FOOD RESEARCH INTERNATIONAL
·
2026
·
IF 8.8
Yuru Tan,Xuancheng Wang,Anlong Song,Song Xu,Xueting Lin,Bao Yang,Jichu Luo,Ying Tong,Mingsen Wen,Xuan Guan,Peiting Li,Zhe Luo,Pingchuan Zhu,Guanghui Chen,Qisong Zhang
LPTe alleviates HFD-induced obesity, hepatic steatosis, and inflammation. • Five circulating LPTe-derived constituents were identified in vivo . • LPTe restores CDCA homeostasis through gut–liver bile acid remodeling. • LPTe strengthens intestinal barrier function via SCFA–GPCR signaling. • LPTe anti-obesity efficacy is gut microbiota-dependent. Metabolic dyshomeostasis of bile acid (BA) and microbiota-derived short-chain fatty acid (SCFA) is a critical driver of obesity pathogenesis. Liupao tea (LPT) has garnered attention for its anti-obesity potential, owing to potent lipid-lowering, microbiota- and BA metabolism-regulatory properties. However, whether LPT coordinately modulates BA and SCFA homeostasis remains unclear. This study investigated the therapeutic potential of LPT extract (LPTe) in alleviating obesity by focusing on the host–microbial re-establishment of SCFA and BA homeostasis. Results showed that five potential bioactive LPTe-derived constituents were identified in vivo. LPTe intervention effectively attenuated body weight gain, dyslipidemia, hepatic steatosis, intestinal barrier dysfunction, and systemic inflammation in HFD mice. LPTe treatment was associated with a shift in BA biosynthesis toward a chenodeoxycholic acid (CDCA)-enriched profile and with altered enterohepatic BA circulation. This shift coincided with increased fecal BA excretion and diminished lithocholic acid (LCA) accumulation, ultimately mitigating hepatic inflammation and lipotoxicity. LPTe altered gut microbial composition, reducing the relative abundances of genera potentially associated with secondary BA metabolism, in parallel with lower LCA levels. Simultaneously, increased SCFA levels were accompanied by higher colonic mRNA expression of GPR41 and GPR109A , increased ZO-1 and Occludin protein expression, and improved mucosal barrier-related indices. Crucially, antibiotic-mediated microbiota depletion abolished these metabolic benefits. Collectively, LPTe alleviated HFD-induced obesity through microbiota-dependent remodeling of the gut–liver axis, driven by the coordinated restoration of SCFA and CDCA homeostasis. These findings offer a theoretical basis for leveraging LPTe as a functional dietary intervention for obesity management. Download: Download high-res image (432KB) Download: Download full-size image
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高影响因子
JOURNAL OF CHROMATOGRAPHY A
·
2026
·
IF 4
Shuo Xie,Mengting Fu,Yike Han,Wanning Li,Penghui Li,Liyun Kong
An in situ DES-LLME/HPLC method was developed for neonicotinoids determination. • COSMO-RS was used to screen hydrogen bond donor for the in situ extraction. • Neonicotinoids content in wastewater and tea infusion was successfully detected. • This method offered a highly efficient, reproducible, and sustainable alternative. Accurate quantification of neonicotinoids (NEOs) in complex water and tea infusion samples is crucial for environmental risk assessment and human exposure evaluation. However, traditional sample pretreatment methods are often time-consuming, labor-intensive, and rely heavily on large volumes of toxic organic solvents. In this study, an innovative in situ deep eutectic solvent (DES)-based liquid-liquid microextraction (LLME) method was developed for the preconcentration of NEOs. Conductor-like Screening Model for Real Solvents (COSMO-RS) was employed to screen suitable hydrogen bond donors as extractants. The extraction mechanism relies on stable hydrogen bonding interactions between the target analytes (acting as hydrogen bond acceptors) and the hydrogen bond donor, hexyl 4-hydroxybenzoate. The optimized LLME procedure employs 10 mL aqueous sample, 150 mg hexyl 4-hydroxybenzoate, and 120 s vortex mixing. Compared with conventional extraction method, this approach significantly reduces sample volume to 10 mL, eliminates volatile organic solvents, simplifies the workflow, and completes sample preparation in < 20 min. In combination with high-performance liquid chromatography (HPLC), the proposed method enables sensitive simultaneous determination of six NEOs, with limits of detection (LODs) ranging from 0.390 to 3.165 μg/L, recoveries of 81.61–123.04%, and relative standard deviations precision of 2.32–16.13%. The developed in situ DES-LLME method, combined with HPLC, provides a rapid, sensitive, and practical approach for monitoring NEOs in aqueous environments, showing considerable potential for applications in environmental surveillance and human exposure assessment. Download: Download high-res image (231KB) Download: Download full-size image
