CHEMISTRY OF MATERIALS
·
2025
·
IF 7
Wei Shen,Zhihua Chen,Junmin Xia,Jiayu Jiang,Yanfeng Chen,Yanxing He,Hao Cui,Wei Zhao,Suyun Liu,Shufen Chen
The soft ionic nature, tunable lattice structure, variable component, and solution processability make metal halide perovskite (MHP) materials good candidates as high-entropy materials. Although composition regulation of the X site can be easily achieved by mixing two types of halogens, it remains challenging to prepare high-entropy MHP (HEMHP) with three types of halogens due to the large octahedral factor (μ) difference of [PbX6]4–. Fundamental research is explored to synthesize HEMHP incorporating Cl–, Br–, and I– via μ regulation engineering, which breaks the limitation of a 6% Cl/I ratio in perovskite to achieve 116%. Doping AlCl3 in CsPbBrI2 could successfully reduce the μ differences for [Pb1–aAlaX6](4–a)–, shorten the Pb–X bond length, and enhance the Pb–X bond energy via the Al–X covalent bond. Therefore, the crystal distortion and halogen ion migration could be inhibited to form a homogeneous HEMHP, such as Cs1.18Pb0.92Al0.08(Cl0.13Br0.51I0.36)2.45L–0.81, Cs1.12Pb0.88Al0.12(Cl0.25Br0.49I0.26)2.53L–0.71, and Cs1.06Pb0.85Al0.15(Cl0.29Br0.46I0.25)2.43L–0.78. Such μ regulation engineering method is feasible and universal to use other metal ions (Zn2+, Mn2+, and In3+) to synthesize single-phase HEMHP. Furthermore, the optical band gap and emission peak wavelength for HEMHP and MHP are linearly dependent on their lattice distances, which is the intrinsic characteristic for composition-depended perovskite.
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Journal of Integrative Neuroscience
·
2025
·Vol. 24
·期 8
·40079
·
IF 2.7
Jixin Chen,Guoyou Chen,Yueheng Wu,Shuai Liu,Yifan Ma,Maonan Liu,Wei Yu
Background and Purpose:Ciprofol, a novel intravenous anesthetic, has been shown to exert protective effects against ischemic stroke, a leading cause of death and disability; however, its molecular mechanisms remain unclear. This study aimed to explore the molecular mechanisms underlying the neuroprotective effects of ciprofol using metabolomics.Methods:This study used a middle cerebral artery occlusion (MCAO) rat model to simulate cerebral ischemia-reperfusion injury (CIRI). The rats were divided into ciprofol, MCAO, and sham groups. Histological and neurobehavioral testing methods were used to investigate the therapeutic effects of ciprofol in rats. Ultra-high-performance liquid chromatography-quadrupole time-of-flight mass spectrometry was used to screen for differential metabolites and related metabolic pathways in the serum and brain of the three groups. Spectrophotometry was used to detect in vitro mitochondrial respiratory chain complex I (MRCC-I) activity.Results:Neurological behavioral scores and cerebral infarct volumes of rats in the ciprofol group were significantly lower than those of rats in the MCAO group. Metabolomic analysis revealed 19 differential metabolites in serum samples and 31 differential metabolites in brain samples, including flavin mononucleotide (FMN). These metabolites were mainly enriched in the tricarboxylic acid cycle, respiratory electron transport chain, and amino acid and lipid metabolism. In vitro experiments demonstrated that ciprofol promoted the activity of MRCC-I during CIRI by increasing FMN levels.Conclusion:The mechanisms of action of ciprofol during treatment of cerebral ischemia involve the tricarboxylic acid cycle, respiratory electron transport chain, and amino acid and lipid metabolism and may directly affect MRCC-I activity by regulating FMN.
