RSC Advances
·
2026
·
IF 6.1
Mingchao Yang,Yaqi Liang,Danhong Zhang,Linfeng Wan,Junsong Liu,Xiaoxi Yuan,Hongdong Li
The development of rapid, sensitive, stable, and reliable detection methods for 2-aminophenol is critical for accurately monitoring its environmental concentration and effectively mitigating the associated health risks. In this work, a boron-doped diamond (BDD) film is proposed as a high-performance electrode to systematically investigate the electrochemical behavior and enable trace-level determination of 2-aminophenol. The oxidation peak current ( I p ) increased significantly with the increasing concentration of 2-aminophenol in the standard phosphate buffer solution (pH = 5). The BDD electrode presents a broad linear detection range of 0.5 to 10 µmol L −1 , with a sensitive detection limit of 0.115 µmol L −1 . The BDD electrode also demonstrated excellent reproducibility and repeatability. Furthermore, considering its unique properties, including super-hardness, chemical inertness, biocompatibility, and outstanding reusability, the BDD electrode offers a robust electrochemical platform for the rapid, accurate, and stable detection of 2-aminophenol in diverse practical applications. The development of rapid, sensitive, stable, and reliable detection methods for 2-aminophenol is critical for accurately monitoring its environmental concentration and effectively mitigating the associated health risks.
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ACS Nano
·
2026
·
IF 17.3
Yinghua Liu,Xufei Wang,Xiaotong Ma,Lu Huang,Penghui Yang,Tao Li,Wenjun Wu,Daoning Zhou,Jin Su,Yang Li
Collagen receptors orchestrate vital extracellular matrix signaling, yet the inability to distinguish functional receptor activation from mere expression in real-time has obscured our understanding of fibrotic progression. Here, we develop a fluorescent triple-helical collagen-mimetic peptide (CMP) probe, [GVMGFO]3, designed to selectively target the ligand-engaging conformation of Discoidin Domain Receptor 2 (DDR2)─the sole receptor tyrosine kinase family that signals collagen. In pulmonary fibrosis, this probe identifies active fibrotic niches in vivo and directly tethers to disease-driving activated fibroblasts to enable precise ex vivo mapping, all without perturbing baseline signaling. Utilizing this tool, we decipher the long-standing mystery of DDR2’s characteristically slow, hours-long activation kinetics. We reveal that while monomeric collagen engagement fails to override constitutive DDR2 internalization, supramolecular fibrillar collagen provides a multivalent physical anchor that arrests DDR2 trafficking at the cell–matrix interface to sustain receptor clustering and phosphorylation. To recapitulate this biophysical requirement, we engineered Zn2+-coordinated supramolecular assemblies of a histidine-modified CMP, [H-GVMGFO-H]3, triggering rapid DDR2 activation within minutes. Our work transforms CMPs from structural models of collagen into programmable chemical tools for dissecting the spatiotemporal dynamics of collagen–receptor interplay, offering a platform for imaging and modulating fibrotic disease.
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ACS Omega
·
2026
·Vol. 11
·期 29
·43288-43299
·
IF 5.2
Li Qiulin,Wang Qiuhong,Li Gang,Han Xiang,Su Bin,Liu Jing,Zhou Anning,Luo Zhenmin,Chen Fuxin
The nitrogen-containing
compounds in coal tar have always
been
an essential focus in the field of sustainable resources. They play
a crucial role in the full utilization of coal-derived energy substances.
The molecular-level structural characterization and quantitative analysis
of nitrogen-containing compounds in coal tar represent key challenges
for the energy and chemical industries. However, the two-dimensional 1 H– 15 N HMBC method suffers from limitations
in quantitative applications owing to low signal sensitivity and poor
compatibility with internal standards. This study screened and validated
a small-molecule internal standard and systematically investigated
its linear response characteristics across various nuclear magnetic
resonance experiments ( 1 H NMR, 19 F NMR, 13 C NMR, 1 H– 13 C HMBC, 1 H– 13 C HSQC, and 1 H– 15 N HMBC). The results showed that the internal standard exhibited
a good linear relationship ( R 2 ≥
0.984) under all tested pulse sequences within a specified concentration
range. In the 1 H– 15 N HMBC experiment,
the peak integral values of the internal standard signal showed excellent
linear correlation with the characteristic signal integral values
of various quinoline compounds ( R 2 ≥
0.957). The internal standard was applied to the analysis of raw and
nitrogen-doped coal tar samples, successfully enabling signal identification
and relative quantification of specific nitrogen-containing compounds
in nitrogen-doped tar, and clearly revealing the structural evolution
patterns in the transformation of particular nitrogen functional groups
during pyrolysis. The cross-sequence linear internal standard developed
in this study addresses the poor internal standard compatibility of
internal standards for quantitative analysis using multipulse NMR
sequences in complex matrices, which helps reduce intersequence systematic
errors, achieve cross-validation, and streamline experimental design
and sample preparation in future applications, and provides a novel
strategy and reliable data support for the quantitative application
of 1 H– 15 N HMBC technology in the fields
of energy and materials.
