Journal of Water Reuse and Desalination
·
2018
·Vol. 9
·期 1
·18-30
·
IF 0.688
Wen Yue,Zhang Xingran,Chen Mei,Wu Zhichao,Wang Zhiwei
In this study, we systematically evaluated the antibiofouling behavior of quaternary ammonium compound (QAC) blended polyvinylidene fluoride (PVDF) membrane using quartz crystal microbalance with dissipation monitoring (QCM-D) combined with flow cytometry (FCM) and confocal laser scanning microscopy (CLSM) measurements. QCM-D tests showed that the introduction of QAC reduced bacterial attachment due to the biocidal functions of QAC. FCM indicated that cell integrity of the bacteria in the suspension flowing along QAC-modified membrane surfaces during the QCM-D test was severely affected. CLSM confirmed the significantly lower attachment of bacteria and higher dead/live cell ratio onto the surface of modified membranes after the washing step in QCM-D tests. Both FCM and CLSM results validated the antibacterial behavior of QAC-modified membranes by a contact-killing mechanism, which is in agreement with that of QCM-D tests. In addition, the bacterial cells accumulated on modified membrane surface exhibited higher reversibility compared to the control membrane, indicating ease of membrane cleaning. The results highlight that the combined use of QCM-D, FCM, and CLSM can comprehensively characterize the antibiofouling behavior of membranes.
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Foods
·
2026
·Vol. 15
·期 21
·3874
·
IF 6
Fangling Wu,Lingli Chen,Chuanlong Yu,Hui Chen,Yi Han,Wenbing Hu,Suyun Lin,Xiong Li,Chunlan Liu,Wenjun Wang
Petroleum-derived plastic packaging suffers from poor degradability, environmental pollution and small-molecule migration. To develop high-performance green active packaging, we fabricated composite films via solution casting using chitosan (CS), konjac glucomannan (KGM), and ethyl-cellulose-coated D-limonene nanoparticles (DENPs). Compared with the CS/KGM control film, the optimized CS/KGM/DENPs 15% film increased tensile strength by 72% (18.05 MPa) and elongation at break by 67% (46.65%), and achieved improved UV shielding, water vapor and oxygen barrier performance, with oxygen permeability decreased to 5.32 × 10−8g·mm/m2·s·Pa. Fourier-transform infrared spectroscopy (FTIR) confirmed intermolecular hydrogen bond interactions between CS and KGM. The composite films exerted obvious antibacterial activity againstEscherichia coli,Pseudomonas aeruginosa,Staphylococcus aureus, andBrochothrix thermosphacta. When applied for chilled-beef preservation, the CS/KGM/DENPs 15% film effectively retarded beef spoilage, maintained meat color and pH, and suppressed lipid–protein oxidation. Under the present experimental conditions, it prolonged the acceptable storage period of chilled beef to approximately 15 d. Meanwhile, the composite film achieved a maximum weight loss of 85.66% within 28 d during soil burial disintegration, showing great potential as an eco-friendly active food-packaging material for industrial applications.
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BIORESOURCE TECHNOLOGY
·
2015
·
IF 4.494
Xuliang Lin,Xueqing Qiu,Duming Zhu,Zihao Li,Ningxin Zhan,Jieyi Zheng,Hongming Lou,Mingsong Zhou,Dongjie Yang
Effect of the molecular structure of lignin-based polyoxyethylene ether (EHL–PEG) on enzymatic hydrolysis of Avicel and corn stover was investigated. With the increase of PEG contents and molecular weight of EHL–PEG, glucose yield of corn stover increased. EHL–PEG enhanced enzymatic hydrolysis of corn stover significantly at buffer pH 4.8–5.5. Glucose yield of corn stover at 20% solid content increased from 32.8% to 63.8% by adding EHL–PEG, while that with PEG4600 was 54.2%. Effect of EHL–PEG on enzymatic hydrolysis kinetics of cellulose film was studied by quartz crystal microbalance with dissipation monitoring (QCM-D) and atomic force microscopy (AFM). An enhancing mechanism of EHL–PEG on enzymatic hydrolysis kinetics of cellulose was proposed. Cellulase aggregates dispersed by EHL–PEG excavated extensive cavities into the surface of cellulose film, making the film become more loose and exposed. After the maximum enzymatic hydrolysis rate, the film was mainly peeled off layer by layer until equilibrium.
