INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Xinxing Sun,Xinzhao Chen,Sihui Wang,Hongchun Gu,Hongyang Bao,Zixun Ning,Xun Feng,Yang Chen
Sonodynamic therapy is an emerging therapeutic approach for combating bacterial infections. However, the characteristics of hypoxia, high H 2 O 2 microenvironment, and the formation of persistent biofilms in diabetic wound sites limit its efficacy in this field. To address these issues, we developed a multifunctional antibacterial hydrogel dressing PPCN@Pt-AMPs/HGel with the cross-linked gelatin and sodium alginate as the matrix, where the nanosonosensitizer PCN-224 was decorated with the oxygen-generating Pt nanoenzyme and further coupled with a biofilm-targeting antimicrobial peptide via an interacting polydopamine layer. This nano-composite hydrogel displayed improved mechanical properties as well as good biocompatibility and biodegradability. The catalase-like activity of the nanoparticles facilitated the ultrasound-induced generation of the singlet oxygen due to the catalytic decomposition of the H 2 O 2 into O 2 . In vitro results showed that the hydrogel dressing exhibited excellent antimicrobial ability under low-intensity ultrasound stimulation, which could effectively inhibit the newly formed biofilm and eliminate the full-grown biofilms. In the infected diabetic wound of rats, PPCN@Pt-AMPs/HGel significantly enhanced the wound healing rate under low-intensity ultrasound stimulation and improved the regeneration outcomes by promoting granulation tissue formation, angiogenesis, and type III collagen deposition. In conclusion, our study provides a novel and effective antibacterial hydrogel dressing for sonodynamic treatment of diabetic wounds.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
DYES AND PIGMENTS
·
2018
·
IF 3.767
Ruming Jiang,Meiying Liu,Hongye Huang,Liucheng Mao,Qiang Huang,Yuanqing Wen,Qian-yong Cao,Jianwen Tian,Xiaoyong Zhang,Yen Wei
Aggregation-induced emission (AIE) is a unique fluorescence phenomenon that has attracted great interest for various applications especially for the fabrication of AIE-active polymeric nanoparticles . The AIE-active fluorescent polymeric nanoparticles (FPNs) showed attractive optical properties , which could elegantly overcome the lousy aggregation-caused quenching (ACQ) effect of FPNs based on conventional organic fluorogens. Although great advances and progress have been achieved for the fabrication of AIE-active FPNs, the preparation of AIE-active carbohydrate polymers is still challengeable for the poor solubility of carbohydrate polymers in organic solvents . In this work, we reported the sodium alginate-based fluorescent biopolymers (OSA-PA-PhE) with AIE characteristic could be facilely fabricated via an ultrafast one-pot multicomponent reaction (named as Döbner reaction) with the assistance of microwave irradiation. Among the Döbner reaction system, the oxidized sodium alginate (OSA) and AIE-active dye (named as PhE-NH 2 ) were conjugated using pyruvic acid (PA) as the molecular “bridge”. A number of characterization techniques, such as proton nuclear magnetic resonance ( 1 H NMR), fourier transform infrared (FT-IR) spectroscopy, UV–Vis absorption spectroscopy , fluorescent spectroscopy and transmission electron microscopy (TEM), have been utilized to confirm the successful preparation of OSA-PA-PhE biopolymers. The biological evaluation results confirmed that the OSA-PA-PhE FPNs possessed ultrahigh biocompatibility and desirable imaging properties. Moreover, compared with the previous work about FPNs, this work had at least two obvious advantages, one was the original materials of sodium alginate are resourceful, cheaper, and compatible for human tissue and cells, and another was the novel Döbner reaction is a facile conjugation reaction under mild experimental conditions (e.g. catalyst-free, air atmosphere and in the presence of water). Considered the features of microwave-assisted Döbner reaction and OSA, the OSA-PA-PhE FPNs should be of great potential for different biomedical applications .
