iScience
·
2026
·
IF 4.5
Hanlin Yang,Weiwei Li,Hailong Zhang,Yameng Liu,Miaomiao Cui,Yurong Zhu,Li Hou,Shaoju Min,Jie Ren,Yujie Tan
Conventional cervical cancer therapies often cause severe side effects and face recurrence challenges. Although the natural flavonoid fisetin (FIS) exhibits strong anticancer properties, its clinical utility is restricted by poor aqueous solubility. To overcome this, we engineered a tumor-targeting nanotherapeutic, PEG-FA@ZIF-8@FIS, by encapsulating FIS within a zeolitic imidazolate framework-8 (ZIF-8) core surface-functionalized with polyethylene glycol-folic acid(PEG-FA). Both in vitro and in vivo models demonstrate that this system effectively suppresses cancer cell proliferation, migration, and tumor growth with excellent biocompatibility. Mechanistically, transcriptomic and lipidomic analyses reveal that PEG-FA@ZIF-8@FIS exerts its anticancer effects by downregulating aquaporin-3 (AQP3) expression, which subsequently disrupts tumor lipid metabolism. By linking AQP3 inhibition to metabolic impairment via a targeted delivery platform, this work establishes a highly biocompatible and effective translational strategy for cervical cancer intervention.
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高影响因子
NEW JOURNAL OF CHEMISTRY
·
2026
·
IF 2.6
Wen Su,Tao Yao,Fen Ran
ZIF-8 have been extensively studied in water treatment membranes, and they exhibit excellent modification effects in the membranes. In this study, tea polyphenol-coated ZIF-8 nanoparticles are synthesized via one-pot synthesis and then are blended to modify polyethersulfone ultrafiltration membrane. The shape of the nanoparticles is affected by changing the content of tea polyphenol. Different nanoparticles blends polyethersulfone for ultrafiltration membranes. It is found that adding ZIF-8@Tea polyphenol with hydrophilic properties could significantly improve wettability of membrane; when 0.3 g of ZIF-8@Tea polyphenol is added, the film contact angle decreases to 27.3 ° and shows an excellent rejection rate for methylene blue, methyl orange, and Congo red. The addition of ZIF-8 significantly enhances the retention rate of bovine serum albumin by water treatment membranes, which is mainly attributed to its precise size sieving effect. The accumulation or growth of ZIF-8 particles creates more uniform nanoscale channels, ultimately reducing the average and maximum pore diameters. The effective separation layer of membranes make much smaller than the size of bovine serum albumin. The strategy not only enables the ultrafiltration membrane to maintain high water flux under different pressures but also endows it with the ability to resist Escherichia coli microorganisms.
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JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
·
2026
·
IF 7.1
Maoxuan Zhi,Mengxin Li,Deqing Shi,Xinliang Liu,Ming Wang,Yingfei Hou
The release of textile dyeing wastewater results in significant environmental pollution and endangers human health. Membrane separation technology offers distinct advantages in textile wastewater treatment due to its energy efficiency, high performance, and excellent separation capabilities. This study demonstrates a facile MOF-polymer hybrid membrane fabrication strategy through amine-enhanced interfacial coordination. The introduced –NH 2 groups via Noria and polyethyleneimine (PEI) co-deposition would chelate metal ions, which enhances the heterogeneous nucleation and the compatibility of metal–organic framework (MOF) and polymer. The optimized membrane exhibits superior dye sieving performance, achieving Congo red rejection of 98.9% and water permeance of 23.2 L m -2 h −1 bar −1 . Microstructural analysis reveals dense intergrown zeolitic imidazolate framework-8 (ZIF-8) architectures, validating the co-deposition approach as an effective surface engineering protocol for constructing continuous MOF-polymer hybrid membranes with defect-free interfaces. The membrane also shows superior operational stability at different pH levels and during long-term operation, which shows great potential for practical application.
