JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2025
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IF 9.7
Yesheng Fu,Huayu Chen,Zehao Wang,Dandan Yu,Junhui Liang,Yuexiang Huang,Ismaila Taiwo Bello,Gayi Nyongombe Ekambo,Mokhotjwa Simon Dhlamini,Da Chen
The development of efficient and stable electrocatalysts for the oxygen evolution reaction (OER) in acidic media remains a critical challenge. Here, we designed a hierarchical structure catalyst comprises of MnO 2 and carbon‑nitrogen compound (CN) coated MoO 2 (denoted as MoO 2 @CN/MnO 2 ), in which the Mn species is identified as the real active site for OER and the Mo-containing species (MoO 2 @CN) serves as the promoter. The incorporation of CN into the interface between the MoO 2 and MoO 2 facilitates the inner electron transfer from Mo to Mn, thereby increasing the quantity of Mn 3+ active sites for more efficient OER process, and at the meantime, the presence of CN effectively suppresses Mn dissolution during OER, stabilizing these active sites and improving the overall catalytic stability. The MoO 2 @CN/MnO 2 heterostructure exhibits decreases of 29 mV and 74 mV for the overpotential at 20 mA cm −2 compared with the MoO 2 /MnO 2 and the MnO 2 , and shows enhanced electrocatalytic stability. This work provides a promising and facile strategy for enriching and stabilizing the active species for acidic OER catalysts.
研究领域:
电化学
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催化
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材料科学
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纳米技术
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能量转换
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产品关联
DOI
PubMed
高影响因子
Biomaterials Advances
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2025
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IF 6
Wajiha Ahmed,Shifen Li,Min Liang,Pai Peng,Wali Muhammad,Qiaoxuan Wang,Changyou Gao
Reactive oxygen species (ROS) and subsequent inflammatory cascades hinder the healing of diabetic wounds, which should be tackled simultaneously when designing wound dressings. In this study, ROS-responsive di‑selenium-containing polyurethane nanofibers (PUF) loaded with manganese dioxide nanoparticles (MnO 2 NPs) and gelsevirine (GSV) with an average diameter of 0.6 ± 10 μm, were prepared to specifically target ROS and inflammation control, thereby enhancing healing in diabetic wounds. The resulting nanofibers exhibited a porous architecture and enhanced drug delivery capability. The MnO 2 /GSV/PUF dressing showed negligible cytotoxicity with cell viability over 80 %, effective ROS-scavenging ability of 87 %, and inhibition of pro-inflammatory cytokine expression. This dual mechanism of ROS-scavenging and inflammation modulation accelerated the healing of diabetic wounds up to 92 % in 14 d in a full-thickness diabetic wound model, as evidenced by reduced cytokine levels, enhanced epithelialization, and uniform collagen deposition with the highest percentage of 60 %.
研究领域:
生物材料学
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医学
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药理学
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产品关联
DOI
PubMed
高影响因子
Journal of Water Process Engineering
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2024
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IF 6.3
Yajie Wen,Jiabin Zhou,Lin He,Dan Liu
In this study, manganese from the cathodes for waste batteries (WBCs) was recovered by hydrometallurgical method as a raw material for the peroxymonosulfate (PMS) activator MnCO 3 , which was successfully synthesized by a simple and environmentally friendly process. MnCO 3 had a good degradation properties for oxytetracycline hydrochloride (OTC-HCl). Under the best conditions through the BoxBehnken Design (BBD), the MnCO 3 /PMS system effectively decomposed 91.3 % of OTC-HCl (initial concentration of 60 mg/L), and the Total Organic Carbon (TOC) removal rate was 63.6 % within just 10 min. Moreover, the system exhibits effectiveness over a wide pH range, with its degradation rate remaining largely unaffected by the presence of inorganic anions. Reactive species, including sulfate radicals (SO 4 ·− ), hydroxyl radicals (･OH), superoxide radicals (O 2 ·− ), and singlet oxygen ( 1 O 2 ), are generated by the degradation system. A series of experiments and characterizations demonstrated that 1 O 2 plays a significant role in the degradation system. This study paves the way for the recycling of spent zinc‐manganese batteries and establishes an efficient multi-mechanism degradation system for treating recalcitrant organic wastewater.
