JOURNAL OF ELECTROANALYTICAL CHEMISTRY
·
2022
·
IF 4.598
Yuting Zhong,Zhirui Wu,Xiaoguang Liu,Ling Li
The combination of multi-metallic alloys and support materials is a promising approach for the design of electrocatalysts. In this study, Pd-M (M = Fe, Sb, Pb, Sn, Ag) bimetallic alloys embedded composites of 2D Ca-based metal–organic framework (Ca-MOF) nanosheets and reduced graphene oxide (rGO) were fabricated by a facile hydrothermal and impregnation reduction method, then applied as ethylene glycol oxidation reaction (EGOR) electrocatalysts. Remarkably, the forward peak current density of the best catalytic performer PdAg@rGO/Ca-MOF is as high as 258.30 mA cm −2 , which is 9.55 times greater than that of Pd/C. It also exhibits the biggest electrochemical active surface area of 3022.51 m 2 g −1 . After 3600 s chronoamperometry test, the retained current density of PdAg@rGO/Ca-MOF is about 87.94 % of the initial current density. These results imply that bimetallic Pd-M@rGO/Ca-MOF have superior electrocatalytic activity and anti-CO poisoning capacity compared to monometallic and Pd/C for EGOR, especially PdAg@rGO/Ca-MOF. The enhanced EGOR performance is due to the combined effect of Pd-M alloys and folded thin layer wrapped nanosheet rGO/Ca-MOF composites.
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DOI
高影响因子
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2020
·
IF 3.573
Xingang Li,Qingyu Zhang,Hong Li,Xin Gao
To solve the problem of catalyst recovery, high investment, and high energy consumption in the traditional manufacturing process of triethylene glycol di-2-ethylhexoate (TGDE), sulfated zirconia (HND-32) and reactive distillation (RD) were used in this work. Kinetics experiments for the esterification of triethylene glycol and 2-ethylhexanoic acid catalyzed by sulfated zirconia were performed at 463.15–493.15 K. The pseudo-homogeneous model was used to obtain the kinetics equation. Then, the process analysis results of the RD column indicate that there is an optimal theoretical plate number of the stripping section to obtain the highest yield of TGDE. The yield of TGDE can be enhanced to 98.15%, and 98.5 wt % TGDE can be obtained in the bottom of the RD column when the feed molar ratio is the stoichiometric ratio.
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DOI
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2015
·
IF 2.752
Yinwen Li,Huilong Guo,Jian Zheng,Jianqun Gan,Kun Wu,Mangeng Lu
Star polymers (CD-POEGMAs and CD-PNIPAMs), and pseudo-graft polymer (PADMA-(CD-POEGMAs) x ) formed from PADMA with adamantyl(Ad) pendants and CD-POEGMAs by host–guest inclusion complexation were prepared and characterized. This work compared the thermoresponsive and self-assembly mechanisms of the POEGMAs as branches to that of PNIPAMs branched cyclodextrin cored star polymers. In contrast to CD-PNIPAMs which behaved abrupt and intensive dehydration process near its LCST, CD-POEGMAs exhibited thermally induced aggregation process with consecutive conformation changes during the temperature increase process, and gradually self-assembled into cyclodextrin centered aggregates with hydrophobic methacrylate backbone and dehydrated POEGMAs side chains. Moreover, this work provided a supramolecular method controlling and adjusting the thermoresponsive properties of pseudo-graft PADMA-(CD-POEGMAs) x formed from CD-POEGMAs and PADMA via inclusion complexation, which underwent a reversible thermally induced transition from micelle to nano-aggregates. Pseudo-graft PADMA-(CD-POEGMAs) x behaved gradually conformation changes as temperature rising, and self-assembled into aggregates with hydrophobic methacrylate backbone, residual Ads, and dehydrated POEGMAs side chains.
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DOI
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JOURNAL OF APPLIED POLYMER SCIENCE
·
2019
·Vol. 137
·期 17
·48617
·
IF 2.188
Bing Yang,Yu Zhou,Hongxiang Chen,Song Zhang,Jingyi Liu
In order to improve the dispersity and stability of nano-SiO 2 aqueous system with high solid content, acrylic acid/allyloxy polyethylene glycol copolymer dispersants with methoxysilicon end groups (KH590-AA x -APEG y ) were synthesized by photopolymerization. After adding KH590-AA x -APEG y into the nano-SiO 2 aqueous system, the viscosity, the curing time, the particle size, and the zeta potential of these systems were respectively measured. The results showed that introducing polyethylene glycol chain into the dispersant was beneficial to better exerting its electrostatic repulsion and steric hindrance effects and further improving the dispersibility of the nano-SiO 2 aqueous system. Moreover, the dispersion stability of SiO 2 nanoparticles in water was closely related to the composition, the molecular weight, and the addition amount of KH590-AA x -APEG y and the solid content. When the molecular weight of KH590-AA x -APEG y was 3200 g mol −1 and its addition amount was 0.1 wt %, the nano-SiO 2 aqueous system with 20 wt % solid content showed the best dispersity and stability. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2020 , 137 , 48617.