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BIOPHARMACEUTICS & DRUG DISPOSITION
·
2018
·Vol. 39
·期 6
·298-307
·
IF 1.677
E Zhang,Fulong Chu,Lixu Xu,Hao Liang,Shuliang Song,Aiguo Ji
A new method to label fucoidan sulfate was established with tyramine and fluorescein isothiocyanate isomer I (FITC). Fluorescence spectrophotometry and high performance liquid chromatography verified the successful labelling of fucoidan by FITC. The results of the single-pass intestinal perfusion indicated that the jejunum and ileum are the main absorption sites, and there was carrier saturation. In addition, fucoidan sulfate at 1 mg/ml had no inhibitory effect on Caco-2 cell proliferation. Studies on the transmembrane transport mechanism showed that fucoidan can be absorbed because the apparent permeability coefficient of the drugs (P app ) A → B was 3.78 + 0.03 ×10 −6 and that of B → A was 1.42 + 0.19 ×10 −6 . The peak absorption of fucoidan occurred at 120 min after administration; moreover, the higher the concentration used, the worse the absorption was, suggesting the saturation of transport carriers. The absorption was temperature dependent: the absorption at 37°C was much better than that at 4°C. Further, the absorption of fucoidan sulfate might rely on clathrin endocytosis as chlorpromazine (10 μg/ml) significantly inhibited it.
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MICROCHIMICA ACTA
·
2019
·Vol. 186
·期 6
·1-10
·
IF 5.479
Luo Zibin,Sun Duanping,Tong Yanli,Zhong Yongsheng,Chen Zuanguang
An ultrasensitive voltammetric aptasensor was constructed to analyze cardiac troponin I (cTnI). It is based on DNA nanotetrahedron (NTH) linked dual-aptamer (dAPT) and magnetic metal organic frameworks (mMOFs) of type Fe 3 O 4 @UiO-66. Firstly, the DNA NTH linked dAPT (Tro4 and Tro6) were immobilized on a gold electrode for improving the capture efficiency of cTnI. The novel mMOFs Fe 3 O 4 @UiO-66 was then decorated by Au@Pt nanoparticles (Au@PtNPs), horseradish peroxidase (HRP), G-quadruplex/hemin (GQH) DNAzyme, and two types of aptamers to form signaling nanoprobes. In the presence of cTnI, an aptamer-protein-nanoprobe sandwich-type structure is formed. Afterward, the nanoprobes including enzyme, GQH DNAzyme and Fe 3 O 4 @UiO-66/Au@PtNP were utilized to catalyze the oxidation of hydroquinone by hydrogen peroxide for the electrochemical signals amplification, typically at a working potential of −0.1 V (vs. Ag/AgCl). The voltammetric signal increases linearly in the 0.01 to 100 ng·mL −1 cTnI concentration range, and the detection limit is 5.7 pg·mL −1 .
An ultrasensitive voltammetric aptasensor was constructed to analyze cardiac troponin I (cTnI) based on DNA nanotetrahedron linked dual-aptamer and magnetic metal organic frameworks of type Fe 3 O 4 @UiO-66. The results indicated the aptasensor has a wide linear response range (0.01 to 100 ng/mL) and low detection limit (5.74 pg/mL) for cTnI. GE: gold electrode; MCH: 6-Mmercapto-1-hexanol; HRP: horseradish peroxidase; HQ: hydroquinone; BQ: benzoquinone.
