COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2025
·
IF 5.4
Dong Liu,Ziqi Zou,Xin Hu,Shiyu Huang,Tongsheng Huang,Jiawei Gu,Weifeng Zhu,Meiying Liu,Shaorong Huang,Xiaoyong Zhang
Natural products showed many benefits for human health and are important resources in drug discovery and herbal medication development. However, their pharmacological activities are often constrained by their poor water solubility. To address these challenges, various drug delivery systems (DDS) have been developed to enhance the physicochemical properties of drugs, thereby improving their pharmacological effects or reducing adverse effects. In this study, we reported the construction of a novel natural products-based DDS through a self-assembly engineering approach, in which curcumin (Cur) was encapsulated by phosphorylated capsaicin (Cap-p). The physicochemical properties, drug loading and release behavior as well as therapeutic effects of Cap-p and Cap-p@Cur were investigated in detail. Results demonstrate that both Cap-p and Cap-p@Cur can self-assemble into nanovesicles and exhibit high water dispersibility. Results from biological assays suggested Cap-p exerts favorable biocompatibility toward MDA-MB-231 cells at concentration of 40 µg/mL. Compared to free Cur and Cap-p, Cap-p@Cur displays obviously enhanced cell killing capability against MDA-MB-231 cells and its cell killing ability was significantly amplified upon light irradiation. In addition, Cap-p displayed obvious bone-targeting capability, indicating its potential for eradicating bone-metastasis of triple-negative breast cancer (TNBC). The above results suggest that Cap-p@Cur holds considerable promise in treatment of TNBC via combining chemotherapy and photodynamic therapy. This work will provide some valuable insights into construction of natural product-based carrier-free DDS.
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Journal of Materials Chemistry B
·
2014
·Vol. 2
·期 18
·2714-2724
·
IF 0
Zhou-Hao Xing,Jin-Huan Wei,Tuck-Yun Cheang,Zong-Ren Wang,Xiao Zhou,Sha-Sha Wang,Wei Chen,Shen-Ming Wang,Jun-Hang Luo,An-Wu Xu
To overcome drug resistance, the combination of two or more therapeutic strategies with different mechanisms has received much attention in recent years. In this study, a common approach has been used to process curcumin and Zn2+ into colloidal dispersions known as “nanoparticles”, which are cheap and easy to prepare with high reproducibility. This novel vehicle has good biocompatibility and high cellular uptake for simultaneously delivering the curcumin drug and siRNA into tumor cells. Complexation of Zn2+ with curcumin enhances the aqueous solubility of the hydrophobic drug curcumin and further improves the cellular uptake and bioavailability. The acid-labile coordination Zn(II)–O bond in Zn(II)–curcumin drug nanoparticles (Zn(II)–Cur NPs) can respond to tumor intracellular acidic pH environments to release curcumin, and promoting acid-triggered intracellular drug release. The positively charged Zn(II)–Cur NPs can efficiently deliver siRNA into human bladder cancer cells, protect siRNA against enzymatic degradation, and facilitate the escape of loaded siRNA from the endosome into the cytoplasm, which successfully downregulates the targeted EIF5A2 oncogene and consequently inhibits cancer cell growth in vitro and in vivo. Proliferation and migration of cancer cells are inhibited by silencing the expression of EIF5A2 and increasing the ratio of pro-apoptotic BAX to anti-apoptotic BCL-2. In vitro and in vivo experiments have demonstrated that bifunctional Zn(II)–Cur NPs/siEIF5A2 can combine chemotherapy with gene therapy to afford higher therapeutic efficacy than the individual therapeutic protocols.
