce technologically useful polymeric materials with 3-D interconnected nanopores of ∼1 nm. However, their practical applications have been hindered by the exceptionally complicated syntheses of the needed polymerizable amphiphiles and the susceptible morphological destruction upon polymerization. Here, we present a scalable strategy to fabricate polymeric membranes with 3-D interconnected nanopores by photo-crosslinking of easily accessible Q LCs. We leverage a readily synthesized, cost-effective zwitterionic monomer as the building block to construct “normal” lyotropic double gyroid (G1) mesophases that afford radical polymerization. Although self-assembly of the amphiphile in neat water forms no Q LCs, additional phosphoric acid can drive the emergence of G1 mesophases by inducing the non-constant interfacial curvature. An intriguing advantage exhibited by this polymerizable G1 system is the ability to persist upon swelling by large volumes of commercially available cross-linkers, thereby effectively facilitating structural lock-in through photo-initiated cross-linking. High-brilliance synchrotron small-angle X-ray scattering has unambiguously confirmed the excellent retention of periodic G1 morphologies in the mechanically robust polymers. Transmission electron microscopy further provides unprecedented, detailed visualization of the spacing and symmetry in the cross-linked G1 assemblies over large areas. The exceptionally easy access to the building blocks and the high-fidelity structural preservation enable the scalable fabrication of nanoporous membranes for applications such as ionic transportation, as preliminarily demonstrated.
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高影响因子
Frontiers in Plant Science
·
2019
·
IF 4.106
Hussain Sajid,Bai Zhigang,Huang Jie,Cao Xiaochuang,Zhu Lianfeng,Zhu Chunquan,Khaskheli Maqsood Ahmed,Zhong Chu,Jin Qianyu,Zhang Junhua
Salt stress in soil is a critical constraint that affects the production of rice. Salt stress hinders plant growth through osmotic stress, ionic stress, and a hormonal imbalance (especially ethylene), therefore, thoughtful efforts are needed to devise salt tolerance management strategies. 1-Methylcyclopropene (1-MCP) is an ethylene action inhibitor, which could significantly reduce ethylene production in crops and fruits. However, 1-MCPs response to the physiological, biochemical and antioxidant features of rice under salt stress, are not clear. The present study analyzed whether 1-MCP could modulate salt tolerance for different rice cultivars. Pot culture experiments were conducted in a greenhouse in 2016–2017. Two rice cultivars, Nipponbare (NPBA) and Liangyoupeijiu (LYP9) were used in this trial. The salt stress included four salt levels, 0 g NaCl/kg dry soil (control, CK), 1.5 g NaCl/ kg dry soil (Low Salt stress, LS), 4.5 g NaCl/kg dry soil (Medium Salt stress, MS), and 7.5 g NaCl/kg dry soil (Heavy Salt stress, HS). Two 1-MCP levels, 0 g (CT) and 0.04 g/pot (1-MCP) were applied at the rice booting stage in 2016 and 2017. The results showed that applying 1-MCP significantly reduced ethylene production in rice spikelets from LYP9 and NPBA by 40.2 and 23.9% (CK), 44.3 and 28.6% (LS), 28 and 25.9% (MS), respectively. Rice seedlings for NPBA died under the HS level, while application of 1-MCP reduced the ethylene production in spikelets for LYP9 by 27.4% compared with those that received no 1-MCP treatment. Applying 1-MCP improved the photosynthesis rate and SPAD value in rice leaves for both cultivars. 1-MCP enhanced the superoxide dismutase production, protein synthesis, chlorophyll contents (chl a, b, carotenoids), and decreased malondialdehyde, H2O2, and proline accumulation in rice leaves. Application of 1-MCP also modulated the aboveground biomass, and grain yield for LYP9 and NPBA by 19.4 and 15.1% (CK), 30.3 and 24% (LS), 26.4 and 55.4% (MS), respectively, and 34.5% (HS) for LYP9 compared with those that received no 1-MCP treatment. However, LYP9 displayed a better tolerance than NPBA. The results revealed that 1-MCP could be employed to modulate physiology, biochemical, and antioxidant activities in rice plants, at different levels of salt stress, as a salt stress remedy.
