INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2024
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IF 7.7
Peiyao Wang,Yupeng Lv,Xinhui Hou,Xiaoluan Yang,Qian Tao,Guiying Li
Fluorescent probe with aggregation-induced emission (AIE) property has been widely used because of the advantages of high sensitivity, good selectivity and non-destructive testing. The development of fluorescent probe with good biocompatibility, photostability and biodegradability is of great significance in biomedicine and environmental detection. Herein, a novel type of fluorophore CS-TPE for detection of Fe 3+ and bacteria was prepared by the Schiff base reaction of chitosan (CS) and 4-(1,2,2-triphenylethenyl) benzaldehyde (TPE-CHO). The fluorescence response mechanism of CS-TPE system was investigated by various characterization techniques. CS-TPE had an obvious AIE behavior with strong blue-green emissions at 473 nm and reaches the highest photoluminescence (PL) emission in 90 % H 2 O/ethanol mixtures. CS-TPE fluorescent probe exhibited sensitive quenching response to Fe 3+ , which can be used as a biosensor for detecting the concentration of Fe 3+ with short response time (5 min), low detection limit (0.998 μM) and wide detection range (10–300 μM). Meanwhile, CS-TPE exhibited good antibacterial performance for S. aureus and E. coli . It is expected to realize the real-time fluorescence monitoring of metal ion detection and antibacterial process.
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LWT-FOOD SCIENCE AND TECHNOLOGY
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2025
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IF 6.6
Limin Wang,Qianfei Jia,Yuan Li,Hui Zhao,Zijian Wu
This study investigated the chitosan (CS)-octenyl succinic anhydride (OSA) starch complex as a stabilizer for Pickering emulsions. The effects of OSA concentration (0.5wt%-2.5wt%) and viscosity (OSA1, OSA2, OSA3) on the stability and physiochemical properties of emulsion were examined. The results showed that CS-OSA with 2.0wt% concentration OSA stabilized emulsion exhibited optimal emulsifying capacity. Contact angle analysis, Fourier transform infrared spectrometer (FTIR) and X-difference diffractometer (XRD) were utilized to explore the stabilized mechanism of CS-OSA on emulsion, results confirmed the CS and OSA interactions, and strong adsorption of CS-OSA particles at the oil-water interface. Furthermore, CS-OSA stabilized emulsion loading curcumin were assessed, results showed that curcumin loaded emulsion exhibited high stability and better antioxidant capacity than free CS during 10-day storage. The overall study offers valuable insights into the utilization of CS-OSA emulsifiers in delivery application for lipophilic bioactive molecules.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2025
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IF 8.5
Huajuan Wang,Tian Shi,Jiale Ma,Shutong Meng,Ziyu Wei,Ying Sun,Hongxun Wang,Min Zhou
In this work, a nanocomposite film, designated as CS/PA, was fabricated by integrating chitosan (CS), porphyrinic porous coordination network (PCN), and silver nanoparticles (AgNPs). PCN modified AgNPs was denoted as PCN-AgNPs (PA). The synthesis of PA was verified through transmission electron microscope, Zeta potential, hydrated particle size, element mapping. Furthermore, varying concentrations of PA (0.3 %, 0.4 %, 0.5 %, and 0.6 % w /w) were integrated into the CS matrix to preparate the CS/PA nanocomposite film. The experimental data demonstrated a significant enhancement ( p < 0.05) in the tensile strength and elongation at break of the nanocomposite films, while water vapor permeability and water solubility significantly decreased (p < 0.05) as the PA content increased. Additionally, the CS/PA film showed good antibacterial properties against both gram-positive ( Staphylococcus aureus ) and gram-negative ( Escherichia coli ) bacteria. Notably, the CS/PA film effectively retarded the spoilage of fresh fish slices. The silver migration from the CS/PA film, measured at 33.02 μg/L, was found to be within the permissible limits set by the USEPA. Consequently, the CS/PA nanocomposite film holds immense promise for applications in food packaging industry.
