NEW JOURNAL OF CHEMISTRY
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2013
·Vol. 37
·期 7
·2174-2178
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IF 2.966
Xing Liu,Qi Wang,Yu Zhang,Lichun Zhang,Yingying Su,Yi Lv
In this paper, a novel and simple colorimetric method for the determination of glutathione (GSH) was developed. The BSA–MnO2 NPs possess oxidase-like activity that can catalyze the oxidization of 3,3′,5,5′-tetramethylbenzidine (TMB), and the existence of GSH can cause reduction of oxidized TMB along with a visual color variation. A good linear relationship can be obtained from 0.26 to 26 μM with a limit of detection of 0.1 μM. Furthermore, the good recoveries for serum samples indicated that the present colorimetric methodology was feasible, simple and sensitive, with a promising application in routine analysis of biosamples.
研究领域:
分析化学
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生物化学
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纳米技术
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产品关联
DOI
高影响因子
JOURNAL OF NANOBIOTECHNOLOGY
·
2021
·Vol. 19
·期 1
·1-13
·
IF 10.435
Zhang Gutian,Cheng Wenting,Du Lin,Xu Chuanjun,Li Jinlong
Background Phototherapy is a promising strategy for cancer therapy by reactive oxygen species (ROS) of photodynamic therapy (PDT) and hyperthermia of photothermal therapy (PTT). However, the therapeutic efficacy was restricted by tumor hypoxia and thermal resistance of increased expression of heat shock protein (Hsp). In this study, we developed albumin nanoparticles to combine hypoxia relief and heat shock protein inhibition to overcome these limitations for phototherapy enhancement. Results Near-infrared photosensitizer (IR780) and gambogic acid (GA, Hsp90 inhibitor) were encapsulated into albumin nanoparticles via hydrophobic interaction, which was further deposited MnO 2 on the surface to form IGM nanoparticles. Both in vitro and in vivo studies demonstrated that IGM could catalyze overexpress of hydrogen peroxide to relive hypoxic tumor microenvironment. With near infrared irradiation, the ROS generation was significantly increase for PDT enhancement. In addition, the release of GA was promoted by irradiation to bind with Hsp90, which could reduce cell tolerance to heat for PTT enhancement. As a result, IGM could achieve better antitumor efficacy with enhanced PDT and PTT. Conclusion This study develops a facile approach to co-deliver IR780 and GA with self-assembled albumin nanoparticles, which could relive hypoxia and suppress Hsp for clinical application of cancer phototherapy.
研究领域:
癌症治疗
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纳米技术
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光疗
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药理学
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DOI
PubMed
高影响因子
MICROCHEMICAL JOURNAL
·
2024
·
IF 4.9
Xiuhua Zhang,Heqin Liu,Wanrong Hong,Yumin Wang,Jin-Wen Liu,Yingfeng Qin
In this work, a novel fluorescence nanoprobe based on MnO 2 nanosheets and DNAzyme cyclic amplification was developed for label-free detection of GSH. In our design, the DNA@MnO 2 nanoprobe was facilely prepared through the adsorption of DNA probes on the surface of MnO 2 nanosheets. Importantly, MnO 2 nanosheets in the DNA@MnO 2 nanoprobe can act as the recognizer of analytical target GSH. In the presence of GSH, the DNA@MnO 2 nanoprobe are decomposed owing to redox-responsive reaction between GSH and MnO 2 nanosheets, resulting in the generation of abundant Mn 2+ and the desorption of DNA probes. Subsequently, the Mn 2+ -dependent DNAzyme recycling amplification was rapidly initiated and a large number of the blocked G-rich sequences in DNA probes was released. The G-rich sequences were efficiently folded into G-quadruplex structures, which can remarkably light up the fluorescence intensity of thioflavin T (ThT). Experimental data demonstrated that the DNA@MnO 2 nanoprobes for GSH detection have a wide linear range from 0 to 2000 µM. Moreover, this fluorescence sensing strategy was successfully applied for the detection of GSH in complex biological media with satisfying results, providing a simple, facile and cost-efficient nanoplatform for GSH-related clinical disease diagnosis.