研究领域:
生物质转化
·
酶工程
·
高分子化学
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表面科学
·
可再生能源
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Small
·
2024
·Vol. 21
·期 4
·2410657
·
IF 13
Jia Wang,De Wang,Zelin Zhao,Ganggang Chang,Wei Guo,Jun Xu,Yinyu Xiang,Junrui Li,Junsheng Li
Developing cost-effective ruthenium (Ru)-based HER electrocatalysts as alternatives to commercial Pt/C is crucial for the advancement of proton exchange membrane water electrolysis (PEMWE). However, the strong hydrogen adsorption of Ru-based catalysts restricts its activity. Herein, a strategy is reported to tune the electronic structure and improve mass transfer by implanting Ru atoms onto the (002) facet of two-dimensional zeolitic imidazolate framework-67 (Ru@ L ZIF (002) ) to optimize the d -band center ( ε d ) of Ru and the hydrogen spillover behavior. Benefiting from the ultrathin nanosheet structure and optimized ε d of Ru, the over-strong H adsorption energy is weakened and the electron/mass transfer is facilitated. Ru@ L ZIF (002) exhibits an overpotential of 9.2 mV at 10 mA cm −2 and a long-lasting stability of 35 days at 100 mA cm −2 . The mass activity and price activity of Ru@ L ZIF (002) is 2.9 and 14.7 times higher than Pt/C, respectively. More impressively, Ru@ L ZIF (002) delivers a cell voltage of 2.01 V at a high current density of 4 A cm −2 in PEMWE. The excellent long-term durability of 1200 hours operating at 4 A cm −2 with an ultralow decay rate of 7.5 × 10 −3 mV h −1 has been achieved, making it promising as a cost-effective alternative to Pt/C catalyst for PEMWE applications.
研究领域:
电催化
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材料科学
·
能源化学
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纳米材料
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电化学工程
·
可持续能源技术
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高影响因子
Frontiers in Pharmacology
·
2026
·
IF 5.4
Fang Wang,Yan Qing Liu,Jun Nan Wei,Xiao Fen Wang,Feng Qin Li,Xiu Jia Tian,Dan Li,Yu Xuan Gao,Xin Zhi Guo,Xue Yan Li,Ping Luo
Introduction Metabolic dysfunction-associated steatotic liver disease (MASLD) is a highly prevalent chronic liver disorder characterized by intrahepatic lipid accumulation, oxidative stress, and inflammatory responses, underscoring the urgent need for effective therapeutic strategies. D-limonene, a cyclic monoterpenoid primarily derived from citrus fruits, possesses well-documented antioxidant, anti-fibrotic, and wound-healing properties. However, its therapeutic potential in MASLD remains largely unexplored. Methods To evaluate the therapeutic efficacy of D-limonene, a rat model of MASLD was established using a high-fat diet (HFD). An integrated approach combining metabolomics, transcriptomics, and network analysis was employed to identify key signaling pathways and molecular targets. The expression levels of candidate targets were validated by RT-qPCR and Western blotting. Molecular docking simulations were performed to predict the binding affinity between D-limonene and the target proteins. Furthermore, a cellular thermal shift assay (CETSA) was conducted to confirm direct binding and protein stabilization. In parallel, cellular experiments using BRL-3A and HepG2 cells were carried out to assess the effect of D-limonene on lipid accumulation. Results D-limonene treatment significantly ameliorated liver injury, reduced excessive lipid deposition, attenuated inflammation, and suppressed oxidative stress in HFD-induced rats. Integrated multi-omics and network analyses identified the PPAR signaling pathway as the core pathway mediating the regulatory effects of D-limonene on lipid metabolism, with PPARγ and SCD-1 pinpointed as key downstream targets. RT-qPCR and Western blot analyses confirmed that D-limonene significantly downregulated the expression of both PPARγ and SCD-1. Molecular docking simulations revealed stable binding of D-limonene to PPARγ and SCD-1. Importantly, CETSA further demonstrated that D-limonene directly binds to and stabilizes these two proteins. Consistently, cellular assays showed that D-limonene significantly reduced lipid accumulation in BRL-3A and HepG2 cells by inhibiting the PPARγ/SCD-1 axis. Conclusion Collectively, these findings suggest that D-limonene alleviates HFD-induced MASLD, and its protective effects may be mediated, at least in part, through inhibition of the PPARγ/SCD-1 axis. This study provides preliminary evidence supporting the potential development of D-limonene as a targeted therapeutic agent for MASLD. Further studies are warranted to validate these findings and elucidate additional underlying mechanisms.
