Nanomaterials
·
2023
·Vol. 13
·期 2
·323
·
IF 5.3
Yang Chen,Ziqing Li,Nianjing Ji,Chenxi Wei,Xiulan Duan,Huaidong Jiang
Rare-earth-doped mixed crystals have demonstrated tunable optical properties, and it is of great importance to study the structural characteristics of the mixed-crystal hosts. Herein, LuxGd1-xVO4(0 ≤x≤ 1) solid solution nanocrystals were synthesized by a modified sol–gel method, with a pure crystalline phase and element composition. The X-ray diffraction (XRD) and Rietveld refinement results showed that LuxGd1−xVO4nanocrystals are continuous solid solutions with a tetragonal zircon phase (space groupI41/amd) and the lattice parameters strictly follow Vegard’s law. The detailed local structures were studied by extended X-ray absorption fine structure (EXAFS) spectra, which revealed that the average bond length of Gd-O fluctuates and decreases, while the average bond length of Lu-O gradually decreases with the increase in Lu content. Furthermore, the binding energy differences of core levels indicate that the covalent V-O bond is relatively stable, while the ionicity of the Lu-O bond decreases with the increasingxvalue, and the ionicity of the Gd-O bond fluctuates with small amplitude. The valence band structures were further confirmed by the first-principles calculations, indicating that the valence band is contributed to by the O 2pnonbonding state, localized Gd 4fand Lu 4fstates, and the hybridized states between the bonding O 2pand V 3d. The binding energies of the Lu core and the valence levels tend to decrease gradually with the increase in Lu content. This work provides insight into the structural features of mixed-crystal hosts, which have been developed in recent years to improve laser performance by providing different positions for active ions to obtain inhomogeneous broadening spectra.
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CRYSTAL GROWTH & DESIGN
·
2018
·
IF 3.972
Xiaodong Feng,Yufei Wang,Faheem Muhammad,Fuxing Sun,Yuyang Tian,Guangshan Zhu
It has been widely recognized that nanosized metal–organic frameworks (nano-MOFs) possess prominent advantages over bulky MOFs in both chemical and physical aspects, while the synthesis of nano-MOFs with well-tuned crystal sizes and shapes still remains a challenge. Herein, with the aid of microwave heating and growth modulation, we successfully synthesized the nanosized counterpart of medi-MOF-1. Cubic-shaped, nanosized medi-MOF-1 with the length of 200 nm has been produced by adding a certain amount of capping ligands which cause competitive coordination interactions during the crystal growth process. It is found that crystal sizes and morphology were controlled by changing the concentration of the capping ligand. Furthermore, hierarchical porosity was introduced to nanosized medi-MOF-1 due to the existence of defects. It is believed that the nanosized counterpart of medi-MOF-1 would have remarkable potential applications in gas storage as well as the medical and pharmaceutical fields.
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JOURNAL OF CHEMICAL AND ENGINEERING DATA
·
2014
·
IF 2.045
Lijuan Peng,Qinbo Wang,Binwei Shen,Chuxiong Chen,Zhenhua Xiong
Liquid–liquid equilibrium (LLE) data for the ternary system water + ethylbenzene + acetophenone and water + ethylbenzene + 1-phenylethanol were determined at temperatures T = (298.2, 308.2, 318.2, and 328.2) K and atmospheric pressure. The immiscibility region was found to be relatively small and not sensitive to the change of temperature. The Othmer–Tobias and the Bachman correlations were used to test the consistency of the LLE data. The experimental data were correlated by both the nonrandom two-liquid and the universal quasichemical activity coefficient models. The relevant model interaction parameters were regressed by data fitting. The model correlated results show good agreement with the measured data. The obtained interaction parameters can be used in the calculation of LLE for the ternary system water + ethylbenzene + acetophenone and water + ethylbenzene +1-phenylethanol as well as for the design and optimization of the related separation process.
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POLYMER
·
2025
·
IF 4.5
Xiangyuan Meng,Huifang Ma,Yaping Ma,Chenguang Liu,Aihua He
High-temperature resistant shape memory polyolefins, which also exhibit resistances to creep and raw petroleum, are highly crucial for the pipelines in severe environments, like high temperature, high pressure and petroleum medium. Herein, a series of crosslinked polybutene-1 alloys (PBA-X) were firstly fabricated, which presented excellent high-temperature resistances to creep and raw petroleum at 85 °C, as well as outstanding shape memory behaviors like 93.7-100.0 % shape recovery ratio ( R r ), 90.6-98.4 % shape fixation ratio ( R f ), and easy recovered from varied programmed three-dimensional (3D) shapes through thermal stimulation. PBA-X are anticipated to offer significant potential as innovative pipeline lining materials for deep-ocean petroleum transportation systems.
