JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2019
·
IF 3.571
Wei Wei,Jie Yang,Dan Yang,Xiangyu Wang,Zhenyu Yang,Qingzhe Jin,Manyi Wang,Jianqiang Lai,Xingguo Wang
We compared phospholipids (PLs), PL fatty acid (FA) composition, and milk fat globule size and structure in human milk (n = 120) from mothers of full-term and preterm infants during lactation (colostrum, transition, 1 mo, 2 mo, and 3 mo) and 8 brands of infant formulas. The absolute quantification of PLs was analyzed using 31P NMR spectroscopy. Sphingomyelin was the dominant PLs (35.01 ± 3.31%) in human milk, whereas phosphatidylcholine and phosphatidylethanolamine were the dominant PLs in infant formulas. The PL content in preterm milk increased during lactation, whereas that in term milk remained stable. Saturated FAs (mainly 16:0 and 18:0) were the most abundant (>60%) PL FA in both preterm and term milk and increased throughout lactation. The mean diameter of milk fat globules in infant formulas was much smaller than that found in human milk (200 nm vs 5.63 μm). Significant differences were observed between human milk and infant formulas with regard to PLs, suggesting that more research is needed to mimic the PL profile in infant formulas.
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CARBOHYDRATE POLYMERS
·
2020
·
IF 7.182
Dongmei Wu,Jiaqi Zheng,Weiwei Hu,Xiaoliang Zheng,Qiaojun He,Robert J. Linhardt,Xingqian Ye,Shiguo Chen
Rhamnogalacturonan I (RG-I) pectin are regarded as strong galectin-3 (Gal-3) antagonist because of galactan sidechains. The present study focused on discussing the effects of more structural regions in pectin on the anti-Gal-3 activity. The water-soluble pectin (WSP) recovered from citrus canning processing water was categorized as RG-I pectin. The controlled enzymatic hydrolysis was employed to sequentially remove the α-1,5-arabinan, homogalaturonan and β-1,4-galactan in WSP. The Gal-3-binding affinity KD (kd/ka) of WSP and debranched pectins were calculated to be 0.32 μM, 0.48 μM, 0.56 μM and 1.93 μM. Moreover, based on the more sensitive cell line (MCF-7) model, the IC 30 value of WSP was lower than these of modified pectins, indicating decreased anti-Gal-3 activity. Our results suggested that the total amount of neutral sugar sidechains, the length of arabinan and cooperation between HG and RG-I played important roles in the anti-Gal-3 activity of WSP, not the Gal/Ara ratio or RG-I/HG ratio. These results provided a new insight into structure-activity relationship of citrus segment membrane RG-I as a galectin-3 antagonist and a new functional food.
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INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2019
·
IF 3.375
Hao Zhang,Hanxiao Zheng,Ying Wang,Runhua Yan,Dingyuan Luo,Wei Jiang
Petal bismuth salt semiconductors are promising as visible-light-driven photocatalysts, but their short service times due to strong oxidation limit their application. In this research, the in situ construction of a p–n heterojunction, by growing BiOX on a KBiO3 surface, is used as a strategy to improve the performance and stability. Evaluation of the photocatalytic degradation of crystal violet and phenol shows that the KBiO3/BiOX (X = Cl, Br, I) heterostructures exhibit significant improvement in photocatalytic performance and stability compared to KBiO3. The best one, KBiO3/(5.85%) BiOI, shows 98% degradation of crystal violet within 20 min, and of phenol within 1.5 h. No significant performance decay can be detected after repeated use. The development of KBiO3/BiOX heterostructure improves the applicability of KBiO3 as an efficient visible-light-driven photocatalyst.
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ANALYTICAL CHEMISTRY
·
2025
·
IF 6.7
Yongfei Huang,Junping Liang,Wenbo Lu,Chenzhong Li,Zhefeng Fan
Cancer is a serious threat to human health, and it is essential to find effective methods for detecting and treating cancer. Diagnostic integration is a new strategy for cancer diagnosis and treatment that enables localized detection and treatment of tumors in a single administration and effectively reduces the toxic side effects on normal tissues. It remains a challenge for small-molecule probes to achieve multifunctionality in sensing, targeting, imaging, and therapy. Photodynamic therapy (PDT), which uses photosensitizers to generate reactive oxygen species under specific wavelengths of light to ablate tumor tissue, has demonstrated unique advantages in tumor treatment. However, the high expression of Cys/GSH in the tumor region will consume the reactive oxygen species generated by photosensitizers during PDT and reduce the therapeutic effect of the tumor. In this study, the highly expressed Cys/GSH in the tumor microenvironment was used as the activation source, and benzopyrylium salt and coumarin dyes were selected as fluorophores, with the ether bond and aldehyde group as recognition sites, to construct a near-infrared-activated Cys/GSH fluorescent probe (Bpl-O-Cou). Based on the intramolecular rearrangement mechanism and intramolecular cyclization mechanism, Bpl-O-Cou could discriminate the detection of Cys/GSH accompanied by different fluorescence emissions. Under near-infrared laser irradiation, Bpl-O-Cou + Cys/GSH could produce •OH and O2–•, leading to 4T1 cell death. In vivo experiments further illustrated the interventional role of Bpl-O-Cou in the PDT process. This study provides a new idea for the design of multifunctional probes for cancer diagnostics and therapeutics.
