BIOMACROMOLECULES
·
2024
·
IF 5.5
Zhimin Luo,Yunan Yuan,Ling Li,Dayang Xie,Chong Liu,Tong Li,Zhaopei Guo,Kai Hao,Yanhui Li,Huayu Tian
Poly(amino acid)s (PAAs) are one kind of favorable biopolymer that can be used as a drug or gene carrier. However, conventional ring-opening polymerization of PAAs is slow and needs a strict anhydrous environment with an anhydrous reagent as well as the product without enough high molecular weight (Mn), which limits the expanding of PAAs’ application. Herein, we took BLG-NCA as the monomer to quickly synthesize one kind of high Mn amphiphilic copolymer, poly(ethylene glycol)-b-poly(γ-benzyl-l-glutamic acid) (PEG-PBLG), by relay polymerization with a simple one-pot method within 3 h in mild conditions (open air, moisture insensitive). In the polymerization process, ring-opening polymerization-induced self-assembly in sodium bicarbonate aqueous solution first occurred to obtain low Mn PEG-PBLG seeds without purification. Then γ-benzyl-l-glutamate N-carboxyanhydride (BLG-NCA) dichloromethane solution was added into PEG-PBLG seeds directly and stirred vigorously to form am emulsion; during this process, the amphiphilic PEG-PBLG seeds will anchor on the interface of DCM and water to ensure the concentration of α-helix rigid PBLG in DCM to maintain the following relay polymerization. Then, high Mn PEG-PBLG was obtained in mild conditions in one pot. We found that the α-helix rigid structure was essential for relay polymerization by studying the synthetic speed of amphiphilic copolymer with different secondary structures. MOE simulation results showed that PBLG and BLG-NCA tended to form a double hydrogen bond, which was beneficial to relay polymerization because of higher local concentrations that can produce more double hydrogen bonds. Our strategy can quickly obtain high Mn PEG-PBLG (224.9 KDa) within 3 h from PEG-NH2 and BLG-NCA in one pot and did not need an extra initiator. After deprotection, the poly(ethylene glycol)-b-poly(l-glutamate acid) (PEG-PGA) with high Mn as a second product can be used as an excellent antitumor drug carrier. The high Mn PEG-PGA can achieve an encapsulation rate of 86.7% and a drug loading rate of 47.3%, which is twice that of the low Mn PEG-PGA. As a result, the synthesis of PEG-PBLG by relay polymerization simplified the process of PEG-PAA polymerization and increased the Mn. In addition, this method opened a way to obtain other kinds of high Mn PEG-PBLG values in the future.
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高影响因子
APPLIED SURFACE SCIENCE
·
2025
·
IF 6.9
Xin Liu,Liping Yang,Li Chen,Shuxia Li,Peng Li,Yongrong Sun,Ning Kang,Chenglong Wang
It is still challenged to propose a straightforward and in-situ growth method of fabricating perovskite-type metal oxide films with dense and uniform surface coverage. This paper presents a simple strategy to prepare LaBO 3 (where B = Ni, Co, Fe, Mn) films by metal oleate (MO) route, in which metal oleates (La(OA) 3 and (B(OA) x , x = 2 or 3) serve as effective ligands to inhibit the self-aggregation among crystal grains. The as-prepared LaNiO 3 film with uniform and dense surface shows a reduced contact angle (31.5° vs 51.2°) and surface roughness (Ra = 14.2 vs 23.9 nm) compared with film prepared by Sol-gel (SG) method. Finally, the LaNiO 3 film by MO route is successfully employed as hole transport layer (HTL) in perovskite solar cells (PSCs) to obtain a power conversion efficiency (PCE) up to 15.62 %, which is 1.54 times that of PSCs by SG method. This work opens an avenue for fabricating LaBO 3 films with dense and uniform surface coverage by MO route.
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高影响因子
CERAMICS INTERNATIONAL
·
2025
·
IF 5.6
Yiwen Niu,Fan Zhang,Zhiqiang Zhang,Meiyue Li,Jihang Liu,Zhan Jie Wang
Due to the novel high-entropy effects, entropy engineering strategies have been widely implemented in perovskite dielectric ceramics to improve their comprehensive energy storage performance. In this study, by designing (Bi 0.5 Na 0.5 ) 0.94 Ba 0.06 ) 0.75 (Ca 0.5 Sr 0.5 ) 0.25 TiO 3 matrix and co-doping of Nd 3+ at A-site and (Zr 1/3 Hf 1/3 Sn 1/3 ) 4+ at B-site, novel (Bi 0.5 Na 0.5 ) 0.94 Ba 0.06 TiO 3 -based high-entropy ceramics (HECs) are developed to optimize energy storage performance. The results reveal that the configuration entropy can be improved by co-regulation of A/B-site compositions, and the increased entropy can promote the suppression of grain size, the enhancement of dielectric relaxation and impedance, and the widening of band gap, giving rise to small remanent polarization and great breakdown strength ( E b ). Eventually, the composition with the maximum entropy of 1.92R exhibits superior recoverable energy storage density ( W rec ∼ 6.84 J/cm 3 ) and high efficiency ( η ∼ 82.9 %) at a large E b ∼ 597 kV/cm, as well as good temperature stability, frequency stability and charge-discharge characteristics. These findings imply that designing high-entropy systems through A/B-site co-regulation is an effective approach for developing high-performance energy storage devices.
