HIGH PERFORMANCE POLYMERS
·
2019
·
IF 1.584
Huabo Huang,Renpeng Chen,Shuaiyi Yang,Liang Li,Yulan Liu,Juan Huang
To obtain the promising pseudocapacitance of MnO2, the composite hydrogel of MnO2 and polyaniline (PANI) was fabricated using in situ polymerization of aniline hydrochloride in the aqueous solution containing commercial MnO2 nanoparticles and additives. Both scanning electron microscopy and transmission electron microscopy results indicated that the composite hydrogel exhibited a 3-D porous structure, within which MnO2 nanoparticles were uniformly embedded. The investigations of cyclic voltammetry, galvanostatic charge−discharge, and electrochemical impedance spectroscopy demonstrated superior supercapacitor (SC) performance of the hydrogel electrode even with high loading. The electrode with loading of 1.5 mg cm–2 showed a favorable specific capacitance (293 F g–1, 10 mV s–1), which only decreased to 258 F g–1 when the loading of the electrode was seven times higher (10.8 mg cm–2). Furthermore, the hydrogel electrode displayed good cycle stability in the acidic solution (81% capacitance retention after 1000 charge/discharge cycles). The favorable electrochemical performance of the composite hydrogel should be attributed to the fast electron/ion transport and good protection for MnO2 in the 3-D porous structure. Due to the facile one-pot synthesis and optimized nanostructure, it could be expected that MnO2-embedded 3-D porous PANI composite hydrogels have great application in the field of high-performance electrode with high loading for SCs.
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Energy Technology
·
2018
·Vol. 6
·期 9
·1755-1762
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IF 3.175
Kai Wu,Wenjun Ying,Zhengjun Shi,Haiyan Yang,ZhiFeng Zheng,JiaYan Zhang,Jing Yang
To screen and evaluate possible functional factors in the bamboo lignin moiety that could block non-productive adsorption of enzyme proteins on lignin, milled wood lignin (MWL) and Fenton oxidized lignin (FOLs) were prepared and incorporated in the enzymatic hydrolysis of Avicel. The addition of MWL decreased the 72 h glucose yields of cellulose from 57.1 % to 45.3 %, while FOLs effectively improved the enzymatic digestibility up to 69.5 %, which was 22 % higher than the system without the use of FOLs. The adsorption affinity and binding strength of cellulase with FOLs were lower than that with MWL. After Fenton pretreatment, hydrophilicity of lignins increased due to formation of C−O− and O−C=O bonds. Furthermore, high surface negative charges on FOLs resulted in strong electrostatic repulsion against the negatively charged cellulases. Finally, analysis of FOLs with 13C and 2D-HSQC NMR indicated that the cleavage of β-O-4 linkages and demethoxylation occurred, and that less condensed structures at the C β and C γ positions were observed. These oxidation reactions of the bamboo lignin lead to the formation of functional factors to alleviate irreversible adsorption of cellulase onto FOLs, and thus were responsible for promoting enzymatic digestibility efficiency.
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INTERNATIONAL POLYMER PROCESSING
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2018
·Vol. 33
·期 1
·127-134
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IF 0.535
L. Q. Xu,Y. Q. Zhao
Commercial poly(l-lactic acid) (PLLA) was blended with different contents of graphene oxide-graft-poly(d-lactic acid) (GO-g-PDLA), which was synthesized via ring-opening polymerization using modified GO as initiator. PLLA and PLLA/GO-g-PDLA blend foams were prepared in a batch process via varying-temperature mode using supercritical carbon dioxide as physical foaming agent. The results showed that the addition of GO-g-PDLA in PLLA leads to the formation of stereocomplex (sc)-crystallites. Increase in the GO-g-PDLA content enhances the IR absorption, diffraction peak and melting peak corresponding to the sc-crystallites. The addition of GO-g-PDLA to PLLA leads to the decrease of the cell diameter, increase of the cell density and to a little change in expansion ratio, which is attributed to the fact that the enhancement of PLLA crystallization restricts cell growth and GO-g-PDLA acts as nucleation point.
