Acta Pharmaceutica Sinica B
·
2022
·
IF 14.903
Xianzi Zheng,Zhezheng Fang,Weizi Huang,Jianping Qi,Xiaochun Dong,Weili Zhao,Wei Wu,Yi Lu
Due to the overwhelming percentage of poorly water-soluble drugs, pharmaceutical industry is in urgent need of efficient approaches for solubilization and permeability improvement. Salts consisting of lipophilic fatty acid anions and hydrophilic choline cations are found to be surface active and able to form ionic co-aggregates (ICAs) in water. Choline oleate-based ICAs significantly enhance oral absorption of paclitaxel (PTX) as compared with cremophor EL-based micelles (MCs). Aggregation-caused quenching probes enable tracking of intact ICAs in in vivo transport and cellular interaction. Prolonged intestinal retention of ICAs than MCs implies stronger solubilizing capability in vivo . Ex vivo imaging of major organs and intestinal tracts suggests transepithelial transport of intact ICAs. Cellular studies support the enhanced absorption of PTX and transmembrane transport of intact ICAs. In conclusion, ICAs, consisting of lipophilic ions and hydrophilic counter-ions, are of great potential in delivery of poorly water-soluble drugs by enhancing solubility and permeability.
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PubMed
高影响因子
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2021
·
IF 4.098
Xiao-Lan Zhao,Jia-Li Liu,Fa-Ting Xie,Tong Yang,Rong Hu,Yun-Hui Yang
In this paper, a simple, rapid, and low-cost colorimetric method was designed based on Co/Fe-MOFs-iodide composite for the quantitative detection of H 2 S. It is know that iodide can improve the catalytic activity of bimetallic porous material Co/Fe-MOFs via adsorption into the framework of MOFs. Herein, we demonstrate a novel strategy to enhance the peroxidase-like activity of MOFs. Compared to horseradish peroxidase (HRP), the kinetic measurement results show that Co/Fe-MOFs-iodide exhibits excellent affinity to substrates, promoting electron transfer. Due to the synergetic effect of Co/Fe-MOFs and iodide, and rapid electron transfer process, Co/Fe-MOFs-iodide demonstrates improved peroxidase-like activity. As a proof-of-concept application, a novel, highly sensitive H 2 S colorimetric method is established with a detection limit (LOD) of 0.33 nM. In the absence of iodide, LOD is approx. 200-fold higher than that of the amplified colorimetric assay. The proposed method can also accurately detect traces of H 2 S in serum samples.
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PubMed
高影响因子
Nature Communications
·
2025
·
IF 15.7
Xue Liwei,Wei Fengyuan,Wang Jieyu,Huang Xuelin,Wang Huijuan,Wang Guangzhe,Xiao Li,Wang Gongwei,Zhuang Lin
The identity of cations plays a critical role in electrochemical CO 2 and CO reduction reactions. While most research has focused on elucidating the effects of alkali metal cations, the influence of organic cations, which are widely employed in practical anion exchange membrane (AEM) electrolyzers, remains underexplored. Here, we systematically investigate the effects of a series of organic cations with varying sizes and hydrophilic/hydrophobic properties on the CO reduction reaction (CORR). By combining electrochemical online mass spectrometry for kinetic analysis, in-situ Raman spectroscopy for interfacial species characterization, and ab initio molecular dynamics (AIMD) simulations to probe interfacial structures, we uncover that the structure of organic cations significantly influences the accessibility of interfacial water to the electrode surface, and thus the potential-dependent behavior of surface *H coverage, ultimately modulating the CORR selectivity. These findings provide new insights into the mechanisms governing CORR and can guide the development of efficient AEM electrolyzers for CO conversion.
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DOI
PubMed
高影响因子
Nature Communications
·
2025
·
IF 15.7
Gu Ming-Zheng,Min Yuan,Jiang Ling,Zhou Fu,Chen Qiao,Zhang Xiao-Jun,Chen Jie-Jie,Yu Han-Qing,Wang Guang-Feng
The challenge in precisely controlling the adsorption configuration of oxygen-binding intermediates in the branching path following C–C coupling constrains the directed selectivity of electroreduction CO 2 -to-ethanol. Here, we present a subsurface Co-doped CuS (Co-Sub-CuS) catalyst, which exhibits directed selectivity toward ethanol. We elucidate the role of subsurface doping in enhancing the oxophilicity of surface Cu sites, thereby facilitating the conversion of key intermediates ( * CHCHO * ) via the formation of surface-O bonds, guiding subsequent protonation towards ethanol. Moreover, the surface sulfur vacancies created by subsurface Co-doping help regulate the optimal distance between dual sites, facilitating asymmetric C–C coupling. Theoretical calculations combined with in-situ isotopic spectroscopy validate these views, and the branching pathway for converting * CHCO to * CHCHO * is captured. Consequently, in a membrane electrode assembly electrolyzer, the optimized Co-Sub-CuS achieves an ethanol Faradaic efficiency of 78.7% at a partial current density of 550.9 mA cm -2 , with stability over 305 h at industrial-level current density of 700 mA cm -2 . These findings provide a rational design for the development of directionally selective catalysts for CO 2 electroreduction.