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高影响因子
CRYSTENGCOMM
·
2011
·Vol. 14
·期 3
·1038-1044
·
IF 4.006
Ming Ge,Lu Liu,Wei Chen,Zhen Zhou
With Rhodamine B as a model compound, the photocatalytic oxidation of organic contaminants in aqueous solution was investigated within a cooperating porous BiVO4/H2O2 system under simulated sunlight irradiation. Peanut-shaped porous BiVO4 was prepared through a simple template-free solvothermal method with high yield, and was used in the cooperating catalyst/H2O2 system. The possible formation mechanism of peanut-shaped BiVO4 nanostructures was investigated. In the peanut-shaped BiVO4/H2O2 system, nearly complete degradation of Rhodamine B was observed after 60 min of irradiation under sunlight irradiation. The as-obtained porous BiVO4 photocatalyst displayed higher photocatalytic activity than those of the reference product hydrothermally synthesized and the photocatalyst P25 in the same catalyst/H2O2/sunlight system. The photocatalytic processes of the BiVO4/H2O2/sunlight system may consist of both OH˙ oxidation and direct hole attack. In addition, the peanut-shaped porous BiVO4 nanostructures were stable and maintained high photocatalytic efficiency during repeated recycles in the H2O2-containing system.
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ACS Applied Nano Materials
·
2024
·
IF 5.3
Yuting Li,Jiaming Song,Xin Zhao,Bingda Li,Zhuo Wang,Juanjuan Yang,Guoshuai Ban,Feng Teng,Jialong Ma,Chaoying Meng,Honggang Ye,Guangde Chen,Zhonghua Dai,Yu Cong
With increasing environmental pollution, the utilization of green techniques, such as photocatalysis, is required to degrade harmful sources without secondary pollution. In this study, we synthesized an efficient photocatalyst, i.e., a h-BN/BiPO4 heterostructure modified by Ag nanoparticles at the interface (Ag/BN/BPO) by photodeposition and a hydrothermal method, and investigated photocatalytic degradation performance for rhodamine B dye (RhB). It was found that 95% of RhB was removed by Ag/BN/BPO (optimal ratio) after 60 min of light exposure. Compared to BiPO4 and BN/BiPO4, the removal efficiency was improved by 50 and 30%, respectively. The high photocatalytic degradation activity of Ag/BN/BPO could be possibly attributed to the synergistic effect of the improved separation efficiency of electron–hole pairs by the special heterostructure design and the increased adsorption capacity due to the large specific surface area of the layered h-BN. This study provided a possible route for the development of highly efficient photocatalysts for the degradation of organic pollutants.
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Environmental Science-Nano
·
2024
·Vol. 11
·期 7
·3104-3113
·
IF 5.8
Feijin Zhou,Wenying Cui,Chenggang Liu,Cheng Yao,Chan Song
Exploring novel nanozymes with high activity and stability is necessary in sensing to replace some natural enzymes. Here, iron phthalocyanine (FePc) was supported on two-dimensional (2D) reduced graphene oxide (rGO), synthesizing FePc@rGO nanocomposites by a one-pot method. FePc@rGO nanocomposites not only can catalyze the oxidation of colorimetric substrates, but also can degrade rhodamine B (RhB) with the help of permonosulfate (PMS). With the introduction of rGO, FePc was loaded on their surfaces. Compared with free FePc, FePc supported on rGO has smaller size, resulting in its larger specific surface area. These factors are better for exposing the active sites of catalysts and increasing the mass transfer rate between catalysts and substrates. Therefore, FePc@rGO nanocomposites exhibit enhanced catalytic activity. Based on the oxidase-like activity of FePc@rGO nanocomposites, a sensing platform was constructed for the detection of thiosulfate (S2O32−) with a detection limit of 0.124 μM and a detection range of 2–50 μM. In addition, this sensing system can be used for the visual detection of S2O32− by a portable smartphone. Furthermore, the degradation efficiency of FePc@rGO nanocomposites to RhB could be as high as above 94% for just 10 min when the pH ranged from 3 to 10. This work provides an avenue for the synthesis of novel catalysts as multifunctional nanozymes for detection and organic pollutant degradation.