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JOURNAL OF MEMBRANE SCIENCE
·
2026
·
IF 8.8
Xiangyu Guo,Changxue Xie,Xinyao Dong,Huina Wang,Kaidi Mao,Tongan Yan,Huiye Wei,Hongliang Huang,Chongli Zhong
The efficient recovery of high-value solutes from saline wastewater is highly demanded in dyeing and pharmaceutical industries, yet conventional polyamide nanofiltration membranes face the challenge in combining high solute rejection with rapid salt permeation and water transport. Metal-organic framework (MOF) membranes are attractive for this purpose because of their well-defined porosity; however, the formation of continuous, defect-free MOF separation layer on polymeric supports remains challenging. Herein, a facile precursor-regulated strategy is developed to prepare ZIF-8@PEG composite membranes on hydrolyzed polyacrylonitrile (H-PAN) substrates. The composition of poly(ethylene glycol) (PEG) with zinc hydroxide nanostrands (ZnHNs) can suppress excessive Ostwald ripening and modulate ZIF-8 crystal growth, thereby promoting compact intergrowth and reducing grain-boundary defects. Moreover, PEG retained at crystal interfaces creates hydrophilic transport channels that facilitate the diffusion of water molecules and hydrated ions while restricting the passage of dye molecules. The optimized membrane exhibits high water permeance of 549 L·m −2 ·h −1 ·MPa −1 and high retention rates (>97.5%) to methyl blue and congo red, while maintaining a very low rejection toward inorganic salts (<2.0%). This work provides a simple and scalable route to defect-minimized MOF composite membranes for high-value solute recovery from saline wastewater.
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高影响因子
INORGANIC CHEMISTRY
·
2026
·Vol. 65
·期 35
·20723-20730
·
IF 4.6
Cong Shenzhen,Sun Si,Wang Ming,Zhang Yijing,Shen Qin,Zhang Yatao,Pang Huan
Membrane-based separation technology holds great promise
for CO 2 capture, yet conventional membranes are often constrained
by the permeability-selectivity trade-off. In this study, we developed
a zirconium-cluster (Zr 6 )-incorporated ZIF-8 membrane via
an electrochemical synthesis strategy to address this limitation.
The resulting Zr 6 @ZIF-8 composite membrane exhibits high
crystallinity, a dense microstructure, and homogeneous dispersion
of Zr 6 clusters within the ZIF-8 framework. The optimized
Zr 6 @ZIF-8–2 membrane demonstrates outstanding CO 2 separation performance with a CO 2 permeance of
up to 300.0 gas permeation unit and CO 2 /N 2 and
CO 2 /CH 4 selectivities of 27.0 and 14.8, respectively.
The Zr 6 clusters enable effective structural regulation
of ZIF-8 membranes, resulting in enhanced CO 2 separation
performance and leading to improved diffusion selectivity. Furthermore,
the membrane shows a stable separation performance under varying feed
pressures and temperatures, along with excellent long-term operational
stability. This work provides an effective electrochemical approach
for fabricating high-performance MOF-based membranes, offering a promising
candidate for industrial CO 2 capture and natural-gas purification.
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Applied Water Science
·
2026
·Vol. 16
·期 9
·250
·
IF 5.7
Eltaweil Abdelazeem S.,Alzain Rania,Fawzy Manal,El-Monaem Eman M. Abd,Elmaghrabi Nourhan
Antibiotic pollution poses significant ecological and human health risks in aquatic environments, making their removal an urgent environmental challenge. This study presents the development of an eco-friendly and efficient adsorbent fabricated from Hyphaene thebaica plant biochar along with Zeolitic imidazolate framework and Beta-cyclodextrin (ZIF-67/BC-β-CD). The fabricated ZIF-67/BC-β-CD nanocomposite demonstrates remarkable mechanical, thermal, and chemical stability as confirmed via different characterization techniques, including Fourier-transform infrared spectroscopy, X-ray diffraction, scanning electron microscopy, zeta potential, and X-ray photoelectron spectroscopy. To examine the adsorption ability and optimize the performance of ZIF-67/BC-β-CD nanocomposite, a series of adsorption experiments of tetracycline (TC) were conducted. Results revealed that the maximum adsorption capacity of ZIF-67/BC-β-CD nanocomposite for TC is 294.11 mg.g − 1 at 25 ℃ and pH 5. The findings clarified that the process followed a pseudo-second-order kinetics model with a good fit to the Freundlich isotherm, rather than the Langmuir isotherm, suggesting a combination of physical and chemical adsorption. The adsorption of TC onto ZIF-67/BC-β-CD was found to be governed by a combination of physisorption (electrostatic, hydrophobic, and π–π interactions) and chemisorption (hydrogen bonding and n–π electron donor–acceptor interactions). Furthermore, the adsorbent demonstrated significant regeneration potential after five successive cycles, proving its potential to be used as a sustainable and efficient adsorbent for treating water contaminated with antibiotics.