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JOURNAL OF NANOBIOTECHNOLOGY
·
2023
·Vol. 21
·期 1
·1-19
·
IF 10.2
Zhang Zi-Jian,Hou Ying-Ke,Chen Ming-Wa,Yu Xue-Zhao,Chen Si-Yu,Yue Ya-Ru,Guo Xiong-Tian,Chen Jin-Xiang,Zhou Quan
The occurrence of osteoarthritis (OA) is highly correlated with the reduction of joint lubrication performance, in which persistent excessive inflammation and irreversible destruction of cartilage dominate the mechanism. The inadequate response to monotherapy methods, suboptimal efficacy caused by undesirable bioavailability, short retention, and lack of stimulus-responsiveness, are few unresolved issues. Herein, we report a pH-responsive metal-organic framework (MOF), namely, MIL-101-NH2, for the co-delivery of anti-inflammatory drug curcumin (CCM) and small interfering RNA (siRNA) for hypoxia inducible factor (HIF-2α). CCM and siRNA were loaded via encapsulation and surface coordination ability of MIL-101-NH2. Our vitro tests showed that MIL-101-NH2 protected siRNA from nuclease degradation by lysosomal escape. The pH-responsive MIL-101-NH2 gradually collapsed in an acidic OA microenvironment to release the CCM payloads to down-regulate the level of pro-inflammatory cytokines, and to release the siRNA payloads to cleave the target HIF-2α mRNA for gene-silencing therapy, ultimately exhibiting the synergetic therapeutic efficacy by silencing HIF-2α genes accompanied by inhibiting the inflammation response and cartilage degeneration of OA. The hybrid material reported herein exhibited promising potential performance for OA therapy as supported by both in vitro and in vivo studies and may offer an efficacious therapeutic strategy for OA utilizing MOFs as host materials.
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高影响因子
ACS Chemical Neuroscience
·
2020
·
IF 4.486
Ruiqi Huang,Yanjing Zhu,Lijuan Lin,Simin Song,Liming Cheng,Rongrong Zhu
Oxidative stress of neurons caused by a series of complex neuropathological processes will induce certain neurodegenerative disorders including epilepsy. Curcumin (Cur) is an effective natural antioxidant compound; however, the poor bioavailability obstructs its neural protective applications. In this study, Cur is encapsulated in solid lipid nanoparticles (SLNs) for better neuroprotective efficacy. In vitro study certified that Cur-SLNs functioned obviously better against neuronal apoptosis than Cur, by significantly decreasing the level of free radical and reversing mitochondrial function through the activation of the Bcl-2 family. In vivo experiments showed that SLNs transported Cur through the blood–brain barrier (BBB). The behavioral performance of epileptic mice was improved by Cur-SLNs, with more NeuN but less TUNEL positive cells observed in hippocampus. The in vivo mechanism was also explored. Cur-SLNs reduced neuronal apoptosis through Bcl2 family and P38 MAPK pathways. Overall, Cur-SLNs have better protective effects toward oxidative stress in neurons than free Cur both in vitro and in vivo, which suggests they may be a promising agent against neurodegenerative disorders including epilepsy.
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高影响因子
BIOMEDICINE & PHARMACOTHERAPY
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2025
·
IF 7.5
Fatemeh Ajalloueian,Atena Malakpour-Permlid,Marzieh Yeganegi,Somayeh Azizi,Aleka Vasos,Gohar Soufi,Anja Boisen
In this study, we addressed the challenge of enhancing the efficacy of curcumin (Cur) delivery for cancer treatment by developing Cur-loaded electrospun sheets (ES) fabricated from PLGA (poly(lactic-co-glycolic acid)) with a focus on tailoring both the dosage and the physical dimensions of the delivery device to suit specific therapeutic applications. Two formulations containing 10 % and 50 % Cur by weight relative to PLGA were designed and produced. We demonstrated that both formulations maintained the amorphous structure of PLGA, where increasing the Cur concentration enhanced the sheets' wettability, tensile extensibility, and mucoadhesive properties. Comparing the drug release trends and the cytotoxicity of the Cur-loaded ES against HeLa cells (human cervical cancer) revealed that both the Cur dosage and the sheet dimensions influenced drug release kinetics and anticancer efficacy. Hence, we highlight the importance of considering specific size-dose relevance measurements when applying polymer-drug systems in solid form. For instance, when maintaining the same dose, a smaller segment of the high dose sheet is suitable for oral delivery, thanks to the higher drug content and better mucoadhesion properties. The low dosage sheet enjoying a larger surface area, could fit local applications requiring uniform static delivery, such as post-surgery recurrence inhibition dressing.