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NEW JOURNAL OF CHEMISTRY
·
2017
·Vol. 41
·期 9
·3352-3357
·
IF 3.269
Wenjuan Guo,Na Sun,Yankai Du,Luyan Wang,Meishan Pei
A poly(glycidyl methacrylate) (PGMA) grafted bentonite (Bent) was prepared by surface-initiated atom transfer radical polymerization (SI-ATRP), followed by modification with tetraethylenepentamine (TEPA) through a ring-opening reaction of the epoxy groups in PGMA to form polyamine grafted bentonite (Bent–PGMA–TEPA). The as-prepared novel material was characterized by Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), scanning electron microscopy (SEM), and thermal gravimetric analysis (TGA). The ability of Bent–PGMA–TEPA to adsorb Orange I (OI), a negatively charged dye, was tested. The effects of pH, initial concentration, contact time and temperature were investigated. The equilibrium adsorption isotherm and adsorption kinetics fitted well with the Langmuir model and the pseudo-second-order kinetic model respectively.
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RSC Advances
·
2014
·Vol. 4
·期 109
·64043-64052
·
IF 3.708
Anqi Ju,Yafeng Yan,Dawei Wang,Jun Luo,Mingqiao Ge,Mengjuan Li
A bifunctional comonomer β-methylhydrogen itaconate (MHI) was employed to prepare high molecular weight poly[acrylonitrile-co-(β-methylhydrogen itaconate)] [P(AN-co-MHI)] copolymers by radical polymerization in a mixed solvent of dimethyl sulfoxide/deionized water = 60/40 (wt/wt), which was used as a carbon fiber precursor instead of acrylonitrile terpolymers for improving the stabilization and spinnability simultaneously. The structure and stabilization of P(AN-co-MHI) copolymers with different monomer feed ratios were characterized by elemental analysis (EA), Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD) and differential scanning calorimetry (DSC). The results show that both the polymerization conversion and molecular weight reduce with the increase of MHI content in the feed due to the larger molecular volume of MHI. The monomer reactivity ratios were calculated by Fineman–Ross and Kelen–Tüdõs methods and the reactivity of MHI is higher than that of AN. Two parameters Es = A1618 cm−1/A2244 cm−1 and SI = (I0 − Is)/I0 were defined to evaluate the extent of stabilization and the activation energy (Ea) of the cyclization. The FTIR, XRD and DSC results show that P(AN-co-MHI) copolymers exhibit significantly improved stabilization characteristics than the PAN homopolymer and poly(acrlonitrile–methyl acrylate–acrylic acid) terpolymer, such as a larger extent of stabilization, lower initiation temperature and smaller Ea of cyclization, which is attributed to the ionic initiation of the MHI comonomer and is beneficial for preparing high performance carbon fiber.
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BIOORGANIC CHEMISTRY
·
2025
·
IF 4.7
Lei Huang,Lichao Yu,Xiaohui Fang,Hangxin Gong,Yiting Qiu,Guohan Huang,Xiaoxia Ye,Lingtian Wang,Yun-Yun Quan,Zu-Sheng Huang
Photodynamic therapy (PDT), operates through a distinctive reactive oxygen species (ROS)-mediated cytotoxic mechanism, offering therapeutic potential against malignant tumors and bacterial infections. The development of multifunctional photosensitizers (PSs) capable of simultaneously exhibiting potent antitumor and antibacterial activities represents a promising yet challenging frontier in PDT research. Herein, three donor-π bridge-acceptor (D-π-A) aggregation induced emission (AIE) photosensitizers TPTM , TPTP and TPTQ with type I and type II ROS production abilities were successfully constructed by acceptor engineering strategy. TPTP stands out from others by advantages of rapid cellular internalization behavior, potent ROS production capacity, dual-organelle targeting (mitochondria and endoplasmic reticulum) ability. TPTP displayed antitumor effects in 4T1 tumor-bearing nude mice, inducing ROS-mediated apoptosis and suppressing tumor growth. Simultaneously, TPTP enhanced its affinity for bacteria through its cationic part, and exhibited potent antibacterial activity against Gram-positive (G+) bacteria Staphylococcus aureus ( S. aureus ), methicillin-resistant Staphylococcus aureus (MRSA), Staphylococcus epidermidis ( S. epidermidis ), and Gram-negative (G−) bacteria Escherichia coli ( E. coil ) and Acinetobacter baumannii ( A. baumannii ) upon light irradiation. TPTP also performed well in promoting infected wounds healing. This work provides a versatile molecular platform for future applications in infectious diseases and oncology, with potential for further applications in combination therapies.