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CARBOHYDRATE POLYMERS
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2024
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IF 10.7
Xuelian Wei,Caikun Liu,Zhiqian Li,Zhengxiang Gu,Junxiao Yang,Kui Luo
A long-term inflammatory phase of diabetic wounds is the primary cause to prevent their effective healing. Bacterial infection, excess reactive oxygen species (ROS), especially failure of M2-phenotype macrophage polarization can hinder the transition of diabetic wounds from an inflammation phase to a proliferation one. Herein, a chitosan-based hydrogel dressing with the ability of regulating M2 macrophage polarization was reported. The PAAc/CFCS-Vanillin hydrogel dressing was synthesized by one step thermal polymerization of catechol-functionalized chitosan (CFCS), acrylic acid , catechol functional methacryloyl chitosan‑silver nanoparticles (CFMC-Ag NPs) and bioactive vanillin. The PAAc/CFCS-Vanillin hydrogel possessed sufficient mechanical strength and excellent adhesion properties, which helped rapidly block bleeding of wounds. Thanks to CFCS , CFMC-Ag NPs and vanillin in the hydrogel, it displayed excellent antibacterial infection in the wounds. Vanillin helped scavenge excess ROS and regulate the levels of inflammatory factors to facilitate the polarization of macrophages into the M2 phenotype. A full-thickness skin defect diabetic wound model showed that the wounds treated by the PAAc/CFCS-Vanillin hydrogel exhibited the smallest wound area, and superior granulation tissue regeneration , remarkable collagen deposition, and angiogenesis were observed in the wound tissue. Therefore, the PAAc/CFCS-Vanillin hydrogel could hold promising potential as a dressing for the treatment of diabetic chronic wounds.
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Marine Drugs
·
2025
·Vol. 23
·期 3
·134
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IF 5.4
Yanglong Liu,Jiawei Sun,Qihao Yan,Bingjian Wen,Yan Bai,Qishi Che,Hua Cao,Jiao Guo,Zhengquan Su
Alcoholic liver disease (ALD) is a liver disorder resulting from excessive alcohol intake, and currently, there are no therapeutics approved by the FDA for its treatment. This study investigates the protective effects and underlying pharmacological mechanisms of two chitosan oligosaccharides, COST (MW ≤ 1000 Da) and COSM (MW ≤ 3000 Da), in mitigating alcohol-induced liver disease (ALD). In animal models, we evaluated the changes in ALD following treatment with COST and COSM. Histopathological analysis revealed that both COST and COSM interventions mitigated hepatic steatosis and inflammatory infiltration. Additionally, these compounds reduced various markers of liver injury, enhanced antioxidant enzyme levels, and significantly improved liver function. Western blot analysis demonstrated that COSM markedly decreased the expression of the hepatic metabolic enzyme CYP2E1, activated the Keap-1/Nrf-2/HO-1 pathway, and restrained the NF-κB and MAPK pathways. In an in vitro model of alcohol-induced hepatocyte L02 injury, both COST and COSM exhibited protective effects on hepatocytes, corroborating the findings from the animal studies. Collectively, in vivo and in vitro experiments confirmed that COST and COSM can reduce oxidative damage, enhance antioxidant capacity, and ameliorate steatosis and inflammatory damage in the liver, thereby significantly attenuating alcohol-induced injury. Notably, COSM exhibited slightly superior efficacy compared to COST.
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BIOMACROMOLECULES
·
2024
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IF 5.5
Wei Gao,Huichun Kang,Ming Zhong,Lijuan Han,Xue Guo,Bitao Su,Ziqiang Lei
The loading of photocatalysts on hydrogels can significantly reduce the loss of catalysts and effectively prevent secondary contamination, thus demonstrating great application potential and advantages in the field of wastewater treatment, especially in the removal of dyes. Herein, the semiconductor TiO2 was successfully loaded into a polyacrylic acid/chitosan (PAA/CS) double-network (DN) hydrogel, which exhibited superior removal of dyes in wastewater such as MG, MB, MV, and RhB. The dye degradation process followed first-order kinetics, and the first-order rate constants for dye degradation were further calculated under UV light irradiation. Furthermore, the photocatalytic mechanism of the hydrogel was explored and analyzed. More interestingly, the PAA/CS-TiO2 DN hydrogel has excellent tensile properties and superior electrical conductivity, which can be assembled into flexible sensors for real-time monitoring of mechanical deformations and human joint motions. It is envisioned that these excellent properties make hydrogel photocatalysts promising for a wide range of applications.