✓ 已验证
产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Chang Dai,Yun Li,Benkun Qi,Zhitao Li,Bin Wang,Fei Fang,Xuhuan Dai,Zhiheng Qin,Xiaopeng Qin,Yinhua Wan
The treatment of kitchen oily wastewater has often been neglected, despite its significant annual discharge and associated environmental risks. This study addresses the issue by developing a novel composite paper membrane, using A4 paper as a substrate coated with a simple and durable hydrogel composite of nanoparticles (SiO 2 or TiO 2 ) and sodium alginate. The optimal membrane preparation conditions were determined to be 0.6 wt% sodium alginate and 0.1 wt% nanoparticles, ensuring a stable and effective coating. Oil-in-water emulsions can be effectively separated by the resultant membrane, which exhibits superhydrophilic and underwater superoleophobic properties, with a water contact angle in air close to 14° and an oil contact angle in water close to 150°. According to experimental findings, adding nanoparticles improved the composite membrane's surface roughness and selective wettability. The membrane demonstrated outstanding oil removal efficiency for five types of oil-water emulsions (>95 %) and exhibited excellent reusability (over 15 cycles), without causing significant environmental concerns after prolonged use. This study introduces an inexpensive and eco-friendly hydrogel composite membrane that is easy to fabricate and demonstrates excellent emulsion separation capabilities, regeneration performance, and practical application potential. It is positioned as a viable material for treating oily wastewater because of these qualities.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Yirong Wang,Yan Liu,Hongyu Yang,Yan Fu,Lianhao Huan,Feng Zhu,Dongxu Wang,Changling Liu,Dandan Han
The design of polyelectrolyte hydrogel with unique tensile and adhesive properties which can be applied across disciplines has gradually become a popular trend. However, the phenomenon of global warming and the emergence of extreme weather, it still faces some urgent problems that should be solved, such as the optimal utilization of polyelectrolyte hydrogel across a wide range of temperatures. Herein, a wide temperature sensitivity and conductivity hydrogel based on sodium alginate, acrylamide and N-isopropylacrylamide was constructed, which exhibited excellent adhesion and temperature conductivity. It is worth noting that after the inclusion of CaCO 3 and NaCl in the hydrogel, the hydrogel showed excellent tensile properties (fracture strain >2000 %). Within a wide temperature range (−15–50 °C), it exhibits exceptional electrical conductivity (2.75 S ∗ m −1 ) and sensitivity (GF = 8.76 under high strain). This innovative intelligent polyelectrolyte hydrogel provides suitable strategy for flexible sensors, smart wearable devices and medical monitoring equipment.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Innovative Food Science & Emerging Technologies
·
2025
·
IF 6.8
Huizhong Hu,Peijian Cai,Yi Liu,Yufu Li,Jinhong Zhong,Fansheng Kong
Apple peel polyphenols (APPs) have high bioactivity, but are susceptible to pH and temperature changes and have low bioavailability. In this study, liposomes encapsulating APPs were prepared from reverse evaporation, and surface-modified with chitosan (CS) and sodium alginate (SA) to enhance the physicochemical stability, gastrointestinal stability, and bioactivity of APPs. Liposomes were characterized using DLS, FTIR, SEM, and TEM. After layer-by-layer modification, the particle size of the liposomes increased from 267.03 ± 1.04 to 421.86 ± 3.84 nm. The encapsulation rate increased from 86.52 ± 0.60 to 92.04 ± 0.13, and polydispersity index was 0.29 ± 0.01. Double-layered modified liposomes exhibit excellent encapsulation efficiency and form nanoscale spheres. SA-CS-APPL demonstrates significantly enhanced in vitro antioxidant, hypoglycemic, and antibacterial activities compared to CS-APPL and APPL. SA-CS-APPL exhibits superior physicochemical stability over CS-APPL and APPL under various storage conditions, pHs, and temperatures. In vitro digestion experiments indicate SA-CS-APPL exhibits higher stability and a slower release rate of APPs compared to CS-APPL and APPL. The bioavailability of SA-CS-APPL is 39.63 %, representing a 28.28 % increase compared to free APPs. Therefore, SA-CS double-layered modified nanoliposomes can serve as a potential nanocarrier for APPs, aiding in the development of more effective bioactive substance release systems.
