Nature Communications
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2023
·Vol. 14
·期 1
·1-14
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IF 16.6
Li Qiwei,Chen Zaozao,Zhang Ying,Ding Shuang,Ding Haibo,Wang Luping,Xie Zhuoying,Fu Yifu,Wei Mengxiao,Liu Shengnan,Chen Jialun,Wang Xuan,Gu Zhongze
Current techniques for visualizing and quantifying cellular forces have limitations in live cell imaging, throughput, and multi-scale analysis, which impede progress in cell force research and its practical applications. We developed a photonic crystal cellular force microscopy (PCCFM) to image vertical cell forces over a wide field of view (1.3 mm ⨯ 1.0 mm, a 10 ⨯ objective image) at high speed (about 20 frames per second) without references. The photonic crystal hydrogel substrate (PCS) converts micro-nano deformations into perceivable color changes, enabling in situ visualization and quantification of tiny vertical cell forces with high throughput. It enabled long-term, cross-scale monitoring from subcellular focal adhesions to tissue-level cell sheets and aggregates.
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JOURNAL OF NANOBIOTECHNOLOGY
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2023
·Vol. 21
·期 1
·1-15
·
IF 10.2
Jin Nianqiang,Wang Binhang,Liu Xinyao,Yin Chengcheng,Li Xing,Wang Zilin,Chen Xi,Liu Yunling,Bu Wenhuan,Sun Hongchen
Background The implementation of pyroptosis exhibits significant potential as a tactic to enhance tumor immune microenvironments. Previous applications of pyroptosis inducers have encountered various limitations, such as the development of drug resistance, manifestation of toxic side effects, and a deficiency in targeting capabilities. As a result, there is a growing demand for tumor therapeutic molecules that can overcome these obstacles. Therefore, the objective of this study is to develop a multifunctional nanospheres that addresses these challenges by enabling high-precision targeting of tumor cells and inducing effective pyroptosis. Results We prepared a mannose-modified MOF called mannose-doped Fe 3 O 4 @NH 2 -MIL-100 (M-FNM). M-FNM could enter CAL27 cells through MR-mediated endocytosis, which caused in a significant increase in the level of intracellular ROS. This increase subsequently triggered ER stress and activated the PERK-eIF2α-ATF4-CHOP signaling pathway. CHOP then mediated the downstream cascade of Caspase-1, inducing pyroptosis. In in vivo experiments, M-FNM demonstrated excellent targeting ability and exhibited anti-tumor effects. Additionally, M-FNM reshaped the immune microenvironment by promoting the infiltration of anti-tumor immune cells, primarily T lymphocytes. Conclusions M-FNM significantly decreased tumor growth. This novel approach to induce pyroptosis in tumor cells using M-FNM may offer new avenues for the development of effective immunotherapies against cancer.
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JOURNAL OF NANOBIOTECHNOLOGY
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2023
·Vol. 21
·期 1
·1-23
·
IF 10.2
Mu Zhixiang,Jin Ting,Chu Tengda,Lu Hongyang,Chen Yuanqi,Li Sisi,Zeng BaiRui,Huang Chen,Lei Kezheng,Cai Xiaojun,Deng Hui,Hu Rongdang
Bacterial infection in skin and soft tissue has emerged as a critical concern. Overreliance on antibiotic therapy has led to numerous challenges, including the emergence of multidrug-resistant bacteria and adverse drug reactions. It is imperative to develop non-antibiotic treatment strategies that not only exhibit potent antibacterial properties but also promote rapid wound healing and demonstrate biocompatibility. Herein, a novel multimodal synergistic antibacterial system (SNO-CS@MoS 2 ) was developed. This system employs easily surface-modified thin-layer MoS 2 as photothermal agents and loaded with S-nitrosothiol-modified chitosan (SNO-CS) via electrostatic interactions, thus realizing the combination of NO gas therapy and photothermal therapy (PTT). Furthermore, this surface modification renders SNO-CS@MoS 2 highly stable and capable of binding with bacteria. Through PTT’s thermal energy, SNO-CS@MoS 2 rapidly generates massive NO, collaborating with PTT to achieve antibacterial effects. This synergistic therapy can swiftly disrupt the bacterial membrane, causing protein leakage and ATP synthesis function damage, ultimately eliminating bacteria. Notably, after effectively eliminating all bacteria, the residual SNO-CS@MoS 2 can create trace NO to promote fibroblast migration, proliferation, and vascular regeneration, thereby accelerating wound healing. This study concluded that SNO-CS@MoS 2 , a novel multifunctional nanomaterial with outstanding antibacterial characteristics and potential to promote wound healing, has promising applications in infected soft tissue wound treatment.
