Nature Communications
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2025
·Vol. 16
·期 1
·1-17
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IF 15.7
Dai Hao,Han Ali,Wang Xijun,Zhu Peng,Wang Dingsheng,Wang Yuguang
Noninvasive phototherapy with functional preservation is considered to be a promising cancer therapeutic method. However, the clinical application of tumor phototherapy is severely restrained by the lack of appropriate multimodal phototherapy agents exhibiting an ideal tissue penetration depth to maximize the antitumor efficiency as well as to maintain important tissue functions. Herein, an innovative near-infrared ray (NIR)-triggered photodynamic-photocatalytic-photothermal therapy (PDT-PCT-PTT) agent based on an atomically dispersed cobalt single-atom enzyme (Co-SAE) anchored on hollow N-doped carbon sphere (HNCS) has been strategically developed. Reactive oxygen species (ROS) are highly activated and amplified through both the photogenerated electrons and the photothermal conversion induced by NIR irradiation, as systematically demonstrated by the experimental and density functional theory (DFT) calculation results. Mild hyperthermia is eventually achieved through apoptosis and ferroptosis caused by ROS, significantly boosting the interaction of ROS dynamic effects and thermodynamic effects in the tumor microenvironment (TME). More importantly, Co-SAEs/HNCS not only causes multimodal damage through limited TME products but also preserves important organ functions by the induction of mild local hyperthermia. This work expands the biomedical application field of SAEs and presents an innovative all-in-one, multimodal concept for the noninvasive treatment of head and neck cancer.
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Advanced Healthcare Materials
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2024
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IF 10
Lijun Zhu,Zhong Du,Jiabao Xiong,Hui Li,Chi Zhang,Xueliang Zhang,Nuernisha Alifu,Biao Dong
Precise theranostics of tumors is intricately linked to the early detection and monitoring of lymph nodes (LN) and metastases, making the targeted localization of LNs essential for tumor identification. However, designing LN-targeting probes remains a significant challenge due to issues such as lymphatic uptake, biocompatibility, and fluorescence stability. To address these challenges, near-infrared II (NIR-II) fluorescence probes are developed through meticulous analysis of LN physiological structure and passive targeting strategy for LN detection and tumor therapy. An LPP-QDs-IR-820 nanocomposite (NCs) is engineered, comprising the IR-820 molecules and ultrabright PbS@CdS quantum dots (QDs), which are encapsulated within a liposome-SH-mPEG 2000 polymer matrix. These NCs demonstrates remarkable lymphatic enrichment, facilitating real-time tracking of LN via electrostatic repulsion and extracellular matrix effects. Importantly, the NCs exhibit negligible in vivo toxicity and high biocompatibility. The intense NIR-II fluorescence emissions of IR-820 and PbS@CdS QDs confer upon the NCs a high NIR-II fluorescence quantum yield (6%). The cervical tumors and their deep microvessels are clearly observed via NIR-II fluorescence imaging. Moreover, the photothermal properties of IR-820 enable the NCs to achieve a photothermal conversion efficiency of 36.56%, leading to effective photothermal therapy in cervical tumor mice.
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Nanoscale
·
2025
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IF 5.1
Wentao Lei,Yinghui Wang,Tangyue Zheng,Qihang Wu,Hui Wen,Tingting Sun,Jun Liu,Zhigang Xie
It remains a clinical challenge to treat triple-negative breast cancer due to its aggressiveness and metastasis. Photothermal therapy (PTT) in combination with checkpoint blockade immunotherapy offers a promising strategy for such intractable tumors. In this study, a second near-infrared (NIR-II) photothermal agent (PCD NPs) and a tumor microenvironment-activatable nanoprodrug (NLG NPs) for indoleamine 2,3-dioxygenase 1 (IDO-1) blockade have been designed for the therapy of orthotopic triple-negative breast cancer. The NIR-II absorption of PCD NPs can guarantee the high penetration depth of the laser during PTT. At the same time, NLG NPs can be decomposed into the NLG919 monomer in the tumor microenvironment, which can effectively strengthen the immunogenic cell death-induced immune response. NIR-II PTT in synergy with IDO-1 blockade can effectively inhibit tumor growth and prevent tumor recurrence and metastasis. This work thus provides a safe, efficient and feasible method for the treatment of malignant tumors.