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PubMed
高影响因子
Pharmaceuticals
·
2026
·Vol. 19
·期 9
·1336
·
IF 5.7
Shini Zhang,Xiao-Li Luo,Hangxing Yang,Ganghua Huang,Jing Leng,Tao Yang
Background:Alzheimer’s disease (AD) is a prevalent neurodegenerative disorder for which effective treatments remain limited. Liubao tea, a distinctive post-fermented dark tea, develops unique aged and areca nut aromas through prolonged storage. However, comprehensive studies on its anti-Alzheimer’s disease effects are lacking. This study aimed to identify the bioactive constituents of Liubao tea with varying storage durations and aroma profiles, and to further evaluate its neuroprotective potential against Alzheimer’s disease.Methods:Chromatography and spectrophotometry were employed to quantitatively determine the primary bioactive components in various Liubao tea samples. A D-galactose-induced Alzheimer’s disease zebrafish (Danio rerio) model was established to evaluate the neuroprotective effects of the aqueous extract of Liubao tea.Results:The contents of theabrownins, theaflavins, tea pigments, and catechins showed potential associations with the anti-AD capacity of Liubao tea. Variations in these bioactive components appeared to correlate with the neuroprotective activity.Conclusions:This study elucidates the anti-AD potential of aged Liubao tea and associates its characteristic constituents with neuroprotective effects. The findings provide essential theoretical support for developing Liubao tea as a promising natural product candidate worthy of further anti-AD research.
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Collagen and Leather
·
2026
·Vol. 8
·期 1
·39
·
IF 10.1
Li Can,Zhang Yuanhang,Li Wan,Wang Li,Xiang Jun,Fan Haojun,Jiang Hongmei,Sun Lijuan,Tang Jinsong
Unsaturated vegetable fatty acids, as a renewable resource, are abundantly present in vegetable oils, exhibiting significant potential for the synthesis of bio-polyols and bio-based polyurethanes (PUs). Herein, castor oil (CO) and tea seed oil (TSO) were selected as feedstocks to fabricate bio-based hydrophilic chain extenders (HCEs) for water-based polyurethane (WPU). Firstly, the raw oils were treated through a three-step process involving saponification, acidification and urea inclusion purification, yielding unsaturated ricinoleic acid (RA) and oleic acid (OA) with high purities of 93.99% and 92.72%, respectively. Subsequently, an efficient thiol-ene click reaction was carried out to prepare amphiphilic ricinoleic acid-based chain extender (RACE) and amphiphilic oleic acid-based chain extender (OACE) under ambient conditions (1 h, room temperature) with relatively lower molecular weight ( M w ) and accurate functionality ( f − OH = 2 ). The activation energies for the reactions of RACE/OACE and dimethylolpropionic acid (DMPA) with isophorone diisocyanate (IPDI) were evaluated via non-isothermal DSC kinetic analysis (Kissinger method and Ozawa method), and the apparent activation energy ( Ea from Kissinger/ Eo from Ozawa) values were found to be 76.66/78.88 kJ·mol − ¹ for RACE and 74.58/76.91 kJ·mol − ¹ for OACE, respectively, which were slightly higher than that of DMPA (Ea/Eo = 73.01/75.32 kJ·mol − ¹). Application of these bio-HCEs for preparing WPU revealed that the particle size and absolute zeta potential of emulsion with more than 0.0248 mol bio-HCEs were equivalent to those of the emulsion with 0.0192 mol DMPA, and the resultant WPU films showed enhanced broken elongation, increased water contact angles, and reduced water absorption ratio. Collectively, the significance of this work resides in providing a feasible and potentially universal strategy for fabricating bio-HCEs from natural unsaturated oils and offering a sustainable alternative for the advancement of WPU. Graphical
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高影响因子
FOOD CHEMISTRY
·
2026
·
IF 10.4
Rui Zhang,Huahong Liu,Jinfang Nie,Zhusheng Liu,Yuelan Pang,Haiyan Fu,Yun Zhang