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PLANT AND SOIL
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2023
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IF 4.9
Qin Shuyue,Gao Weichang,Jing Yuan,Quan Wenxuan,Cai Kai
Aims Soil metabolites have a great influence on regulating the growth and development of plants and microbes in forest ecosystems. This study aims to reveal the characteristic metabolite profiles and their enriched metabolic pathways in the rhizosphere soil of Masson pine plantations at three different ages. Method The rhizosphere soil of Masson pine from 10, 31, and 52 years plantation was collected. The metabolites were analyzed using a soil pseudotargeted metabolomics approach and then the relationships between soil metabolites and chemical properties, enzyme activities were established. Results A total of 172 rhizosphere soil metabolites in 26 classes were identified. There was a decreasing trend in the total concentration of rhizosphere soil metabolites with increasing stand age. Seventy-two characteristic metabolites were screened, mainly saccharides, fatty acids, amino acids, phenolic acids, polyols and terpenoids. Among them, benzoic acid and galactonic acid contributed the most to the young forest, and stearic acid had the greatest influence on the near-mature forest plantation. Erythritol had great effects on the mature forest plantation. Seven metabolic pathways changed with increasing stand age. Correlation analysis showed that available potassium (AK) and soil alkaline protease (S-ALPT) were significantly positively correlated with phenolic acids, polyhydroxy carboxylic acids, etc. Conclusion The rhizosphere soil of Masson pine had different metabolite profiles at different developmental stages, and the soil nutrient pools were effectively improved. These results provide a reference for plantation management in Masson pine and a deeper understanding of forest metabolic characteristics.
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EXPERIMENTAL AND APPLIED ACAROLOGY
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2023
·Vol. 91
·期 4
·615-628
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IF 2.2
Zou Minghui,Xue Qiqi,Teng Qiao,Zhang Qiqi,Liu Ting,Li Yuanyuan,Zhao Jinhong
Aleuroglyphus ovatus (Acari: Acaridae) is a major pest mite of stored grains that is distributed worldwide. Paeonol, a phenolic component of the essential oil extracted from the Chinese herb Paeonia moutan , possesses a range of biological activities, including antiviral, antifungal and acaricidal activity. This study investigated the bioactivity of paeonol against A. ovatus and its effect on the activity of detoxification enzymes. The bioactivity of paeonol against A. ovatus was determined by contact, fumigation and repellency bioassays, and the mechanism was preliminarily explored via morphological observation of the color changes of mite epidermis and determination of the changing trend of some important enzymes associated with acaricidal efficacy in the mites. The results showed that the median lethal concentration (LC 50 ) in the contact and fumigation bioassays was 9.832 μg/cm 2 and 14.827 μg/cm 3 , respectively, and the acaricidal activity of paeonol was higher under direct contact than under fumigation. Dynamic symptomatology studies registered typical neurotoxicity symptoms including excitation, convulsion and paralysis in A. ovatus treated with paeonol. The enzyme activity of catalase (CAT), nitric oxide synthase (NOS) and glutathione-S-transferase (GST) was higher, whereas the activity of superoxide dismutase (SOD) and acetylcholinesterase (AChE) was lower, compared to the control group. CAT, NOS and GST were activated, whereas SOD and AChE activities were inhibited after paeonol intervention. Our findings suggest paeonol has potent acaricidal activity against A. ovatus and thus may be used as an agent to control the stored-product mite A. ovatus .