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Journal of Neuroinflammation
·
2023
·Vol. 20
·期 1
·1-21
·
IF 9.3
Li Nan,Wang Chunyan,Zhao Yuying,Wang Yigang,Gao Tianyu,Yu Yonghao,Wang Guolin,Zhang Linlin
Background Patients receiving epidural or intrathecal opioids administration for neuraxial analgesia frequently suffer from an irritating itch. STING (stimulator of interferon genes), an innate immune modulator, is strongly implicated in pain pathogenesis via neuron-immune modulation. Given that pain and itch share some common neurocircuits, we evaluate the therapeutic potential of STING agonists in opioid-induced itch and chronic itch.Methods Opioids (morphine, fentanyl and sufentanil) were intrathecally injected to induce acute itch. Chronic itch was induced by dry skin and contact dermatitis. Opioids analgesic effect, itch-induced scratching behavior, spinal expression of STING, phosphorylation of TBK1 (tank-binding kinase 1), IRF3 (interferon regulatory factor-3) and ERK (extracellular signal-regulated kinase), as well as production of IFN-α and IFN-β were examined. STING agonists (DMXAA and ADU-S100), TBK1 inhibitor, recombinant IFN-α and IFN-β elucidated the mechanism and treatment of itch. Whole-brain functional connectivity was evaluated using resting-state fMRI.Results We report the primary expression of STING protein by the spinal dorsal horn neurons. Intraperitoneal injection of DMXAA dose-dependently reduces morphine-induced scratch bouts, without impairing morphine antinociception. Simultaneously, DMXAA alleviates fentanyl- and sufentanil-induced itching-like behavior, and chronic scratching behavior caused by dry skin and contact dermatitis. Furthermore, DMXAA drastically increases spinal phosphorylation of TBK1 and IRF3 following morphine exposure, dry skin and contact dermatitis. DMXAA-induced anti-pruritus effects and spinal productions of IFN-α and IFN-β are compensated by intrathecal delivery of the TBK1 inhibitor. Also, ADU-S100, recombinant IFN-α and IFN-β exhibits remarkable attenuation in scratching behaviors after morphine injection and dermatitis. Recombinant IFN-α inhibits morphine-induced spinal phosphorylation of ERK. Finally, DMXAA prevents dermatitis-induced the increase of cerebral functional connectivity between regions of interests such as primary somatosensory cortex, piriform cortex, retrosplenial cortex, colliculus and ventral thalamus.Conclusion sSTING activation confers protection against opioid-induced itch and chronic itch through spinal up-regulation of TBK1-IRF3-type I interferon cascades in mice, suggesting that STING agonists are promising candidates in translational development for pruritus relief.
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Frontiers in Cellular and Infection Microbiology
·
2021
·
IF 5.293
Zhang Qi,Chen Zhiqiang,Huang Chenxiao,Sun Jiuyuan,Xue Minfei,Feng Tingting,Pan Wen,Wang Kezhen,Dai Jianfeng
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has spread worldwide and has infected more than 250 million people. A typical feature of COVID-19 is the lack of type I interferon (IFN-I)-mediated antiviral immunity in patients. However, the detailed molecular mechanisms by which SARS-CoV-2 evades the IFN-I-mediated antiviral response remain elusive. Here, we performed a comprehensive screening and identified a set of SARS-CoV-2 proteins that antagonize the IFN-I response. Subsequently, we characterized the mechanisms of two viral proteins antagonize IFN-I production and downstream signaling. SARS-CoV-2 membrane protein binds to importin karyopherin subunit alpha-6 (KPNA6) to inhibit interferon regulatory factor 3(IRF3) nuclear translocation. Further, the spike protein interacts with signal transducer and activator of transcription 1 (STAT1) to block its association with Janus kinase 1 (JAK1). This study increases our understanding of SARS-CoV-2 pathogenesis and suggests novel therapeutic targets for the treatment of COVID-19.
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ANALYTICA CHIMICA ACTA
·
2015
·
IF 4.513
Zhong Feng Gao,Dong Mei Chen,Jing Lei Lei,Hong Qun Luo,Nian Bing Li
Improving the reproducibility of electrochemical signal remains a great challenge over the past decades. In this work, i-motif oligonucleotide probe-based electrochemical DNA (E-DNA) sensor is introduced for the first time as a regenerated sensing platform, which enhances the reproducibility of electrochemical signal, for label-free detection of glucose and urea. The addition of glucose or urea is able to activate glucose oxidase-catalyzed or urease-catalyzed reaction, inducing or destroying the formation of i-motif oligonucleotide probe. The conformational switch of oligonucleotide probe can be recorded by electrochemical impedance spectroscopy. Thus, the difference of electron transfer resistance is utilized for the quantitative determination of glucose and urea. We further demonstrate that the E-DNA sensor exhibits high selectivity , excellent stability, and remarkable regenerated ability. The human serum analysis indicates that this simple and regenerated strategy holds promising potential in future biosensing applications.