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APPLIED SURFACE SCIENCE
·
2026
·
IF 6.6
Runcheng Liu,Jie Yan,Wen Yang,Cuiyun Qu,Mingshun Jiang
Sensitive detection of metabolites in biofluids is fundamentally limited by surface-related challenges, including insufficient enrichment, nonspecific adsorption, and poor interfacial durability. Here, we report an interface-engineering strategy for surface plasmon resonance (SPR) biosensors based on tri-functional Au@ZIF-8 core–shell nanostructures. By integrating plasmonic enhancement, molecular sieving, and photocatalytic activity into a single interface, the architecture simultaneously addresses trade-offs between sensitivity, selectivity, and reusability. The ZIF-8 shell serves as a size-selective molecular sieve for target enrichment and protein exclusion, while the plasmonic Au core provides electromagnetic field enhancement and enables light-driven degradation of adsorbed species. Finite element simulations were employed to analyze the interfacial optical response and near-field distribution, quantitatively revealing the interplay between field confinement and molecular capture volume to identify an optimal shell thickness. This interface, integrated onto a tilted fiber Bragg grating (TFBG)-SPR platform, was validated using uric acid. The system exhibits a detection limit of 3.28 × 10 −10 M, 93.4% recovery in artificial serum, and over 92.2% signal retention after ten visible-light-driven regeneration cycles. This work establishes a generalizable, robust, and regenerable interface framework for high-fidelity sensing in complex biological environments.
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SEPARATION AND PURIFICATION TECHNOLOGY
·
2026
·
IF 9.1
Jia Wang,Yizhen Situ,Wenyu Zheng,Weidong Zhang,Qingyuan Yang
Polymer transport resistance was tuned by controlling the solvent evaporation rate. • Reduced polymer transport resistance promoted a more effective contribution of ZIF-8 transport pathways to CO 2 /N 2 separation. • The 7.8 wt% in situ-grown MMM achieved a CO 2 permeability of 510 Barrer and a CO 2 /N 2 selectivity of 33.0. Beyond filler modification, regulating the polymer structure is also crucial for optimizing gas transport in mixed-matrix membranes (MMMs), yet this aspect remains insufficiently explored. Herein, the solvent evaporation rate was controlled to regulate the transport resistance of Pebax 2533 and elucidate its influence on the transport contribution of ZIF-8 in ZIF-8/Pebax MMMs for CO 2 /N 2 separation. For Pebax 2533 membranes, increasing the evaporation rate reduced both crystallinity and relative fractional free volume, resulting in a non-monotonic variation in CO 2 permeability and a decrease in CO 2 /N 2 selectivity. At a moderate evaporation rate of 2.5 × 10 −5 kg·m −2 ·s −1 , the balance between reduced crystallinity and preserved free volume resulted in lower polymer transport resistance, enabling the contribution of ZIF-8 to be more effectively translated into membrane separation performance. As a result, the in situ-grown MMM containing 7.8 wt% ZIF-8 achieved a CO 2 permeability of 510.0 Barrer and a CO 2 /N 2 selectivity of 33.0, with its CO 2 permeability exceeding that of most reported Pebax-based MMMs. This work demonstrates that controlling solvent evaporation is an effective strategy to regulate polymer transport resistance and enhance the contribution of ZIF-8 in MMMs. Download: Download high-res image (207KB) Download: Download full-size image
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Advanced Science
·
2025
·
IF 14.1
Yongrui Ti,Ziqiang Qin,Xiaohong Guo,Zheng Wu,Qi Jiang,Beihua Dong,Olaniyi Amos Fawole,Di Wu,Su Chen,Xian Li,Kunsong Chen
Carbon dots (CDs) have elicited attention in photodynamic antimicrobial applications, but their susceptibility to aggregation limits their effectiveness. Herein, CDs@ZIF-8 nanocomposites are synthesized. The results reveal that they have superior dual photodynamic enhanced antimicrobial properties, specifically 7.63 log 10 CFU mL −1 (lg) elimination for Escherichia coli (only 3.12 lg with CDs and 4.18 lg with ZIF-8) and 7.27 lg elimination for Staphylococcus aureus (only 4.17 lg with CDs and 2.94 lg with ZIF-8). Optoelectronic property analysis and density functional theory calculations show that the enhanced photodynamic antimicrobial properties of CDs@ZIF-8 can be attributed to their narrow bandgap and higher binding affinity for O 2 , which facilitates the photo-generated e − –h + pairs separation and promotes the generation of 1 O 2 and •O 2 − . Furthermore, the CDs@ZIF-8/polycaprolactone/ethyl cellulose nanofibrous films are prepared by microfluidic-blow-spinning, which have prominent antimicrobial properties and extend the shelf life of strawberries from 6 to 12 d. Overall, this study provides a novel idea for designing synergistically enhanced photodynamic antimicrobial materials and photodynamic preservation of perishable fruits.