研究领域:
环境科学
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化学工程
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废物管理
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水处理
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产品关联
DOI
高影响因子
MICROCHEMICAL JOURNAL
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2024
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IF 4.9
Xiuhua Zhang,Heqin Liu,Wanrong Hong,Yumin Wang,Jin-Wen Liu,Yingfeng Qin
In this work, a novel fluorescence nanoprobe based on MnO 2 nanosheets and DNAzyme cyclic amplification was developed for label-free detection of GSH. In our design, the DNA@MnO 2 nanoprobe was facilely prepared through the adsorption of DNA probes on the surface of MnO 2 nanosheets. Importantly, MnO 2 nanosheets in the DNA@MnO 2 nanoprobe can act as the recognizer of analytical target GSH. In the presence of GSH, the DNA@MnO 2 nanoprobe are decomposed owing to redox-responsive reaction between GSH and MnO 2 nanosheets, resulting in the generation of abundant Mn 2+ and the desorption of DNA probes. Subsequently, the Mn 2+ -dependent DNAzyme recycling amplification was rapidly initiated and a large number of the blocked G-rich sequences in DNA probes was released. The G-rich sequences were efficiently folded into G-quadruplex structures, which can remarkably light up the fluorescence intensity of thioflavin T (ThT). Experimental data demonstrated that the DNA@MnO 2 nanoprobes for GSH detection have a wide linear range from 0 to 2000 µM. Moreover, this fluorescence sensing strategy was successfully applied for the detection of GSH in complex biological media with satisfying results, providing a simple, facile and cost-efficient nanoplatform for GSH-related clinical disease diagnosis.
研究领域:
分析化学
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纳米技术
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生物医学工程
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生物化学
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产品关联
DOI
高影响因子
Journal of Energy Storage
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2024
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IF 8.9
He Wang,Hongjie Wang,Chengwen Hu,Yaling Cheng,Lan Yao,Fangtao Ruan,Quan Feng,Changliu Chu,Tong Lin,Hongxia Wang
Polymer waste is a global problem. How to convert it into high value-added applications has been a challenge. Herein, we prepare a flexible all-solid-state asymmetric supercapacitor using carbon fiber composite waste resin and disposable nonwoven fabrics as starting materials. For this purpose, we prepared activated carbon (RAC) from the waste resin, and then loaded MnO 2 on the RAC. In parallel, we applied a silver paste to the waste nonwoven fabric. By loading RAC and MnO 2 -RAC separately onto the silver-coated nonwoven, they were used as the negative and positive electrodes to form an all-solid-state supercapacitor with 6.0 M KOH/PVA solid electrolyte. The devices have a specific capacitance of 148.7 F/g with an energy density of ∼52.9 Wh/kg. After 10,000 charge/discharge cycles, the devices have a capacitance retention rate of 83.9 %, indicating excellent cycle life. They also have excellent flexibility, maintaining the high capacitance almost unchanged under various bending conditions.
