Pharmaceutics
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2026
·Vol. 18
·期 1
·135
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IF 5.5
Kai Wang,Ayijiang Taledaohan,Liujia Chan,Yu Lu,Yijiang Jia,Yuji Wang
Background: Diabetic wound healing is hampered by persistent inflammation and excessive neutrophil extracellular traps (NET) formation. Peptidylarginine deiminase 4 (PAD4) is a key enzyme driving this pathology. This study developed a thermosensitive chitosan/β-glycerophosphate hydrogel for the local delivery of a novel PAD4 inhibitor, YJ-2, to promote diabetic wound repair.Methods: A YJ-2-loaded hydrogel (CGY) was synthesized and characterized.In vitrostudies used HaCaT cells and macrophages to assess proliferation, migration, NETs (via H3cit), and polarization. Efficacy was evaluated in diabetic C57 mouse wound models.Results: CGY exhibited temperature-sensitive gelation and sustained YJ-2 release.In vitro, YJ-2 inhibited NETs formation, reduced pro-inflammatory markers, promoted HaCaT migration, and induced M2 macrophage polarization.In vivo, CGY treatment significantly accelerated wound closure.Conclusions: Local hydrogel delivery of the PAD4 inhibitor YJ-2 effectively mitigates inflammation and NETs, promoting healing in diabetic wounds. This strategy represents a promising targeted therapy for diabetic wounds.
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POLYMER
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2026
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IF 5.1
Junhong Liu,Xiang Wang,Ruomei Wu,Haiyun Jiang
The copolymer P(TT -co- ICA) was prepared with different ratio of 2,2’:5′,2″-trithiophene (TT) and indole-6-carboxylic acid (ICA) via the potentiostatic method. The film structure was characterized by using field emission scanning electron microscopy (FE-SEM), ultraviolet-visible (UV-vis) spectroscopy and Fourier transform infrared spectroscopy (FTIR). The electrochemical and electrochromic properties were investigated through chromametry, cyclic voltammetry (CV), and spectroelectrochemical techniques. The P(TT -co- ICA) achieves a color difference (ΔE) of 85.19, substantially higher than the 12.30 observed for the PICA. The optical bandgap of P(TT -co- ICA) (2.43-2.49 eV) is lower than that of PICA (2.52 eV). P(TT -co- ICA) exhibited excellent color modulation capability, displaying reversible transitions between orange-yellow, gray-green, and blue-gray at different applied potentials. Furthermore, P(TT -co- ICA) demonstrates superior optical contrast (35.6–56.8%), high coloration efficiency (127–252 cm 2 /C), and satisfactory cycling stability (53–78% retention). These findings indicate that the incorporation of the TT monomer effectively enhances both the color difference and electrochromic performance of the P(TT -co- ICA) , establishing it as a promising candidate material for electrochromic applications.
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CERAMICS INTERNATIONAL
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2026
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IF 6
Chenyang Li,Yaping You,Zesheng Pan,Zesen Gao,Yunluo Wang,Yan Yang,Minghui Wang,Lianjun Wang,Haijie Chen,Wan Jiang
White light-emitting diodes (WLEDs) play a crucial role in solid-state lighting technologies. Among the key factors contributing to their performance, the development of high-quality cyan phosphors is critical in achieving excellent color rendering index (CRI) and stable long-term operation. In this study, a cyan-emitting phosphor, NaBa 2 Al(P 2 O 7 ) 2 : x Eu 2+ ( x = 0.01-0.06), was explored. The material's structures, morphology, optical behavior, and thermal stability were analyzed. Rietveld refinement reveals that the phosphor exhibits high crystallinity and confirms the successful substitution of Eu 2+ ions into Ba 2+ sites within the crystal lattice. Upon excitation at 320 nm, the phosphor emits broad, asymmetric cyan light, with peak intensity occurring at an Eu 2+ concentration of 0.03 achieving internal quantum efficiency (IQE) of 68.9%. Energy transfer and Gaussian fitting analyses show that Eu 2+ ions occupy two distinct crystallographic sites, and concentration quenching is attributed to dipole-dipole interactions. The phosphor retains 77% of its intensity at 425 K, with an activation energy of 0.3173 eV, demonstrating high thermal stability and color consistency. When integrated with a red-emitting phosphor onto a 320 nm UV chip, a white light-emitting diode (WLED) is fabricated, exhibiting a correlated color temperature (CCT) of 5727 K and a color rendering index (CRI) of 95.6. These results highlight this phosphor for applications in advanced white light-emitting diode (WLED) technologies across diverse lighting systems.