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高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2024
·
IF 9.4
Guoliang Cai,Ruifeng Li,Xubin Chai,Xiao Cai,Kaifeng Zheng,Yanyan Wang,Kelong Fan,Zhiping Guo,Jiancheng Guo,Wei Jiang
Diabetic wounds are characterized by chronic trauma , with long-term non-healing attributed to persistent inflammation and recurrent bacterial infections. Exacerbation of the inflammatory response is largely due to increased levels of reactive oxygen species (ROS). In this study, catalase (CAT) was used as a biological template to synthesize nanozyme-supported natural enzymes (CAT-Mn(SH) x ) using a biomimetic mineralization method. Subsequently, polymyxin B (CAT-Mn(SH) x @PMB) was immobilized on its surface through electrostatic assembly. CAT-Mn(SH) x @PMB demonstrates the ability for slow and sustained release of hydrogen sulfide (H 2 S). Finally, CAT-Mn(SH) x @PMB loaded microneedles (MNs) substrate were synthesized using polyvinyl alcohol (PVA) and hydroxyethyl methacrylate (HEMA), and named CAT-(MnSH) x @PMB-MNs. It exhibited enhanced enzyme and antioxidant activities , along with effective antibacterial properties. Validation findings indicate that it can up-regulate the level of M2 macrophages and reduce the level of pro-inflammatory cytokine tumor necrosis factor-α (TNF-α). Additionally, it promotes angiogenesis and rapid nerve regeneration, thereby facilitating wound healing through its dual anti-inflammatory and antibacterial effects . Hence, this study introduces a time–space tissue-penetrating and soluble microneedle patch with dual anti-inflammatory and antibacterial effects for the treatment of diabetic wounds.
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高影响因子
CERAMICS INTERNATIONAL
·
2024
·
IF 5.1
Jinyang Li,Wenye Deng,Yan Xue,Ni Ai,Kai Ding,Xianghui Chen,Pengjun Zhao,Aimin Chang,Yongxin Xie
This study used the solid-phase method to prepare thermosensitive perovskite ceramics, La 0.9 B 0.1 AlO 3 (B = Pr, Nd, Sm). The XRD and EDS results indicated that all components presented a single phase and all elements were uniformly distributed, formed a good solid solution. The SEM results clearly illustrated that the doped elements had enhanced the surface morphology, resulting in more uniform grain formation. The TEM results showed that linear defects were present, which led to an uneven stress distribution; consequently, this enhanced the carrier transport. The alternating current (AC) impedance showed that the grain boundary resistance determined the overall complex impedance and exhibited a different conductive mechanism with increasing temperature, from polariton to ion conduction. With the introduction of Nd 3+ , the conductivity of La 0.9 Nd 0.1 AlO 3 increased and its temperature range increased from 600 – 1400 °C to 100–1500 °C. In La 0.9 Sm 0.1 AlO 3 , the presence of Sm 2+ enhances the aging stability by elevating the oxygen vacancy concentration and the aging drift rate (ΔR/R0) was found to be lower than 2 %. In addition, DFT-based calculations were performed to investigate the property changes in the crystal structure and energy band structure of pure and doped LaAlO 3 . This study demonstrated an effective way to improve the performance of high-temperature thermistor materials using different doping strategies.