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NEW JOURNAL OF CHEMISTRY
·
2024
·Vol. 48
·期 38
·16683-16691
·
IF 2.7
Xiaoyu Cao,Huifang Yang,Jihui Luo,Jianxian Zeng,Zhanfang Cao,Xiaoping Huang
Highly efficient and selective extraction of silver ions from wastewater remains a formidable challenge in ensuring public health and protecting ecosystems. Herein, an acyl-based thiourea extractant known as N-benzoyl-N′,N′-dibutyl thiourea (BDBTU) was used for the selective extraction of silver ions from aqueous solution by a solvent extraction method. BDBTU displayed an outstanding extraction efficiency of Ag(I) with an extraction ratio of 96.7% under the optimal extraction conditions, surpassing its effectiveness for Cu(II) and Mn(II) ions. In addition, BDBTU retained high effectiveness even after undergoing eight regeneration cycles, with only a slight decrease in the extraction efficiency from 96.7% to 95.2%. Moreover, it displayed selective extraction towards Ag(I) ions under the interference of metal ions (i.e., Cu(II), Pb(II), Mn(II), Zn(II), Ni(II), Co(II) and Na(I)). The investigation into the extraction mechanism of BDBTU towards Ag(I) unveiled that BDBTU provided a high affinity for Ag(I) accompanied by the formation of Ag–O–C and Ag–S–C bonds. These results indicated that the exceptional extraction stability and selectivity of BDBTU offer promising prospects for diverse applications, highlighting its potential in silver-containing wastewater treatment fields.
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JOURNAL OF ALLOYS AND COMPOUNDS
·
2022
·
IF 6.371
Yanmei Zhou,Shaoru Wu,Guobin Huang,Jingbin Zeng,Benjamin Edem Meteku,Xiaohong Tan,Heng Lu,Feiming Li,Zhixiong Cai,Xudong Wang,Maosheng Zhang
Intrinsic and surface defects are the crucial factors that affect the stability and luminescence efficiency of nanocrystals (NCs). Ion-doping and surface passivation are considered as the most effective strategies to suppress the intrinsic and surface defects of NCs, respectively. Herein, an efficient and facile double passivation process, simultaneously realizes ion-doping and surface passivation, for Cs 3 Cu 2 X 5 (X Cl, Br and I) NCs is developed by using potassium oleate (K-OA) as passivator. K ion is used as ion-doping passivation and OA ion is used as the organic ligand for surface passivation of NCs. Compared to the free passivated NCs, the Photoluminescence quantum yield (PLQYs) of dual-passivated Cs 3 Cu 2 X 5 (X Cl, Br and I) NCs increase significantly from 2.87%, 11.6% and 49.4–31%, 69.9%, and 97.2%, respectively. Moreover, the stability of proposed NCs is greatly improved (Cs 3 Cu 2 Cl 5 NCs maintain 63% of PL efficiency after 100 h, Cs 3 Cu 2 Br 5 and Cs 3 Cu 2 I 5 NCs maintain 65% and 97% of PL efficiency after 100 days, respectively) at 50–86% relative humidity and room temperature under ambient atmosphere.
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FOOD CHEMISTRY
·
2025
·
IF 9.8
Sili Xiao,Xiaoxia Huang,Xiting He,Zitao Chen,Xiaoyan Li,Xianling Wei,Qiaoyu Liu,Hao Dong,Xiaofang Zeng,Weidong Bai
This study aims to elucidate the interaction mechanisms between curcumin (Cur) and four collagen subtypes (fish type I [FCI], bovine type I [BCI], fish type II [FCII], bovine type II [BCII]), with parallel characterization of the structural and functional attributes of their derived nanoparticles. Type I Collagen/Cur nanoparticles exhibited superior solution stability compared to type II. Cur binding significantly enhanced the surface hydrophobicity, absolute ζ potential, and surface tension of collagen, while reduced dynamic interfacial tension. The binding type of Cur to collagen was static, and binding process was enthalpy-driven exothermic reaction. Molecular dynamics simulations revealed that hydrophobic interactions, hydrogen bonds, and electrostatic forces dominated the binding process. The binding affinity followed the order: FCI/Cur > BCI/Cur > FCII/Cur > BCII/Cur. The binding sites of Cur to type I collagen and type II collagen were around Ser129-Glu135 and Asn179-Ser183 residues. Collagen/Cur nanoparticle stabilized emulsions and improved oxidative stability and storage modulus.