研究领域:
材料科学
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环境科学
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能源科学
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产品关联
DOI
高影响因子
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
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2026
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IF 3.9
Yang-Yang Xu,Xing Fan,Hai-Xu Zou,Yu Wang,Shan-Zhao Feng,Xiao-Yan He,Xiang Bai,Yierxiati Dilixiati,Guligena Pidamaimaiti,Xian-Yong Wei
Efficient resource utilization of coal gasification coarse slag (CGCS) is critical for ecological sustainability and industrial economics. A low-cost, high-performance catalyst loaded with cerium-manganese oxide (CeO2–MnO2/CGCS) was prepared via an impregnation-hydrothermal synthesis. The catalytic ozonation activity of CeO2–MnO2/CGCS was evaluated based on the removal rate of chemical oxygen demand (COD) for both simulated and actual coal chemical wastewater. For simulated wastewater, the COD removal rates of phenol-, naphthalene-, and benzofuran-containing wastewater were 81.2%, 58.9% and 56.6%, respectively, with the existence of CeO2–MnO2/CGCS, and the COD removal rate of mixed simulated wastewater containing the above compounds reached 66.3%. When CeO2–MnO2/CGCS was applied to actual coal chemical wastewater, the COD decreased from 200 to 36.5 mg/L with a removal rate of 81.7%. In comparison, the COD removal rate using a commercial catalyst was 72.9%, indicating the potential industrial application of CeO2–MnO2/CGCS. Furthermore, it was demonstrated that hydroxyl radicals (·OH) are the key reactive substances in the degradation of organics by adding a free radical scavenger (5,5-dimethyl-1-pyrroline-N-oxide) into the catalytic ozonation degradation of phenol-containing wastewater. Meanwhile, the mechanism of catalytic ozonation degradation of organics in coal chemical wastewater using CeO2–MnO2/CGCS as the catalyst is also proposed.
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产品关联
DOI
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2022
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IF 9.965
Jinlei Wang,Weijun Xu,Junmin Qian,Yaping Wang,Guanghui Hou,Aili Suo,Yu Ma
Hydrogel-based drug delivery holds great promise in topical tumor treatment. However, the simple construction of multifunctional therapeutic hydrogels under physiological conditions is still a huge challenge. Herein, for the first time, a multifunctional hyaluronan/MnO 2 nanocomposite (HHM) hydrogel with injectable and self-healing capabilities was constructed under physiological conditions through innovative in situ mineralization-triggered Mn-hydrazide coordination crosslinking. The hydrogel formed from Mn 2+ and hydrazided hyaluronan under optimized conditions exhibited a high elastic modulus >1 kPa, injectability, self-healing function, stimuli-responsiveness and catalase-like activity. In vitro and in vivo biological experiments demonstrated that our HHM hydrogel could not only efficiently relieve hypoxia by in situ catalytic decomposition of endogenous H 2 O 2 into O 2 but also achieve synergistic photodynamic/photothermal therapy of 4T1 breast cancer in a mouse tumor model. This study presented a novel mineralization-driven metal-hydrazide coordination crosslinking approach and developed a multifunctional therapeutic platform for O 2 -enhanced efficient topical dual-phototherapy of breast cancer.
研究领域:
生物医学工程
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材料科学
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癌症治疗
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纳米技术
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DOI
PubMed
高影响因子
BIOSENSORS & BIOELECTRONICS
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2020
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IF 10.257
Li Xue,Ruya Guo,Fengchun Huang,Wuzhen Qi,Yuanjie Liu,Gaozhe Cai,Jianhan Lin
Screening of pathogenic bacteria in foods is an effective way to prevent foodborne diseases. In this study, an impedance biosensor was developed for rapid and sensitive detection of Salmonella typhimurium using multiple magnetic nanobead (MNB) nets in a ring channel for continuous-flow separation of target bacteria from 10 mL of sample, manganese dioxide nanoflowers (MnO 2 NFs) for efficient amplification of biological signal, and an interdigitated microelectrode for sensitive measurement of impedance change. First, the MNBs modified with capture antibodies were vortically injected from outer periphery of this ring channel to form multiple ring MNB nets at specific locations with high gradient magnetic fields . Then, the bacterial sample was continuous-flow injected, resulting in specific capture of target bacteria onto the nets, and the MnO 2 NFs modified with detection antibodies were injected to form MNB-bacteria-MnO 2 NF complexes. After the complexes were washed with deionized water to remove excessive nanoflowers and residual ions, H 2 O 2 with poor conductivity was injected to reduce MnO 2 NFs to conductive Mn 2+ at neutral medium, leading to impedance decrease. Finally, impedance change was measured using the microelectrode for quantitative determination of Salmonella . This biosensor was able to separate ~60% of Salmonella from 10 mL of bacterial sample and detect Salmonella with a linear range of 3.0 × 10 1 to 3.0 × 10 6 CFU/mL in 1.5 h with lower detection limit of 19 CFU/mL. This biosensor might be further improved with higher sensitivity using a larger volume (100 mL or more) for routine screening of foodborne bacteria without bacterial pre-culture.