The 100 to 500 nm spherical nanoparticles were confirmed in Liupao tea infusions. • The aging exerted a significant influence on the morphology and activity of LTNs. • LTNs5 exhibited the smallest diameter and the strongest antioxidant activity. • Glycosylated flavonoids and amino acids were significantly up-regulated in LTNs5. • K was the most abundant element and rich in the LTNs aging for 5, 10, and 15 years. Nanoparticles are bioactive carriers with significant application value, and the aging influence on the formation and bioactivity of Liupao tea nanoparticles (LTNs) was investigated in this study. Stable spherical nanoparticles with diameters of 100–500 nm were present in Liupao tea infusions, and polysaccharides as well as proteins were their primary components. Multi-omics analysis showed that glycosylated flavonoids accumulated in LTNs5 and LTNs15, and amino acids and K were enriched in LTNs5, LTNs10, and LTNs15, which were associated with smaller particle size and higher antioxidation. In contrast, methylated flavonoids, methylxanthine alkaloids, Ca, Al, and Mn concentrated in samples with larger particle sizes and lower antioxidation, such as LTNs0, LTNs3, and LTNs8. Interestingly, consistent changes of polyphenols and Cu suggested a potential synergistic role in the formation and bioactivity of LTNs. Overall, these findings enhanced the understanding of the connection between vintage quality and functional value in Liupao tea. Download: Download high-res image (323KB) Download: Download full-size image
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高影响因子
Current Research in Food Science
·
2025
·
IF 7
Qihuan Deng,Shiyi Xiong,Wenjun Wang,Guodong Zheng,Jingjing Xie,Xiaojin He,Liang Ye,Lili Yu,Jingen Li
In this study, the effect of Gougunao tea polysaccharide (GTP40) on lipid metabolism in high-fat diet (HFD)-induced hyperlipidemic mice and its core structure were investigated. GTP40 effectively reversed the increase in weights of the liver and adipose tissues induced by HFD. The oxidative stress of the liver was also significantly alleviated following GTP40 intervention. According to the results of Real-Time quantitative Polymerase Chain Reaction (RT-qPCR), the genes associated with lipolysis were upregulated after GTP40 treatment, while lipogenesis-related genes were downregulated. Additionally, a homogeneous polysaccharide (GTP40–5P, obtained by degrading GTP40 for 5 h) with a molecular weight of 27858 Da was fractionated from GTP40 by the partial acid hydrolysis method. GTP40–5P was mainly composed of 62.30 ± 0.70 % neutral sugar, 54.82 ± 0.51 % uronic acid and 2.52 ± 0.74 % protein. The results of methylation and nuclear magnetic resonance (NMR) analysis indicated that the backbone of GTP40–5P was consisted of →4)- α -D-Gal p A-(1 → 4)- β -D-Gal p -(1→ units, with the terminal residue β -D-Gal p -(1→ linked to →3,4)- α -D-Gal p A-(1→ at the O -3 site, suggesting that it should be classified as homogalacturonan (HG)-type pectin with partial methyl esterification. These findings indicate that GTP40 alleviates lipid metabolism disorders in hyperlipidemic mice primarily via the AMPK signaling pathway. Furthermore, the elucidation of the primary structure of Gougunao tea polysaccharide enhances the understanding of the structure-activity relationship.
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PubMed
高影响因子
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2026
·
IF 6.7
Jirui Wei,Xiaozheng He,Tingting Shi,Xiayu Jin,Jun Huang,Qingyao Du,Junda Huang,Tao Li,Xunjie Xie,Yuxin Huang,Chengtao Nie,Yiqi Fan,Xixiao Yang,Luyao Song,Waijiao Tang
Epidemiological studies indicate that Metabolic Associated Fatty Liver Disease (MAFLD) has become the most prevalent chronic liver disease globally. Identifying bioactive molecules from natural plants that can prevent and ameliorate MAFLD is an effective approach to discovering new MAFLD therapeutics. Liupao tea possesses antioxidant and metabolic regulatory properties. This study aimed to identify the active components of Liupao tea polyphenol extract (PLE), and its potential targets and mechanisms of action in the prevention of MAFLD. We performed experiments on MAFLD mice to establish the prevention efficacy of PLE against MAFLD and determine its optimal dosage. Furthermore, network pharmacology, molecular docking, and SPR were performed to predict that PLE’s targets for preventing MAFLD concentrate on the hepatic EGFR target. Knockout of EGFR in hepatocytes attenuated the effects of PLE. These findings indicate that PLE inhibits lipid accumulation by downregulating the EGFR/pEGFR-AKT/pAKT-SREBP-1-ACC1 pathway through binding to the EGFR receptor, thereby preventing MAFLD.