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MICROCHIMICA ACTA
·
2019
·Vol. 186
·期 8
·1-10
·
IF 5.479
Ma Zhangyan,Wu Tengteng,Li Peipei,Liu Meiling,Huang Si,Li Haitao,Zhang Youyu,Yao Shouzhuo
A fluorimetric and colorimetric method is described for the determination of glutathione (GSH) and silver (I). It is based on the use of MnO 2 nanosheets that were prepared by solution mixing and exfoliation. They display oxidase-mimicking activity and can catalyze the oxidation of o-phenylenediamine (OPD) to form yellow 2,3-diaminophenazine (DAP) with an absorption maximum at 410 nm. DAP also has a yellow fluorescence (with a peak at 560 nm). The MnO 2 nanosheets can be rapidly reduced to Mn 2+ by GSH. This reduces the efficiency of the oxidase mimic MnO 2 and causes a decrease in fluorescence and absorbance intensity. However, on addition of Ag + , a complex is formed with GSH. It prevents the destruction of MnO 2 nanosheets so that the enzyme mimicking activity is retained. A dual-method for the determination of GSH and Ag(I) was developed. It has excellent sensitivity for GSH with lower detection limits of 62 nM (fluorimetric) and 0.94 μM (colorimetric). The respective data for Ag(I) are 70 nM and 1.15 μM. The assay was successfully applied to the determination of GSH and Ag(I) in spiked serum samples.
Schematic presentation of a method for colorimetric and fluorometric determination of glutathione (GSH) and silver(I). MnO 2 nanosheets are reduced to Mn(II) by GSH. This reduces the enzyme-mimicking activity of MnO 2 nanosheets and causes a decrease in fluorescence and absorbance. On addition of Ag(I), the enzyme-like activity is increasingly retained. A decrease in fluorescence and absorbance is not observed any longer.
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Journal of the American Chemical Society
·
2017
·
IF 13.858
Senyun Ye,Haixia Rao,Ziran Zhao,Linjuan Zhang,Hongliang Bao,Weihai Sun,Yunlong Li,Feidan Gu,Jianqiang Wang,Zhiwei Liu,Zuqiang Bian,Chunhui Huang
It is extremely significant to study the trap state passivation and minimize the trap states of perovskite to achieve high-performance perovskite solar cells (PSCs). Here, we have first revealed and demonstrated that a novel p-type conductor Cu(thiourea)I [Cu(Tu)I] incorporated in perovskite layer can effectively passivate the trap states of perovskite via interacting with the under-coordinated metal cations and halide anions at the perovskite crystal surface. The trap state energy level of perovskite can be shallowed from 0.35–0.45 eV to 0.25–0.35 eV. In addition, the incorporated Cu(Tu)I can participate in constructing the p–i bulk heterojunctions with perovskite, leading to an increase of the depletion width from 126 to 265 nm, which is advantageous for accelerating hole transport and reducing charge carrier recombination. For these two synergistic effects, Cu(Tu)I can play a much better role than that of the traditional p-type conductor CuI, probably due to its identical valence band maximum with that of perovskite, which enables to not only lower the trap state energy level to a greater extent but also eliminate the potential wells for holes at the p–i heterojunctions. After optimization, a breakthrough efficiency of 19.9% has been obtained in the inverted PSCs with Cu(Tu)I as the trap state passivator of perovskite.
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