研究领域:
生物技术
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纳米技术
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食品安全
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生物传感器
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微生物学
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DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF PHARMACEUTICS
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2020
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IF 4.845
Yunbo Nie,Dan Li,Ying Peng,Shengfeng Wang,Shuo Hu,Miao Liu,Jinsong Ding,Wenhu Zhou
The RNA-cleaving DNAzyme (DZ) holds promising potential for RNA interference (RNAi) applications and is favored over siRNA owing to its high chemical stability, biocompatibility , predictable activity, and substrate versatility. However, its pharmaceutical applications for disease treatment are limited by the requirement of metal cofactor for activation, as well as the lack of effective co-delivery systems to combine with other therapeutic modalities. Herein, we designed and constructed metal organic framework (MOF) coated MnO 2 nanosheets to realize the co-delivery of a survivin inhibiting DZ and doxorubicin (DOX) for chemo-gene combinatorial treatment of cancer. In our design, the DOX was adsorbed on MnO 2 planar surface, and the DZ was loaded into the MOF shell layer through the coordination between Mn 2+ and tannic acid . The nano-system could stably encapsulate the payloads under physiological condition, but rapidly degraded after endocytose into tumor cells in response to intracellular stimuli, resulting in triggered drugs release. Notably, the coreleased Mn 2+ could act as metal cofactor for effective DZ activation. Both in vitro and in vivo studies have demonstrated the enhanced anti-tumor efficacy of the nanosystem, with co-contributions from anti-neoplastic DOX, survivin silencing effect of DZ, and to some extent, ROS generation by Mn 2+ . This work provides an ingenious strategy to address the key limitation of DZ for RNAi applications and realize the combination of DZ with other therapeutic modalities, in which the DZ can be in-situ activated for target gene silencing.
研究领域:
癌症治疗
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纳米技术
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药物递送系统
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基因治疗
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材料科学
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DOI
PubMed
高影响因子
Advanced Science
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2026
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IF 14.1
Jie Lin,Haoqi Pan,Ke Wu,Junjie Nan,Jinyao Dai,Yushun Chang,Hao Shen,Qingxuan Ye,Haowen Lu,Yuxuan Shen,Boqiang Liu,Ming Wu,Jicheng Yu,Xiujun Cai,Dong Cen
Recurrence and metastasis are the primary causes of mortality in hepatocellular carcinoma (HCC), primarily driven by an immunosuppressive tumor microenvironment. This study developed a multifunctional flexible patch (MnO 2 -P-ICG NFs) based on electrospun SiO 2 gel fibers whose surface is modified with a layer of “nest-like” MnO 2 . The patch enables the co-delivery of indocyanine green (ICG) and pachymaran directly to the tumor site via a laparoscopic system. Under near-infrared light irradiation, ICG serves as a photosensitizer for photodynamic therapy (PDT), effectively ablating tumors and inducing immunogenic cell death (ICD), thereby activating antitumor immunity. Meanwhile, pachymaran, with its immunomodulatory effects, preferential activates natural killer (NK) cells to exert antitumor effects. Additionally, PDT further enhances this immune response by activating the cGAS-STING pathway. In mouse models, implantation of the patch significantly inhibited primary liver tumor progression and ascites formation. In a malignant liver tumor model, MnO 2 -P-ICG NFs prevented local recurrence in 80% of treated mice. Notably, both the depletion of NK cells and the blockade of the cGAS-STING pathway compromised the therapeutic efficacy of MnO 2 -P-ICG NFs. Clinically, tumors with higher NK cell infiltration were associated with improved patient outcomes. In conclusion, this versatile patch provides a promising therapeutic strategy for patients with advanced HCC.