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Nutrients
·
2026
·Vol. 18
·期 9
·1389
·
IF 5.8
Fan Wu,Nan Chen,Yu Peng,Mo Li,Yuanying Ni,Tong Li,Ruihai Liu,Xin Wen
Background/Objectives: Zeaxanthin and lutein, which are essential dietary xanthophylls existing abundantly in free and esterified forms, require efficient intestinal absorption due to their insufficient synthesis in humans. However, limited knowledge on intestinal uptake and transport of xanthophyll esters is available. Methods: This study investigated the cellular uptake and transport mechanism of free and esterified xanthophylls using human Caco-2 cell monolayer, with lutein, zeaxanthin and their dipalmitates as representatives. Results: The results showed that free xanthophylls were uptaken without cellular re-esterification. Esterified xanthophylls were predominantly uptaken in free forms, as evidenced by Caco-2 cells incubated with zeaxanthin and lutein dipalmitates containing 80.8% and 89.4% of zeaxanthin and lutein, along with minor amounts of monoesters and diesters, respectively. Subsequent basolateral detection of both free xanthophylls and monoesters also confirmed intact ester uptake. Additionally, time- and concentration-dependent uptake patterns were observed, with all xanthophylls showing moderate permeability. Mechanistically, SR-BI and NPC1L1 were involved in the uptake of both free and esterified xanthophylls. At the expression level, free and esterified xanthophylls differentially affected ABCG5, with significant upregulation observed only in response to free xanthophylls. Tight junction integrity remained unaffected, excluding paracellular transport. Uptake of free and esterified xanthophyll micelles also involved clathrin- and caveolae-dependent endocytosis, whereas macropinocytosis was excluded. Conclusions: These findings provide insight into the uptake behavior of free and esterified xanthophylls and the transporter- and endocytosis-related processes involved.
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LWT-FOOD SCIENCE AND TECHNOLOGY
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2026
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IF 7.1
Lu Yu,Kaige Zhang,Mengting Wang,Tingting Liu,Qingyun Wang,Qinlu Lin,Lizhong Lin,Wenhua Zhou
As an edible flavoring agent, 2-ethylhexanol (2-EH) has been reported for its broad-spectrum antifungal activity in recent years, highlighting its potential as an alternative to conventional chemical antifungal agents. However, its efficacy against Aspergillus ochraceus and the underlying mechanisms remain unclear. This study evaluated the inhibitory effects of 2-EH on A. ochraceus , elucidated its action mechanisms, and conducted grain fumigation experiments to validate its practical efficacy. The results demonstrated that 2-EH effectively inhibited A. ochraceus spore germination, hyphal growth, sporulation,and ochratoxin A (OTA) production in vitro, Treatment of 2-EH led to spore surface depression and fragmentation, cytoplasmic leakage, and organelle destruction, accompanied by increased extracellular conductivity and intracellular reactive oxygen species levels. Transcriptional analysis revealed that 2-EH downregulated key OTA biosynthetic genes ( pks , nrps , bzip , and hal ), global regulatory factors ( laeA and veA ), and ergosterol biosynthesis genes ( Erg2 and Erg11 ). Grain fumigation experiments confirmed that 2-EH effectively reduced total mold count, free fatty acid content, and OTA levels in corn, wheat, peanuts, and unhulled rice. These findings provide preliminary evidence supporting 2-EH's potential as an effective fumigant for grain storage.
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iScience
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2026
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IF 4.5
Jing Xia,Shuhan Chen,Ping Qian,Minghong Gan,Jiashuo Wu,Huiyang Wang,Fangqing Zhang,Yanfei Mo,Lili Yin,Li Gu,Dongfang Zhang
Diabetes is a serious global health concern. Notably, individuals who prefer spicy food exhibit a lower diabetes risk, making the exploration of capsaicin—the pungent compound in chili peppers—highly relevant. The gut microbiota and its metabolites are key targets in diabetes management. This study demonstrates that dietary capsaicin alleviates type 2 diabetes (T2D) in mice. It reduces intestinal levels of conjugated bile acids (e.g., TDCA, GCA, TCA) and normalizes abundance of bile acid-related bacteria, Parabacteroides and Lactobacillus . Capsaicin also lowers the compensatory increase of intestinal bile salt hydrolase and regulates the function of bile acid-stimulated receptors. Bioinformatics analysis of ileum gene profiles indicated that regulated genes are primarily linked to immunity. This was confirmed by measuring inflammatory cytokines in serum and pancreas, and by assessing immune-related gene expression in the ileum. In conclusion, capsaicin can prevent and treat T2D by modulating gut microbiota, bile acid metabolism, and inflammatory responses.