✓ 已验证
产品关联
DOI
高影响因子
FOOD CHEMISTRY
·
2024
·
IF 8.5
Ling-Zhi Liu,Rui Zhou,Yong-Li Li,Yue-Hong Pang,Xiao-Fang Shen,Jun Liu
Neonicotinoids, the fastest-growing class of insecticides, have posed a multi-media residue problem with adverse effects on environment, biodiversity and human health. Herein, covalent organic framework-sodium alginate-Ca 2+ -polyacrylic acid composite beads (CACPs), facilely prepared at room temperature, were used in convenient dispersive solid-phase extraction (dSPE) and combined with high-performance liquid chromatography (HPLC) for the detection of five neonicotinoid insecticides (thiamethoxam, acetamiprid, dinotefuran, clothianidin, imidacloprid). CACPs can be completely separated within 1 min without centrifugation. After seven adsorption/desorption cycles, it maintained high extraction efficiencies (>90%). The developed method exhibited a wide linear range (0.01 ∼ 10 μg mL −1 ), low limits of detection (LODs, 0.0028 ∼ 0.0031 mg kg −1 ), and good repeatability (RSD ≤ 8.11%, n = 3). Moreover, it was applied to the determination of five neonicotinoids in fruit and vegetables (peach, pear, lettuce, cucumber, tomato), and recoveries ranged from 73.6% to 116.2%.
✓ 已验证
DOI
PubMed
高影响因子
LWT-FOOD SCIENCE AND TECHNOLOGY
·
2025
·
IF 6.6
Xu Zhang,Xiaozhuo Sun,Yelinxin Chen,Fangzhu Zheng,He Ban,Jingsheng Liu,Dan Cai,Lin Xiu
Curcumin, a bioactive compound characterized by its limited solubility in water and low bioaccessibility, which requires an effective delivery system to enhance stability and absorption. This research focused on creating Pickering emulsions stabilized by zein-adzuki bean seed coat polyphenol-sodium alginate composite nanoparticles (ZAS) to improve curcumin delivery. The effects of different concentrations of sodium alginate (SA) on the properties of ZAS were investigated. Fourier transform infrared spectroscopy (FTIR) showed that there were hydrophobic and hydrogen bonds interactions between SA and nanoparticles, and Differential Scanning Calorimetry demonstrated an improvement in thermal stability. Accelerated oxidation experiments showed that ZAS stabilized Pickering emulsions had good anti-oxidant capacity. In comparison to the control group, the addition of SA increased the loading rate of curcumin to 81.65 ± 1.56 % with improved bioaccessibility (27.99 ± 0.26 %) and in vitro digestion stability (55.72 ± 0.22 %). The findings indicate that ZAS nanoparticles modified with SA markedly enhance the stability of Pickering emulsions, while also attaining a high loading efficiency of 81.65 % and bioaccessibility of 27.99 %. This suggests their potential utility in functional food applications.