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FOOD CHEMISTRY
·
2025
·
IF 9.8
Sili Xiao,Xiaoxia Huang,Xiting He,Zitao Chen,Xiaoyan Li,Xianling Wei,Qiaoyu Liu,Hao Dong,Xiaofang Zeng,Weidong Bai
This study aims to elucidate the interaction mechanisms between curcumin (Cur) and four collagen subtypes (fish type I [FCI], bovine type I [BCI], fish type II [FCII], bovine type II [BCII]), with parallel characterization of the structural and functional attributes of their derived nanoparticles. Type I Collagen/Cur nanoparticles exhibited superior solution stability compared to type II. Cur binding significantly enhanced the surface hydrophobicity, absolute ζ potential, and surface tension of collagen, while reduced dynamic interfacial tension. The binding type of Cur to collagen was static, and binding process was enthalpy-driven exothermic reaction. Molecular dynamics simulations revealed that hydrophobic interactions, hydrogen bonds, and electrostatic forces dominated the binding process. The binding affinity followed the order: FCI/Cur > BCI/Cur > FCII/Cur > BCII/Cur. The binding sites of Cur to type I collagen and type II collagen were around Ser129-Glu135 and Asn179-Ser183 residues. Collagen/Cur nanoparticle stabilized emulsions and improved oxidative stability and storage modulus.
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Biomimetics
·
2026
·Vol. 11
·期 8
·599
·
IF 4.2
Haiguang Zhang,Feng Jiang,Qianmin Gao,Qingxi Hu,Jiaxuan Feng
Vascular stent implantation is a major treatment for vascular diseases, yet postoperative infection and persistent inflammation increase the risk of in-stent restenosis. Herein, core–shell structured PCL/PEO-PVP fiber membranes co-loaded with ciprofloxacin hydrochloride (CIP) and curcumin (CUR) were fabricated via coaxial electrospinning. Orthogonal experiments were conducted to optimize critical spinning parameters through multi-index comprehensive evaluation. Characterizations confirm intact core–shell architecture and stable polymeric backbone structure. In vitro release tests reveal sequential drug-delivery behavior: a rapid initial release of hydrophilic CIP and a delayed sustained release of hydrophobic CUR were observed, contributing to early-stage antibacterial and long-term anti-inflammatory effects, respectively. The “antibacterial zone” method verifies favorable antibacterial activity againstStaphylococcus aureus(S. aureus) andEscherichia coli(E. coli). ELISA results demonstrate the enhanced anti-inflammatory capacity of the dual-drug-loaded coaxial fiber membrane. Cellular assays confirm satisfactory cytocompatibility, and endothelial cells achieve normal proliferation and exhibit typical polygonal morphology on the membrane surface. This dual-drug-loaded coaxial-fiber membrane realizes coordinated sequential antibacterial and anti-inflammatory properties, which provides a feasible strategy for developing functional coatings toward vascular stents.