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Chem Catalysis
·
2026
·
IF 10.7
Qingmao Yang,Yang Zhang,Xiao Liang,Haodong Chu,Mengdi Li,Runqing Xiao,Weichen Zhao,Chun Shen,Tianwei Tan
Green synthesis of biobased adipic acid (AA) from hydroxyacid feedstocks is challenging due to competing reactivity of hydroxyl and carboxyl groups. Here, we report an aqueous strategy that enables selective removal of the hydroxyl group in 2-hydroxyadipic acid (2-HAA) using a MoO x -Pd/TiO 2 catalyst with in situ -generated Mo–O–H sites. The catalyst achieves 97.3% selectivity to AA. Kinetic analyses, CO and H 2 pulse titration experiments, in situ X-ray photoelectron spectroscopy (XPS), and density functional theory (DFT) calculations show that Mo–O–H sites preferentially interact with the hydroxyl group and promote C–O bond cleavage while suppressing side reactions. This study provides mechanistic guidance for rational catalyst design in upgrading biomass-derived hydroxyacids to value-added diacids.
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Catalysts
·
2026
·Vol. 16
·期 7
·634
·
IF 4.5
Yue Zhao,Ling An,Hui Zhang,Tong Zhang,Xing Zhang,Li Huang,Song Jin,Wei Wang,Ning Li
4-Hydroxycyclopent-2-enone (HCP), a chemical substance with a unique molecular structure and distinct physical properties, is an important intermediate for the synthesis of natural products, chemicals, and liquid fuels, demonstrating exceptionally high application value. This study introduces a novel approach for HCP synthesis via the rearrangement of furfuryl alcohol (FAL). A series of ZnAl-based hydrotalcite (HT) catalysts was prepared and characterized by SEM, XPS, XRD, NH3-TPD, and CO2-TPD. HCP is efficiently synthesized by the rearrangement of furfuryl alcohol in water at a relatively low temperature of 205 °C. Using a 10 wt.% aqueous solution of furfuryl alcohol as the raw material, the yield of HCP remained stable at 80.2% under the selected reaction conditions (ZnAl-HT-1: 1–500 °C as catalyst, 205 °C, and 5 min). It is worth noting that when the concentration of furfuryl alcohol solution was reduced to 5%, the conversion of furfuryl alcohol reached 100%, and the HCP yield reached an excellent 92.5%. The exceptional performance observed can be primarily attributed to several key factors associated with the ZnAl-HT-1: 1–500 °C catalyst: its expansive specific surface area and ample pore volume, the distinctive layered structure inherent to hydrotalcites, and its well-balanced acid–base properties, featuring optimal densities of acid and base sites with a uniform distribution of acidic and basic active centers that cooperate synergistically to promote the reaction.
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JOURNAL OF VIROLOGY
·
2026
·
IF 4.1
Huiying Zhang,Yihan Liu,Ting Xu,Junwen Luan,Leiliang Zhang
Hepatitis C virus (HCV) entry is a critical step in establishing infection and is highly dependent on host cell co-receptors. We previously identified that the tight junction protein CLDN12 facilitates HCV entry. However, the regulatory mechanisms governing the dynamic post-translational modifications of CLDN12 remain unclear. This study employs targeted mutagenesis, palmitoylation level analysis, plasma membrane localization, manipulation of key enzymes, and functional virology assays to reveal whether and how reversible palmitoylation regulates the function of CLDN12 in HCV entry. We found that the palmitoylation occurs at cysteine residues C3 and C109 of CLDN12, a modification critical for its role in mediating HCV entry. The palmitoyltransferase ZDHHC7 is a key enzyme that catalyzes the palmitoylation of CLDN12, positively promoting HCV entry. Acyl-protein thioesterases APT1 and APT2 regulate the de-palmitoylation of CLDN12 through differential modulation at the two sites, thereby negatively regulating HCV entry. Our study discovers that ZDHHC7 and APT1/2 form a reversible palmitoylation switch, which regulates the efficiency of HCV entry by dynamically controlling the plasma membrane localization of CLDN12. This finding reveals a new mechanism by which HCV exploits the host’s palmitoylation cycle to promote infection, and highlights this regulatory axis as a potential target for antiviral intervention.