✓ 已验证
产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Zelin Meng,Yang Liu,Mingyang Song,Na Wang,Heming Zhao,Yang Wang,Shuai Bai,Jianglei Hu,Ruiping Shi
A sustainable one-pot co-condensation strategy was developed for the fabrication of sodium alginate (SA)-silica hybrid carriers (SA-SiO 2 ), via the covalent cross-linking via carboxyl and hydroxyl groups. The SA-SiO 2 matrix was used as a bio-based platform to immobilize Cu 2+ ions via carboxyl coordination, enabling in situ growth of MOF-199 crystals (denoted as MOF-199@xSA-SiO 2 ). FT-IR, XPS, and UV–vis demonstrated the successful cross-linking of SA with SiO 2 , the effective loading of MOF-199 through −COOH in the SA matrix, and the strong interaction between the carrier SA-SiO 2 and MOF-199. Additionally, SEM and N 2 adsorption-desorption analyses showed that the MOF-199@xSA-SiO 2 composites exhibited a spongy pore structure and possessed a typical mesoporous structure. The [email protected] 2 composite exhibited good catalytic activity in the reduction of 4-NP to 4-AP. Under optimal reaction conditions, the K app of the 4-NP reduction reaction was 0.45 min −1 . In contrast, the MOF-199/0.15SA-SiO 2 composite that was prepared using a post-synthesis method achieved a K app of only 0.11 min −1 . The catalyst maintained 98.23 % conversion of 4-NP five cycles, demonstrating good catalytic activity and stability. This study highlights the dual roles of SA as a porous guide and a metal ligand site, providing a green pathway for designing polysaccharide-MOF complexes for efficient environmental catalysis.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
FOOD CHEMISTRY
·
2022
·
IF 9.231
Linlin Li,Li Xia,Feng Xiao,Yewen Xiao,Lanhua Liu,Shaotong Jiang,Hualin Wang
Colorimetric active double-layer composites of [email protected] were developed via direct electrospinning functional nanofibers on colorimetric film. In the structure, oxidized sodium alginate cross-linked carboxymethyl chitosan (CO) was used as colorimetric film matrix to incorporate the anthocyanins extract from Oxalis triangularis ssp. papilionacea (OTA); while the blend of gelatin/zein (GZ) was used as fibrous matrix for linalool (L) encapsulation. Besides good barrier and water resistance, the outer-layer of CO-OTA showed colorimetric sensitivity towards pH-stimuli with reversible color changes. The inner-layer of GZ-L exhibited good antibacterial activities against Staphylococcus aureus and Escherichia coli . The volatile release of L from fibrous matrix was well controlled and mainly followed Fickian diffusion. Moreover, the antioxidant activity of the composites is source from the released linalool. The high reliability on milk freshness monitoring and double shelf-life extending at 25 °C suggest the potential of [email protected] in colorimetric active food packaging.
✓ 已验证
DOI
PubMed
高影响因子
CARBOHYDRATE POLYMERS
·
2025
·
IF 12.5
Yue Ming,Zhuangzhuang Shi,Yufei Zhao,Jue Li,Wei Sha,Weilong Wang,Guoqiang Li,Mengmeng Wu,Ting Ma
The oral delivery of probiotics faces numerous challenges, particularly the acidic gastric environment. This study aimed to construct microcapsules using acid-resistant polysaccharide sanxan gum (SG) combined with sodium alginate (SA) and chitosan (CS), and to evaluate their protective effects on the probiotic bacteria Lactobacillus plantarum ( Lp ) during in vitro simulated gastrointestinal digestion. Sanxan gum, an edible polysaccharide produced by Sphingomonas sanxanigenens strain, is composed of mannose, glucuronic acid, rhamnose, and glucose. Sodium alginate has been widely used to protect probiotics because it is cheap, safe, and easy to form into microcapsules. Chitosan is a cationic polysaccharide with excellent mucoadhesive properties and film-forming capabilities. Herein, the microcapsules were prepared using the extrusion drop method. Compared with microcapsules based solely on sodium alginate, those with a ratio of sanxan gum to sodium alginate of 4:6 demonstrated enhanced encapsulation efficiency (97.66 ± 0.79 %) and freeze-dried cell viability (9.97 ± 0.03 log CFU/g). Furthermore, the incorporation of chitosan yielded the highest encapsulation efficiency for the Lp @SG-SA@CS microcapsules (99.14 ± 1.46 %) and significantly enhanced their tolerance to heat, bile salts, and gastric acid. Our findings suggest that sanxan gum can confer acid resistance to microcapsules, highlighting its potential for applications in diverse acidic environments.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Rasha S. Mohamed,Engy M. Akl,Sawsan Dacrory