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高影响因子
MICROCHIMICA ACTA
·
2025
·Vol. 192
·期 7
·1-11
·
IF 5.3
Kuang Xia,Zhao Guocai,Guo Jingyi,Tang Qin,Yu Jun,Wang Fang
Harnessing the exceptional enzyme immobilization capabilities of metal–organic frameworks (MOFs) and the exceptional electrochemical characteristics of graphene, we designed a highly efficient and cost-effective glucose sensor utilizing zeolitic imidazolate framework-8 (ZIF-8) and laser-induced graphene (LIG) with the aid of mediator ferrocene (Fc). By incorporating a cellulose acetate (CA) film as an anti-interference layer and a polyurethane (PU) film as a diffusion-limiting layer, the sensor exhibited a wide linear detection range for glucose (0.62 mM to 20 mM) with a low detection limit of 0.16 mM (S/N = 3). Notably, it demonstrated excellent selectivity, with no interference from common biological substances. The sensor also exhibited good stability, retaining 96.38% of its initial performance after 7 days of storage. Additionally, the sensor was effectively utilized for glucose detection in whole blood, with results closely matching those obtained from a commercial blood gas analyzer (GEM5000), as evidenced by a high Pearson's correlation coefficient (r = 0.9974). This method provides a portable glucose sensor that produces results highly consistent with those obtained from large-scale testing devices in hospitals, enabling convenient and accurate blood glucose monitoring for patients. Graphical
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MICROCHEMICAL JOURNAL
·
2025
·
IF 5.1
Guangzhi Nie,Jing Xue,Yuyu Gao,Zhaoqing Wang,Hang Wang,Jiangbin Wu,Yunze Long,Wenpeng Han
The detection of gaseous molecules using surface-enhanced Raman spectroscopy (SERS) remains challenging due to the rapid diffusion and low intensity of gas molecules. In this study, we developed a flexible and breathable SERS substrate by in-situ growth of Ag@ZIF-8 nanoparticles on electrospun nylon 6/6 fibers. The microchannels in the fiber membrane, combined with the high porosity of ZIF-8, enable effective capture and enrichment of volatile organic compounds (VOCs) in SERS hot spots. The optimized substrate demonstrated a detection limit of 6.64 × 10 −8 M for dithiohydroquinone (DP) gas, along with excellent reproducibility, linear correlation (R 2 = 0.99), and stability over 30 days. Furthermore, using a residual neural network (RNN) model for deep learning analysis, the substrate achieved 100 % accuracy in detecting gaseous glutaraldehyde (GA), a typical VOC found in disinfectants. This study showcases the potential of nylon/Ag@ZIF-8 substrates, enhanced by artificial intelligence, for practical and precise detection of gaseous molecules in various environments.
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MOLECULES
·
2026
·Vol. 31
·期 4
·669
·
IF 5.1
Jiarui Liu,Jiachang Feng,Zhefeng Xu,Jinsong Zhang,He Wang
Natural antibacterial food packaging materials endowed with environmental responsiveness are garnering substantial research interest in sustainable food preservation. This study reports the development of a pH-responsive antimicrobial composite film through encapsulation of eugenol—a natural phenolic compound—within zeolitic imidazolate framework-8 (ZIF-8). The engineered eugenol@ZIF-8 system demonstrated pH-dependent release characteristics, with cumulative release reaching 32.2% at pH 6 versus merely 0.61% at pH 7 over 4 h. Subsequent integration of this nanocarrier into a polyvinyl alcohol (PVA)/hydroxypropyltrimethyl ammonium chloride chitosan (HACC) matrix yielded a multifunctional composite film for active food packaging applications. The characterization of film revealed that while eugenol@ZIF-8 incorporation slightly compromised mechanical strength (tensile resistance decreased by 18.7%) and flexibility (elongation at break reduced to 54.3% of control), it significantly enhanced hydrophobicity (water contact angle increased to 92.5°) and thermal stability (decomposition temperature elevated by 34 °C). The composite film demonstrated synergistic antibacterial efficacy through the combined action of Zn2+ions, ZIF-8 nanostructures, and eugenol, achieving 88% inhibition againstE. coli.Practical validation through fresh noodle preservation trials confirmed the material’s effectiveness, with the optimized formulation (PVA-HACC-2% eugenol@ZIF-8, PHEZ2) extending shelf life by >5 days compared to conventional packaging. This work establishes a novel strategy for engineering intelligent ZIF-based packaging systems that respond to food spoilage microenvironments, offering significant potential for reducing food loss.
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