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高影响因子
Journal of Environmental Chemical Engineering
·
2022
·
IF 7.968
Haijian Tong,Yuting Yang,Fengyan Shi,Mengna Ding,Liulin Luo,Yingchun Miao,Yuning Huo,Hexing Li
The serious threat of environmental microbial contamination to the health of human beings has drawn wide attentions. In this work, a series of bimetallic Co x Cu y -CAT-1 metal-organic frameworks (MOFs) with tunable Co/Cu molar ratio was prepared by one-pot route. All of Co x Cu y -CAT-1 samples were in the shape of nanorods with the strong interaction of Co and Cu centers. In addition to the less surface electronegativity and high specific surface area, which were beneficial for the contact of MOFs materials with bacteria, the bimetallic coordination in Co x Cu y -CAT-1 realized the synergistic contribution of photocatalytic-photothermal effect to the effective bacterial inactivation for E. coli , comparing to the photothermal and photocatalytic effect. The thermal effect and the intrinsic antibacterial nature of metal ions in MOFs were difficult to induce the efficient destroy of bacteria. The photocatalytic effect could not remain the stable antibacterial rate and realize the obvious mineralization effect via the photo-induced holes on Co x Cu y -CAT-1. However, the synergistic photocatalytic-photothermal effect could lead to the promoted photo-thermal conversion efficiency by the efficient visible-light absorption and electron separation/transfer, and the strong and stable photothermal effect simultaneously promoted the light absorption and electron transfer . As a result, the more efficient generation of photo-induced holes were beneficial for forming more ·OH radicals, and then ·OH radicals efficiently reacted with bacteria without the surface coverage in MOFs, leading to the stable antibacterial rate and highly effective mineralization of bacteria . This work showed the significance on the synergistic photocatalytic-photothermal contribution of bimetallic MOFs materials to the environmental sterilization in the future.
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Journal of Materials Chemistry A
·
2013
·Vol. 2
·期 6
·1795-1801
·
IF 0
Ling Li,Xiao Lan Liu,Ming Gao,Wei Hong,Gui Zhen Liu,Lu Fan,Bin Hu,Qing Hua Xia,Li Liu,Gong Wu Song,Zu Shun Xu
The adsorption processes of methylene blue from aqueous solution on Fe3O4/HKUST-1 and Fe3O4/HKUST-1/GO composites were compared. The addition of GO has greatly decreased the surface area and pore volume, led to smaller pore size, and enhanced the adsorption capacity of Fe3O4/HKUST-1/GO. The different interesting phenomena and the effect of GO were analyzed. The high adsorption capacity, excellent reusability and stability make Fe3O4/HKUST-1/GO attractive for the removal of MB from aqueous solution.
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Journal of Materials Chemistry B
·
2023
·Vol. 11
·期 17
·3929-3940
·
IF 7
Lei Fang,Yingjie Chen,Wei Shan,Tiankun Hui,Mokni Ilham,Jie Wu,Chuanli Zhou,Liangmin Yu,Meng Qiu
The drug resistance of bacteria seriously reduces the recovery rate of general disease and endangers human health. Consequently, it is urgent to investigate a non-antibiotic antibacterial material. Recently, two-dimensional MXene has shown good antibacterial properties and received extensive attention due to the large number of active sites, extremely high thermal conversion efficiency, excellent cytocompatibility and ability to penetrate pellicula. However, the antibacterial activity of Ti3C2Tx is greatly affected by the morphology and concentration. Herein, an organic–inorganic hybrid of HKUST-1@Ti3C2Tx with high specific surface area and photothermal effect was designed and fabricated. By adjusting the content of Cu(CO2CH3)2·H2O and 1,3,5-benzenetricarboxylic acid, the photothermal properties of the material can be adjusted, and the release of Cu2+ can be easily reduced. The morphological characterization and fluorescent staining of bacteria which were co-incubated with HKUST-1@Ti3C2Tx confirmed that Gram-negative bacteria (Escherichia coli) and Gram-positive bacteria (Staphylococcus aureus) had adhered to the material. NIR irradiation has enabled induced hyperthermia and the release of Cu2+ ions, causing the disruption of the bacterial membrane, resulting in cytoplasmic leakage. Furthermore, HKUST-1@Ti3C2Tx with synergistic antibacterial effect not only exhibits an excellent bactericidal rate (over 99%) but also greatly improves cytocompatibility with the reduction of the Cu2+ ion release. Therefore, organic–inorganic composites have potential for synergistic effects and non-antibiotic antibacterial activity.