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Inorganic Chemistry Frontiers
·
2024
·Vol. 11
·期 13
·3975-3983
·
IF 6.1
Huiqin Yu,Fang Li,Jing Cao,Shifu Chen,Haili Lin
Developing highly active and stable bifunctional electrocatalysts for the oxidation of alcohols is critical for energy and chemical conversion. Herein, a NiCo2O4 nanowire on ultrathin porous carbon (NiCo2O4/C) was fabricated and exhibits superior electrocatalytic performance for both hydrogen evolution and benzyl alcohol (BA) oxidation in comparison with pristine NiCo2O4 free of carbon. It only needed 1.36 V vs. RHE to afford a current density of 50 mA cm−2 for BA oxidation. The overpotential for the HER (η10) is −93.0 mV vs. RHE. Furthermore, high yield (96.0%) and faradaic efficiency (98.6%) of benzoic acid were achieved in 10 consecutive stability tests. The outstanding electrocatalytic activity can be attributed to the following aspects: (1) the hierarchical architecture exposed more catalytic active sites and enhanced mass transport; (2) ultrathin porous carbon strengthened the affinity for the reaction medium; (3) strong electronic interactions optimized the energy band structure. DFT simulations proved that the Gibbs free energy of the rate-determining step was reduced when coupling with ultrathin porous carbon, thus lowering the energy barrier and accelerating the reaction process. Theoretical calculations further reveal that the moderate downshift in the Ed energy levels, which balance the adsorption and desorption of the intermediates, is the intrinsic reason for the promoted oxidation activity. This work could provide valuable insights into the design of highly efficient bifunctional electrocatalysts.
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Journal of Magnetic Resonance Open
·
2025
·
IF 2
Bowen Han,Jing He,Shaohua Huang
Chiral amino acids play an indispensable role in living organisms. Diffusion-ordered NMR spectroscopy is an effective NMR tool and a noninvasive analytical method for the analyses of mixture without the need for physical separation of the analytes. However, conventional diffusion-ordered NMR spectroscopy method usually fails to resolve the mixtures of chiral amino acids because of their same molecular masses, sizes, and shapes. Microcrystalline cellulose has been gradually gained more and more interest owing to its wide compatibility, surface area, excellent separation efficiency, non-toxicity, cost-effective, and mechanical stability in many fields. Herein we provide a fast, simple, specific and sensitive method to resolve some D and L-amino acids mixtures by using microcrystalline cellulose as a matrix. This work recognized some D and L- proteinogenic amino acid enantiomers with diffusion-ordered NMR for the first time.
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International Journal of Nanomedicine
·
2016
·
IF 4.32
Jinyang Shen,Jianping Bi,Hongli Tian,Ye Jin,Yuan Wang,Xiaolin Yang,Zhonglin Yang,Junping Kou,Fei Li
Background Akebia saponin D (ASD) exerts various pharmacological activities but with poor oral bioavailability. In this study, a self-nanoemulsifying drug delivery system (SNEDDS) based on the drug–phospholipid complex technique was developed to improve the oral absorption of ASD.Methods ASD–phospholipid complex (APC) was prepared using a solvent-evaporation method and characterized by infrared spectroscopy, differential scanning calorimetry, morphology observation, and solubility test. Oil and cosurfactant were selected according to their ability to dissolve APC, while surfactant was chosen based on its emulsification efficiency in SNEDDS. Pseudoternary phase diagrams were constructed to determine the optimized APC-SNEDDS formulation, which was characterized by droplet size determination, zeta potential determination, and morphology observation. Robustness to dilution and thermodynamic stability of optimized formulation were also evaluated. Subsequently, pharmacokinetic parameters and oral bioavailability of ASD, APC, and APC-SNEDDS were investigated in rats.Results The liposolubility significantly increased 11.4-fold after formation of APC, which was verified by the solubility test in n-octanol. Peceol (Glyceryl monooleate [type 40]), Cremophor® EL (Polyoxyl 35 castor oil), and Transcutol HP (Diethylene glycol monoethyl ether) were selected as oil, surfactant, and cosurfactant, respectively. The optimal formulation was composed of Glyceryl monooleate (type 40), Polyoxyl 35 castor oil, Diethylene glycol monoethyl ether, and APC (1:4.5:4.5:1.74, w/w/w/w), which showed a particle size of 148.0±2.7 nm and a zeta potential of −13.7±0.92 mV after dilution with distilled water at a ratio of 1:100 (w/w) and good colloidal stability. Pharmacokinetic studies showed that APC-SNEDDS exhibited a significantly greater Cmax1 (733.4±203.8 ng/mL) than ASD (437.2±174.2 ng/mL), and a greater Cmax2 (985.8±366.6 ng/mL) than ASD (180.5±75.1 ng/mL) and APC (549.7±113.5 ng/mL). Compared with ASD, Tmax1 and Tmax2 were both remarkably shortened by APC-SNEDDS. The oral bioavailability in rats was enhanced significantly to 183.8% and 431.8% by APC and APC-SNEDDS, respectively.Conclusion These results indicated that APC-SNEDDS was a promising drug delivery system to enhance the oral bioavailability of ASD.