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JOURNAL OF APPLIED POLYMER SCIENCE
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2012
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IF 1.289
Yu Yi,Canlin Lai,Yuqi Jiang,Jianfeng Mei,Hong Wang,Guoqing Ying
In this article, we present a novel amino-reserved magnetic chitosan microsphere (ARMCM) prepared from chitosan and Fe 3 O 4 through inverse suspension crosslinking by formaldehyde and epichlorohydrin. The density of ARMCM was 1.47 g/mL, and the amino content was 2.44 mmol/g. The measurements data indicated that the saturation magnetization (σ s ) of ARMCM was 23.2 emu/g. The adsorption results showed that these magnetic chitosan microspheres had good adsorption capacity on endotoxin: the maximum absorption capacity was about 1792.1EU/g in 40 min; the endotoxin adsorption efficiency in the protein solution was close to 80% and what is more, protein adsorption efficiency was only 23.2 and 2.0%, respectively, for acidic and basic proteins. It is expected that this ARMCM will have a feasible and useful application in adsorbing endotoxin from biological products. © 2012 Wiley Periodicals, Inc. J Appl Polym Sci, 2012
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RSC Advances
·
2015
·Vol. 5
·期 83
·68200-68208
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IF 3.84
Yuezhong Wen,Ying Liang,Chensi Shen,Hongkai Wang,Dongmei Fu,Hongyu Wang
A green efficient strategy for the combination of biodegradation and adsorption methods is urgently desired nowadays to degrade dyes in an economical and effective way. In this study, a kind of novel, environmentally friendly and efficient hybrid for the fungus and chitosan–Fe membrane has been fabricated by the alginate approach. Myrothecium verrucaria I-5 and C-1, deuteromycete fungi capable of producing laccase to degrade dyes, have been used. It is found that the chitosan–Fe membrane can excellently immobilize the fungi mycelia and enzyme, and after the immobilization, the fungi and enzyme still maintain a high activity after the dye decolorization. Also, the immobilized fungi membranes have been proved to have a high efficiency for dye decolorization. Simultaneously, the decolorization ability of the crude enzymes, which are extracted from I-5 and C-1 medium, and the decolorization ability of chitosan–Fe membrane are also investigated, respectively. The results demonstrate that the dyes can be removed by the fungi and the membrane synergistically. In addition, different kinds of dyes are successfully removed with chitosan–Fe immobilized fungi membranes. These results demonstrate that dyes are first adsorbed on the chitosan–Fe membrane, decreasing the toxicity to the fungus, and then bio-degraded by the laccase produced from the fungi on the membrane.
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JOURNAL OF APPLIED POLYMER SCIENCE
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2015
·Vol. 132
·期 32
·
IF 1.768
Zhengyan Tan,Hong Peng,Hongfang Liu,Linling Wang,Jing Chen,Xiaohua Lu
A novel magnetic adsorbent (EDTA /chitosan/ PMMS) was facilely prepared by reacting chitosan with EDTA anhydride in presence of PEI - coated magnetic microspheres. The as-synthesized EDTA/ chitosan /PMMS was characterized by XRD, SEM, TGA, FT-IR , and VSM, and then employed in removal of heavy metals of Pb(II) from aqueous solution. The results of the batch adsorption experiments revealed that the adsorbents had extremely high uptake capacities for Pb(II) in the pH range of 2 to 5.5, and the adsorption kinetics for EDTA/ chitosan /PMMS was consistent with the pseudo – second - order kinetic model. Moreover, its equilibrium data were fitted with the Langmuir isothermal model well, which indicated that the adsorption mechanism was a homogeneous monolayer chemisorptions process. The maximum adsorption capacity of EDTA/ chitosan /PMMS for Pb(II) was found to be 210 mg g − 1 at pH 4 (30 ° C), and further reuse experiments results suggested that EDTA /chitosan/ PMMS could be a potential recyclable magnetic adsorbent in the practical wastewater treatment. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015 , 132 , 42384.