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DOI
PubMed
高影响因子
BIOMEDICAL CHROMATOGRAPHY
·
2026
·Vol. 40
·期 8
·e70547
·
IF 1.7
Yi Zhou,Yuxin Wu,Chenyao Xu,Chenbin Zhang,Congcong Wen,Xianqin Wang,Jianbo Li
Loureirin D is a bioactive dihydrochalcone isolated from Dracaena resin with very high therapeutic value. A sensitive and high-throughput ultra-performance liquid chromatography–mass spectrometry (UPLC–MS/MS) method was developed for the quantitative analysis of loureirin D in rat plasma with only 50 μL of sample per assay. Sample extraction was protein precipitation using acetonitrile, and isoscoparin was used as internal standard (IS). Separation was achieved on the BEH C18 column with a gradient mobile phase of 0.1% (v/v) aqueous formic acid and acetonitrile. Detection was achieved with negative-ion electrospray ionization (ESI) detector in the multiple reaction monitoring (MRM) mode. The method was validated and proved to be linear in the concentration range of 2–2400 ng/mL ( r ≥ 0.995), intraday and interday precision (RSD) was < 15%, and accuracy was 93.3%–110.1%. The extraction recovery was 88.7%–94.4%, and the matrix effects were 87.3%–92.9%. UPLC-MS/MS was used in pharmacokinetics in the rats after administration of loureirin D. The AUC (0– t ) after intravenous administration (1 mg/kg) was 2074.7 ± 180.3 ng · h/mL, and AUC (0– t ) after oral administration (5 mg/kg) was 563.4 ± 61.4 ng · h/mL; the absolute oral bioavailability was 5.4%. Pharmacokinetics showed rapid absorption, large V z / F (52.7 ± 10.7 L/kg), high CL z / F (8.8 ± 0.9 L/h/kg), and extensive first-pass metabolism.
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DOI
PubMed
高影响因子
Foods
·
2026
·Vol. 15
·期 14
·2526
·
IF 6
Xiaoxiao Liang,Yiru Cheng,Ruxia Wang,Qian Wang,Peng Tang,Yulong Yin,Xia Xiong
Eucommia ulmoidesleaf extract (ELE) boasts a high concentration of bioactive components including flavonoids, chlorogenic acid, and polysaccharides. It exhibits multiple biological functions, including antioxidant, anti-inflammatory, and gut microbiota-modulating properties, showing great potential in enhancing immunity, maintaining intestinal health, and delaying cellular senescence. This study investigated the protective effects and underlying mechanisms of ELE against D-galactose-induced senescence in chick embryo primary intestinal epithelial cells (IECs). Using an in vitro model (200 mmol/L D-galactose), we found that 100 µg/mL ELE pretreatment significantly preserved cell viability, mitigated apoptosis, and delayed cellular senescence, as evidenced by cytological and biochemical assays. Furthermore, RNA-seq transcriptomic analysis identified seven key differentially expressed genes (DEGs) mediating these anti-aging effects. Mechanistic investigations revealed that ELE modulates ATP6V0D2 and NCF2 to activate autophagy signaling pathways. This ELE-induced promotion of autophagy effectively suppresses inflammatory responses in IECs, thereby delaying senescence progression. These findings elucidate the molecular mechanisms by which ELE antagonizes intestinal cellular senescence, providing a solid theoretical foundation for its development as a functional anti-aging additive in the food industry.