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ADVANCED FUNCTIONAL MATERIALS
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2025
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IF 19
Bin Pan,Yang Jin,Yan Chen,Juan Wang,Kangnan Wang,Sunfang Chen,Mingyang Lei,Wenguo Cui,Junjie Li,Yu Qian
The widespread abuse of antibiotics has led to the emergence of drug-resistant bacterial strains, severely complicating the treatment of infectious wounds. Traditional therapies are often limited to antibacterial or anti-inflammatory approaches, making it challenging to manage both early-stage infection and later-stage tissue regeneration simultaneously. Herein, a Cu 2−x Se nanoparticles (CSNPs) spray containing mixed-valence copper ions, enabling the programmed healing of infectious wounds is developed through light-controlled cascade regulation. In the early infection stages, the copper ions released from CSNPs exert antibacterial effects via chemodynamic therapy (CDT), with their activity significantly enhanced under near-infrared (NIR) irradiation. At later stages, Cu 2+ /Cu + ions enter cells, interact with cysteine residues in KEAP1 protein, and induce conformational changes, triggering deubiquitinase activity and suppressing macrophage-driven inflammation. Findings from in vitro and in vivo studies consistently revealed that CSNPs efficiently depleted glutathione and enhanced H 2 O 2 breakdown, leading to the generation of •OH and O 2 •- under NIR exposure, which resulted in an MRSA elimination rate exceeding 99%. Mechanistically, CSNPs bind to KEAP1, removing the ubiquitin linkage from NRF2, thereby inhibiting inflammation. This CSNPs spray provides a dual synergistic effect of antimicrobial and tissue-regenerative properties, offering an innovative approach for treating antibiotic-resistant infections in wounds.
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CHEMICAL ENGINEERING JOURNAL
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2025
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IF 13.2
Binhong Yu,Ziyan Chen,Zhiyuan Sun,Chengjun Yu,Zhenni Lu,Songshan Zeng
Hydroxypropyl cellulose (HPC) forms semi-transparent cholesteric liquid crystals (CLCs) under lyotropic conditions, exhibiting concentration- and temperature-dependent structural colors, covering the spectral region from ultraviolet (UV) to near-infrared (NIR). Notably, HPC CLCs exhibit a milky-white color against a white background owing to the incoherent scattering. Inspired by basal melanin-mediated color saturation between blue and white Steller's jay feathers, black backgrounds significantly enhance the saturation of structural colors by suppressing multiple incoherent scattering. Leveraging this mechanism, we propose a facile three-dimensional (3D) integration method for fabricating thermoresponsive and extreme-condition-resistance devices, composed of HPC CLCs with structural colors and thermochromic powders (TCPs) with a color switch between black and white. A single device displays color transitions among black, blue, green, red, and white, resulting from the synergistic effects of helical pitch modulation and dynamic incoherent scattering upon temperature stimuli. Intriguingly, coupling conductive carbon-oil substrates with hybrids enables electrothermal multicolor displays through Joule heating effects. Furthermore, the devised hybrids show great potential in anti-counterfeiting, smart labeling, camouflage, and information encryption through programmable TCP patterning beneath HPC CLCs. This work pioneers a new paradigm for synergistic integration of stimuli-responsive photonic crystals with adaptive absorbers, enabling scalable fabrication of color-switchable devices with customized control capabilities.
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ACS Applied Nano Materials
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2024
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IF 5.3
Xiaolong Li,Yulu Tang,Jundi Wan,Yahui Zhang,Dongjun Lv,Mingyuan Guo,Yongning Ma,Yuhao Yang
UV–vis–NIR photodetectors are of great importance to extensive applications, while they are limited by the low photon utilization and narrow light response range inherent in a single material. To overcome these limitations, we propose the construction of heterojunction photosensitive materials featuring a hollow structure. In this study, Y-type titanylphthalocyanine nanoparticles (Y-TiOPc NPs) and hollow ZnS nanotubes (ZnS NTs) are employed to fabricate a bulk heterojunction photosensitive material (Y-TiOPc NPs:ZnS NTs). This composite material exhibits a significant cavity enhancement effect, resulting from multiple light reflections and outstanding light absorption spanning from 365 to 1060 nm. The photodetector based on Y-TiOPc NPs:ZnS NTs (referred to as Y:ZT-PD) demonstrates remarkable photodetection capabilities, including photomultiplication phenomena. Specifically, it achieves a high external quantum efficiency of 24042%, an impressive photoresponsivity (R) of 101967 mA/W, and an excellent specific detectivity (D*) of 1.56 × 1012 Jones at 0.01 mW/cm2. Additionally, the multiperiod time-resolved photocurrent response curves exhibit rapid and stable responses across different wavelengths. Characterization results indicate that these exceptional performances primarily arise from the cavity enhancement effect of ZnS NTs and the hole-injection effect resulting from interfacial trapped electrons. Consequently, the outstanding performance, coupled with the broad spectral range and stability, positions the hollow bulk heterojunction as a promising material for the next generation of broadband photodetectors.