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DOI
PubMed
高影响因子
ACS Sustainable Chemistry & Engineering
·
2019
·
IF 6.97
Yanpeng Chen,Xing Zhu,Kongzhai Li,Yonggang Wei,Yane Zheng,Hua Wang
Syngas generation via thermochemical H2O–CO2 splitting relies heavily on a high-temperature decomposition of metal oxides into a reduced state. Meanwhile, typical chemical looping partial oxidation of methane to syngas suffers from the carbon deposition and the low selectivity toward syngas. To overcome these drawbacks, the partial oxidation of methane and H2O–CO2 splitting are coupled to consist of an alternative chemical looping redox scheme for the generation of Fischer–Tropsch (F–T)-ready syngas. The usability of lattice oxygen in a redox catalyst is facilitated, and its redox property is also thermodynamically optimized by using H2O and CO2 as soft oxidants, guaranteeing an effective generation of syngas from both redox steps. The carbon tolerance is greatly enhanced due to H2O or CO2 gasification in the reoxidization step. Experimental studies confirm the redox scheme by using CeO2–LaFeO3 redox catalyst, demonstrating generation of syngas with an H2/CO molar ratio around 2.0 in both methane partial oxidation and H2O–CO2 splitting steps over 30 repeated cycles at 850 °C. A syngas selectivity of 95% in methane partial oxidation and nearly 100% conversion of CO2 to CO can be achieved. Synergistic effect and competing reaction between H2O and CO2 splittings over the reduced redox catalyst are the key factors for the control of syngas composition and the intensification of CO2 splitting. The proposed approach can potentially be applied for production of F–T-ready syngas with an increased yield without the need for gas separation when compared to the state-of-the-art thermochemical splitting or methane chemical looping partial oxidation processes.
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高影响因子
ENERGY & FUELS
·
2020
·
IF 3.421
Wei Zhao,Shanshan Ruan,Siyu Qian,Beibei Feng,Chengcheng Ao,Lei Wang,Fuyi Liu,Lidong Zhang
Catalytic combustion has become a promising technology to address the accelerating volatile organic compounds (VOCs) emissions. In this work, cobalt modified ZSM-5 zeolite catalysts (3–18 wt % Co) were prepared to investigate the combustion of n-butane (one typical model component of VOCs). The performances of catalysts were evaluated by conducting experiments in a flow tube reactor. XRD, BET, FT-IR, and XPS were also utilized to characterize their physicochemical properties. A significant enhancement of the catalytic activity was demonstrated in terms of the cobalt supported over ZSM-5, with an optimal cobalt loading of 7 wt %. The excellent catalytic activity of 7 wt % Co-ZSM-5 is mainly attributed to a higher concentration of active surface Co3+ species. Furthermore, DFT calculations indicated that the role of Co can enhance the activity by decreasing the activation barriers for C–H bond cleavage. In addition, the primary reaction mechanism of n-butane combustion on Co-ZSM-5 was also revealed.
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高影响因子
RSC Advances
·
2015
·Vol. 5
·期 85
·69263-69267
·
IF 3.84
Zhaokun Yang,Dongjian Shi,Xiaodong Zhang,Huanhuan Liu,Mingqing Chen,Shirong Liu
Polyacrylamide (PAM) hydrogel photonic crystals with an inverse opal structure were elaborated using a modified vertical deposition approach involving a co-deposition motif. Free-standing inverse opal hydrogel (IOH) films of different thicknesses that could be peeled from the support were first fabricated. A three-dimensional ordered structure without over-layers could easily be acquired by the co-deposition approach. Moreover, the bi-continuous structure was not affected by the increase in film thickness. All these IOH films showed a fascinating pH response property after hydrolysis, and the color change corresponding to the shift of the Bragg diffraction peak of the acquired hydrogel photonic crystal films could be easily distinguished by the naked eye. Three types of IOH films with different thicknesses showed similar pH response properties. The co-deposition approach is found to be suitable for the construction of thicker IOH film without over-layers.
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高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
·
2021
·
IF 5.316
Weiwei Zhang,Shengsong Du,Baosong Li,Tianyong Mei,Yicheng Miao,Hongqiang Chu,Jiajia Wang
In the present work, TiN nanoparticle reinforced Ni-Co alloy coatings have been synthesized by pulse current electrodeposition under the assistance of magnetic and ultrasonic agitation. Various analytical techniques including X-ray diffraction (XRD), scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDS), atomic force microscope (AFM), X-ray photoelectron spectroscopy (XPS) were used to explore the effects of current densities and agitation modes on the coating composition, morphology and structure of the electrodeposits. The corrosion resistance of the composite coating was examined by electrochemical impedance spectroscopy (EIS) in 3.5 wt% NaCl solution. The electrodeposits prepared under magnetic stirring exhibit nodular-protrusion morphology. The ultrasonic-assisted electrodeposited Ni-Co/TiN coatings are flatter, finer, and denser compared to that of magnetic stirring. The agitation mode affects the Co and TiN content in the composite coatings. The preferred orientation was (111) texture, which was gradually changed to (200) plane as the current density increased. The crystallite size was 14–17 nm, 11–14 nm for the magnetic and ultrasonic-assisted electrodeposited Ni-Co/TiN coatings, respectively. The roughness of the samples prepared under ultrasonic agitation was lower than that of magnetic stirring. EIS measurements show that the composite coating prepared at 6 A dm −2 under ultrasonic assistance exhibits the best corrosion resistance with maximum R ct during the whole immersion period. The ultrasonic-assisted electrodeposited Ni-Co/TiN coating has a denser structure and better corrosion resistance than that prepared under mechanical stirring.
