Frontiers in Bioengineering and Biotechnology
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2024
·
IF 4.3
Rongyi Wang,Hongsen Li,Lu Han,Boao Han,Yiting Bao,Hongwei Fan,Chaoyue Sun,Ruijie Qian,Liying Ma,Jiajing Zhang
The mitochondria act as the main producers of reactive oxygen species (ROS) within cells. Elevated levels of ROS can activate the mitochondrial apoptotic pathway, leading to cell apoptosis. In this study, we devised a molecular prodrug named CTT 2 P, demonstrating notable efficacy in facilitating mitochondrial apoptosis. To develop nanomedicine, we enveloped CTT 2 P within bovine serum albumin (BSA), resulting in the formulation known as CTT 2 P@B. The molecular prodrug CTT 2 P is achieved by covalently conjugating mitochondrial targeting triphenylphosphine (PPh 3 ), photosensitizer TPPOH 2 , ROS-sensitive thioketal (TK), and chemotherapeutic drug camptothecin (CPT). The prodrug, which is chemically bonded, prevents the escape of drugs while they circulate throughout the body, guaranteeing the coordinated dispersion of both medications inside the organism. Additionally, the concurrent integration of targeted photodynamic therapy and cascade chemotherapy synergistically enhances the therapeutic efficacy of pharmaceutical agents. Experimental results indicated that the covalently attached prodrug significantly mitigated CPT cytotoxicity under dark conditions. In contrast, TPPOH 2 , CTT 2 , CTT 2 P, and CTT 2 P@B nanoparticles exhibited increasing tumor cell-killing effects and suppressed tumor growth when exposed to light at 660 nm with an intensity of 280 mW cm −2 . Consequently, this laser-triggered, mitochondria-targeted, combined photodynamic therapy and chemotherapy nano drug delivery system, adept at efficiently promoting mitochondrial apoptosis, presents a promising and innovative approach to cancer treatment.
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DESALINATION
·
2025
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IF 9.8
Yingqi Wang,Wenxin Lu,Hanyi Hou,Fei Yao,Xiaorui Li,Xin Du,Xingang Wang,Hongliang Dai,Hongya Geng
Widespread access to solar-driven steam generation requires monolithic structures with enhanced light absorption, water transportation, and heat allocation. However, the precise assembly of building blocks necessary for this integration remains a considerable challenge. This study develops a superior covalent tensor hydrogel (CTH) consisting of microgels prepared using a microfluidic device. Our self-semisacrificial approach employs chitosan and polyethene glycol as linkers to automatically assembly their microgels, which can be further precisely regulated through ultrasonic treatment and ultraviolet irradiation. The hierarchically porous CTH features a rough upper layer that enhances light absorption and a hierarchically porous hydrogel matrix that localizes heat, promoting energy absorption and thermal management. This design enhances interfacial solar light absorption and thermal insulation, with a low thermal conductivity of 0.3 W m −1 K −1 , achieving a maximum evaporation rate of 3.1 kg m −2 h −1 . The vertical distribution of microgels within CTH creates a gradient capillary force, effectively driving water transport to the interface and enabling self-cleaning properties for prolonged effective water evaporation. This CTH monolith represents a highly effective replacement for current hydrogels in effective green solar energy usage.
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JOURNAL OF ALLOYS AND COMPOUNDS
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2024
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IF 5.8
Liming Zeng,Yongyang Zhu,Daifeng Wu,Huayue Cheng,Qing Zhou
To improve the limited kinetics of alkaline hydrogen evolution reaction (HER), herein, a three-dimensional porous catalyst has been constructed based on the design concept of bi-directional electron modulation and chemical environment regulation of non-metallic and oxophilic transition metal elements with obvious differences in electronegativity on hybrid carbon layer-coated iridium/iridium oxide heterostructure. The Ir/IrO 2 @(N,S)-C possesses significantly superior catalytic activity and electrochemical stability towards alkaline HER with an overpotential of 150 mV reaching 50 mA cm −2 from LSV curve and an increment of 63 mV after 200 h of degradation test at 10 mA cm −2 in 1 M KOH, much lower than 277 mV and an elevation of 116 mV just after 25 h in 0.5 M H 2 SO 4 . The strongly electronegative non-metallic elements effectively modulate the electronic states of iridium/iridium oxide, the ratio of metallic states, and the oxophilic environment of the carbon layer, which enables the catalyst surface favorable for the moderate adsorption of water molecules and intermediates. The material engineering strategy offers a new insight for the development of high-performance catalysts towards water electrolysis based on homologous active species.
