ELECTROPHORESIS
·
2026
·
IF 2.6
Zhixu Chen,Biao Sun,Hanlin Zeng,Xinyang Li,Erwin Adams,Xiaoqi Zhang,Zhengjin Jiang,Jincai Wang
Neuraminidase inhibitors (NAIs) are a crucial therapy for combatting the influenza virus. This study employed an at-line nanofractionation technique to precisely localized potential NAIs in the extract of Humulus lupulus L. Twelve potential compounds, mainly phloroglucinol derivatives, were screened and identified. Seven of these compounds were subsequently isolated, purified, and structurally elucidated by NMR. Among them, Compound 5 showed remarkable inhibitory activity against both neuraminidase (NA, IC 50 = 0.8 µM) and the H3N2 influenza virus (EC 50 = 3.8 µM), confirming its potential as a lead compound for anti-influenza development. Compounds 4 and 8 , identified as hitherto uncharacterized phloroglucinol derivatives, also demonstrated significant inhibition against NA and the H3N2 influenza virus. Molecular docking revealed that Compounds 4 and 5 exhibited superior binding affinities compared to oseltamivir, with 4 forming critical hydrogen bonds with acidic residues (Glu119, Glu227, and Asp151) in the “150-cavity,” which significantly enhances its inhibitory potency against NAs.
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高影响因子
ACS Biomaterials Science & Engineering
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2026
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IF 6
Bingjie Sun,Yuxin Wang,Huaqiang Luo,Zixin Zhang,Bingtian Tu,Xinyu Wang,Jing Tu
Effective treatment of infected wounds requires simultaneous eradication of invading pathogens and scavenging of excess reactive oxygen species (ROS). Herein, we fabricated a multifunctional hydrogel dressing (denoted as PVA/CG/Cu-Cys) by hydrogen-bond cross-linking poly(vinyl alcohol) with ι-carrageenan-Ca2+ helices to generate a double network that was subsequently loaded with copper-l-cysteine nanoparticles. The reversible hydrogen-bonded interpenetrating network provided adequate swelling, moldability, mechanical strength, and tissue adhesion. The Cu-Cys nanoparticles endowed the hydrogel with broad-spectrum antioxidant activity, achieving over 60% scavenging efficiency against a range of reactive oxygen (H2O2, •OH, and •O2–) and nitrogen species (DPPH• and ABTS•+). Controlled release of Cu2+ eradicated 50.84 ± 8.21% of S. aureus biofilms and inhibited both E. coli and S. aureus. At the acidic pH of infected wound area (5.6), the hydrogel released only 56.5 ± 3.0% of total Cu2+ in 24 h, significantly less than free Cu-Cys (81.1 ± 2.7%, p = 0.0025), thereby reducing cytotoxicity and maintaining >80% cell viability. The dressing promoted in vitro cell migration and accelerated closure of infected full-thickness wounds in vivo. These results indicate that PVA/CG/Cu-Cys is a readily fabricated, clinically translatable dressing for the management of bacterially infected wounds.
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高影响因子
ACS Applied Energy Materials
·
2026
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IF 5.5
Fangfang Zhou,Zhiman Bai,Peng Dai,Tongtong Jiang,Mingzai Wu
Due to the high energy density, inherent safety, and cost-effectiveness, aqueous zinc-ion batteries (AZIBs) have been recognized as promising solution for energy storage. Compared to the 2H phase of MoS2, the metallic 1T phase counterpart holds greater potential for application in AZIBs, owing to its higher electrical conductivity and favorable two-dimensional channel structure. Herein, a facile one-step hydrothermal approach was employed to synthesize stable and 1T-rich MoS2 hybrids (MoS2-l-Cys) using l-cysteine as an intercalation modifier. This approach simultaneously induces a spontaneous phase transition from the semiconducting 2H to metallic 1T phase and expands the interlayer spacing of MoS2. The metallic 1T phase of MoS2 promotes electrons transfer, while the expanded interlayer spacing accelerates the Zn2+ ions’ diffusion kinetics and exposes more active sites. These synergistic effects collectively boost charge transfer kinetics of the Zn2+ ions’ redox reaction, thereby dramatically improving the electrochemical performance of AZIBs. Therefore, the discharge specific capacity of the MoS2-l-Cys electrode is as high as 279.0 mAh g–1 with outstanding rate capability. Furthermore, the MoS2-l-Cys electrode exhibits exceptional cycling stability, with a capacity retention of 91.4% after 1000 cycles at 4 A g–1, due to that the expanded interlayer spacing can effectively mitigate volume variations of MoS2-l-Cys during cycling. This work systematically elucidates the crucial role of l-cysteine intercalation-induced phase transition in optimizing reaction kinetics, providing a viable and effective strategy for developing MoS2-based cathodes for high-performance AZIBs.