研究领域:
分析化学
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纳米技术
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生物医学工程
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生物化学
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产品关联
DOI
高影响因子
Journal of Water Process Engineering
·
2024
·
IF 6.3
Yajie Wen,Jiabin Zhou,Lin He,Dan Liu
In this study, manganese from the cathodes for waste batteries (WBCs) was recovered by hydrometallurgical method as a raw material for the peroxymonosulfate (PMS) activator MnCO 3 , which was successfully synthesized by a simple and environmentally friendly process. MnCO 3 had a good degradation properties for oxytetracycline hydrochloride (OTC-HCl). Under the best conditions through the BoxBehnken Design (BBD), the MnCO 3 /PMS system effectively decomposed 91.3 % of OTC-HCl (initial concentration of 60 mg/L), and the Total Organic Carbon (TOC) removal rate was 63.6 % within just 10 min. Moreover, the system exhibits effectiveness over a wide pH range, with its degradation rate remaining largely unaffected by the presence of inorganic anions. Reactive species, including sulfate radicals (SO 4 ·− ), hydroxyl radicals (･OH), superoxide radicals (O 2 ·− ), and singlet oxygen ( 1 O 2 ), are generated by the degradation system. A series of experiments and characterizations demonstrated that 1 O 2 plays a significant role in the degradation system. This study paves the way for the recycling of spent zinc‐manganese batteries and establishes an efficient multi-mechanism degradation system for treating recalcitrant organic wastewater.
研究领域:
环境科学
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化学工程
·
废物管理
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水处理
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产品关联
DOI
高影响因子
ACS Nano
·
2024
·
IF 15.8
Haijian Huang,Hao Feng,Ziyu He,Yanan Huang,Jiawei Xu,Chengzhi Hu,Zhangxian Chen,Zeheng Yang,Weixin Zhang
Enhancing proton storage in the zinc-ion battery cathode material of MnO2 holds promise in promoting its electrochemical performance by mitigating the intense Coulombic interaction between divalent zinc ions and the host structure. However, challenges persist in addressing the structural instability caused by Jahn–Teller effects and accurately modulating H+ intercalation in MnO2. Herein, the doping of high-electronegativity Sb with fully occupied d-orbital in MnO2 is reported. The Sb doping strategy engenders the formation of Mn–O–Sb path in the structure with a strong dipole polarization field, which facilitates the delocalization of eg orbital electron in Mn and thus mitigates the Jahn–Teller effects. Simultaneously, adjusting the level of Sb doping in MnO2 leads to modulation of the p-band center of O, optimizing its interaction with hydrogen and thereby enhancing proton storage. Consequently, MnO2 doped with 6% Sb exhibits commendable performance in both rate capability and cycling endurance, delivering 113 mAh g–1 at 2 A g–1 after 2000 cycles. This investigation underscores the crucial role of electronic structural engineering in elevating the electrochemical performance of cathode materials for zinc-ion batteries.
研究领域:
材料科学
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电化学
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产品关联
DOI
PubMed
高影响因子
CHEMOSPHERE
·
2019
·
IF 5.108
Xiaoxia Li,Qiancheng Zou,Yi Wei,Wenyu Zhang,Xianjie Feng,Xiaochuan Zhou,Aihua Xu
Nonredox metal ions have been widely recognized to be important in a wide range of biological and chemical oxidations as Lewis acids (LA). However, the role of LA in peroxymonosulfate (PMS) activation for wastewater treatment has not been considered until now. This study shows that oxidizing power of PMS can be promoted after binding nonredox metal ions such as Ca 2+ as LA, leading to the easier reduction of the oxidant to radicals and substantial enhancement of dye degradation by employing manganese oxides OMS-2 as model catalysts. Increased with Lewis acidity of the metal ion, the rate of PMS decomposition enhanced linearly, while the dye degradation rate first increased and then declined due to the formation of a larger amount of dioxygen . The interactions between Ca 2+ and PMS were further investigated by Raman, cyclic voltammetry and XPS ; and the detailed mechanism of PMS activation was proposed. The performance of Ca 2+ +OMS-2/PMS system under different conditions was also studied. The findings indicate the importance of LA in PMS activation reaction and their role must be considered in other transition metal oxides/PMS systems. It will be also helpful to design new and highly active catalysts for the reactions.
研究领域:
环境科学
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化学工程
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DOI
高影响因子
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
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2025
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IF 8.3
Bowen Yang,Yangyang Long,Feng Chen,Jiabao Wang,Zhipeng Wang,Ziqiang Zhang,Yanfei Wang,Weihua Zou,Yeguang Zhang,Peng Wang,Zili Zhan,Feihu Li
Hydrogen sensor based on proton exchange membrane fuel cells (PEMFCs) was one of the most extensively studied types. However, traditional Pt/C based electrodes suffered from several drawbacks, including high cost, low catalytic efficiency for oxygen reduction reaction (ORR) and slow reaction kinetics. Herein, we developed a quasi PEMFCs hydrogen sensor utilizing MnO 2 as cathode catalyst, where the electrochemical signal was generated via the direct MnO 2 redox reaction with hydrogen, replacing the ORR process. Membrane electrode assemblies (MEAs) were successfully fabricated incorporating α-MnO 2 , β-MnO 2 , and δ-MnO 2 polymorphs. The β-MnO 2 -based sensor demonstrated best sensing performance with a maximum sensitivity of 96 nA/ppm, a 34-fold enhancement over conventional dual-platinum electrochemical sensors, under the optimized volume ratio of catalyst ink (ethylene glycol: Nafion solution: water = 1:4:4). Moreover, the β-MnO 2 -based sensor exhibited significantly superior response and recovery speed. This strategy provided an effective approach for the commercialization of next generation PEMFCs-type hydrogen sensors.