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Journal of Environmental Chemical Engineering
·
2024
·
IF 7.4
Yifei Chen,Yongru You,Chen Xin,Xiuqin Dong,Hao Gong
The diverse pore structures and excellent tunable proprieties of IRMOFs materials made the possibility to explore the effect of the mode of ligand-immobilization on its catalytic performance for 1-butene hydroformylation. In this work, we report a successful case of theory-guided rational design of a highly active ligand-immobilized Rh/IRMOF catalyst based on previous work. Density functional theory calculations of elementary reaction barriers for 1-butene hydroformylation over 1Rh/IRMOFs-PPh 3 models (IRMOF-1, -8, -10, -14, and -16) were performed. The calculation results and topographic steric maps analysis predicted that 1Rh/IRMOF-10-PPh 3 have superior catalytic performance. This can be attributed to the “shape-selective” effect of phosphine ligands grafted in the backbone on the reactive transition state. In addition, the anchoring positions of the phenyl phosphine ligand grafting on the skeleton of 1Rh/IRMOF-10-PPh 3 was identified in details. The 1Rh/IRMOF-10-PPh 3 [3‐3] was predicted to have the highest n/i ratio. In order to verify the theoretical prediction, 1Rh/IRMOF-10–32PPh 3 catalyst was prepared by post-synthesis strategy and the n/i ratio was experimentally confirmed to be 3.49, which outperform the previous 1Rh/MOF-5-PPh 3 catalyst. This work suggests that the 1Rh/IRMOF-10-PPh 3 catalyst can be a promising catalyst for hydroformylation reactions.
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MOLECULES
·
2024
·Vol. 29
·期 19
·4564
·
IF 4.2
Yanglan Luo,Naixin Cao,Liling Huang,Lanlan Tang,Xuzhou Liu,Wenlong Zhang,Shilv Huang,Xiuchao Xie,Yong Yan
Sanghuang as a medicinal fungus in China has a history of more than 2000 years, and is known as the “forest gold”. Most notably, the polysaccharides of Sanghuangporus sp. have attracted widespread attention due to their significant bioactivity in recent years. At present, extensive studies are being carried out on the extraction methods, structural characterization, and activity evaluation of polysaccharides. Here, we aimed to evaluate the structure and bioactivity of LEPS-1, an exopolysaccharide derived from the S. sanghuang JM-1 strain. The structure was elucidated by chromatography/spectral methods and hydrolyzation, and the solubility, the antioxidant activity, hypoglycemic activity and immunomodulatory activity were investigated. Results showed that LEPS-1 contained a →2)-α-Manp(1→6)-α-Galp(1→[2)-α-Manp(1→] n →2,6)-α-Manp(1→6,2)-α-Manp(1→3)-α-Manp(1→ backbone substituted at the O -6 and O -2 positions with side chains. These two branching fragments were β-Manp(1→. The molecular weight of LEPS-1 is 36.131 kDa. The results of biological activity analysis suggested that LEPS-1 was easily soluble in water, with reducing capability and DPPH radical scavenging capability. Furthermore, the IC 50 values of LEPS-1 against α-amylase and α-glucosidase were 0.96 mg/mL and 1.92 mg/mL. LEPS-1 stimulated RAW264.7 cells to release NO, TNF-α and IL-6 with no cytotoxicity, showing potent potential for immunomodulatory activity. These findings describe a potential natural exopolysaccharide with medicinal value and a basis for the development of S. sanghuang exopolysaccharides.