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International Journal of Electrochemical Science
·
2023
·Vol. 12
·期 12
·11818-11832
·
IF 1.5
Yuli Wei,Huihui An,Wu Yang,Hao Guo
In this work, a simple, sensitive and rapid electrochemical sensor for bisphenol A determination based on a 3D Au NPs-poly-L-glutamate/graphene nanocomposite was proposed and the structures of the nanocomposite were characterized by scanning electron microscopy (SEM), Fourier transform infrared spectroscopic (FTIR) and X-ray diffraction (XRD). The electrochemical behaviors of bisphenol A on the nanocomposite GCE were investigated by cyclic voltammetry (CV) and differential pulse voltammetry (DPV). In the potential range of 0.0 ~ 1.0 V, an irreversible oxidation peak appeared on the modified electrode in 0.1 mol L -1 phosphate buffer solution (pH = 6.0). Under the optimum conditions, the anode peak current of bisphenol A increased linearly with the its concentration in the ranges from 0.009 μmol L -1 to 0.1 μmol L -1 and 0.1 μmol L -1 to 1.0 μmol L -1 with the detection limit down to 3×10 −10 mol L -1 (S/N = 3) and the corresponding linear regression equations were Ipa ( μA)= − 0.1129 C ( μmol L -1 ) + 0.5532 (N = 6, R 2 = 0.9057) and Ipa ( μA) = − 0.05970 C ( μmol L -1 ) + 0.02182 (N = 5, R 2 = 0.9950) respectively. The proposed method was successfully used for the determination of bisphenol A content in wastewater and milk samples, and the recoveries were in the range from 98.10% to 104.9%.
研究领域:
分析化学
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环境监测
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食品安全
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电化学传感
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纳米生物技术
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Discover Food
·
2026
·Vol. 6
·期 1
·155
·
IF 3.6
Xiang Nan,Zhao Yihan,Cheng Yaoyao,Guo Xinbo
With the growing global demand for functional foods and the significant food waste from agricultural byproducts, understanding the nutritional potential of underutilized plant tissues is increasingly critical. While mung bean ( Vigna radiata L. Wilczek) is widely cultivated for its seeds’ nutritional value, its mature pods often discarded due to tough texture. This study systematically analyzed polyphenol profiles (total phenolics and 9 specific compounds) and antioxidant capacities in seeds and pods of six mung bean varieties with distinct colors (Zhonglv No.5 (ZL-5), Zhonglv No.13 (ZL-13), Suhuang No.1 (SH-1), LL655, C36, and C158). All varieties exhibited significantly higher total phenolics in pods than seeds, with SH-1 pods and LL655 seeds reaching the highest 4.19 ± 0.83 and 1.71 ± 0.09 mg GAE/g FW among the studied varieties, respectively. Seeds were dominated by vitexin and isovitexin, while pods had abundant caffeic acid. Comprehensive antioxidant evaluation indicated LL655 and C36 with the highest antioxidant potential separately in seed and pod tissues, making them ideal materials for direct functional food applications. Specifically, abundant phenolics hindered the yellowness of mung bean pods, probably owing to their maintenance and completion on other pigments like chlorophyll or carotenoids. Additionally, SH-1 pods contained high total phenolic content, suggesting the utility as a raw material for functional food by-products. These findings provide a scientific basis for the nutritional value of mung bean pods, therefore may improve the utilization of mung bean tissues and promote the value-added applications in functional foods.