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高影响因子
IONICS
·
2020
·Vol. 27
·期 1
·351-360
·
IF 2.394
Wang Jia,Rui Jiayi,Yin Jingzhou,Zhou Guolang,Zhu Lili,Wang Hao,Zhao Pusu,Zhang Lili
Two-dimensional Mg-substituted cobalt hydroxides (Co x Mg y (OH) z ) with different crystal phases were synthesized via a facile reaction of magnesium (Mg) powder and cobalt aqueous solution. The phases of Co x Mg y (OH) z (amorphous phase and β phase) were controlled by adjusting the cobalt salt precursors. The obtained hybrid amorphous Co x Mg y (OH) z (a-Co x Mg y (OH) z ) showed excellent specific capacitance (662.2 F g −1 , 1 A g −1 ) than β phase Co x Mg y (OH) z (β-Co x Mg y (OH) z ) and pure Co(OH) 2 (p-Co(OH) 2 ). Additionally, the hybrid supercapacitor assembled with a-Co x Mg y (OH) z and the activated carbon showed high specific capacitance (77.8 F g −1 , 1 A g −1 ) and ultrahigh cycling stability with 99.7% retention of the first capacitance at 10 A g −1 after 5000 cycles.
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高影响因子
MRS Advances
·
2022
·Vol. 7
·期 30
·736-740
·
IF 0
Guo Yong,Tan Junlang,Zhao Jingchang
In this work, (La, Eu) co-doped CaCu 3 Ti 4 O 12 ceramics (Ca 1− x La x Cu 3 Ti 4− x Eu x O 12 (CLCTEO)), x = 0.1, 0.3, and 0.5) were prepared by the solid-state method. The phase structure, morphologies, dielectric properties, and impedance spectrum were investigated methodically. The XRD of CLCTEO ceramics confirmed the formation of the complex perovskite with a residual amount of CaTiO 3 . The refined calculation found that the lattice parameter of CLCTEO ceramics will significantly increase due to the co-doping of La and Eu. The FESEM analysis shows that the grain size of co-doped CCTO is smaller, reaching the nanometer scale. Impedance indicates that the (La, Eu) co-doped CCTO ceramics have higher dielectric permittivity than the single-doped with La or Eu. The results show that co-doping is an effective method to improve the dielectric properties of CCTO ceramics. Graphical abstract
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INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
·
2014
·
IF 2.93
Qizhao Wang,Guoxia Yun,Yan Bai,Ning An,Yutao Chen,Rongfang Wang,Ziqiang Lei,Wenfeng Shangguan
TiO 2 photocatalysts loaded CuS and NiS as co-catalyst were prepared by hydrothermal approach and characterized by XRD , UV–visible DRS , BET, XPS, SEM and TEM. When TiO 2 was loaded MS as co-catalyst, it showed higher photocatalytic activities for splitting water into hydrogen in methanol aqueous solution under 500 W Xe lamp. Among the photocatalysts with various compositions , the maximum evolution of H 2 obtained from 5 wt% CuS – 5 wt% NiS – TiO 2 sample was about 800 μmol h −1 , which was increased up to about twenty-eight times than that of TiO 2 alone. It was proven that CuS, NiS can act as effective dual co-catalysts to enhance the photocatalytic H 2 production activity of TiO 2 .
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高影响因子
International Journal of Electrochemical Science
·
2023
·
IF 1.5
Muhammad Sumair Sultan,Waqar Uddin,Salma Hamza,Abdullah K. Alanazi
Replacement of expensive state-of-art catalysts by cost-effective transition metal/composites is not only ease production of oxygen from water by electrochemical technique but also a step for the betterment of the green environment. In this regard, a composite of nickel and cobalt doped molybdenum disulfide (CoNiMoS 2 ) electrochemical catalyst was synthesized by a hydrothermal method which was found efficient for oxygen evolution reaction (OER) in an alkaline medium with an overpotential of 1.477 mV at a current density of 1.0 mA.cm −2 . Morphology of catalysts were analyzed through SEM & TEM. The brief explanation is that the pristine MoS 2 and NiMoS 2 were appeared flower-like petal nano-sheets whereas CoMoS 2 & CoNiMoS 2 seemed as a cubic structures. XRD & X-ray patterns has confirms crystallinity and composition of elements in composites. With the help of linear swept voltammetry (LSV) and electrochemical impedance spectroscopy (EIS), the polarization curves and charge transference resistance of catalysts were examined respectively.
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