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DOI
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JOURNAL OF ALLOYS AND COMPOUNDS
·
2017
·
IF 3.133
Yiyong Zhang,Kun Li,He Li,Yunhui Wang,Yueying Peng,Shuangshuang Lin,Bing Joe Hwang,Jinbao Zhao
Lithium sulfur batteries have been widely studied because of their high energy density . However, their commercialization has been impeded by several problems, such as the poor conductivity of the active material sulfur and its discharge products, the volume expansion and the shuttle effect caused by the polysulfide intermediates dissolving in organic electrolytes. To address these problems well, we have constructed high sulfur content spherical sulfur-carbon nanotube-polyethylene glycol-nickel nitrate hydroxide (SCNT-PEG-NNH) composite material by using a simple ball-milling method. The conductivity of the composite material gets improvement due to the spherical conductive frame constructed by CNT, while the shuttle effect of polysulfides is well inhibited by the wrapping of the PEG and the fixation of NNH. The results of electrochemical tests have shown that the performance of cathode made by the SCNT-PEG-NNH composite material is greatly improved. Therefore, the SCNT-PEG-NNH composite material can be a promising cathode material for lithium sulfur batteries.
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DOI
高影响因子
Polymer Chemistry
·
2011
·Vol. 2
·期 12
·2857-2864
·
IF 0
Jianxun Ding,Fenghua Shi,Chunsheng Xiao,Lin Lin,Li Chen,Chaoliang He,Xiuli Zhuang,Xuesi Chen
A series of disulfide-core-cross-linked poly(ethylene glycol)-poly(amino acid)s star copolymers were synthesized through one-step ring-opening polymerization of L-phenylalanine N-carboxyanhydride (L-Phe NCA) and L-cystine N-carboxyanhydride (L-Cys NCA) with amino group terminated poly(ethylene glycol) monomethyl ether (mPEG-NH2) as macroinitiator. The reduction-responsive PEG-poly(amino acid)s nanogels (NGs) were prepared by directly dispersing the resultant PEG-poly(amino acid)s in phosphate buffer solution at pH 7.4. Dynamic light scattering (DLS) measurements showed that the reducible NG swelled in response to 10 mM glutathione (GSH). Doxorubicin (DOX), an anthracycline anticancer drug, was loaded into the NGs. The in vitro release results revealed that the release behaviors could be adjusted by GSH concentration, and poly(amino acid)s content and composition. The intracellular DOX release results showed that enhanced intracellular DOX release occurred in GSH pretreated Henrietta Lacks (HeLa) cells. In vitro methyl thiazolyl tetrazolium (MTT) assays indicated that the NGs were biocompatible, and DOX-loaded NG showed higher cellular proliferation inhibition towards GSH pretreated HeLa cells than that of non-pretreated cells. Therefore, the NGs can efficiently deliver anticancer drugs into tumor cells and inhibit cell proliferation, rendering highly promising for targeted intracellular delivery of operative chemotherapeutic drugs in cancer therapy.
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DOI
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
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2014
·
IF 2.235
Yong Liu,Yitao Wang,Cuiping Zhai,Weiping Chen,Congzhen Qiao
Novel heteropolyanion-based ionic liquids (HPA-ILs) were obtained by combining Keggin heteropolyanions and organic cations and used as catalysts for an esterification reaction. The kinetic behaviors in the esterification of diethylene glycol monobutyl ether (DGBE) with acetic acid in the presence of HPA-ILs as catalysts were investigated systemically. Different types of HPA-ILs were used for the esterification of DGBE. Compared with H2SO4, H3PW12O40, and Amberlyst-15 resins, [BSEt3N]3PW12O40 and [BSmim]3PW12O40 exhibited excellent catalytic activities. The influences of reaction temperature, catalyst dosage, and reactant molar ratio on the conversion of DGBE were studied in detail. The kinetic data were successfully correlated by a pseudohomogeneous (PH) model in the temperature range of 343.15–363.15 K. The simulation values obtained by the kinetic model were in good agreement with the experimental data. Moreover, [BSEt3N]3PW12O40 and [BSmim]3PW12O40 could be easily recovered and reused six times without any obvious decrease in catalytic activity.