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PubMed
高影响因子
CELLULAR AND MOLECULAR NEUROBIOLOGY
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2016
·Vol. 36
·期 8
·1365-1375
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IF 2.328
Lin Xuemei,Wu Songdi,Wang Qing,Shi Yaling,Liu Guozheng,Zhi Jin,Wang Fang
Neuronal oxidative stress (OS) injury has been proven to be associated with many neurodegenerative diseases, and thus, antioxidation treatment is an effective method for treating these diseases. Saikosaponin-D (SSD) is a sapogenin extracted from Bupleurum falcatum and has been shown to have many pharmacological activities. The main purpose of this study was to investigate whether and how SSD protects PC12 cells from H 2 O 2 -induced apoptosis. The non-toxic level of SSD significantly mitigated the H 2 O 2 -induced decrease in cell viability, reduced the apoptosis rate, improved the nuclear morphology, and reduced caspase-3 activation and poly ADP-ribose polymerase (PARP) cleavage. Additionally, exogenous H 2 O 2 -induced apoptosis by damaging the intracellular antioxidation system. SSD significantly slowed the H 2 O 2 -induced release of malonic dialdehyde (MDA) and lactate dehydrogenase and increased the activity of superoxide dismutase (SOD) and the total antioxidant capacity, thereby reducing apoptosis. More importantly, SSD effectively blocked H 2 O 2 -induced phosphorylation of extracellular-regulated kinase (ERK), c-Jun N-terminal kinase (JNK), and p38 mitogen-activated protein kinase (p38MAPK), and specific inhibitors of ERK, JNK, and p38-reduced OS injury and apoptosis, suggesting that SSD reduces OS injury and apoptosis via MAPK signalling pathways. Finally, we confirmed that SSD significantly reduced H 2 O 2 -induced reactive oxygen species (ROS) accumulation, and the ROS inhibitor blocked the apoptosis caused by MAPK activation and cellular oxidative damage. In short, our study confirmed that SSD reduces H 2 O 2 -induced PC12 cell apoptosis by removing ROS and blocking MAPK-dependent oxidative damage.
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SYNTHETIC METALS
·
2013
·
IF 2.109
Wang Gang,Tan Haijun,Zhang Yiping,Wu Yingying,Hu Zhubin,Yu Guipeng,Pan Chunyue
Novel D-π-A system organic dyes (ID1, ID2 and ID3) based on isoindigo (ID), which contain triphenylamine (ID1) or isoindigo (ID2 and ID3) as electron donors, isoindigo and thiophene as a π-conjugated system and a cyanoacrylic acid moiety as an electron acceptor and anchoring group, have been then synthesized and characterized by 1 H NMR, UV–vis, CV. Dye-sensitized solar cells (DSSCs) based on these dyes were also fabricated and tested. As the photovoltaic performance tests demonstrated, the ID1 exhibits broader absorption spectra , higher maximum incident photon-to-current conversion efficiency (IPCE) and maximum photon-to-electron conversion efficiency ( η ) of 3.33% under 100 mW/cm 2 simulated AM 1.5G solar irradiation.
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Analytical Methods
·
2015
·Vol. 7
·期 7
·3022-3027
·
IF 1.821
Bingdi Liu,Xin Zhang,Yaping Ding,Liqiang Luo,Fenfen Zhang
A new chiral biosensor fabricated by immobilizing bovine serum albumin (BSA) on gold-nanoparticle-modified glassy carbon electrodes, which could discriminate and detect phenylalanine (Phe) enantiomers, was proposed for the first time. The enantioselectivity was characterized by using scanning electron microscopy, cyclic voltammetry, electrochemical impedance spectroscopy and square wave voltammetry. The results showed that the BSA-modified electrode could enantioselectively recognize Phe enantiomers, and larger response signals were obtained from L-Phe. The factors influencing the performance of the biosensor were investigated. The enantiomeric composition of the L-/D-Phe mixture could be determined from the calibration curves. The modified electrodes have the advantages of simple operation, rapid detection and low cost.