Fabrication of new 3D scaffold based on sodium alginate (SA), polyvinyl alcohol (PVA), sesame protein isolate (SPI) and Zinc nanoparticles (ZnNPs) has been prepared. SPI was extracted and evaluated via its amino acid composition, solubility, and antioxidant activity. The scaffolds were formulated with different ratios of SA/PVA/Zn/SPI and investigated via different instruments FTIR, XRD and SEM/EDX. Additionally, the effect of the scaffold on the hepato-protection and immune-stimulating in methotrexate (MTX) treated rats has been studied. The results showed that SPI rich in Arginine (21.33 %), Histidine (15 %), Aspartic acid (12.7 %) and Glutamic acid (9.69 %). SPI exhibited higher solubility and antioxidant activity at pH 7 (47.55 and 87.23 %) when measured by DPPH and ABTS methods respectively. SPI and Zn have the ability to mitigate the effects of MTX on body weight loss. SA/PVA/ZnNPs and SA/PVA/ZnNPs/SPI scaffolds have potential liver protection by down-regulating liver functions (34.83 ± 1.17 U/L and 27.83 ± 1.08 U/L, respectively for ALT and 53.00 ± 1.15 U/L and 48.29 ± 1.29 U/L, respectively for AST) and oxidative and inflammatory markers (MDA, IL-6, IL-1β, and TNF-α) and up-regulating liver antioxidant enzymes (GPx and SOD). Furthermore, the immune-enhancing effects of SA/PVA/ZnNPs and SA/PVA/ZnNPs/SPI scaffolds were demonstrated by the reduction in INF-γ (33.17 ± 0.94 pg/mL and 27.73 ± 0.68 pg/mL, respectively) and CD 8 (381.5 ± 2.56 pg/mL and 337.8 ± 1.87 pg/mL, respectively) levels and the elevation in CD 4 /CD 8 ratio (1.79 ± 0.02 and 3.00 ± 0.01, respectively) comparable to the MTX group (41.25 ± 0.85 pg/mL, 531.7 ± 2.56 pg/mL and 0.99 ± 0.005, respectively). Thus, the scaffold may have a role in liver protection and immune enhancement.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Advanced Healthcare Materials
·
2024
·
IF 10
Yuxiang Liang,Qizhi Shuai,Xiao Zhang,Shanshan Jin,Yuqian Guo,Zhaowei Yu,Xinrui Xu,Ruifang Ao,Zhiwei Peng,Huimin Lv,Sheng He,Chunfang Wang,Guohua Song,Zhizhen Liu,Hong Zhao,Qilong Feng,Ruochen Du,Bin Zheng,Zhaoyang Chen,Jun Xie
Intrauterine adhesion (IUA) stands as a prevalent medical condition characterized by endometrial fibrosis and scar tissue formation within the uterine cavity, resulting in infertility and, in severe cases, recurrent miscarriages. Cell therapy, especially with stem cells, offers an alternative to surgery, but concerns about uncontrolled differentiation and tumorigenicity limit its use. Exosomes, more stable and immunogenicity-reduced than parent cells, have emerged as a promising avenue for IUA treatment. In this study, a novel approach has been proposed wherein exosomes originating from decidual stromal cells (DSCs) are encapsulated within sodium alginate hydrogel (SAH) scaffolds to repair endometrial damage and restore fertility in a mouse IUA model. Current results demonstrate that in situ injection of DSC-derived exosomes (DSC-exos)/SAH into the uterine cavity has the capability to induce uterine angiogenesis, initiate mesenchymal-to-epithelial transformation (MET), facilitate collagen fiber remodeling and dissolution, promote endometrial regeneration, enhance endometrial receptivity, and contribute to the recovery of fertility. RNA sequencing and advanced bioinformatics analysis reveal miRNA enrichment in exosomes, potentially supporting endometrial repair. This finding elucidates how DSC-exos/SAH mechanistically fosters collagen ablation, endometrium regeneration, and fertility recovery, holding the potential to introduce a novel IUA treatment and offering invaluable insights into the realm of regenerative medicine.
✓ 已验证
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）