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Science Advances
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2026
·Vol. 12
·期 9
·
IF 13.9
Haoran Liu,Zihe Jiang,Zhiwei Hu,Banghuan Zhang,Tao He,Xiaohui Dong,Chaowei Sun,Jun Tian,Wei Jiang,Ferruccio Pisanello,Huatian Hu,Wen Chen,Hongxing Xu
Capturing molecular dynamics in nanoconfined channels with high spatiotemporal resolution is a key challenge in nanoscience, crucial for advancing catalysis, energy conversion, and molecular sensing. Bottom-up ultrathin plasmonic nanogaps, such as nanoparticle-on-mirror (NPoM) structures, are ideal for ultrasensitive probing due to their extreme light confinement, but their perceived sealed geometry has cast doubt on the existence of accessible transport pathways. Here, counterintuitively, we demonstrate that ubiquitous ligand-capped NPoM-type nanogaps can form a natural quasi–two-dimensional nanochannel, supporting molecular exchange and infiltration over unprecedented length scales (≳5 micrometers) with an extreme aspect ratio (>10 3 ). Using wavelength-multiplexed Raman spectroscopy, we resolve the underlying centripetal infiltration pathway with a spatial resolving power of ~20 nanometers. This redefines the NPoM architecture as a sensitive and hotspot-accessible platform, enabling in situ, real-time, reusable monitoring of analyte with ~10 −11 molar. This work establishes a versatile platform for advancing super-resolved in situ molecular sensing, nanoscale physicochemical studies, and on-chip nanophotofluidics.
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Nanoscale
·
2026
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IF 5.2
Yaxin Xu,Zhongshuang Xu,Huanran Miao,Zhimao Yang,Chuncai Kong,Qikui Fan
Controlled phase evolution in catalytic architecture design remains challenging for selective CO2-to-formate conversion using non-precious metals. We present a sequential plasma-electrochemical strategy converting BiOCl precursors into nanoporous Bi networks. Plasma treatment of BiCl3-C yields metastable BiOCl with atomic disorder and mesopores; subsequent electrochemical activation reconstructs it into interconnected Bi nanoporous structures (20-50 nm pores) for efficient CO2 reduction. The catalyst affords 93.4% formate Faradaic efficiency at 300 mA cm -2 , >90% selectivity over 100-500 mA cm -2 , and only 3.2% FE loss in 10 h-outperforming thermal Bi catalysts by ~13.3 points in retention. Operando spectroscopy and simulations show plasma-induced lattice distortions lower the reconstruction barrier, creating electric field-enhanced porous Bi that concentrates K + and stabilizes *OCHO -, promoting formate while suppressing HER. This work establishes a paradigm for metastable electrocatalyst design via coupled non-equilibrium synthesis and electrochemical reconstruction, enabling scalable CO2 conversion at industrially relevant currents.2
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JOURNAL OF LIGHTWAVE TECHNOLOGY
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2026
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IF 5.2
Jianwei Huang,Zhi Chen,Wenyu Wang,Shaoxiang Duan,Yan Zhang,Yuan Zhang,Hao Zhang,Bo Liu
The false-positive problem in biosensing significantly compromises detection accuracy. Herein, we present a multi-channel optical fiber microcavity biosensor designed to suppress false-positive responses, which is demonstrated through the quantitative detection and analysis of SARS-CoV-2. The fabrication of sensor accomplished by encapsulating optical fiber Fabry-Perot (FP) interferometer, followed by antibody functionalization. This approach enables the quantitative and specific detection of SARS-CoV-2 through real-time monitoring the interference spectrum wavelength shift. The sensor was designed with three detection channels (experimental, parallel, and control) for the simultaneous detection of SARS-CoV-2. The parallel channel was used to validate the detection accuracy of experimental channel, while the control channel was employed to identify and eliminate false positives caused by non-specific adsorption, which enabled the self-referencing function of the sensor. The experimental results demonstrated that the sensor exhibited a linear sensitivity of 0.493 nm/(μg/mL) for the SARS-CoV-2 recombinant protein antigen, with a detection limit of 32.4 ng/mL and good specificity. Both the parallel and control channels confirmed the sensor's reliability: the former verified detection accuracy by showing comparable results, and the latter enabled the elimination of false positives by providing a correction baseline for non-specific binding.