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Nature Energy
·
2024
·
IF 49.7
Meng Hongguang,Mao Kaitian,Cai Fengchun,Zhang Kai,Yuan Shaojie,Li Tieqiang,Cao Fangfang,Su Zhenhuang,Zhu Zhengjie,Feng Xingyu,Peng Wei,Xu Jiahang,Gao Yan,Chen Weiwei,Xiao Chuanxiao,Wu Xiaojun,McGehee Michael D.,Xu Jixian
The manufacturing of perovskite solar cells under ambient conditions is desirable, yet the efficiency of p–i–n perovskite solar cells fabricated in air still lags behind those made in an inert atmosphere. Here we introduce an ionic pair stabilizer, dimethylammonium formate (DMAFo), into the perovskite precursor solution to prevent the degradation of perovskite precursors. DMAFo inhibits the oxidization of iodide ions and deprotonation of organic cations, improving the crystallinity and reducing defects in the resulting perovskite films. We show the generation of additional p-type defects during ambient air fabrication that suggests the need for improving bulk properties of the perovskite film beyond surface passivation. Upon addition of DMAFo, we demonstrate that the efficiency of inverted p–i–n solar cells based on perovskite layers with 1.53-eV and 1.65-eV bandgaps fabricated under ambient conditions (25–30 °C, 35–50% relative humidity) increases by 15–20%. We achieve a certified stabilized efficiency of 24.72% for the 1.53-eV cell, on a par with state-of-the-art counterparts fabricated in an inert atmosphere.
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MICROPOROUS AND MESOPOROUS MATERIALS
·
2013
·
IF 3.365
Lan-Lan Lou,Huanling Du,Yanbin Shen,Kai Yu,Wenjun Yu,Qiu Chen,Shuangxi Liu
Chiral 9-amino epi -cinchonine was anchored on external surface passivated SBA-15 as well as calcined SBA-15. The two resulting materials were used as catalysts for the asymmetric transfer hydrogenation of aromatic ketones after complexing with [Ir(COD)Cl] 2 . Higher enantioselectivities were obtained over the passivated SBA-15 supported catalyst compared with the catalyst based on calcined SBA-15 as well as the homogeneous counterpart. Especially for the substrate of acetophenone, an obviously high enantiomeric excess (ee) of 74% (homogeneous ee: 60%) was achieved with comparable conversion to the homogeneous catalyst (97% vs. 98%). Furthermore, the passivated SBA-15 supported catalyst demonstrated higher stability during the asymmetric transfer hydrogenation reaction as compared with the catalyst based on calcined SBA-15.
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JOURNAL OF MATERIALS SCIENCE
·
2016
·Vol. 51
·期 22
·10229-10244
·
IF 2.302
Ban Jianfeng,Zhu Linjiang,Chen Shaojun,Wang Yiping
Aiming to elucidate the influence of liquid crystal fillers on the structure and properties of liquid-crystalline (LC) shape-memory polyurethane (SMPU) composites, a series of LC-SMPU composites are successfully prepared by adding various concentrations of 4-dodecyloxybenzoic acid (DOBA) to shape-memory polyurethane containing 40 wt% hard segment content (SMPU40). The structure, morphology, thermal properties, liquid crystalline properties, and shape memory properties are systematically investigated. The results demonstrate that DOBA is successfully incorporated into the polymer matrix of SMPU40 without interrupting the dimerization structure of DOBA that allows it to exhibit LC properties. The incorporated DOBA not only improves the crystallizability of the soft segment but also promotes the crystallizability of the hard segment. The isothermal crystallization kinetics further reveal that the crystallization rate of the hard segment decreases as the DOBA content increases, and the crystallization of the LC-SMPU composites nucleates in a similar manner. The LC-SMPU composites are composed of a DOBA phase and an SMPU phase, which further forms soft phase–hard phase microphase separation structures. The composite tends to only maintain the nematic LC properties of DOBA due to the interruption of polyurethane chains. However, the LC-SMPU composites exhibit good triple-shape memory effects. The first step of strain recovery is associated with the melting transition of soft segment crystals of the polyurethane matrix, and the second step of strain recovery is resulted from the melting transition of the DOBA crystals.