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高影响因子
RADIOCHIMICA ACTA
·
2022
·Vol. 111
·期 1
·63-71
·
IF 2.083
Peng Liu,Zhuang Shen,Jiaxian Cheng,Zhen Han,Wenda Xu,Mingbo Ji,Fuqiu Ma
Due to the relative abundance, long half-life and high mobility of radioactive cesium (Cs), new adsorbents are urgently needed to treat Cs to ensure public health. In this study, a graphene oxide (GO) based adsorbent for Cs(I) adsorption was prepared by 1-aza-18-crown-6 ether modification. XRD, FT-IR, XPS and SEM results showed that the properties of 1-aza-18-crown 6 ether modified GO (18C6-GO) changed dramatically compared with that of raw graphite. The adsorption properties of 18C6-GO for Cs(I) were studied by batch static adsorption experiments. The results showed that the adsorption equilibrium time of 18C6-GO was 20 h. Kinetic study revealed that the adsorption rate of Cs(I) conformed to pseudo-second-order kinetic model. Langmuir adsorption isotherm simulation indicated that the adsorption arises at homogeneous adsorption sites on 18C6-GO. Therefore, crown ether modified GO may have implications for the treatment of wastewater.
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SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2014
·
IF 2.129
Shuya Cui,Tao Wang,Xiaoli Hu
A new chiral ionic liquid was synthesized from (S)-1-phenylethylamine and it was studied by IR, Raman, polarimetry, NMR and X-ray crystal diffraction. Its vibrational spectral bands are precisely ascribed to the studied structure with the aid of DFT theoretical calculations. The optimized geometries and calculated vibrational frequencies are evaluated via comparison with experimental values. The vibrational spectral data obtained from IR and Raman spectra are assigned based on the results of the theoretical calculations by the DFT-B3LYP method at 6-311G(d,p) level. The computed vibrational frequencies were scaled by scale factors to yield a good agreement with observed experimental vibrational frequencies. The vibrational modes assignments were performed by using the animation option of GaussView5.0 graphical interface for Gaussian program.
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高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2021
·
IF 4.539
Meng Yang,Hao Guo,Lei Sun,Ning Wu,Mingyue Wang,Fan Yang,Tingting Zhang,Junye Zhang,Zhilan Pan,Wu Yang
In this present work, a carboxylated multi-walled carbon nanotubes (MWCNT-COOH) and covalent triazine framework (CTF-1) co-modified glassy carbon electrode (GCE) is prepared and used for simultaneous electrochemical detection of hydroquinone (HQ) and catechol (CC). Due to the synergistic effect between the high electrocatalytic activity and good conductivity of MWCNT-COOH and large surface area of CTF-1, the prepared modified electrode exhibits good selectivity and high sensitivity for the simultaneous determination of HQ and CC. In the neutral phosphate buffer, HQ and CC produce a pair of well-defined redox peaks on the MWCNT-COOH/CTF-1/GCE. The concentrations of CC and HQ show good linearity in the range of 2–280 μM and the detection limits of HQ and CC are 0.12 μM and 0.17 μM, respectively. The prepared electrochemical sensor can be employed to determine contents of HQ and CC in real samples.
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