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Pathogens
·
2026
·Vol. 15
·期 6
·567
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IF 3.8
Zixiang Wang,Qianwen Deng,Ziyu Huang,Zixing Lin,Haohui Zhu,Janak L. Pathak,Ying Wang,Min Nie
Porphyromonas gingivalis(P. gingivalis) is a primary pathogen in periodontitis, yet its elimination is limited by complex anatomical structures. Photodynamic therapy (PDT) is a promising adjunct, but its antimicrobial efficacy is compromised in the acidic microenvironment induced byP. gingivalis. Given that 2′,4′,5′,7′-tetraiodofluorescein (TIF) exhibits robust and stable photodynamic activity under acidic conditions, this study investigated the antibacterial effect of TIF-mediated PDT (TIF-PDT) againstP. gingivalis.P. gingivalisATCC 33277 was treated with TIF (5, 10, 20, and 40 μM), light (525 nm), or both. Reactive oxygen species (ROS) generation was assessed at pH 4.5 or 7.4. Bacterial viability and membrane integrity were evaluated by colony-forming unit (CFU) assay and LIVE/DEAD staining. CFU assays demonstrated that TIF-PDT groups achieved an approximately 4-log reduction in bacterial viability compared to the DEMI, Light, and TIF groups, with no dark cytotoxicity and light-alone effects. LIVE/DEAD staining revealed bright yellow fluorescence in the TIF-PDT (40 μM), indicating membrane damage and significantly lower survival rates than controls. TIF-PDT at 10, 20, and 40 μM produced ROS under both neutral and acidic conditions, exhibited low dark cytotoxicity, and demonstrated potent antibacterial activity againstP. gingivalisin vitro, suggesting its potential as an acid-tolerant photosensitizer for periodontitis adjunctive therapy.
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CERAMICS INTERNATIONAL
·
2026
·
IF 6
Zhenjun Qing,Yuexi Zheng,Haiyan Li
A series of Y 3+ -substituted NaSm 1-x Y x (MoO 4 ) 2 (x = 0.05–0.20) ceramics were synthesized via a conventional solid-state method. Y 3+ substitution significantly enhanced the microwave dielectric properties by modulating the crystal structure, microstructure, and chemical bond characteristics. Rietveld refinement confirmed that all samples adopted a single-phase tetragonal scheelite structure (space group I 4 1 /a). Lattice parameters decreased monotonically with increasing x, while the packing fraction increased from 60.80% to 61.00%, indicating lattice densification. All samples achieved relative densities exceeding 95.9%. Notably, Y 3+ doping simultaneously improved the quality factor and temperature stability: Q × f increased from 39,500 GHz to 52,400 GHz, while | τ f | decreased from 38.7 ppm/°C to 22.3 ppm/°C. The optimal properties were obtained at x = 0.20, with ε r = 12.4, Q × f = 52,400 GHz, and τ f = −22.3 ppm/°C. Raman analysis revealed a negative correlation between the FWHM of the ∼886 cm −1 mode and Q × f , confirming reduced lattice anharmonicity. P–V–L bond theory demonstrated that the enhanced ionicity, lattice energy, and bond energy of the Na/Sm/Y–O bonds contributed to the improved ε r , Q × f and | τ f |, respectively. The low sintering temperature of 900 °C makes this composition highly promising for LTCC substrate applications.
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Molecular Therapy-Nucleic Acids
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2026
·
IF 6.5
Honglei Zhang,Yangjian Liu,Jingxuan Ma,Huajie Huang,Wannian Zhang,Donghui Xiu,Teng Ma,Man Zhang,Fei Yu,Gengshen Song
Necessary chemical modifications can enhance the metabolic stability and therapeutic efficacy of oligonucleotide-based drugs. Herein, a series of mononucleotides with different functional group modifications at the ribose 2'-position were designed and synthesized for reducing off-target effects of oligonucleotide drugs. After incorporating them into the antisense strand of small interfering RNAs (siRNAs), we assessed their biophysical and biological properties. The results revealed that, following the substitution of the conventional 2′-O-methyl or 2′-O-fluoro ribose modifications with our newly designed functional groups, although the thermal stability of the duplexes decreased, the in vitro silencing activity against Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) gene was significantly enhanced and the off-target effects of specific genes could be effectively mitigated. These data prove that 2'-ribose-modified nucleotides can be effectively utilized in preclinical and clinical disease model studies for gene silencing and reducing off-target effects.
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