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CHEMICAL ENGINEERING JOURNAL
·
2024
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IF 13.3
Yudong Song,Yang Zou,Qingquan Zhao,Xinjian Shi,Shengyan Yin,Zhenning Liu,Hang Sun
Continuous and dependable underwater motion monitoring and communication are crucial for ensuring the safety of swimming, divers and underwater workers. We have developed a coral-inspired piezoresistive electronic skin (Melamine sponge-poly(pyrrole)-polydimethylsiloxane, MS-ppy-PDMS e-skin) for motion monitoring and underwater communication. The microstructure of the coral-like poly(pyrrole) and the PDMS acting as “limestone” make MS-ppy-PDMS e-skin superhydrophobic, stable (up to 80,000 cycles and acid and alkali resistance), and sensitive over a wide pressure sensing range (1–2,000 kPa). Moreover, MS-ppy-PDMS e-skin exhibits remarkable breathability, photothermal antibacterial efficacy, and biocompatibility, thereby increasing the comfort of wear while maintaining its outstanding sensing functionality. MS-ppy-PDMS e-skin exhibited dependable electrical signals output in motion monitoring tests on land and underwater. Most crucially, the combination of underwater communication commands captured by MS-ppy-PDMS e-skin with a multilayer perceptron (MLP) neural network allows for rapid and precise analysis and recognition, achieving a 99.38% accuracy rate in identifying underwater communication commands. This enables the realization of intelligent perception function, and is expected to further advance the development of human brain-like cognitive systems. Overall, the coral bionic MS-ppy-PDMS e-skin demonstrates tremendous application potential in the fields of motion monitoring and underwater communication.
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Polymers
·
2024
·Vol. 16
·期 8
·1160
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IF 4.7
Ahmed Elhassan,Xiaoshuang Lv,Ibrahim Abdalla,Jianyong Yu,Zhaoling Li,Bin Ding
Ever-increasing electromagnetic pollution largely affects human health, sensitive electronic equipment, and even military security, but current strategies used for developing functional attenuation materials cannot be achieved in a facile and cost-effective way. Here, a unique core-shell-like composite was successfully synthesized by a simple chemical approach and a rapid microwave-assisted carbonization process. The obtained composites show exceptional electromagnetic wave absorption (EMWA) properties, including a wide effective absorption band (EAB) of 4.64 GHz and a minimum reflection loss (RLmin) of −26 dB at 1.6 mm. The excellent performance can be attributed to the synergistic effects of conductive loss, dielectric loss, magnetic loss, and multiple reflection loss within the graphene-based core–shell-like composite. This work demonstrates a convenient, rapid, eco-friendly, and cost-effective method for synthesizing high-performance microwave absorption materials (MAMs).
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Food Chemistry-X
·
2024
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IF 6.5
Jingtao Wu,Yonghui Xia,Tianyu Wang,Yafeng Zhang,Guangli Li
An ultrasensitive and selective voltammetric platform combined a molecularly imprinted poly(pyrrole) membrane with Ag-nanoparticle-functionalized black phosphorus nanosheets (MIP/BPNS-AgNPs) was developed for trace GAT detection. The physicochemical properties of the MIP/BPNS-AgNPs were studied by various spectroscopic and electrochemical techniques. BPNS-AgNPs improved the ambient stability and electrochemical activity of the BPNS and possessed a large surface area for accommodating abundant templates to produce specific imprinted sites. The resulting MIP/BPNS-AgNP-modified glassy carbon electrode (GCE) greatly enhanced voltammetric responses for GAT. The MIP/BPNS-AgNP/GCE exhibited admirable GAT determination performance, with two linear responses (0.001–1 and 1–50 μM), high sensitivity (9.965 and 0.5378 μA μM −1 ), and a low detection limit of 0.2 nM. In addition, the MIP electrode could selectively detect GAT in complex matrices and retain roust responses for a month. The applicability of MIP/BPNS-AgNP/GCE toward the detection of GAT in pharmaceutical formulations, milk, and human serum was verified with satisfactory results.