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JOURNAL OF MATERIALS SCIENCE
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2023
·Vol. 58
·期 45
·17326-17339
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IF 4.5
Jiang Yuchen,Newton Md All Amin,Xin Binjie,Yu Wenjie,Lu Zan
Electrospinning is a simple and effective technique for preparing carbon nanofibers. However, carbon nanofiber materials have some drawbacks, such as low specific surface area, small pore size, and low porosity, which can affect the electrochemical performance of supercapacitors. This article proposes a preparation method for a multi-level porous structure for thick electrodes. Sponge-like nanofibers are formed through electrospinning by adding a certain amount of PMMA to the polyacrylonitrile mixed spinning solution after doping with heteroatoms. After reverse hanging pre-oxidation and carbonization, a hierarchical porous, highly conductive, and flexible carbon nanofiber sponge is obtained. After testing, at a current density of 0.25 A g −1 , its specific capacitance reached 207 F g −1 . As the power density increased from 250 W kg −1 to 3997.89 W kg −1 , the energy density changed from 28.73 W h kg −1 to 8.44 W h kg −1 , demonstrating that the porous active carbon nanofiber sponge electrode has a significant energy storage advantage. Graphical abstract
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JOURNAL OF MATERIALS SCIENCE
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2023
·Vol. 58
·期 41
·16184-16194
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IF 4.5
Gu Xingshuai,Liu Xiukun,Tan Bowen,Liao Yufang,Li Yuqi
Abstract Attitude information during transportation is important for navigation safety, driving status and cargo operation management. The development of an electromechanical integrated tilt sensor, which can work well under different environments is highly desirable. Herein, a self-powered tilt sensor was proposed and fabricated by a high-performance arch triboelectric nanogenerator (IF-TENG) composed of commercial fluorine release membrane and ion gel. The short-circuit current density, maximum energy per cycle, and maximum power density of IF-TENG are 12.56 mA/m 2 , 8839 nJ, and 3.31 W/m 2 , respectively. The self-powered pressure sensor based on IF-TENG demonstrated a sensitivity of 10.19 kPa −1 for low pressure and 1.98 kPa −1 for high pressure. It was able to generate a detectable output signal even at a pressure as low as 0.06 kPa. In addition, by incorporating tilt sensors onto moving vehicles and ships, the self-powered sensor has the potential to create a highly sensitive detection assay for determining the driving state of vehicles and the oscillation amplitude of ships. This advancement holds great practical significance in improving the automation and intelligence of ships and vehicles. Graphical abstract
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Nature Communications
·
2023
·Vol. 14
·期 1
·1-12
·
IF 16.6
An Zhidong,Yang Piaoping,Duan Delong,Li Jiang,Wan Tong,Kong Yue,Caratzoulas Stavros,Xiang Shuting,Liu Jiaxing,Huang Lei,Frenkel Anatoly I.,Jiang Yuan-Ye,Long Ran,Li Zhenxing,Vlachos Dionisios G.
Highly effective and selective noble metal-free catalysts attract significant attention. Here, a single-atom iron catalyst is fabricated by saturated adsorption of trace iron onto zeolitic imidazolate framework-8 (ZIF-8) followed by pyrolysis. Its performance toward catalytic transfer hydrogenation of furfural is comparable to state-of-the-art catalysts and up to four orders higher than other Fe catalysts. Isotopic labeling experiments demonstrate an intermolecular hydride transfer mechanism. First principles simulations, spectroscopic calculations and experiments, and kinetic correlations reveal that the synthesis creates pyrrolic Fe(II)-plN 3 as the active center whose flexibility manifested by being pulled out of the plane, enabled by defects, is crucial for collocating the reagents and allowing the chemistry to proceed. The catalyst catalyzes chemoselectively several substrates and possesses a unique trait whereby the chemistry is hindered for more acidic substrates than the hydrogen donors. This work paves the way toward noble-metal free single-atom catalysts for important chemical reactions.
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JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
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2023
·Vol. 332
·期 12
·5007-5016
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IF 1.6
Wang Weiran,Wang Zhifeng
Modified chitosan-coated nickel ferrite silica nanoparticles were prepared, characterized and experimented for the removal of U(VI). Adsorption amount was 125.30 mg g −1 at pH 5.0. The magnetic chitosan based composite could be successfully recycled from uranium aqueous phase. Finally, calculated data and analysis suggested that the adsorption behaviors of magnetic chitosan based nanoparticles can be explained by pseudo-second order kinetic model ( R 2 = 0.9915), which suggested the adsorption process was probably controlled by chemical adsorption, and langmuir model ( R 2 = 0.9816), which suggested the adsorption process was probably controlled by single-layer adsorption.