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PubMed
高影响因子
International Journal of Gastronomy and Food Science
·
2026
·
IF 3.7
Li Li,Zijian Jiang,Ran Qiu,Li Xuan,Chunli Liu,Xuyan Zong
The development of tea beer has become a current research hotspot in the brewing industry. In this study, following standard beer production procedures, varying amounts of green tea were added during wort boiling to replace hops. The aim was to eliminate hop-related interference, investigate how adding tea affected the fermentation process, and assess the feasibility of using tea as a substitute for hops in beer brewing. The effects of green tea addition on physicochemical properties, volatile compounds, and sensory characteristics were compared both during fermentation and after fermentation was completed. The results indicated that a tea addition level of 8 g/L was the most suitable for brewing tea beer. Tea addition increased the total phenolic content in wort (182-415 mg/L), enhanced the yeast growth rate and maximum cell density, and improved both alcohol content (3.71-4.82%) and real degree of fermentation (54.79-68.42%). Antioxidant indices were also markedly improved, including DPPH radical scavenging capacity (2.58-4.12 mmol/L), ABTS radical scavenging capacity (2.80–18.28 mmol/L), and total reducing power (2.55-3.47 mmol/L). Volatile compounds in tea beer were further analyzed by HS-SPME-GC-MS, showing that tea addition increased the levels of common aroma-active compounds (ethyl acetate, ethyl hexanoate, and ethyl heptanoate), resulting in a richer aroma profile. In addition, several characteristic aroma compounds were identified (heptyl acetate, ethyl benzoate, and ethyl phenylacetate). Overall, these findings could serve as a reference for industrial production of tea beer and the development of novel beer products.
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高影响因子
Applied Food Research
·
2026
·
IF 5.4
Yin-xiang Gao,Li-ping Yao,Fu-ping Wang,Yan-lu He,Luo-jun Chen,Hua Rong,Xin-feng Jiang,Ya-nan Liu,Li Zhang
To elucidate grade-dependent flavor patterns of Ninghong black tea (NBT), an integrated method combining metabolomics, sensory evaluation with multivariate analysis was employed. Chromatographic analyses resolved 73 volatile and 31 non-volatile compounds. Eighteen key volatile compounds were screened based on variable importance in projection (VIP > 1, p<0.05). Among these, 11 components, notably β-ionone, linalool, geraniol, and (2E,4E)-2,4-heptadienal, had OAV > 1, significantly contributing to floral and fruity aroma. For non-volatile compounds, 11 metabolites (caffeine, epigallocatechin, gallic acid, epicatechin gallate, epigallocatechin gallate, theanine, arginine, glutamic acid, tryptophan, serine, and gallocatechin) were identified as key taste contributors, with the first eight compounds exhibiting TAV > 1, identifying them as the primary drivers of bitterness, astringency, and umami. Multivariate analysis (Principal Component Analysis, PCA; Partial Least Squares Discriminant Analysis, PLS-DA; hierarchical clustering; fold change) of 29 marker compounds clearly differentiated four quality grades into Jinhao and Congou categories. The differential abundance patterns of key symbolic metabolites (e.g., β-ionone, ECG, and GC with FC differences), which mark the significant metabolic differences between categories, were consistently mirrored in sensory evaluations. Premium NBT characteristics included: tightly twisted leaves with golden pekoe, bright orange-red liquor, tender floral aroma, brisk/mellow taste, and reddish-bright uniform buds. This study deciphers the hierarchical chemical signatures underlying the sensory quality of NBT grades, and provides a theoretical basis for flavor quality evaluation, with symbolic metabolites serving as objective indicators for grade differentiation and quality control in the tea industry.