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SENSORS AND ACTUATORS B-CHEMICAL
·
2026
·
IF 8.3
Yongfei Huang,Li Zhang,Zhefeng Fan
Photodynamic therapy (PDT) holds great promise for tumor treatment, but its clinical translation is greatly hindered by the drawbacks of conventional photosensitizers (PSs), such as insufficient reactive oxygen species (ROS) generation, exclusive type‑II photoreaction, poor subcellular targeting, and compromised efficacy in hypoxic tumors. Herein, we rationally designed and synthesized a mitochondria‑targeted near‑infrared (NIR) photosensitizer Mito‑IsTp with a classic D-π-A architecture, using isophorone as the electron acceptor, methoxy‑modified triphenylamine as the electron donor, benzene as the π‑bridge, and triphenylphosphonium as the mitochondrial‑targeting group. Mito‑IsTp displays a maximum emission peak at 770 nm within the NIR‑I window, together with satisfactory photostability and solvent‑dependent optical performance. Upon 660 nm NIR light irradiation, Mito‑IsTp can simultaneously produce type‑I (•OH, O 2 -• ) and type‑II ( 1 O 2 ) ROS with much higher efficiency than commercial Rose Bengal and Chlorin e6 (Ce6). Confocal imaging verifies its excellent mitochondrial targeting ability in HeLa cells with a Pearson correlation coefficient of 0.97. In vitro experiments reveal negligible dark toxicity and efficient phototoxicity to induce cancer cell apoptosis through ROS-mediated mitochondrial damage. In vivo studies on HeLa tumor‑bearing nude mice further show that Mito‑IsTp ‑mediated PDT significantly suppresses tumor growth without obvious systemic toxicity or organ injury, confirmed by body weight recording, H&E staining, blood routine tests, and hemocompatibility assessment. This work presents a high‑performance NIR PS with dual‑pathway ROS generation and precise mitochondrial targeting, establishing a feasible paradigm for hypoxia‑resistant and mitochondria‑targeted tumor PDT.
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INORGANIC CHEMISTRY
·
2026
·Vol. 65
·期 31
·18392-18401
·
IF 4.6
Zhang Su,Xu Yu,Sun Hai Yang,Zhai Lu,Tian Zheng-Fang,Ren Xiao-Ming
Low-dimensional emissive Cu(I) halides have garnered
extensive
attention owing to their structural diversity and unique, structure-dependent
photophysical properties. Nevertheless, achieving structural transitions
with switchable physical properties remains a formidable challenge
for high-nuclearity Cu(I) halides, and reported zero-dimensional (0D)
to one-dimensional (1D) structural dimensionality transformations
are extremely scarce. Herein, two decanuclear Cu(I) iodide halides,
namely [Pr 2 -DABCO] 5 [Me 2 NH 2 ]Cu 10 I 20 I·(MeCN) 2 ( 1 ) and [Pr 2 -DABCO] 3 [Me 2 NH 2 ]Cu 10 I 17 ( 2 ) ([Pr 2 -DABCO] 2+ = N , N ′ -dipropyl-1,4-diazabicyclo-[2.2.2]octan-1-ium
cation; [Me 2 NH 2 ] + = dimethylamine
cation; MeCN = acetonitrile) are synthesized. Compound 1 features isolated [Cu 10 I 20 ] 10– clusters, while 2 exhibits infinite 1D [Cu 10 I 17 ] n 7n– chains, and both
represent rare structural prototypes among the reported Cu(I) iodide
clusters. Remarkably, a reversible structural transformation between 1 and 2 is achieved, accompanied by a high-contrast
emission color change from a weakly orange-emissive 0D phase to a
bright green-emissive 1D structure. Compound 2 exhibits
a 3-fold enhancement in the photoluminescence quantum yield (PLQY),
reaching a maximum value of 74.59%. Impressively, 2 also
enables high-contrast, stable, and reversible dielectric “silent
→ active” switching owing to the order–disorder
transition of organic [Me 2 NH 2 ] + cations.
This work reports two decanuclear Cu(I) halides, capable of reversible
0D/1D structural interconversion, which enables dual optical and dielectric
bistable switching, providing a new platform for the design and fabrication
of multifunctional responsive materials.
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