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DOI
高影响因子
Nanomaterials
·
2022
·Vol. 12
·期 16
·2856
·
IF 5.719
Anis Ur Rahman,Nighat Zarshad,Wu Jianghua,Muslim Shah,Sana Ullah,Guigen Li,Muhammad Tariq,Asad Ali
Electrochemical energy storage devices are ubiquitous for personal electronics, electric vehicles, smart grids, and future clean energy demand. SCs are EES devices with excellent power density and superior cycling ability. Herein, we focused on the fabrication and DFT calculations of Na3-δ-MnO2nanocomposite, which has layered MnO2redox-active sites, supported on carbon cloth. MnO2has two-dimensional diffusion channels and is not labile to structural changes during intercalation; therefore, it is considered the best substrate for intercalation. Cation pre-intercalation has proven to be an effective way of increasing inter-layered spacing, optimizing the crystal structure, and improving the relevant electrochemical behavior of asymmetric aqueous supercapacitors. We successfully established Na+pre-intercalated δ-MnO2nanosheets on carbon cloth via one-pot hydrothermal synthesis. As a cathode, our prepared material exhibited an extended potential window of 0–1.4 V with a remarkable specific capacitance of 546 F g−1(300 F g−1at 50 A g−1). Moreover, when this cathode was accompanied by an N-AC anode in an asymmetric aqueous supercapacitor, it illustrated exceptional performance (64 Wh kg−1at a power density of 1225 W kg−1) and incomparable potential window of 2.4 V and 83% capacitance retention over 10,000 cycles with a great Columbic efficiency.Keywords:manganese oxide;pre-intercalation;specific capacitance;wide potential window;asymmetric aqueous supercapacitor;DFT calculation
研究领域:
材料科学
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电化学
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理论计算
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DOI
PubMed
高影响因子
MICROCHIMICA ACTA
·
2021
·Vol. 188
·期 9
·1-9
·
IF 5.833
Ma Zerui,Li Pan,Jiao Meng,Shi Yu-e,Zhai Yongqing,Wang Zhenguang
Butyrylcholinesterase (BChE) can modulate the expression level of cholinesterase, which emerges as an important clinical diagnose index. However, the currently reported assays for BChE are suffering from the problem of interferences. A ratiometric fluorescence assay was developed based on the MnO 2 nanosheet (NS)–modulated fluorescence of sulfur quantum dots (S-dots) and o -phenylenediamine (OPD). MnO 2 NS can not only quench the fluorescence of blue emissive S-dots, but also enhance the yellow emissive OPD by catalyzing its oxidation reactions. Upon introducing BChE and substrate into the system, their hydrolysate can reduce MnO 2 into Mn 2+ , leading to the fluorescence recovery of S-dots and failure of OPD oxidation. BChE activity can be quantitatively detected by recording the change of fluorescence signals in the blue and yellow regions. A linear relationship is observed between the ratio of F 435 / F 560 and the concentration of BChE in the range 30 to 500 U/L, and a limit of detection of 17.8 U/L has been calculated. The ratiometric fluorescence assay shows an excellent selectivity to acetylcholinesterase and tolerance to various other species. The method developed provides good detection performances in human serum medium and for screening of inhibitors. Graphical abstract
研究领域:
分析化学
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生物化学
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纳米技术
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DOI
PubMed
高影响因子
BIOSENSORS & BIOELECTRONICS
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2020
·
IF 10.257
Li Xue,Ruya Guo,Fengchun Huang,Wuzhen Qi,Yuanjie Liu,Gaozhe Cai,Jianhan Lin
Screening of pathogenic bacteria in foods is an effective way to prevent foodborne diseases. In this study, an impedance biosensor was developed for rapid and sensitive detection of Salmonella typhimurium using multiple magnetic nanobead (MNB) nets in a ring channel for continuous-flow separation of target bacteria from 10 mL of sample, manganese dioxide nanoflowers (MnO 2 NFs) for efficient amplification of biological signal, and an interdigitated microelectrode for sensitive measurement of impedance change. First, the MNBs modified with capture antibodies were vortically injected from outer periphery of this ring channel to form multiple ring MNB nets at specific locations with high gradient magnetic fields . Then, the bacterial sample was continuous-flow injected, resulting in specific capture of target bacteria onto the nets, and the MnO 2 NFs modified with detection antibodies were injected to form MNB-bacteria-MnO 2 NF complexes. After the complexes were washed with deionized water to remove excessive nanoflowers and residual ions, H 2 O 2 with poor conductivity was injected to reduce MnO 2 NFs to conductive Mn 2+ at neutral medium, leading to impedance decrease. Finally, impedance change was measured using the microelectrode for quantitative determination of Salmonella . This biosensor was able to separate ~60% of Salmonella from 10 mL of bacterial sample and detect Salmonella with a linear range of 3.0 × 10 1 to 3.0 × 10 6 CFU/mL in 1.5 h with lower detection limit of 19 CFU/mL. This biosensor might be further improved with higher sensitivity using a larger volume (100 mL or more) for routine screening of foodborne bacteria without bacterial pre-culture.