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MICROCHEMICAL JOURNAL
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2023
·
IF 4.8
Qi Ma,Yueyue Zu,Yanan Guan,Pengyi Ma,Shutao Li,Jinping Song,Yong Guo
As a new kind of heavy-metal-free fluorescent nanomaterials, synthesis of sulfur quantum dots (SQDs) using small molecules as capping agents remains a big challenge. In this work, a novel small molecule assisted synthesis strategy of SQDs was reported. L-cysteine was employed as capping reagent for the first time to prepare green fluorescent SQDs. The as-synthesized L-cysteine protected SQDs (Cys-SQDs) samples were further effectively purified by a simple treatment with sodium ion exchange resin. Cys-SQDs samples were characterized in detail using various characterization techniques. In the light of good fluorescence property, excellent optical stability and low biological toxicity, the potential applications of the obtained Cys-SQDs in sensing and bioimaging aspects were investigated. Results showed that Cys-SQDs were highly sensitive and selective towards drug molecule nimesulide (Nim), which can be applied for the detection of Nim. The detection limit was calculated as 160 nM. The developed method was successfully used for the determination of Nim in real samples, demonstrating good recoveries of 93.23 ∼ 110.01% with RSDs of 0.78 ∼ 5.68%. The fluorescence quenching process of Cys-SQDs by Nim mainly involved dynamic quenching mechanism and fluorescence resonance energy transfer. Moreover, Cys-SQDs nanoprobe exhibited low biological toxicity to three different cell lines. By comparing the staining regions of three cell lines using Hoechst dye and followed colocalization analysis, it was definitely confirmed that the synthesized Cys-SQDs can stain both cytoplasm and nucleus, and it can also identify Nim in living cells. This research demonstrated the potential applications of Cys-SQDs in sensing and bioimaging fields.
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EUROPEAN POLYMER JOURNAL
·
2023
·
IF 6
Zhen Zhang,Limin Wang,Qian Zhang,Hongkun Li,Yong Xiang,Xinyu Wang,Xiaoran Hu
Chronic wounds pose an increasing burden not only to patients, but also to the health system. Wound repair requires the timely and orderly migration of fibroblasts to the wound bed. In this respect, electrical stimulation by a piezoelectric generator (PEG) is an attractive approach to wound management because it is noninvasive and effective in promoting chronic wound healing. However, commonly used PEGs based on polyvinylidenefluoride (PVDF) and poly( l -lactic acid) (PLLA) suffer from low biocompatibility and low piezoelectric output, respectively. Herein, we developed a bio-based PEG composed of PLLA blended with vitamin B 2 (VB 2 ), leading to an improvement of crystallinity and β-phase orientation, which exhibited better biocompatibility than PVDF and a higher piezoelectric output than pure PLLA. Such piezoelectricity could serve as effective electrical stimulation and promoted in vitro cell migration and fibroblast proliferation, evidenced by significant higher gene expression levels of extracellular matrix proteins and growth factors. Moreover, it facilitated in vivo wound closure by enhancing the re-epithelialization, collagen deposition, neovascularization, and increase the concentration of growth factors in the wound bed, leading to a 1.4-fold higher wound closure rate than that in the control group. Thus, the PLLA/VB 2 PEG opens an avenue for the application of bio-based PEGs for wound healing.
