CHEMICAL ENGINEERING JOURNAL
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2025
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IF 13.2
Jiayu Ouyang,Wenzhuo Lv,Canhui Wang,Xin Guo,Huiying Lv,Yiqiang Wu
Achieving a balance between catalytic efficiency and structural durability remains a key challenge in heterogeneous photo-Fenton-like systems. Herein, we report a robust sodium alginate hydrogel (ACCN) with hard–soft dual interpenetrating networks, constructed by incorporating Cu@MoS 2 nanosheets and carbon dots-modified cellulose nanofibrils (CNF@CDs). This structural design enables pan-regional photo-Fenton-like catalysis via structural optimization and directed electron transport, thereby ensuring sustained ciprofloxacin (CIP) degradation. Three key features synergistically enhance both catalytic performance and material integrity: (1) a dual interpenetrating network comprising Cu 2+ -crosslinked sodium alginate (SA, soft phase) and hydrogen-bonded CNF@CDs (rigid phase), which reinforces mechanical strength and prevents Cu@MoS 2 leaching; (2) the SA/CNF@CDs network exhibits an ultrahigh CIP adsorption capacity, which spatially concentrates pollutants and accelerates reaction kinetics; and (3) CNF@CDs facilitates electron transfer from Cu@MoS 2 to Cu 2+ crosslinking sites, promoting pan-regional Cu 2+ /Cu + redox cycling. This spatial–electronic integration endows ACCN with a CIP degradation rate constant of 0.0426 min −1 —7.5-fold higher than that of Cu@MoS 2 . Furthermore, ACCN demonstrates excellent durability and reusability, maintaining over 95 % catalytic activity after 10 cycles, with Mo leaching below 8 ppb. This work provides a sustainable strategy for integrating structural and electronic modulation to enable high-efficiency, durable antibiotic wastewater treatment.
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高影响因子
MOLECULES
·
2019
·Vol. 24
·期 18
·3292
·
IF 3.06
Shiyuan Fang,Qianqian Zhou,Yan Hu,Feng Liu,Jun Mei,Jing Xie
The objective of this research was to explore the antimicrobial activity and mechanism of carvacrol againstVibrio Parahemolyticus,Shewanella putrefaciens,Staphylococcus aureusandPseudomonas fluorescensand evaluate the effect of the addition of carvacrol/β-cyclodextrin emulsions to flaxseed gum (FSG)-sodium alginate (SA) edible films on the preservation of Chinese sea bass (Lateolabrax maculatus) fillets during refrigerated storage. The minimum inhibitory concentration (MIC) of carvacrol againstV. parahemolyticus,S. putrefaciens,S. aureusandP. fluorescenswere 0.5, 0.5, 0.125, and 0.5 mg/mL, respectively. Alkaline phosphatase activity assay, nucleotide and protein leakage, and scanning electron microscope demonstrated that carvacrol damaged the external structure of the tested bacterial cells causing leakage of cytoplasmic components. At the same time, when FSG-SA films containing carvacrol used as coating agents for Chinese sea bass fillets cold storage, FSG-SA films containing 1.0 or 2.0 mg/mL carvacrol could significantly reduce TVB-N content, K-value, the degree of microbial deterioration and maintain quality of sea bass fillets according to organoleptic evaluation results.
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JOURNAL OF BIOMATERIALS APPLICATIONS
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2024
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IF 2.3
Yiwan Shi,Zhaozhen Wang,Weikang Xu,Xiaolu Yu,Botao Gao,Xinting Zhou,Jiwen Chen,Kunfeng Jia,Lek Hang Cheang,Man seng Tam,Huajun Wang,Xiaofei Zheng,Tingting Wu
Large bone defect repair is a striking challenge in orthopedics. Currently, inorganic-organic composite scaffolds are considered as a promising approach to these bone regeneration. Silicon ions (Si4+) are bioactive and beneficial to bone regeneration and Si4+-containing inorganic mesoporous silica (MS) can effectively load drugs for bone repair. To better control the release of drug, we prepared biodegradable MS/PLGA (MP) microspheres. MP loaded organic silk fibroin/carboxymethyl chitosan/sodium alginate (MP/SF/CMCS/SA) composite scaffolds were further constructed by genipin and Ca2+ crosslinking. All MP/SF/CMCS/SA scaffolds had good swelling ability, degradation rate and high porosity. The incorporation of 1% MP significantly enhanced the compressive strength of composite scaffolds. Besides, MP loaded scaffold showed a sustained release of Si4+ and Ca2+. Moreover, the release rate of rhodamine (a model drug) of MP/SF/CMCS/SA scaffolds was obviously lower than that of MP. When culturing with rat bone marrow mesenchymal stem cells, scaffolds with 1% MP displayed good proliferation, adhesion and enhanced osteogenic differentiation ability. Based on the results above, the addition of 1% MP in SF/CMCS/SA scaffolds is a prospective way for drug release in bone regeneration and is promising for further in vivo bone repair applications.