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CHEMICAL ENGINEERING JOURNAL
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2024
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IF 13.3
Peng Lv,Yuqi Sheng,Yunrui Xie,Yaolin Hu,Hexuan Wang,Xintong Huo,Xiang Li,Haina Qi,Wensheng Yu,Xiangting Dong
Multi-functionalized thermochromic materials will greatly expand their application scopes. In this work, two functions of electrical conductivity and fluorescence are innovatively integrated into a thermochromic material by designing specific “macro + micro” Janus structures. Tri-functional thermochromic-anisotropic conductive-fluorescent thermochromic microcapsules-45 °C (TCM-45)/polymethyl methacrylate (PMMA) microfibers non-array&{[polypyrrole (PPy)/PMMA]//[Coumarin/PMMA] Janus microfibers array} up-down Janus film (named as TCFJAJF) is constructed by two-step electrospinning techniques of “single axis + parallel axis”. The up layer of TCFJAJF is TCM-45/PMMA microfibers non-array film (defined as U-TCFJAJF, viz. thermochromic layer) and the down layer of TCFJAJF is [PPy/PMMA]//[Coumarin/PMMA] Janus microfibers array film (denoted as D-TCFJAJF, viz. anisotropic conductive-fluorescent layer). The macroscopic up-down Janus structure eliminates the mutual influences between D-TCFJAJF and U-TCFJAJF. U-TCFJAJF has excellent color conversion and fading/coloring performances, achieving a reversible and multiple colors conversion from blue to white upon heating from 25 to 45 °C. A new concept of “transient thermal printing” is proposed based on fast thermal coloring/fading conversion of thermally printed patterns on film. Meanwhile, the microscopic Janus microfiber structure of D-TCFJAJF largely alleviates absorption to the excitation light and emission light of Coumarin by PPy and influence of Coumarin on conduction of PPy, ensuring the intense fluorescence and high conductivity. Due to the ordered arrangement of Janus microfibers, D-TCFJAJF has excellent anisotropic conductivity. As a demo application, TCFJAJF as a conductor can light up LED bulbs in a microcircuit and emit bright blue fluorescence under UV light excitation, achieving the working state visualization of the conductive microcircuit in dark surroundings. The multi-functionalized thermochromic film will have huge application prospects in fields of temperature monitoring, transient information reading and displaying, flexible electronics, fluorescent labeling and thermal-fluorescent dual encryption anti-counterfeiting, etc.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2024
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IF 7.7
Yashi Chen,Danlian Huang,Lei Liu
Against the backdrop of the post-COVID-19 era, the demand for masks has become increasingly steady, discarded masks have brought about new environmental problems due to the lack of effective means of disposal as well as recycling mechanisms. To solve this problem, we make secondary use of discarded polylactic acid (PLA) masks. The nanofiber multilayer membranes PLA/PDA/GO/PPy were synthesized by layer-by-layer self-assembly for flexible supercapacitors (SCs). The multiple coating on PLA significantly increases the capacitive performance. Optimization of the PLA/PDA/GO/PPy demonstrates capacitance up to 1331 mF cm −2 . Symmetric aqueous SCs using PLA/PDA/GO/PPy electrodes show higher energy density than other literature-reported SCs based on nanofiber multilayer membranes. In addition, we also explored the effects of discarded PLA/PDA/GO/PPy on the growth of ryegrass and canola in the soil. The exceptional combination of remarkable electrochemical properties and excellent environmental friendliness makes the PLA membrane promising for supercapacitors .
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JOURNAL OF MOLECULAR STRUCTURE
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2024
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IF 4
Pengfei Liao,Dengjie Zhong,Yunlan Xu,Ran Jiang,Jiayou Zhang,Yuanzhen He
In this work, in order to improve the adsorption capacity of chitosan for Cr(VI), a chitosan-based composite co-modified with lanthanum and polypyrrole (CS-La-PPy) was prepared and its effectiveness in removing Cr(VI) from aqueous solution was investigated. CS-La-PPy was characterized by FT-IR, XRD, BET, SEM, EDS and XPS. The successful synthesis of CS-La-PPy was confirmed by the presence of C=C (pyrrole ring) and La-O in the FT-IR spectrum. The effects of different adsorbent materials, dosage, initial pH, coexisting ions, adsorption time and temperature on the removal of Cr(VI) were investigated by batch experiments. The removal efficiency of 50 mL Cr(VI) with concentration of 150 mg L −1 by CS-La-PPy is 95.28 % at pH=2.0, T = 298 K. The adsorption process is spontaneous, which is consistent with pseudo-second-order kinetic model and Freundlich adsorption isotherm model. The maximum adsorption capacity is 321.96 mg g −1 . XPS analysis showed that the removal mechanism of Cr(VI) by CS-La-PPy was mainly based on the electrostatic adsorption between Cr(VI) and lanthanum, -NH 2 + , and -NH 3 + , the ion exchange between Cr(VI) and Cl − , the reduction of Cr(VI) to Cr(III) by PPy 0 and -OH groups, and the complexation between Cr(III) ions and COO- groups. This work provides a reference for the design and preparation of efficient chitosan-based adsorption materials.