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Journal of Environmental Chemical Engineering
·
2026
·Vol. 14
·期 3
·123143
·
IF 7.5
Sobia Yaseen,Saddam Hussain,Sabeen Fatima,Nabi Ullah,Lu Zaijun
Photocatalysis has emerged as a promising strategy for antibiotic remediation in wastewater treatment owing to its environmentally benign nature, high efficiency, and cost-effectiveness. Herein, a PEDOT- NiCo(OH) 2 hybrid photocatalyst is successfully synthesized and, systematically investigated for visible-light-driven tetracycline (TC) degradation. Structural engineering via optimized incorporation of bimetallic hydroxide (NiCo(OH) 2 ) into the PEDOT markedly enhances the specific surface area (∼188 m 2 g −1 ) and pore size of 5.29 nm, while significantly narrowing the optical band gap to ∼1.79 eV, enabling efficient visible light harvesting. Electrochemical analyses demonstrate a substantially reduced charge-transfer resistance and an enhanced photocurrent response for PEDOT-Ni(OH) 2 2:1 (P-NCH21), indicating accelerated interfacial charge transport and suppressed electron–hole recombination. Consequently, P-NCH21 achieves an exceptional TC removal efficiency of 97.6% within 35 min under visible-light irradiation, far outperforming P-NH and PEDOT-Ni(OH) 2 3:1 (P-NCH31), having degradation efficiencies of 67 and 92%, respectively. Electron paramagnetic resonance (EPR) measurements confirm that the generation of reactive oxygen species, such as superoxide (•O 2 ⁻) and (•OH) are the reactive species that drives the photocatalytic degradation process. Furthermore, the hybrid photocatalyst exhibits excellent stability, retaining ∼96.8% of its initial activity after five consecutive cycles. This study highlights the potential of P-NCH21 as an efficient and robust photocatalyst for antibiotic remediation, providing new insights into the design of conductive polymer–based hybrid materials for environmental applications.
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Nature Communications
·
2026
·
IF 18.1
Wang Xiaojuan,Pan Xiaosen,Jiang Junzhi,Song Wanlong,Zhou Xiaoqi,Lin Xu,Zhao Jingye,Zhang Zhengjian,Liu Zhenxing,Ma Xiaojun,Liu Hongbin,Gao Meng
Epidermal electronics, which are flexible and conformable electronic systems designed to interact seamlessly with human skin, hold great promise for healthcare monitoring and personal electronics. However, traditional fabrication methods face challenges of reliance on non-sustainable materials, intricate and time-consuming processes, and material softness-induced fragile transfer to target substrates. Inspired by the “milk skin” phenomenon, we developed a rapid dipping-dipping molecular assembly method to fabricate cellulose-based bio-skin in situ within seconds, exhibiting ultra-thin, highly conformal, shape-customizable, degradable, and low-impedance performances. This technique immerses substrates sequentially into carboxymethyl cellulose (CMC) and Cu(II) solutions, leveraging strong metal-coordination interactions. Membrane formation efficiency, influenced by the oxidation and coordination characteristics of metal ions, follows the order: Cu(II) > Fe(II) > Ca(II). CMC-Ag(I)/CMC-Cu(II) form stable membranes, whereas CMC-Fe(II) forms fragmented structures, and CMC-Mg(II)/CMC-Ca(II) remain in solution. This adaptable method can also be extended to other biomacromolecules like methylcellulose and carboxymethyl chitosan, broadening applications. The bio-skin enables real-time monitoring of electrocardiograms (ECG), electrooculograms (EOG), electroencephalograms (EEG), and electromyograms (EMG), showcasing its potential for wearable, biocompatible electronics in healthcare.
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JOURNAL OF LIGHTWAVE TECHNOLOGY
·
2026
·
IF 5.2
Jianwei Huang,Zhi Chen,Wenyu Wang,Shaoxiang Duan,Yan Zhang,Yuan Zhang,Hao Zhang,Bo Liu
The false-positive problem in biosensing significantly compromises detection accuracy. Herein, we present a multi-channel optical fiber microcavity biosensor designed to suppress false-positive responses, which is demonstrated through the quantitative detection and analysis of SARS-CoV-2. The fabrication of sensor accomplished by encapsulating optical fiber Fabry-Perot (FP) interferometer, followed by antibody functionalization. This approach enables the quantitative and specific detection of SARS-CoV-2 through real-time monitoring the interference spectrum wavelength shift. The sensor was designed with three detection channels (experimental, parallel, and control) for the simultaneous detection of SARS-CoV-2. The parallel channel was used to validate the detection accuracy of experimental channel, while the control channel was employed to identify and eliminate false positives caused by non-specific adsorption, which enabled the self-referencing function of the sensor. The experimental results demonstrated that the sensor exhibited a linear sensitivity of 0.493 nm/(μg/mL) for the SARS-CoV-2 recombinant protein antigen, with a detection limit of 32.4 ng/mL and good specificity. Both the parallel and control channels confirmed the sensor's reliability: the former verified detection accuracy by showing comparable results, and the latter enabled the elimination of false positives by providing a correction baseline for non-specific binding.