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Materials Today Communications
·
2026
·
IF 4.9
Lei Nie,Xinran Li,Jingyu Li,Yanfang Sun,Guohua Jiang
Nanoparticle-reinforced composite hydrogels have been widely used for tissue engineering and biomedicine. In particular, hydrogels with multiple functionalization, such as self-healing, antibacterial, and cytocompatible properties, can facilitate their use in wound-healing and bio-adhesive applications. In this work, the multifunctional composite hydrogels were fabricated using silk fibroin (SF) and gelatin methacrylate (GelMA), incorporating silver-doped reduced graphene oxide (Ag@rGO) nanosheets and curcumin-loaded PF127 (PF127-Cur) micelles. The obtained hydrogels possessed an interconnected microstructure, good swelling properties (250–350%), and strong adhesion to the surface of different matrices, including rubber, metal, glass, plastic, wood, and finger skin. In addition, the hydrogels demonstrated self-healing, injectability, and electrical conductivity. Furthermore, the designed composite hydrogels demonstrated good antibacterial properties against the typical bacteria, Gram-positive S. aureus and Gram-negative E. coli . CCK-8 assay, fluorescent images, and cell scratch assay confirmed that the composite hydrogels exhibited excellent cytocompatibility and cell pre-migration ability. The obtained data confirmed that the designed hydrogels possessed great potential for biomedical applications, such as wound healing and bio-adhesives.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2026
·
IF 8.7
De Zhou,Zejian Xu,Tian Lan,Xiaonan Sui
Hydrogels, due to their excellent properties, were widely noted and held great potential for application in wound healing. However, conventional wound dressings are limited by insufficient antioxidant and antibacterial properties, which restricted their effectiveness in treating infected wounds. In this study, a multifunctional hydrogel (PCS/Cur@Fe&TA) was fabricated from carboxymethyl chitosan, polyvinyl alcohol, and sodium alginate via a freeze-thaw cycle method to evaluate its potential as a wound dressing. The hydrogel incorporated nanocomplex composed of curcumin, tannic acid, and Fe 3+ , which endowed the material with enhanced antioxidant and antibacterial properties. The resulting hydrogel exhibited excellent swelling capacity (400–800%) and water holding capacity (>62%), and a good degradation rate, enabling it to maintain a moist microenvironment conducive to wound healing. Moreover, after hydrogel treatment, the cell viability remained >80%, >99% hemocompatibility (hemolysis rate < 1%), and significantly enhanced antioxidant enzyme activities ( P < 0.05). The hydrogel showed marked antibacterial activity, with inhibition zones of 1.03 cm against E. coli and 0.61 cm against S. aureus . Overall, the developed hydrogel exhibits considerable promise as a therapeutic material for accelerating wound healing. Download: Download high-res image (157KB) Download: Download full-size image
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2025
·
IF 5.4
Jinrui Hou,Shiji Liu,Xinyue Wu,Shujuan Zhuo,Jinyan Du
Wound healing in skin infections is frequently compromised by multi-drug-resistant bacterial colonization, persistent inflammation, and bacterial biofilm formation. To address these issues, we engineered an innovative multifunctional biomaterial (Cur@MIL-101(Cr/Ag)) which integrates potent antibacterial, anti-biofilm, and tissue-regenerative properties. This composite was constructed via a bimetallic synergistic and molecularly confined strategy, where Ag + and Cr 3+ were co-anchored within a terephthalic acid-based framework (MIL-101) through hydrothermal method, followed by the in situ encapsulation of curcumin. In vitro evaluations revealed potent broad-spectrum antibacterial activity against both Staphylococcus aureus ( S. aureus ) and Escherichia coli ( E. coli ), along with significant inhibition of biofilm formation and minimum inhibitory concentrations (MICs) of 8 ppm and 2 ppm, respectively. In vivo, topical application of Cur@MIL-101(Cr/Ag) in a wound-infected mouse model further demonstrated complete bacterial eradication, mitigated inflammatory responses, accelerated wound closure, and promoted tissue regeneration with no observable systemic toxicity within the scope of assessment (i.e., stable body weight and non-pathological organ morphology). The therapeutic efficacy can be attributed to a synergistic triple-therapy mechanism comprising: (i) electrostatic interaction, (ii) ROS-mediated oxidative stress induction, (iii) synergistic interaction of multiple antimicrobial components (Ag⁺, Cr³⁺, and curcumin). This nanoengineered platform presents a clinically translatable strategy for precision therapy of infected wounds, combining antimicrobial robustness, biofilm penetration, and pro-regenerative functions within an integrated therapeutic system.