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PubMed
高影响因子
CARBON
·
2026
·
IF 12.7
Xiaoyan Liu,Wei Ding,Guoxu Wang,Jizheng Zhu,Suzhen Yin,Chengbiao Wei
Lithium-sulfur (Li-S) batteries are promising next-generation energy-storage systems because of their high theoretical energy density. However, their practical application is severely hindered by sluggish sulfur redox kinetics and the shuttle effect of soluble lithium polysulfides (LiPSs). Herein, a MoS 2 @NPCNFs interlayer is designed to immobilize LiPSs and accelerate bidirectional sulfur conversion. The porous and conductive carbon nanofiber framework provides rapid electron/ion transport pathways and facilitates electrolyte penetration, while the MoS 2 component offers abundant catalytic sites for polysulfide adsorption and conversion. As revealed by density functional theory (DFT) calculations, the nitrogen-regulated electronic environment modulates the Δd-p value associated with MoS 2 . This optimized d-p orbital interaction strengthens the coupling between MoS 2 and lithium polysulfides, thereby promoting their chemical adsorption and catalytic conversion. X-ray photoelectron spectroscopy shows obvious binding-energy shifts after Li 2 S 6 adsorption, indicating strong interfacial electronic interactions. Density functional theory calculations further demonstrate that this electronic-structure regulation enhances the LiPSs chemisorption, optimizes the Gibbs free-energy evolution of sulfur redox reactions, and lowers the energy barriers for Li 2 S decomposition and Li + diffusion. Consequently, the MoS 2 @NPCNFs interlayer enables efficient bidirectional catalysis of polysulfide reduction, effectively suppressing the shuttle effect and improving reaction kinetics. The assembled Li-S battery delivers high initial discharge capacities of 1262.9 mAh·g −1 at 0.2C and 916.0 mAh·g −1 at 1C, and maintains excellent cycling stability over 1000 cycles at 1C with a low capacity decay rate of 0.043% per cycle. This work provides an electronic-structure-regulation strategy for designing advanced interlayers toward high-performance Li-S batteries. Download: Download high-res image (276KB) Download: Download full-size image
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Small
·
2025
·
IF 12.1
Xin Jin,Xuemei Jia,Haili Lin,Qianlong Wang,Xiaoxin Feng,Yujie Zhang,Haoyu Zhang,Jing Cao
Although red phosphorus (RP) is a promising photocatalyst, its performance in simultaneous benzyl alcohol (BA) oxidation and H 2 evolution is constrained by undesirable carrier recombination and sluggish surface reaction kinetics. The d–p orbital hybridization, serving as a crucial mechanism for electronic structure regulation, offers an effective strategy to address the aforementioned challenges. Hence, RP is synergistically regulated by defect-rich nickel oxide (NiO x ) and Co single atoms (Co SA ) to construct a dual d−p orbital hybridized photocatalyst (NiO x @RP@Co SA ). In the NiO x @RP@Co SA system, the Ni 3d–P 2p orbital hybridization optimizes the BA adsorption at Ni sites and reducing the C─H bond activation energy barrier. Meanwhile, the Co 3d–P 2p orbital hybridization is conducive to balancing the hydrogen reduction reaction. In situ characterization combined with density functional theory (DFT) calculations confirms that precise regulation of dual d–p orbital hybridization not only enhances charge separation efficiency but also promotes surface reaction kinetics. The 5NiO x @RP@0.2Co SA exhibited superior photocatalytic performance, which is approximately a 15.48-fold enhancements compared to RP. This work not only elucidates the mechanism of dual d−p orbital hybridization but also establishes a novel paradigm for the design of efficient and multifunctional solar-driven catalytic systems.