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高影响因子
SENSORS
·
2020
·Vol. 20
·期 17
·4912
·
IF 3.275
Xuexue Xu,Rongbin Nie,Jingwen Huang,Li Yang
Optical fiber based immunosensors are very attractive for biomarker detection. In order to improve the sensor response, we propose a promising strategy which combines porous-layer modification of the fiber surface and streptavidin-biotin-peroxidase nano-complex signal amplification in chemiluminescent detection. Two hepatitis B antigens, hepatitis B surface antigen (HBsAg) and hepatitis B e antigen (HBeAg), are used as the targets for analysis using the proposed sensor. Comparing to immunoassays using normal optical fiber sensors, the response of the present sensor is enhanced by a factor of 4.8 and 6.7 for detection of HBsAg and HBeAg, respectively. The limit-of-quantitation of the proposed method is as low as 0.3 fg/mL (0.01 fg/mL) with a wide linear response range of 3 fg/mL–150 ng/mL (0.1 fg/mL–160 ng/mL) for sensing HBsAg (HBeAg). Quantitative determination of HBsAg and HBeAg in human serum samples is performed, showing the applicability of the proposed method for biomarker detection.Keywords:optical fiber immunosensor;surface modification;signal amplification;hepatitis B surface antigen;hepatitis B e antigen
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高影响因子
MOLECULAR BIOTECHNOLOGY
·
2025
·
IF 2.5
Chang Rui,Fang Wenjuan,Yang Xing,Jin Jiahui,Han Xijun,Ma Linlin,Li Yanfei,Chen Xiaoyan
Myocardial DNA damage plays a critical role in the pathogenesis of cardiovascular diseases, frequently leading to adverse outcomes such as myocardial infarction and heart failure. This study elucidated the protective effects of sodium alginate (SA) against myocardial DNA damage and explored the underlying molecular mechanisms involved. Hydrogen peroxide (H₂O₂) -stimulated AC16 cells were employed as an in vitro model to induce myocardial DNA damage, and CCK-8 assays established that SA exhibited no cytotoxicity at concentrations up to 800 µM. The protective effects of SA on myocardial DNA damage were shown to be mediated by VSNL1 using immunofluorescence, western blotting and qPCR analyses. To further substantiate this mechanism, lentiviral transduction was utilized to achieve VSNL1 overexpression, whereas targeted siRNA silencing was employed for VSNL1 knockdown. Following VSNL1 overexpression, a reduction in γ-H2AX protein expression was observed, accompanied by increased levels of CNP and NPR-B proteins on the cell membrane, as well as a decrease in intracellular calcium ion concentrations. Conversely, knockdown of VSNL1 reduced the protective effects of SA, highlighting its critical role in the mediation of cardioprotective mechanisms. Taken together, these findings suggest that SA exerts a potential protective effect against myocardial DNA damage through upregulating VSNL1, activating the CNP/NPR-B signaling pathway, and decreasing intracellular calcium ion accumulation. These results underscore that SA is a promising therapeutic candidate for the attenuation of myocardial injury.
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高影响因子
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
·
2024
·
IF 11.2
Ting Sai,Xiaodi Ye,Bingtao Wang,Zhenghong Guo,Juan Li,Zhengping Fang,Siqi Huo
A series of transparent, intrinsically flame-retardant, and impact-resistant poly(carbonates- b -siloxanes) were synthesized by incorporating Schiff-base modified polysiloxanes (DMS-Schiff) and naphthalene-sulfonate units into the polycarbonate (PC) chain. In addition to high transparency, the resultant copolymers (SS-co-PC5, SS-co-PC9, SS-co-PC14, and SS-co-PC20) exhibited remarkable improvements in fire safety and mechanical performance. Compared to pure PC, these copolymers demonstrated significantly enhanced limiting oxygen index (LOI, up to 34.5%) and a UL-94 V-0 rating under a thickness of only 1.6 mm. The incorporation of the polysiloxane blocks not only improved flame retardancy but also enhanced the impact strength, with SS-co-PC9 showing a 48% increase in elongation at break and a 38% rise in impact toughness compared to pure PC. In addition, SS-co-PC9 presented high mechanical strength. The synergistic effects between the naphthalene-sulfonate and polysiloxane blocks, along with the well-controlled polysiloxane phase separation (sulfonate units enabled lower processing viscosity of copolymers), led to superior comprehensive performance. These findings provide a promising pathway to create high-performance copolycarbonates for real-world applications.
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高影响因子
CERAMICS INTERNATIONAL
·
2024
·
IF 5.1
Yangyang Liu,Yang Li,Xuexin Li,Juru Zhang,Lu Wang,Kailai Lu,Xuechen liu,Xinya Feng,Yizhou Xiao,Shuai Yang,Mingwen Wang,Jie Wu,Jinglei Li,Fei Li
dielectric capacitors are highly desired in advanced high-power electrical systems owing to their fast charge-discharge capabilities, such as electromagnetic devices, high-power microwaves, and hybrid electric vehicles. While the performance of dielectric capacitors is mainly dominated by dielectric materials. (Na 0.5 Bi 0.5 )TiO 3 -(Sr 0.7 Bi 0.2 )TiO 3 (NBT-SBT) as well-known dielectric ceramics attracted much attention and are widely studied owing to their combining antiferroelectric and relaxor features which achieve high energy density and efficiency. However, few studies report the compositional modification of B-site in NBT-SBT dielectric ceramics. Here, we prepared a series of MgNb 2 O 6 doped NBT-SBT ceramics at B-Sites of the perovskite structure. Their phase structure, microstructure morphology structure, elemental distribution, dielectric and energy storage properties are systemically investigated. The resultant characterization showing minor doping MN into NBT-SBT ceramic decreases the polarization hysteresis generating an outstanding energy storage property. In addition, their energy-density variation of less than 10 % over a wide temperature range of −50 to 150°. The present research offers a route for designing dielectric ceramics with enhanced energy storage performance.
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