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高影响因子
ANALYTICA CHIMICA ACTA
·
2026
·
IF 6.1
Xin-Li Song,Tong Sun,Ke-Chao Liao,Hui Lv,Pin-Pin Wang,Dong-Dong Wang,Yan Lu,Lin Li
The perfluoroalkyl substances (PFAS) residue are considered as serious environmental pollution that create a great risk of exposure to humans and other living beings. Rapid, simple and sensitive detection technology of PFAS is necessary and challenging. Compared with conventional pretreatment techniques, magnetic solid-phase extraction (MSPE) possesses several advantages of high efficiency, simplicity and rapid separation process. So an approach possesses these attractive merits is highly desired. An efficient and sensitive sorbent materials is of vital importance in MSPE pretreatment techniques. The self-assembly strategy was utilized to prepare novel graphene oxide (GO) on magnetic carbon (Fe 3 O 4 @C) particles in this work. The prepared materials GO@Fe 3 O 4 @C were used as sorbents in MSPE for six PFAS. Single factor experiment method was utilized to systematically evaluate the main extraction parameters influencing the adsorption efficiency. Wide linearities (0.01–1000 ng L −1 ) and low detection limits (0.003–0.02 ng L −1 ) for six PFAS were exhibited under optimal conditions. The proposed GO@Fe 3 O 4 @C/MSPE method was also used to monitor analytes in tea samples. These results demonstrated that GO@Fe 3 O 4 @C adsorbents would be potential alternatives for the adsorption and detection of PFAS at trace level from real samples. The design of GO@Fe 3 O 4 @C with high efficiency extraction is expected to provide new ideas and methods for trace PFAS determination and other structural analogues in environmental samples based on the prominent advantages. This method is simple, rapid, green and sensitive and could advance PFAS detection application in food industry.
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高影响因子
MICROCHEMICAL JOURNAL
·
2022
·
IF 5.304
Yahuan Li,Yang Li,Qingyun Chang,Xiaohuan Zang,Shuaihua Zhang,Chun Wang,Zhi Wang
MXene-polyvinylpyrrolidone (MXene-PVP) was first prepared by physically doping combined with spray drying, which can overcome the aggregation of the MXene. Then, the MXene-PVP was carbonized to result in a carbonized MXene-PVP (MXene-PVP-C), which was then immobilized on stainless steel wire by sol–gel approach to prepare a new solid-phase microextraction (SPME) fiber. The prepared MXene-PVP-C coated fiber was studied for the extraction of 10 polycyclic aromatic hydrocarbons (PAHs) from tea beverages by using SPME method prior to gas chromatographic detection. The main SPME parameters, including extraction temperature, extraction time, salt concentration, sample solution pH and stirring rate, were investigated by central composite design methodology. Under the optimized conditions, the developed method gave the limits of detection of 0.03–0.15 µg/L, and the limits of quantification of 0.10–0.50 µg/L for the PAHs. The method recoveries for the PAHs in spiked tea beverages ranged from 78.6 % to 122 %. The single-fiber and fiber-to-fiber relative standard deviations were lower than 8.2 % and 9.6 %, respectively.
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高影响因子
Journal of Materials Chemistry A
·
2022
·Vol. 10
·期 27
·14326-14335
·
IF 14.511
Qihua Sun,Zhaofeng Wu,Zhangjie Qin,Xuan Chen,Chuanchuan Zhang,Biaobing Cao,Haiming Duan,Jun Zhang
Inspired by the similarity between the pleated structure of rose petals and the pleated structure of a dog's maxillary turbinate, porous biomass carbon materials with a pleated structure have been successfully prepared from rose petals by direct carbonization. Detailed SEM and TEM characterization showed that the carbonized rose tea (CRT) at 600 °C exhibited a mimetic structure very similar to the dog's maxillary turbinate. The trace K element was detected in the prepared CRT materials, which effectively improved the adsorption capacity of the CRT materials for NH3 as revealed by density functional theory based on first-principles calculations. As a result, the CRT sensor showed an ultra-high response (60.16k%) to 500 ppm NH3 with a theoretical detection limit of only 4.82 ppb, in addition to showing a fast recovery (2.0 s), excellent repeatability and long-term stability. Moreover, the formation of nanopores in the pleated structure of the CRT and the sensing mechanism of NH3 were analyzed. Through a simple, inexpensive and efficient method, this study provides a new strategy for the preparation of a high-performance gas sensor with a bionic structure by directly using the similarity between the biomass structure and dog nose structure.
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高影响因子
危险品化学品经营许可证（带存储）