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FOOD CONTROL
·
2015
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IF 2.806
Zhiyong Zhao,Na Liu,Lingchen Yang,Jianhua Wang,Suquan Song,Dongxia Nie,Xianli Yang,Jiafa Hou,Aibo Wu
The primary objective of this study was to synthesize three types of cross-linked chitosan polymers and further investigate their adsorption capability for multiple mycotoxins , including aflatoxin B 1 (AFB 1 ), ochratoxin A (OTA), zearalenone (ZEN), fumonisin B 1 (FB 1 ), deoxynivalenol (DON) and T-2 toxin (T2). Among these synthetic adsorbents, cross-linked chitosan-glutaraldehyde complex presented the highest adsorption capability for AFB 1 (73%), OTA (97%), ZEN (94%) and FB 1 (99%), but no obvious adsorption for DON and T2 (<30%). The effect of various incubation conditions (contact time, dosage and pH) was also studied. Subsequently, the experimental data were fitted to Langmuir, Freundlich and Hill models. The best fitting model to describe AFB 1 and FB 1 adsorption was Langmuir model ( R 2 ≥ 0.99), with the theoretical maximum adsorption amounts of 5.67 mg/g for AFB 1 and 15.7 mg/g for FB 1 . The Hill model was the best model for OTA and ZEN adsorption ( R 2 > 0.98), with the predicted maximum adsorption amounts were 24.8 mg/g for OTA and 9.18 mg/g for ZEN. In addition, the adsorption capability of adsorbent for the simultaneous presence of multiple mycotoxins was also evaluated in buffer system and simulated gastrointestinal condition. The results indicated that the coexisted multiple mycotoxins didn't affected the adsorption capability of adsorbent, whereas the adsorption amounts of toxins were decreased by some gastrointestinal components. The findings of this research suggest that chitosan–glutaraldehyde complex has the potential to be applied as multitoxin adsorbent material for reducing the combined adverse effect of multiple mycotoxins on humans and animals.
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INTERNATIONAL JOURNAL OF PHARMACEUTICS
·
2016
·
IF 3.994
Juntao Yin,Cuiyu Xiang,Xiaoyong Song
Psoralidin (PL) has recently been attracting more attention as a new anticancer agent candidate. Nevertheless, peroral administration of PL is largely challenged by its insoluble nature and intestinal efflux. This article aimed to develop a nanoencapsulation formulation of PL using water-soluble chitosan and Eudragit S100 and to evaluate its potential for bioavailability enhancement. PL-loaded nanocapsules (PL-NCs) were prepared by a solvent diffusion and high-pressure homogenization technique with Poloxamer 188 as a stabilizer. The resultant PL-NCs were approximately 132.5 nm in particle size and possessed a high entrapment efficiency (98.1%). In vitro release showed that PL was released less from the nanocapsules due to electrostatic complexation. A lipolytic experiment demonstrated that our prepared PL-NCs were not degraded by lipase , in contrast with the most commonly used lipid nanoparticles. Furthermore, PL-NCs appeared to have less affinity for intestinal mucins. Following oral administration, the bioavailability of PL was significantly enhanced via the PL-NCs, with a value of 339.02% relative to the reference (suspensions). Excellent intestinal adhesion and transepithelial permeability accounted for the enhancement of oral bioavailability. Taken together, these results indicate that nanoencapsulation of PL with chitosan and Eudragit S100 is a promising strategy for improved PL oral delivery.
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CARBOHYDRATE POLYMERS
·
2016
·
IF 4.219
Zhong Lu,Jingting Gao,Qingfeng He,Jie Wu,Donghui Liang,Hao Yang,Rong Chen
Nano Ag/ZnO hybrid material has been considered to be a promising nanocomposites for biomedical application because it has enhanced antibacterial activity and low cytotoxicity. Here a sponge-like nano Ag/ZnO-loaded chitosan composite dressing was first synthesized via preparing a chitosan sponge by lyophilization process, followed by the incorporation of Ag/ZnO nanocomposites into chitosan sponge. The porosity, swelling, blood clotting and in vitro antibacterial activity against drug-sensitive and drug-resistant pathogenic bacteria were evaluated. The results demonstrate that the prepared composite dressing shows high porosity and swelling as well as enhanced blood clotting and antibacterial activity. Cytocompatibility test evaluated in vitro illustrates the very low toxic nature of the composite dressing. Furthermore, the in vivo evaluation in mice reveals that the chitosan-Ag/ZnO composite dressing enhances the wound healing and promotes re-epithelialization and collagen deposition. These results strongly support the possibility of using this novel chitosan-AgZnO composite dressing for wound care application.
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