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JOURNAL OF APPLIED POLYMER SCIENCE
·
2023
·Vol. 140
·期 19
·e53839
·
IF 3
Zhengwei Wan,Meili Li,Yaozhong Zhuang,Zaizai Tong
Poly( L -lactic acid) (PLLA) is a biodegradable polymer that has attracted increasing attention due to its fantastic properties. Nevertheless, the disadvantages of PLLA, such as low crystallization rate and brittleness, limit its wide commercial applications. In the present work, electrospun stereocomplex PLA fibers (Sc-fibers) and PLLA grafted cellulose nanocrystals (g-CNCs) are prepared as nano-fillers and then blended with PLLA matrix to prepare different nanocomposites. Both of nano-fillers would accelerate the crystallization rate of PLLA, and as expected, g-CNCs have much stronger nucleation ability towards PLLA than Sc-fibers. Nevertheless, the crystallization of PLLA will decrease to some extent in the presence of both nano-fillers of g-CNCs and Sc-fibers due to the preferential formation of stereocomplex crystals on the surfaces of CNCs. Moreover, the presence of nano-fillers would enhance the mechanical properties of PLLA, such as the elongation at break can increase by four times after incorporating both g-CNCs and Sc-fibers. This work provides a new consideration for designing different nano-fillers, especially for polymer matrices with low crystallization ability and brittleness.
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CHEMOSPHERE
·
2023
·
IF 8.8
Hanxin Wu,Xiaohan Jiang,Jianhao Tong,Jing Wang,Jiyan Shi
Nowadays, Lead (Pb) and Cadmium (Cd) contamination in rice is an important worldwide environmental concern. Fe 3 O 4 nanoparticles (Fe 3 O 4 NPs) and Nano hydroxyapatite (n-HAP) are promising materials to manage Pb and Cd contamination. This study systematically investigated the effect of Fe 3 O 4 NPs and n-HAP on Pb and Cd stressed rice seedlings’ growth, oxidative stress , Pb and Cd uptake and subcellular distribution in roots. Furthermore, we clarified the immobilization mechanism of Pb and Cd in the hydroponic system. Fe 3 O 4 NPs and n-HAP could reduce Pb and Cd uptake of rice mainly through decreasing Pb and Cd concentrations in culture solution and combining with Pb and Cd in root tissues. Pb and Cd were immobilized by Fe 3 O 4 NPs through complex sorption processes and by n-HAP through dissolution-precipitation and cation exchange, respectively. On the 7th day, 1000 mg/L Fe 3 O 4 NPs reduced the contents of Pb and Cd in shoots by 90.4% and 95.8%, in roots by 23.6% and 12.6%, 2000 mg/L n-HAP reduced the contents of Pb and Cd in shoots by 94.7% and 97.3%, in roots by 93.7% and 77.6%, respectively. Both NPs enhanced the growth of rice seedlings by alleviating oxidative stress and upregulating glutathione secretion and antioxidant enzymes activity . However, Cd uptake of rice was promoted at certain concentrations of NPs. The subcellular distribution of Pb and Cd in roots indicated that both NPs decreased the percentage of Pb and Cd in the cell wall, which was unfavorable for Pb and Cd immobilization in roots. Cautious choice was needed when using these NPs to manage rice Pb and Cd contamination.
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FOOD CHEMISTRY
·
2023
·
IF 8.8
Yan-Jun Li,Li-Li Yang,Li Ni,Jia-Min Xiong,Jia-Yuan He,Lian-Di Zhou,Ling Luo,Qi-Hui Zhang,Chun-Su Yuan
An imbalance of l -tryptophan ( l -Trp), a basic component of a healthy diet, is harmful to human health. Traditional methods for detecting l -Trp have many limitations. To correct a deficiency or excess of l -Trp in human diets, it is necessary to develop a novel method that is rapid, low-cost, and high-sensitivity. Herein, a molecularly imprinted polysaccharide electrochemical sensor termed MIP/CS/MWCNTs/GCE (molecularly imprinted polymer/chitosan/multiwalled carbon nanotubes/glassy carbon electrode) targeting l -Trp was first constructed on a glassy carbon electrode, which was modified with multiwalled carbon nanotubes and chitosan using bifunctional monomers. The MIP/CS/MWCNTs/GCE obtained a wide linear range (1–300 μM) for detecting l -Trp and accurately detected the proportion of l -Trp in mixtures of Trp enantiomers. In milk samples, the spiked recoveries of l -Trp were 86.50 to 99.65%. The MIP/CS/MWCNTs/GCE electrochemical sensor possessed good recognition and detection performance for l -Trp and has promising potential for practical application.