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ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
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2023
·Vol. 30
·期 50
·109110-109122
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IF 5.8
Liu Jiadi,Dong Yawen,Kang Yu,Kong Qian,Wang Kuaibing,Mao Feifei,Bu Yuanqing,Zhou Rong,Zhang Chunyong,Wu Hua
Developing multifunctional catalysts applied in diversiform modes via advanced oxidation processes (AOPs) is a promising and attractive approach for organic pollution degradation. Herein, a novel hollow bamboo-like structural cobalt/nitrogen-doped carbonized material (CoC/N) was employed as a catalyst for AOPs, in which CoC/N was prepared in situ through calcining a Co-based coordination polymer. When CoC/N was utilized as a peroxymonosulfate (PMS) activator, the catalyst stood out prominent activities for effective CA oxidation. Furthermore, a five-level central composite rotatable design (CCRD) model describing CA decay as a function of PMS concentration, CoC/N dosage, and solution pH value was successfully constructed and engaged to explore the optimal operating conditions. Finally, the possible degradation mechanism of CA in CoC/N-PMS system was proposed by quantum chemistry calculation and LC/MS analysis. This work shed light on the structural morphology of the catalyst and its PMS synergy degradation pathway, which promotes its applications in miscellaneous pollutant degradation. Graphical Abstract A new Co/N-doped material was used to degrade unconventionality organic pollutant creatinine (CA) for the first time, in which the scientific approaches of five-level central composite rotatable design (CCRD) model, response surface methodology (RSM) and density function theory (DFT) were employed to evaluate the material performance and CA degradation pathway. The toxicity evaluation, statistical modeling and mechanisms study have been investigated meticulously
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Nano Research
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2023
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IF 9.9
Wu Zenghui,Shifan Chen,Wu Zitong,Liu Yi,Shao Wei,Liang Xinchao,Hou Chuang,Tai Guoan
In-situ integration of multiple materials with well-defined interfaces as heterostructures is of great interest due to their unique properties and potential for new device functionality. Because of its polymorphism and diverse bonding geometries, borophene is a promising candidate for two-dimensional heterostructures, but suitable synthesis conditions have limited its potential applications. Toward this end, we demonstrate the vertical borophene and graphene heterostructures which form by epitaxial growth of borophene onto multilayer graphene on Cu substrates via chemical vapor deposition, where hydrogen and NaBH 4 are respectively used as the carrier gas and the boron source. The lattice structure of the as-synthesized borophene well coincides with the predicted α′-boron sheet. The borophene-based photodetector shows an excellent broadband photoresponse from the ultraviolet (255 nm) to the infrared (940 nm) wavelengths, with enhanced responsivity compared to pristine borophene or graphene photodetectors. This work informs emerging efforts to integrate borophene into nanoelectronic applications for both fundamental investigations and technological applications.
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ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
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2023
·
IF 5.8
Li Qi,Jiang Jiarui,Lan Yiyang,Kang Shiyun,Yang Yixia,Zhang Jiahui
Microplastics and perfluorooctanoic acid coexist in the aquatic environment. Duckweed was exposed to a range of concentrations (0.1–1000 μg L −1 ) of solutions containing polypropylene (PP) and perfluorooctanoic acid (PFOA) for 14 days to measure their toxicity. The result showed the single and combined PP and PFOA treatments did not significantly influence the growth of duckweed. The greatest PP and PFOA concentrations of combined pollution affect plant chlorophyll. Moreover, the combined treatment of duckweed consistently resulted in increased malondialdehyde (MDA) levels, indicating oxidative damage. As an antioxidant stress response, the combination-treated plants were encouraged to produce superoxide dismutase (SOD), peroxidase (POD), and catalase (CAT). Meanwhile, 3519 Operational Taxonomic Units (OTUs) were identified in the duckweed rhizosphere. Proteobacteria was the most predominant microbial community. Shannon, Simpson, and Chao1 discovered that microbial communities changed in response to single and combination PP and PFOA treatments, with decreased diversity and increased abundance. In addition, SEM analysis also revealed that the combined treatment significantly phyllosphere microorganisms. The findings of this investigation add to our knowledge of how PP and PFOA affect duckweed and the rhizospheric microorganisms, expanding the theoretical basis for employing duckweed in complex contamination.
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