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DOI
高影响因子
JOURNAL OF PHARMACY AND PHARMACOLOGY
·
2013
·Vol. 66
·期 4
·557-563
·
IF 2.033
Zhang Zhaoliang,Xu Lu,Chen Hao,Li Xingyi
ObjectivesAllograft rejection is the major cause of corneal graft failure. To inhibit corneal allograft rejection, rapamycin as a novel immunosuppressive agent has been discovered. However, the high water insolubility and low bioavailability of rapamycin has strongly hindered its application in the clinical setting. In this paper, we attempted to develop a novel rapamycin nano-formulation using poly(ε-caprolactone)-poly(ethylene glycol)-poly(ε-caprolactone) (PCEC) nanoparticles as carrier by an emulsion evaporation method for potential application in corneal transplantation.MethodsThe solubility of rapamycin in the nano-formulation was determined and in-vitro release studies were performed. The developed rapamycin-loaded PCEC nanoparticles were further characterized by dynamic light scattering, transmission electron microscopy, X-ray diffraction and differential scanning calorimetery. Toxicity studies were performed in eye-related cell lines.Key findingsThe rapamycin in nano-formulation exhibited ∼103-fold increased solubility as compared with native rapamycin. According to the results of the in-vitro cytotoxicity assay, the developed PCEC nanoparticles did not exhibit any apparent cytotoxicity against various eye-related cell lines with PCEC nanoparticle concentrations in the range of 0.05–10 mg/ml. In-vitro release study showed that the release of rapamycin was sustained from PCEC nanoparticles over a period of 48 h.ConclusionsAll the results suggested that the developed rapamycin-loaded PCEC nanoparticles might be suitable for immunosuppression in corneal transplantation by instillation administration.
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DOI
高影响因子
EJNMMI Research
·
2024
·Vol. 14
·期 1
·1-13
·
IF 3.1
Liu Yang,Xia Li,Li Haiyang,Cai Ping,Tang Sufan,Feng Yue,Liu Guangfu,Chen Yue,Liu Nan,Zhang Wei,Zhou Zhijun
Background Prostate cancer is the second most frequent cancer and the fifth leading cause of cancer-related deaths in men. Prostate-specific membrane antigen (PSMA) as a target has gained increasing attention. This research aims to investigate and understand how altering size of PEG impacts the in vitro and in vivo behavior and performance of PSMA inhibitors, with a specific focus on their pharmacokinetic characteristics and targeting properties. Results Two 68 Ga-labeled PSMA-targeted radiotracers were developed, namely [ 68 Ga]Ga-PP4-WD and [ 68 Ga]Ga-PP8-WD, with varying sizes of polyethylene glycol (PEG). [ 68 Ga]Ga-PP4-WD and [ 68 Ga]Ga-PP8-WD had excellent affinity for PSMA with IC50 being 8.06 ± 0.91, 6.13 ± 0.79 nM, respectively. Both tracers enabled clear visualization of LNCaP tumors in PET images with excellent tumor-to-background contrast. They also revealed highly efficient uptake and internalization into LNCaP cells, increasing over time. The biodistribution studies demonstrated that both radioligands exhibited significant and specific uptake into LNCaP tumors. Furthermore, they were rapidly cleared through the renal pathway, as evidenced by [ 68 Ga]Ga-PP4-WD and [ 68 Ga]Ga-PP8-WD showing a tenfold and a fivefold less in renal uptake, respectively, compared to [ 68 Ga]Ga-Flu-1 in 30 min. Both in vitro and in vivo experiments demonstrated that PEG size significantly impacted tumor-targeting and pharmacokinetic properties. Conclusions These radiotracers have demonstrated their effectiveness in significantly reducing kidney uptake while maintaining the absorbed dose in tumors. Both radiotracers exhibited strong binding and internalization characteristics in vitro, displayed high specificity and affinity for PSMA in vivo .