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CHEMICAL ENGINEERING JOURNAL
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2025
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IF 13.2
Youpei Wang,Xiang Zheng,Shiyun Liang,Danyan Wang,Xiaojun He,Lingxia Pang
Traditional treatments for drug-resistant bacterial keratitis and pneumonia often prove ineffective due to the presence of biofilm barriers and multidrug resistance. Existing nano-antibacterial systems face several limitations, including insufficient tissue penetration depth in the first near-infrared (NIR I) window, the inability of a single treatment modality to simultaneously disrupt biofilms and eradicate residual bacteria, and a lack of efficacy validation in cross-organ (ocular-pulmonary) infection models. In this study, we employed a defect engineering strategy, to construct a palladium-doped TiO 2 nanozyme with oxygen vacancies (PdO V -TiO X ). This nanozyme achieves multiple antibacterial effects through the synergistic combination of second near-infrared (NIR-II) laser-activated photothermal therapy and chemodynamic therapy. Under 1064 nm laser excitation, the system utilizes oxygen vacancy-enhanced peroxidase-like activity to continuously generate hydroxyl radicals (•OH), resulting in a 5.2-fold increase in radical production compared to dark conditions. Additionally, it induces a local temperature rise (ΔT = 28.2 °C). These combined effects—physical disruption of the biofilm matrix and ROS-mediated oxidative stress—effectively dismantle the defense mechanisms of drug-resistant bacteria. In models of drug-resistant Staphylococcus aureus keratitis and pneumonia, PdO V -TiO X demonstrated therapeutic efficacy in both the eye and lung, indicating the broad cross-organ applicability of this treatment. Under NIR-II irradiation, the PdO V -TiO X nanozyme significantly elevated ROS levels at the infection site, achieving efficient bactericidal action while effectively penetrating and disrupting mature biofilms. This work presents a novel defect-engineering-regulated nanozyme synergistic therapeutic strategy for the treatment of multidrug-resistant bacterial infections.
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Advanced Optical Materials
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2025
·
IF 7.2
Kejie Li,Haikuo Liu,Zhiying Wang,Mengmeng Dai,Jiaqi Zhao,Zuoling Fu
Near-infrared II (NIR-II, 1000–1700 nm) luminescence has emerged as a powerful tool for biomedical applications, including sensing, imaging, and drug delivery, owing to its superior tissue penetration depth and high spatial resolution. Lanthanide-based NIR-II nanoprobes are particularly promising due to their outstanding photostability and minimal cytotoxicity. However, two critical challenges impede their widespread implementation: severe thermal quenching at elevated temperatures and inefficient downshifting processes. Herein, a novel strategy is reported to address these limitations by precisely modulating energy transfer dynamics between Ho 3+ and Pr 3+ ions in NaYF 4 core–shell engineering. By carefully optimizing the concentration ratio and spatial distribution of these lanthanide ions in NaYF 4 core–shell nanocrystals, the population of 1 G 4 (Pr 3+ ) is significantly increased, effectively suppressing thermal quenching while boosting downshifting efficiency. The optimized system leverages dual NIR-II emission channels ( 1 G 4 and 5 I 6 ) in NaYF 4 :Yb 3+ /Ho 3+ @NaYF 4 :Yb 3+ /Pr 3+ nanocrystals, enabling ultrasensitive temperature sensing with a maximum relative sensitivity ( S r ) of 2.03% K −1 . Furthermore, the synergistic up/down-conversion properties of Ho 3+ and Pr 3+ facilitate multimodal anti-counterfeiting, offering a robust platform for advanced information encryption and storage. This work not only establishes a new paradigm for engineering NIR-II luminescence but also underscores their vast potential in advanced applications, from precision biosensing to high-security encoding technologies.
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CHEMICAL ENGINEERING SCIENCE
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2025
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IF 4.3
Chenyuan Guo,Chunqing Niu,Yushan Li,Jinhua He,Jian Shi,Yiyu Wang,Kai Zhao
The modulation of structural and mechanical properties through construction of interpenetrating (IPN) hydrogels offers significant potential for expanding their applications as drug carriers. In this study, a silk fibroin (SF)/Polyvinyl alcohol (PVA)/polydopamine particles (PDA) hydrogel with IPN structure for near-infrared (NIR)-responsive controlled release of drugs were prepared by combining enzyme crosslinking with freeze–thaw cycles treatment. Compared with SF/PVA hydrogels prepared solely by enzyme crosslinking, the IPN hydrogels exhibited enhanced stability, a more ordered pore structure, and improved mechanical property. The hydrogels withstood 90 % of compressive deformation without breaking, and the maximum tensile strain at break reached 140.07 %. Moreover, the mechanical properties of the hydrogels were tunable by adjusting the ratio and concentration of SF and PVA. The incorporation of PDA particles into the IPN SF/PVA hydrogel endowed the material with excellent NIR responsiveness. Upon 808 nm NIR irradiation for 10 min, the temperature increased by 19.8°C, with stable photothermal conversion performance maintained over three irradiation cycles. In addition, SF/PVA/PDA hydrogels exhibited good biocompatibility and NIR-responsive drug release capability. These findings highlight the potential of this SF/PVA/PDA hydrogel as a promising material for drug-controlled release applications.