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JOURNAL OF BIOTECHNOLOGY
·
2024
·
IF 4.1
Yufeng Zhou,Xiaolong Sun,Jiahuan Hu,Yingjie Miao,Xiangyu Zi,Xi Luo,Yongqian Fu
Serving as a vital medical intermediate and an environmentally-friendly preservative, D-PLA exhibits substantial potential across various industries. In this report, the urgent need for efficient production motivated us to achieve the rational design of lactate dehydrogenase and enhance catalytic efficiency . Surprisingly, the enzymatic properties revealed that a mutant enzyme , Lr LDH T247I/D249A/F306W/A214Y ( Lr LDH-M 1 ), had a viable catalytic advantage. It demonstrated a 3.3-fold increase in specific enzyme activity and approximately a 2.08-fold improvement of K cat . Correspondingly, molecular docking analysis provided a supporting explanation for the lower K m and higher K cat /K m of the mutant enzyme. Thermostability analysis exhibited increased half-lives and the deactivation rate constants decreased at different temperatures (1.47–2.26-fold). In addition, the mutant showed excellent resistance abilities in harsh environments, particularly under acidic conditions. Then, a two-bacterium ( E. coli /pET28a- lrldh -M 1 and E. coli /pET28a- ladd ) coupled catalytic system was developed and realized a significant conversion rate (77.7%) of D-phenyllactic acid, using 10 g/L L-phenylalanine as the substrate in a two-step cascade reaction.
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JOURNAL OF MEMBRANE SCIENCE
·
2024
·
IF 8.4
Nan Sun,Huan Wang,Huazhang Zhao,Fangqin Cheng,Jianfeng Li
Low flux and membrane fouling are major challenges in membrane distillation (MD) for treating concentrated wastewater. This study compared the performance of GO composite membranes with different interlayer distances , by covalently bonding the terminal amine groups of ethylenediamine (EDA) and 1,12-diaminododecane (DADD) with the carboxyl groups present on the GO sheets. The results indicated that the GO-DADD/PTFE membrane, with longer carbon chain cross-linking, achieved the highest flux and antifouling properties. At 70 °C, the pure water flux reached 68.5 kg/m 2 ·h, and the fluxes for treating NaCl, HA containing NaCl, and BSA containing NaCl were 29.8 %, 37.1 %, and 38.5 % higher than the uncrosslinked GO/PTFE, and 95.7 %, 121.2 %, and 146.9 % higher than the PTFE membrane, respectively. Through mathematical models for mass and heat transfer, the study identified the key to this enhancement as the increased d-spacing within the GO layer due to cross-linking, which weakened the Kelvin effect and enhanced the vapor partial pressure on the hot side. The unique surface structure and electrostatic interactions induced by long-chain cross-linking further boosted the antifouling effect. These modifications not only overcome the typical trade-off between retention rates and flux but also offer a scalable and efficient solution for advanced membrane distillation applications.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2025
·
IF 9.7
Yahui Zhu,Xiaohua Ma,Wenjie Lai,Zengxiang Tang,Weiming Xiao,Rong Zeng,Shunmin Ding,Chao Chen
D-π conjugated coordination polymers (CCPs) are often widely used in photocatalysis and electrocatalysis due to their unique electronic conductivity and structural flexibility. However, it remains a challenge to overcome the self-degradation of d-π CCPs in thermal catalysis and to effectively utilize their excellent electron transfer properties. Here, we present a series of d-π CCPs derivative after calcination treatment. The derivatives were optimized for overall electron cloud density by constructing two-dimensional pyridinic-nitrogen (N) doped carbon carriers, which exhibited the inherent π-electron delocalization and charge transfer properties of d-π CCPs. The presence of electron transfer was confirmed by X-ray Photoelectron Spectroscopy (XPS), Raman and kinetic analysis, demonstrating that this d-π CCPs derivative possesses excellent electron conduction ability and low activation energies for the reaction. Density-functional theory (DFT) calculations further confirmed the modulation of the nickel nanoparticles (Ni NPs) electronic state by the carriers, which resulted in strong Ni NPs interactions with the high-electron-density π-bonds of the C C bond. This property significantly enhances the target adsorption and activation of the C C bond, leading to a substantial enhancement of the reaction performance. This strategy provides a new development direction for the application of d-π CCPs in thermal catalysis.
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