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CERAMICS INTERNATIONAL
·
2026
·
IF 6
Chenyang Li,Yaping You,Zesheng Pan,Zesen Gao,Yunluo Wang,Yan Yang,Minghui Wang,Lianjun Wang,Haijie Chen,Wan Jiang
White light-emitting diodes (WLEDs) play a crucial role in solid-state lighting technologies. Among the key factors contributing to their performance, the development of high-quality cyan phosphors is critical in achieving excellent color rendering index (CRI) and stable long-term operation. In this study, a cyan-emitting phosphor, NaBa 2 Al(P 2 O 7 ) 2 : x Eu 2+ ( x = 0.01-0.06), was explored. The material's structures, morphology, optical behavior, and thermal stability were analyzed. Rietveld refinement reveals that the phosphor exhibits high crystallinity and confirms the successful substitution of Eu 2+ ions into Ba 2+ sites within the crystal lattice. Upon excitation at 320 nm, the phosphor emits broad, asymmetric cyan light, with peak intensity occurring at an Eu 2+ concentration of 0.03 achieving internal quantum efficiency (IQE) of 68.9%. Energy transfer and Gaussian fitting analyses show that Eu 2+ ions occupy two distinct crystallographic sites, and concentration quenching is attributed to dipole-dipole interactions. The phosphor retains 77% of its intensity at 425 K, with an activation energy of 0.3173 eV, demonstrating high thermal stability and color consistency. When integrated with a red-emitting phosphor onto a 320 nm UV chip, a white light-emitting diode (WLED) is fabricated, exhibiting a correlated color temperature (CCT) of 5727 K and a color rendering index (CRI) of 95.6. These results highlight this phosphor for applications in advanced white light-emitting diode (WLED) technologies across diverse lighting systems.
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CERAMICS INTERNATIONAL
·
2026
·
IF 6
Zhenjun Qing,Yuexi Zheng,Haiyan Li
A series of Y 3+ -substituted NaSm 1-x Y x (MoO 4 ) 2 (x = 0.05–0.20) ceramics were synthesized via a conventional solid-state method. Y 3+ substitution significantly enhanced the microwave dielectric properties by modulating the crystal structure, microstructure, and chemical bond characteristics. Rietveld refinement confirmed that all samples adopted a single-phase tetragonal scheelite structure (space group I 4 1 /a). Lattice parameters decreased monotonically with increasing x, while the packing fraction increased from 60.80% to 61.00%, indicating lattice densification. All samples achieved relative densities exceeding 95.9%. Notably, Y 3+ doping simultaneously improved the quality factor and temperature stability: Q × f increased from 39,500 GHz to 52,400 GHz, while | τ f | decreased from 38.7 ppm/°C to 22.3 ppm/°C. The optimal properties were obtained at x = 0.20, with ε r = 12.4, Q × f = 52,400 GHz, and τ f = −22.3 ppm/°C. Raman analysis revealed a negative correlation between the FWHM of the ∼886 cm −1 mode and Q × f , confirming reduced lattice anharmonicity. P–V–L bond theory demonstrated that the enhanced ionicity, lattice energy, and bond energy of the Na/Sm/Y–O bonds contributed to the improved ε r , Q × f and | τ f |, respectively. The low sintering temperature of 900 °C makes this composition highly promising for LTCC substrate applications.
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Molecular Therapy-Nucleic Acids
·
2026
·
IF 6.5
Honglei Zhang,Yangjian Liu,Jingxuan Ma,Huajie Huang,Wannian Zhang,Donghui Xiu,Teng Ma,Man Zhang,Fei Yu,Gengshen Song
Necessary chemical modifications can enhance the metabolic stability and therapeutic efficacy of oligonucleotide-based drugs. Herein, a series of mononucleotides with different functional group modifications at the ribose 2'-position were designed and synthesized for reducing off-target effects of oligonucleotide drugs. After incorporating them into the antisense strand of small interfering RNAs (siRNAs), we assessed their biophysical and biological properties. The results revealed that, following the substitution of the conventional 2′-O-methyl or 2′-O-fluoro ribose modifications with our newly designed functional groups, although the thermal stability of the duplexes decreased, the in vitro silencing activity against Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) gene was significantly enhanced and the off-target effects of specific genes could be effectively mitigated. These data prove that 2'-ribose-modified nucleotides can be effectively utilized in preclinical and clinical disease model studies for gene silencing and reducing off-target effects.
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