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PubMed
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JOURNAL OF MEDICINAL CHEMISTRY
·
2024
·
IF 6.8
Yi Huang,Fengling Liu,Shuhua Ren,Yuanqing Ding,Man Chi,Weiwei Huang,Wenjing Gu,Hewen Qian,Yaxia Yuan,Shurong Hou,Xiabin Chen,Lei Ma
Idiopathic pulmonary fibrosis (IPF) is a progressive and lethal lung disease with an elusive etiology. Aberrant activation of c-Jun N-terminal kinase 1 (JNK1) has been implicated in its pathogenesis. Through a combination of structure-based drug design and structure–activity relationship (SAR) optimization, a series of pyrimidine-2,4-diamine scaffold derivatives have been developed as potent JNK1 inhibitors. Compound E1 was identified with low nanomolar JNK1 inhibitory potency (IC50 = 2.7 nM). The introduction of a dimethylamine side chain has significantly enhanced the ability of E1 to inhibit c-Jun phosphorylation, surpassing the clinical candidate CC-90001. Molecular dynamics simulations revealed a binding free energy of −50.46 kcal/mol for E1. Moreover, E1 displayed satisfactory pharmacokinetic properties, with a bioavailability of 69% in rats. Furthermore, compound E1 exerted significant antifibrotic effects in a bleomycin-induced IPF mouse model and prevented a TGF-β-induced epithelial-to-mesenchymal transition in vitro. These findings position E1 as a promising lead for further drug development targeting IPF.
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Annals of Dermatology
·
2024
·
IF 1.5
Lin-Xia Liu,Zhi-Kai Liao,Bing-Qi Dong,Shan Jiang,Tie-Chi Lei
Background Although reports suggest that tranexamic acid (TXA) has clinical benefits for melasma patients by oral, intralesional and topical treatment, the optimal route of TXA therapy and the underlying mechanism involved remain poorly defined. Objective To compare the skin lightening effect between oral TXA and topical TXA and to dissect the molecular mechanisms using ultraviolet B (UVB)-induced hyperpigmentation mouse model, ex vivo cultured human skin explant, and cultured melanocytes (MCs) and endothelial cells. Methods Melanin content and cluster of differentiation 31 (CD31)-positive cell numbers were measured in tail skins from UVB-irradiated mice treated by intragastral or topical TXA using immunofluorescent and Fontana-Masson staining. The conditioned medium (CM) was harvested from human umbilical vein endothelial cells treated with or without 3 mM TXA and was used to treat MCs for 48 hours. mRNA and protein levels of tyrosinase and microphthalmia-associated transcription factor were measured using quantitative real-time reverse transcription polymerase chain reaction and western blotting assays. HMB45- and CD31-positive cell numbers as well as melanin content were also examined in ex vivo cultured human skin explants. Results The hyperpigmented phenotype were significantly mitigated in UVB-irradiated tail skin plus intragastral TXA-treated mice compared with mice treated with UVB only or with UVB plus topical TXA. CD31-positive cell numbers correlated with the anti-melanogenic activity of TXA therapy. The data from cultured cells and skin tissues showed that suppression of endothelin-1 (ET-1) in vascular endothelial cells by TXA reduced melanogenesis and MC proliferation. Conclusion Oral TXA outperforms topical TXA treatment in skin lightening, which contributes to suppression of ET-1 in dermal microvascular endothelial cells by TXA.
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CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Jihan Yang,Airong Li,Junping Guo,Zhihong Wang
The control of sulfur dioxide (SO 2 ) emissions from natural gas purification processes has become an urgent environmental priority due to increasing regulatory pressures and public concerns over air pollution. In this study, a series of 1-methylimidazolium-based ionic liquids ([MIM]-ILs) were synthesized and structurally characterized, followed by systematic evaluation of their SO 2 absorption capacities under simulated flue gas conditions (2000 ppm SO 2 ). Among them, [MIM]Lac showed the relatively better absorption performance, reaching a saturated capacity of 1.986 mol SO 2 per mol IL at a low concentration of 2000 ppm SO 2 . The regeneration experimental results demonstrated that [MIM]Lac achieved an optimal SO 2 removal efficiency of 99.71 % at 85 °C, indicating excellent thermal responsiveness. Even after 10 consecutive absorption-desorption cycles, [MIM]Lac retained 92.52 % of its initial absorption capacity, highlighting its outstanding cyclic stability and thermal durability. The insights based on FT-IR and 1 H NMR analyses revealed that SO 2 absorption by [MIM]Lac primarily involved the reversible chemical interactions between SO 2 and the lactate anion, particularly at the S O and S−O sites. This study provides a practical strategy for designing efficient SO 2 absorbents and the development of ionic liquid-based desulfurization systems.