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DOI
PubMed
高影响因子
Carbon Letters
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2026
·
IF 6.2
Liang Yuwei,Huang Yufan,Hu Chunling,Cai Jinyu,Cao Yifan,Meng Guihua,Wu Jianning,Li Qi,Liu Zhiyong
Designing catalysts with suitable valence conduction band positions to generate reactive oxygen species (ROS) with moderate redox capacity is to achieve efficient photocatalytic biomass-selective value-added oxidation. This protocol addresses the issue by tuning material structural defects, altering the surface electronic structure, and ultimately enhancing the raw material’s performance. Here, an appropriate amount of one - dimensional nanorods α -MnO 2 adjusted material structural defects, increased the adsorbed oxygen (O ads )/lattice oxygen (O latt ) and Mn 3+ ratios, and served as an electron transport conduit, facilitating O₂ activation to generate ROS. The Cd 1.7 In 2 S 4.7 solid solution enables the optimal valence band position by adjusting the Cd 2+ : In 3+ ratio, thus selectively oxidizing 5-hydroxymethylfurfural (HMF) to 2,5-dicarbonylfuran (DFF). In situ XPS revealed that photogenerated electrons in Cd 1.7 In 2 S 4.7 quickly transferred to the conduction band of α -MnO 2 , and photogenerated holes from α -MnO 2 moved to the valence band of Cd 1.7 In 2 S 4.7 . This significantly enhanced the separation and transfer efficiency of photogenerated carriers at the interface. The optimal sample achieved 56% conversion of HMF and 72% selectivity of DFF under simulated sunlight. This protocol provides a new approach for the establishment of electron transport channel structures based on α -MnO 2 constructs and value-added biomass photocatalytic conversion under simulated sunlight.
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产品关联
DOI
高影响因子
APPLIED CATALYSIS B-ENVIRONMENTAL
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2019
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IF 14.229
Yang Liu,Hao Zhou,Ranran Cao,Xingyun Liu,Pengyi Zhang,Jingjing Zhan,Lifen Liu
Volatile organic compounds (VOCs) are notorious for global air pollution. It is key to find a material with high and stable activity to catalytically oxidize VOCs at low temperatures. In this paper, benzene, as a typical VOC contaminant, could be completely oxidized on a highly efficient and moisture-resistant birnessite MnO 2 at temperatures significantly lower than the reported values in literature. The best catalyst (H-MnO 2 (30-0.2-6)) could be tailored via a facile and green process by engineering a proper combination of treatment temperature (30 °C), HNO 3 aqueous concentration (0.2 M) and treatment period (6 h). The thus-obtained MnO 2 exhibited a stable removal efficiency of ˜94% for 318 ppm of benzene under a high space velocity of 120 L·g −1 h −1 and 1.5 vol.% H 2 O at 250 °C. XRD, SEM, (HR)TEM, EDS mapping, XPS, H 2 -TPR, O 2 -TPD and pyridine adsorption IR were combined with the deliberately designed C 6 H 6 -TPD, surface oxidation reaction of benzene and CO 2 -TPD to disclose the tremendous role of acid treatment in benzene oxidation. The increased acid sites and acidity of the acid-treated surface promoted the adsorption and activation of gaseous benzene, and the lattice oxygen and surface adsorbed oxygen became more facile and reactive due to the generated active oxygen vacancies via acid treatment, these two favorable factors together with the easy desorption of reaction products resulting in the excellent performance of the acid-treated sample. Finally, the acid treatment method can be extended to most of other crystal structures of manganese dioxides except α-MnO 2 .
研究领域:
环境科学
·
材料科学
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产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）