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高影响因子
IRANIAN POLYMER JOURNAL
·
2018
·Vol. 28
·期 1
·39-49
·
IF 1.278
Yang Zhouxiaoshuang,Zou Hu,Liu Hui,Xu Wenshuang,Zhang Lulu
To compare the synthesis and drug release of random and block copolymers, random and block copolymerizations of oligo(ethylene glycol)methyl ether methacrylate (OEGMA) and 1′-(2-methacryloxyethyl)-3′,3′-dimethyl-6-nitrospiro-(2H-1-benzopyran-2,2′-indoline) (SPMA) were carried out by atom transfer radical polymerization. The 1 H NMR and GPC results indicated the targeted random and block copolymers were successfully synthesized. Critical micelle concentrations of random and block copolymers were determined as 0.0178 mg/mL and 0.0265 mg/mL, and the micelle aggregation numbers of the random and block copolymers were calculated as approximately 17 and 13, respectively, indicating that more molecular chains were required to form a stable polymeric micelle for a random than its block copolymer. A lower critical solution temperature of 37 °C, the human body temperature, was obtained for two copolymer samples, suggesting that they might have potential application in the biomedical field. During the self-assembly, the morphology of block copolymer micelles was more regular than that of random copolymer, and both copolymers exhibited the exchange of hydrophilic and hydrophobic segments called as “Schizophrenic” behavior under UV light irradiation at 50 °C. With doxorubicin as a model molecule in drug release control, heating and ultraviolet light irradiation could accelerate the drug release process to some extent, indicating the potential application of the resulting random and block copolymers in drug release and bioengineering.
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PROGRESS IN ORGANIC COATINGS
·
2024
·
IF 6.5
Yuhan Zhang,Nan Xiao,Yanjing Gao,Fang Sun
This study introduces a novel p -diethylene glycol monomethyl ether cinnamyl formamide-based disulfide monomer , N,N′ -(disulfanediylbis(2,1-phenylene)) bis(4-(4-(2-(2-methoxyethoxy)ethoxy) phenyl)-2-oxobut-3-enamide) (Mp-BSCF), designed to reduce the volume shrinkage of photosensitive resins and initiate monomer polymerization under 455 nm LED light irradiation. The photochemical properties and photoinitiation efficiency of Mp-BSCF are systematically investigated using UV–vis absorption spectroscopy , electron paramagnetic resonance (EPR) and real-time infrared spectroscopy . Although its weak absorption around 455 nm, Mp-BSCF can generate arylthiyl radicals under 455 nm LED irradiation, and then effectively initiate the polymerization of triethylene glycol dimethacrylate (TEGDMA)/A glycerolate dimethacrylate (Bis-GMA) system. Increasing Mp-BSCF addition enhances the final double bond conversion and maximum polymerization rate of the TEGDMA/Bis-GMA system, reaching up to 82.0 % and 2.02 % s −1 , respectively. Notably, Mp-BSCF significantly reduces the volume shrinkage of the photopolymerization system, with the addition of 10 % Mp-BSCF resulting in a 50 % reduction compared to the control system. This reduction is attributed to the dynamic reversible nature of the S S bond “breaking-recovery” and the intermolecular hydrogen bond interaction. Additionally, Mp-BSCF improves the thermal stability, friction resistance, and hardness of the TEGDMA/Bis-GMA photopolymerization system.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2025
·
IF 9.7
Anqi Zhao,Wei Zhou,Xin Wang,Zhongjie Song,Nannan Zhang,Huan Zhang,Xinyu Gu,Jiawei Qiang,Zhengying Wu,Yong Wang,Yukou Du
Strong electronic interactions at the heterojunction interfaces of heterostructured catalysts can effectively regulate the electronic structure, optimize the adsorption of reactants and intermediates, and enhance the electrooxidation of alcohols. Due to this unique structural advantage, heterostructured catalysts are widely utilized as anode catalysts for alcohol fuel cells. However, the controlled synthesis of ternary metal heterostructures remains a significant challenge. In this study, we successfully synthesized Pt-PdPtFe ternary metal hetero-nanosheets (HNSs) using a seed-mediated method. The synergistic effects of the three metals, along with the strain effect at the heterojunction interface, contribute to the enhanced alcohol oxidation performance of Pt-PdPtFe HNSs compared to commercial Pd/C and numerous previously reported advanced catalysts. The mass activities for ethylene glycol oxidation reaction (EGOR) and glycerol oxidation reaction (GOR) are 9.77 A mg Pd+Pt −1 and 6.04 A mg Pd+Pt −1 , respectively. Furthermore, CO stripping tests and durability tests indicate that Pt-PdPtFe HNSs exhibit excellent anti-poisoning ability and cyclic stability. This research presents a viable strategy for the controlled synthesis of ternary metal heterostructures, while also offering valuable insights into the rational design of high-performance electrocatalysts.
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