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ADVANCED FUNCTIONAL MATERIALS
·
2025
·
IF 19
Biao Zeng,Hao Yuan,Zhen Guo,Xinmeng Er,Yifei Liu,Bohua Dong,Fei Ma
Ultrafine nanocatalysts can provide abundant catalytic sites, but typically it is less stable and susceptible to dissolution diffusion. Here, this work reports a selenium-mediated strategy to construct sub-nanometers amorphous shell on ultrafine Pt nanocrystal core, forming a Pt@PtSe x core/shell nanostructure. In this developed strategy, the active Se-oleylamine precursor after Pt nucleation confines the overgrowth and oriented attachment of Pt, allowing the in situ formation of core/shell nanostructures combining ultrafine size and sub-nano amorphous shell. Essentially, the sub-nano amorphous PtSe x shell can not only optimize the hydrogen adsorption energy and lower the water dissociation energy, but also retard the dissolution of Pt atoms, thus leading to significantly improved activity and durability in both acidic and alkaline electrolytes. The overall water splitting can be driven by a small cell voltage of 1.48/1.53 V at 10 mA cm −2 in 0.5 M H 2 SO 4 /1.0 M KOH, respectively. Moreover, Pt@PtSe x -1 with ≈0.8 nm thick amorphous shell exhibits ultra-high mass activity of 75.2 A mg Pt −1 in acidic and 18.4 A mg Pt −1 in alkaline at −70 mV, as well as a robust durability with stable operation for 1100 h at 100 mA cm −2 in alkaline (1300 h at 160 mA cm −2 in acidic), superior to the most reported Pt-based electrocatalysts.
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TALANTA
·
2025
·
IF 6.1
Mengyu Du,Fangfang Sun,Yilin Sun,Zhenzhen Ma,Chenshuo Wang,Mengyu Liu,Ling Zhu,Hanchun Yao
Acute kidney injury (AKI) is a swiftly advancing condition that may result in kidney failure and pose a significant threat to life. Therefore, diagnosis of AKI is crucial for treating AKI and preventing the worsening of the condition. We developed a near-infrared fluorescent probe, CyO@CD-Ser, designed for the diagnosis of AKI. This probe targets kidney injury molecule-1 (KIM-1) and is activated by ONOO − . It consists of L-serine-modified β-cyclodextrin and compound CyO. In this system, ONOO − , a novel biomarker for AKI, triggers the oxidation of CyO to produce compound CyOH, resulting in a pronounced enhancement of near infrared fluorescence, offering a clear, visual signal for the detection of AKI. Through its modification with L-serine, β-cyclodextrin is able to efficiently penetrate cells by targeting KIM-1 receptors, thereby enhancing its specificity and effectiveness. In vitro and in vivo experiments demonstrate the probe's high sensitivity and biocompatibility, with a detection limit of 42.7 nM for ONOO − . Fluorescence is detectable in cisplatin-induced AKI after 12 hours, becoming significant at 24 hours. This suggests that CyO@CD-Ser can identify AKI earlier than traditional methods, offering a valuable tool for studying and diagnosing drug-induced AKI. Consequently, the probes we constructed can detect AKI early by precisely targeting and identifying biomarkers, preventing the deterioration of the condition, and providing an opportunity for early treatment for patients.
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Protection of Metals and Physical Chemistry of Surfaces
·
2020
·Vol. 56
·期 1
·180-188
·
IF 0.985
Li Min,Li Ying
— In this work, it found that zinc oxide (ZnO) and zinc chloride (ZnCl 2 ) can be dissolved well in 1-methylimidazolium trifluoromethylsulfonate (MIMTfO) ionic liquid with a high concentration (1.5 mol L −1 ). The electrochemical behavior of Zn(II) in MIMTfO ionic liquid containing ZnO or ZnCl 2 was investigated at 373 K. Cyclic voltammetry results indicated that the electrodeposition of zinc from both ZnO and ZnCl 2 is a one-step and two-electron reaction. Chronoamperometry studies revealed that the electrodeposition of zinc from both ZnO and ZnCl 2 is fit instantaneous nucleation, and the average values of the diffusion coefficient of Zn(II) were determined to be approximately 4.1 × 10 –8 cm 2 s –1 and 7.7 × 10 –9 cm 2 s –1 , respectively, at 373 K. The electrodeposition experiments were performed at 373 K and 383 K using potentiostatic electrolysis. The SEM images showed that dense and compact electrodeposits were obtained at 373 K in MIMTfO ionic liquid for both Zn(II) sources, and the EDS and XRD analysis confirmed that the obtained electrodeposits are metallic zinc.
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