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JOURNAL OF INORGANIC BIOCHEMISTRY
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2025
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IF 3.2
Meixuan Zhang,Qin Zhang,Xuemin Mu,Xiaolin Wang,Shuhui Zhang,Wenyi Zhao,Xiaoming Song,Lulu Pan,Yanyan Li
The escalating threat of bacterial infections underscores the pressing need for innovative antibacterial solutions. In this study, BA-BBR@MPN nanoparticles (BA-BBR@MPN NPs) were synthesized through the self-assembly of berberine (BBR) and baicalin (BA), followed by modification with a metal-phenolic network (MPN) derived from caffeic acid and Fe 3+ . In the slightly acidic environment of the infected site, the MPN decomposes to release iron ions, BBR, and BA. The iron ions catalyze the generation of hydroxyl radicals (·OH) from hydrogen peroxide (H 2 O 2 ), enabling chemodynamic therapy (CDT) while simultaneously depleting glutathione levels. When combined with 808 nm laser-induced photothermal therapy (PTT), the system demonstrates synergistic antibacterial effects. Both in vitro and in vivo studies confirmed the platform's broad-spectrum antibacterial activity against Gram-positive and Gram-negative bacteria, along with excellent biocompatibility and significant wound-healing promotion. This multifunctional nanoplatform represents a promising strategy for combating bacterial infections while simultaneously promoting tissue repair.
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Food Chemistry-X
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2024
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IF 6.5
Dai-xin Yu,Cheng Qu,Jia-yi Xu,Jia-yu Lu,Di-di Wu,Qi-nan Wu
Perillae Folium (PF) is a well-known food and herb containing different chemotypes, which affect its quality. Herein, a method was proposed to classify and quantify PF chemotypes using gas chromatography–mass spectrometry (GC–MS) and Fourier transform-near infrared spectroscopy (FT-NIR). GC–MS results revealed that PF contains several chemotypes, including perilla ketone (PK) type, α -asarone (PP-as) type, and dillapiole (PP-dm) type, with the PK type being the predominant chemotype. Based on FT-NIR data, different chemotypes were accurately classified. The random forest algorithm achieved >90 % accuracy in chemotype classification. Furthermore, the main components of perilla ketone and isoegomaketone in PF were successfully quantified using partial least squares regression models, with prediction to deviation values of 3.76 and 2.59, respectively. This method provides valuable insights and references for the quality supervision of PF and other foods.
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Journal of Materials Chemistry B
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2024
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IF 6.1
Wenqian Zhang,Man Fan,Ruchao Yang,Zhihao Li,Yuzhi Qiu,Mengna Dong,Peng Song,Nan Wang,Yajiang Yang,Qin Wang
Second near-infrared (NIR-II) laser-mediated photothermal therapy and sonothermal therapy using low-intensity focused ultrasound exposure for tumors have attracted increasing attention owing to their ability to penetrate deep tissues and provide noninvasive ablation with high therapeutic efficacy. However, their applications were limited by the shortness of optimal NIR-II photothermal agents and sonothermal agents. In this study, we discovered that the edge-selectively hydroxylated graphene nanosheets (EHG NSs) with excellent water dispersibility and an “intact conjugated plane” were not only an outstanding NIR-II photothermal agent but also an effective sonothermal agent for tumor therapy. EHG NSs were incorporated into an injectable adhesive thermosensitive hydrogel with a characteristic sol–gel phase transition behavior. EHG NSs endowed the injectable hydrogel with an exceptional photothermal effect under the laser irradiation (1064 nm, 1.0 W cm−2) as well as an effective sonothermal effect under ultrasonic exposure (3.0 MHz, 2.1 W cm−2), effectively killing tumor cells in vitro and inhibiting tumor growth after intratumoral injection. Especially, the NIR-II photothermal therapy based on the hybrid hydrogel completely ablated the primary tumors and effectively activated systemic anti-tumor immune responses benefiting from the protein adsorption capacity of the injectable hydrogel, significantly inhibiting the growth of the distal tumors. Collectively, EHG nanosheets loaded in the injectable hydrogel will be a promising “all-rounder” for noninvasive deep penetrating thermotherapy and a potent platform that integrates various therapies.
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