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EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
·
2025
·
IF 4.3
Xiaohui Wang,Lin Zhou,Yingying Shi,Wang Wang,Peng Li,Rui Cui,Yajuan Wu,Feng Wang,Qiuzheng Du
The mortality rate of primary liver malignant tumors is very high. Curcumin (Cur) is one of the most commonly used drugs for the treatment of liver cancer. However, due to its low bioavailability, nano-drug delivery systems are rapidly developing. Zeolitic imidazolate framework-8 (ZIF-8), is pH-sensitive and biodegradable in acidic environments, providing a very suitable platform for drug delivery. Here, the anti-tumor properties of Cur and the anti-inflammatory properties of gold nanoparticles (Au NPs) were integrated and encapsulated in ZIF-8 material to prepare a composite drug delivery system (Cur/Au@ZIF-8). The prepared materials were characterized by scanning electron microscopy and elemental analysis, transmission electron microscopy, and powder X-ray diffraction. The drug loading efficiency of Cur in this delivery system reached 47.16 %. The drug release curve showed that the release rate of Cur/Au@ZIF-8 was faster at pH 5.5, with a release rate of 72.34 %. Ultrasound-guided in situ liver cancer models were constructed in SD rats to investigate the in vivo anti-tumor effects of Cur/Au@ZIF-8 and its impact on the metabolomics of tumor-bearing rats before and after treatment. In vivo results indicated that Cur/Au@ZIF-8 showed better anti-tumor effects, with a tumor inhibition rate of 46.81 %. After treatment, 26 key differential metabolites (p < 0.05) were identified from expression patterns and metabolic pathways, which were mainly related to fatty acid metabolism. This treatment strategy provides a reference for future cancer treatment and mechanism exploration.
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DRUG DELIVERY
·
2026
·
IF 8.1
Nan Jin,Yaling Chen,Huangyu Luo,Yanhong Su,Yumin Weng,Xin Lin,Tingting Zheng,Bingbing Li,Tianhui Liu,Jianmin Chen
The recurrence following the discontinuation of medication is a formidable challenge in managing psoriasis. Changes in the microbiome accompany the onset of psoriasis relapse, highlighting a potential therapeutic modality. To evaluate the superiority of the topical administration of aptamer-functionalized curcumin mesoporous silica (Apt-GA+Cur@μmS) plus blue light (BL) in restoring dysbiosis and intervening in recurrence in a murine model, a psoriasis relapse murine model with double imiquimod induction was established. With a BL-responsive shell, Apt-GA+Cur@μmS released curcumin (Cur) to assist BL to improve the preventative and therapeutic effects in the psoriasis relapse murine model, as evidenced by the psoriasis area and severity index, histology, splenic index, and dorsal IL-17A level. We also observed a negative correlation between splenic nitric oxide (NO) levels and the splenic index, indicating a possible mechanism by which Apt-GA+Cur@μmS&BL may function in the treatment of splenomegaly. Treatment with Apt-GA+Cur@μmS&BL exhibited a higher alpha diversity than the model group, with levels similar to those of healthy mice, indicating that this combination could adjust the composition of the dorsal microbiome to a healthier state. A reduction in the combined relative abundance of Staphylococcus, Streptococcus, and Corynebacterium as well as restoration of dysbiosis was also verified through 16S rDNA gene sequencing in vivo. Collectively, BL and Apt-GA+Cur@μmS cotherapy alleviates psoriasiform lesions in a double imiquimod-induced murine model by inhibiting IL-17A and increasing splenic NO. Additionally, this cotherapy restores the eubiosis of the dorsal lesions. Thus, it is a promising and innovative therapeutic modality for psoriasis inflammation alleviation and recurrence intervention.
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