研究领域:
生物技术
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纳米技术
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食品安全
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生物传感器
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微生物学
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DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF PHARMACEUTICS
·
2020
·
IF 4.845
Yunbo Nie,Dan Li,Ying Peng,Shengfeng Wang,Shuo Hu,Miao Liu,Jinsong Ding,Wenhu Zhou
The RNA-cleaving DNAzyme (DZ) holds promising potential for RNA interference (RNAi) applications and is favored over siRNA owing to its high chemical stability, biocompatibility , predictable activity, and substrate versatility. However, its pharmaceutical applications for disease treatment are limited by the requirement of metal cofactor for activation, as well as the lack of effective co-delivery systems to combine with other therapeutic modalities. Herein, we designed and constructed metal organic framework (MOF) coated MnO 2 nanosheets to realize the co-delivery of a survivin inhibiting DZ and doxorubicin (DOX) for chemo-gene combinatorial treatment of cancer. In our design, the DOX was adsorbed on MnO 2 planar surface, and the DZ was loaded into the MOF shell layer through the coordination between Mn 2+ and tannic acid . The nano-system could stably encapsulate the payloads under physiological condition, but rapidly degraded after endocytose into tumor cells in response to intracellular stimuli, resulting in triggered drugs release. Notably, the coreleased Mn 2+ could act as metal cofactor for effective DZ activation. Both in vitro and in vivo studies have demonstrated the enhanced anti-tumor efficacy of the nanosystem, with co-contributions from anti-neoplastic DOX, survivin silencing effect of DZ, and to some extent, ROS generation by Mn 2+ . This work provides an ingenious strategy to address the key limitation of DZ for RNAi applications and realize the combination of DZ with other therapeutic modalities, in which the DZ can be in-situ activated for target gene silencing.
研究领域:
癌症治疗
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纳米技术
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药物递送系统
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基因治疗
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材料科学
✓ 已验证
DOI
PubMed
高影响因子
Biomaterials Advances
·
2025
·
IF 6
Wajiha Ahmed,Shifen Li,Min Liang,Pai Peng,Wali Muhammad,Qiaoxuan Wang,Changyou Gao
Reactive oxygen species (ROS) and subsequent inflammatory cascades hinder the healing of diabetic wounds, which should be tackled simultaneously when designing wound dressings. In this study, ROS-responsive di‑selenium-containing polyurethane nanofibers (PUF) loaded with manganese dioxide nanoparticles (MnO 2 NPs) and gelsevirine (GSV) with an average diameter of 0.6 ± 10 μm, were prepared to specifically target ROS and inflammation control, thereby enhancing healing in diabetic wounds. The resulting nanofibers exhibited a porous architecture and enhanced drug delivery capability. The MnO 2 /GSV/PUF dressing showed negligible cytotoxicity with cell viability over 80 %, effective ROS-scavenging ability of 87 %, and inhibition of pro-inflammatory cytokine expression. This dual mechanism of ROS-scavenging and inflammation modulation accelerated the healing of diabetic wounds up to 92 % in 14 d in a full-thickness diabetic wound model, as evidenced by reduced cytokine levels, enhanced epithelialization, and uniform collagen deposition with the highest percentage of 60 %.
研究领域:
生物材料学
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医学
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药理学
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产品关联
DOI
PubMed
高影响因子
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