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ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
·
2022
·
IF 7.129
Siyuan Lu,Jing Chen,Junyuan Wang,Donghui Wu,Hongfeng Bian,Haibo Jiang,Lianxi Sheng,Chunguang He
The absorption and accumulation of nanoplastics (NPs) by plants is currently attracting considerable attention. NPs also tend to adsorb surrounding organic pollutants, such as pesticides, which can damage plants. However, molecular mechanisms underlying the phytotoxicity of NPs are not sufficiently researched. Therefore, we analyzed the toxicological effects of 50 mg/L polystyrene NPs (PS 50 nm) and 5 mg/L the herbicide quinolinic (QNC) on rice ( Oryza sativa L.) using 7-day hydroponic experiments, explaining the corresponding mechanisms by transcriptome analysis. The main conclusion is that all treatments inhibit rice growth and activate the antioxidant level. Compared with CK, the inhibition rates of PS, QNC, and PS+QNC on rice shoot length were 3.95%, 6.68%, and 11.43%, respectively. The gene ontology (GO) term photosynthesis was significantly enriched by QNC, and the combination PS+QNC significantly enriched the GO terms of amino sugar and nucleotide sugar metabolisms. The chemicals QNC and PS+QNC significantly affected the Kyoto Encyclopedia of Genes and Genomes (KEGG) of the MAPK signaling pathway, plant hormone signal transduction, and plant-pathogen interaction. Our findings provide a new understanding of the phytotoxic mechanisms and environmental impacts of the interactions between NPs and pesticides. It also provides insights into the impact of NPs and pesticides on plants in the agricultural system.
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SEPARATION AND PURIFICATION TECHNOLOGY
·
2022
·
IF 9.136
Linzhi Zuo,Yang Li,Long Cheng,Tao Yu,Yiting Che,Shitan Yan,Kiushkin Vladimir Yurievich,Ting Bian,Daifen Chen
Interfacial solar steam generation (ISSG) technology is considered to be one of the most promising approaches to alleviating the global shortage of clean water due to its high solar thermal conversion efficiency. However, achieving stable evaporation in high salinity solutions and preventing the occurrence of salt deposition phenomena remains a challenge. Here, an efficient and stable photothermal membrane-based evaporator has been developed, which consists of polydopamine (PDA) modified leaf-like zeolitic imidazolate framework (ZIF-L) implanted in sodium alginate (SA) membrane supported on a melamine sponge (S-ZIF-L/PDA sponge), providing more advantages for boosting the photothermal conversion performance and preventing salt deposition. This S-ZIF-L/PDA sponge displays an excellent light absorption (>95 %), and remarkable evaporation rate of 1.66 kg·m −2 ·h −1 with a solar-thermal efficiency of 91.06 % under 1.0 sun (1 kW·m −2 ) illumination. Benefiting from the super hydrophilic feature of the melamine sponge and the rejection properties of the SA membrane structure, the obtained sponge effectively prevents salt and contaminants from depositing on the surface. Particularly, the S-ZIF-L/PDA sponge achieves an evaporation efficiency of 86.17 % in 20 wt% NaCl solution, along with excellent resistance to salt deposition and marvelous stability in cycling tests. The salt ion concentration of the obtained fresh water is much lower than the World Health Organization (WHO) drinking water standard, and the organic removal rate exceeds 99 %. This work provides a competitive solution for high-salinity desalination and wastewater treatment.
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