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ACS Applied Materials & Interfaces
·
2024
·
IF 8.3
Luying Chen,Liushan Luo,Zhiping Mao,Bijia Wang,Xueling Feng,Xiaofeng Sui
Flexible electrothermal composite phase change materials (PCMs) are promising candidates for portable thermotherapy. However, a great challenge remains to achieve high PCM loading while maintaining reasonable flexibility. Herein, the polypyrrole-decorated melamine foam (PPy@MF) was fabricated and thereafter applied to confine binary PCM mixtures composed of a high-enthalpy long-chain polyethylene glycol (PEG4000) and its short-chain homologue (PEG200) to make the novel PPy@MF-PEG4000+200 composite PCM. At a high loading of up to 74.1% PEG4000 and a high latent heat energy storage density of 150.1 J/g, the composite PCM remained flexible at temperature (−20 °C) far below its phase transition point thanks to the plasticine effect of PEG200. The composite also demonstrated good Joule heating performance, providing fast heating from 28 to 70 °C at low applied voltages (4.5–6.0 V). The energy could be stored efficiently and released to maintain the composites at the proper temperature. The electrothermal performance of the composite remained undisturbed during curved or repeated bending, showing good potential to be used for personal thermal management and thermotherapy.
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RARE METALS
·
2025
·
IF 11
Yin Hong,Xiao Bo,Yu Zhi-Peng,Cunha Joao,Çaha İhsan,Zhang Tian-Qi,Hou Zhao-Hui,Li Gang-Yong
Cubic phase cobalt disulfide (CoS 2 ) is recognized as a potential negative material for sodium-ion batteries (SIBs) because of its low band gap, simple synthesis process, and high capacity. Nonetheless, the challenges of slow ion diffusion and substantial volume change during cycling, resulting in inadequate rate and cycling performances, remain unresolved. Here, a porous structure is fabricated by etching electrospun carbon nanofibers, subsequently facilitating the growth of CoS 2 nanoparticles at the pore locations. A nitrogen-doped carbon layer is then applied to the surface to buffer the volumetric expansion effect of CoS 2 . The findings indicate that the carbon nanofibers establish a stable conductive network, while the porous architecture of the carbon fibers, in conjunction with the carbon coating, efficiently mitigates volumetric expansion. Furthermore, density functional theory (DFT) studies show the presence of an interlayer van der Waals force between the sulfur atoms in CoS 2 and the carbon atoms, which reduces the band gap, enhances the conductivity of the structure, and lowers the energy barrier of Na + migration. The as-prepared anode achieves a reversible capacity of 302.6 mAh g −1 at 3.2 A g −1 and maintains a capacity of 384.6 mAh g −1 at 1.0 A g −1 over 800 cycles, demonstrating exceptional rate performance and improved cycling stability. This work shows that the combination of hierarchical porous architecture and a unique electronic structure offers valuable insights for designing high-performance negative materials for SIBs. Graphical abstract
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ACS Applied Materials & Interfaces
·
2024
·
IF 8.3
Rui Zhu,Peng Sun,Guofeng Cui,Jie Zhao,Yaoguang Yu
Ion transportation via the mixed mechanisms of hydrogels underpins ultrafast biological signal transmission in nature, and its application to the rapid and sensitive sensing detection of human specific ions is of great interest for the field of medical science. However, current research efforts are still unable to achieve transmission results that are comparable to those of bioelectric signals. Herein, 3D interconnected nanochannels based on poly(pyrrole-co-dopamine)/poly(vinyl alcohol) (P(Py-co-DA)/PVA) supernetwork conductive hydrogels are designed and fabricated as stimuli-responsive structures for K+ ions. Distinct from conventional configurations, which exhibit rapid electron transfer and permeability to biosubstrates, interconnected nanofluidic nanochannels collaborated with the P(Py-co-DA) conductive polymer in the supernetwork conductive hydrogel significantly improve conductivity (88.3 mS/cm), ion transport time (0.1 s), and ion sensitivity (74.6 mV/dec). The faster ion response time is attributed to the synergism of excellent conductivity originating from the P(Py-co-DA) polymer and the electronic effect in the interconnected nanofluidic channels. Furthermore, the supernetwork conductive hydrogel demonstrates K+ ion selectivity relative to other cations in biofluids such as Na+, Mg2+, and Ca2+. The DFT calculation indicates that the small solvation energy and low chemical transfer resistance are the main reasons for the excellent K+ ion selectivity. Finite element analysis (FEA) simulations further support these experimental results. Consequently, the P(Py-co-DA)/PVA supernetwork conductive hydrogels enriched with the 3D interconnected nanofluidic channels developed in this work possess excellent sensing of K+ ions. This strategy provides great insight into efficient ion sensing in traditional biomedical sensing that has not been explored by previous researchers.
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危险品化学品经营许可证（带存储）