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Journal of Mechanical Science and Technology
·
2026
·
IF 2.2
Khalil Muhammad Kaleem Ullah,Gul Rizwan M.,Shah Nouman Ali,Jan Syed Rooh Ullah,Ahmad Adnan,Kamran M. Ali,Xu Jia-Zhuang,Li Zhong-Ming
Wear and oxidation resistance are among the primary requirements for successful and sustainable total joint replacements (TJRs). Both of these factors are major causes of TJRs failure. To address these issues and enhance the service life of TJRs, the effects of vitamin E (VE) and vitamin E-D-sorbitol (VE-DS), which are antioxidants (AOs), on stabilizing ultrahigh-molecular-weight polyethylene (UHMWPE) are presented. These antioxidants were blended with control-UHMWPE at a concentration of 0.3 % by weight and consolidated by compression molding. Wear occurs on the surface, and restricting the crosslinking to a layer on the surface is desirable, as bulk crosslinking reduces the toughness and fatigue strength of the implant. In this study, surface chemical crosslinking of control-UHMWPE, VE-UHMWPE and VE-DS-UHMWPE with dicumyl peroxide (DCP) is presented. The crosslinked density, crystallinity, wear volume, mechanical performance, biocompatibility and oxidation stability assessed by oxidation induction time (OIT) of the UHMWPE blends were characterized through different techniques. The control-UHMWPE blend showed the highest wear resistance but the lowest OIT, while the VE-DS-UHMWPE blend displayed highest crystallinity, best mechanical performance and the highest OIT, exhibiting the synergistic effect of vitamin E and D-sorbitol on the oxidation resistance of UHMWPE.
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SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2026
·
IF 4.8
Mengjiao Pang,Yanjie Wang,Zengcheng Du,Qiqing Chen,Wenhao Liu,Miaoduo Deng,Yuanyuan Xie,Mingfang Zhu
In this study, a water-soluble perovskite quantum dot (PQDs) based on CsPbI 3 "on-off-on" fluorescent probe was successfully constructed. The probe exhibits red fluorescence emission at 660 nm under 465 nm excitation, and the response mechanism of Cu 2+ -induced fluorescence quenching (OFF) and D-penicillamine (D-PA) triggered fluorescence recovery (ON) is realized. In addition, the dual target detection platform of both copper ions (Cu 2+ ) and D-PA was established. Quantitative analysis showed that the detection linearity range was 0.5–15 μM (LOD = 0.21 μM) for Cu 2+ and 0.4–60 μM (LOD = 16.7 nM) for D-PA. Meanwhile, D-PA can be semi-quantitatively measured based on the change in solution color. The fluorescent probe provides a fast response time, high sensitivity, and convenient solution for real-time detection of Cu 2+ and D-PA. And it was applied in the determination of D-PA in serum samples with satisfactory results. It is particularly noteworthy that the synthesized perovskite quantum dots exhibit excellent stability in the aqueous environment, which provides a new strategy for expanding the application of perovskite materials in the field of biomedical analysis.
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高影响因子
Pharmaceuticals
·
2026
·Vol. 19
·期 9
·1336
·
IF 5.7
Shini Zhang,Xiao-Li Luo,Hangxing Yang,Ganghua Huang,Jing Leng,Tao Yang
Background:Alzheimer’s disease (AD) is a prevalent neurodegenerative disorder for which effective treatments remain limited. Liubao tea, a distinctive post-fermented dark tea, develops unique aged and areca nut aromas through prolonged storage. However, comprehensive studies on its anti-Alzheimer’s disease effects are lacking. This study aimed to identify the bioactive constituents of Liubao tea with varying storage durations and aroma profiles, and to further evaluate its neuroprotective potential against Alzheimer’s disease.Methods:Chromatography and spectrophotometry were employed to quantitatively determine the primary bioactive components in various Liubao tea samples. A D-galactose-induced Alzheimer’s disease zebrafish (Danio rerio) model was established to evaluate the neuroprotective effects of the aqueous extract of Liubao tea.Results:The contents of theabrownins, theaflavins, tea pigments, and catechins showed potential associations with the anti-AD capacity of Liubao tea. Variations in these bioactive components appeared to correlate with the neuroprotective activity.Conclusions:This study elucidates the anti-AD potential of aged Liubao tea and associates its characteristic constituents with neuroprotective effects. The findings provide essential theoretical support for developing Liubao tea as a promising natural product candidate worthy of further anti-AD research.
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高影响因子
危险品化学品经营许可证（带存储）