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高影响因子
JOURNAL OF NANOBIOTECHNOLOGY
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2026
·
IF 15
Qiao Xia,Liu Jiayue,Bai Jing,Xu Chao,Zhao Qianying,Guo Songlin,Ding Lu,Ma Duan,Zhang Xu,Tian Bingren
Oral administration can deliver targeted nanoparticles directly to colorectal cancer (CRC) lesions, bypassing systemic circulation. However, orally administered nanoparticles may become physically entrapped in the small intestine, compromising therapeutic efficacy. To overcome this limitation, we designed and prepared folic acid-modified, CRC cell-targeting nanoparticles (FA/CS/TPP/β-acids) and incorporated them into a sodium alginate hydrogel (Alg/FA/CS/TPP/β-acids). The release of β-acids from the nanoparticles was pH-dependent, with cumulative release following the order: pH 7.8 > pH 6.8 > pH 1.2. The nanoparticle/hydrogel system exhibits good biocompatibility (hemolytic activity < 5%; non-toxic to NCM460 cells) and significantly enhances cellular uptake in HCT116 and HT29 cells. In vivo studies showed that the nanoparticles were non-toxic and effectively inhibited CRC. Interestingly, the hydrogel undergoes a sol-gel transition under acidic gastric conditions (pH 1.2). Upon reaching the colorectum, where the pH is higher, it undergoes a gel-sol transition. These results demonstrate that the alginate-modified hydrogel can protect the nanoparticles in the gastrointestinal environment, enabling targeted release for CRC therapy. Graphical
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2026
·
IF 8.7
Fang-Jun Cao,Xiang Hou,Li Ma,Tie-Zhi Jin,Wei-Ping Yang,Hui Feng
Diabetic ulcer is a common chronic wound, and also one of the typical complications of diabetes. The pathological environment of diabetic ulcer caused by high glucose levels is extremely complex, so the treatment for diabetic ulcers remains a challenge. As a proof of concept, we herein propose to use an ultra-small self-assembled gallic acid (Ga)‑iron (Fe)‑copper-(Cu) metal–phenolic nanoparticles (Ga-Fe-Cu NPs) based sprayable hydrogel for diabetic wound treatment. The Ga-Fe-Cu NPs is synthesized and then incorporated into sprayable hydrogel dressing with sodium alginate/chitosan quaternary ammonium salts to improve therapeutic compliance, culminating in the formulation of Ga-Fe-Cu NPs based sprayable hydrogel. The Ga-Fe-Cu NPs effectively scavenges reactive oxygen species (ROS), reduces oxidative stress, shortening the transition between inflammation and proliferative phase and maintaining redox balance. The Ga-Fe-Cu NPs-based sprayable hydrogel exhibits excellent mechanical properties. The sprayable hydrogel aided in alleviating the hypoxic conditions in bacteria-infected diabetic wound healing, killing bacteria, decreasing inflammation, promoting vascularization, alleviate hypoxia to achieve scarless repair of diabetic infected wound. Ultimately, the Ga-Fe-Cu NPs-based sprayable hydrogel demonstrates superior therapeutic efficacy, achieving 96.6% closure of infected wounds.
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SEPARATION AND PURIFICATION TECHNOLOGY
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2026
·
IF 9.1
Shujing Zhao,Guoshun Gao,Wenjia Long,Jiyan Wang,Xinyan Luo,Lihua Chen
Solar energy, as a renewable and clean energy source, is utilized to obtain freshwater and power generation, serving as a sustainable solution to address water scarcity and power shortages. This study proposes a strategy for power generation based on salinity gradients and designs an inclined composite evaporator. The evaporator features a nickel foam substrate functionalized through cross-linking of sodium alginate (SA) and tannic acid (TA) with trivalent iron ions (Fe 3+ ), enabling efficient electricity generation and freshwater production, named as SA/TA-Fe@Ni. (“Fe” indicates trivalent iron ions (Fe 3+ ) crosslinking) The TA-Fe 3+ coordination complex formed in situ on the evaporator surface appears black and exhibits excellent broad-spectrum light absorption capability. The evaporator is designed with an inclined configuration, which can significantly enhance the water transport performance. The enhanced evaporation flux establishes a stable salinity gradient at the interface, which constitutes the core driving mechanism for salinity gradient power generation. The inclined SA/TA-Fe@Ni evaporator achieves an evaporation rate of 2.14 kg•m −2 •h −1 under standard sun irradiation (one sun). It simultaneously demonstrates excellent seawater desalination and wastewater purification, while generating an open-circuit voltage of 83.7 mV. The system demonstrates outstanding salt tolerance, stability, durability, and environmental adaptability, fully demonstrating the potential of practical applications.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2023
·
IF 9.9
Zheng Yang,Zhou Zhao,Hanlong Cheng,Yuhua Shen,Anjian Xie,Manzhou Zhu
Multimodal combined therapy (MCT) is an emerging avenue to eliminate tumor cells by the synergistic effect of various therapeutic methods. However, the complex tumor microenvironment (TME) is becoming the key barrier to the therapeutic effect of MCT due to the excessive existence of H + ions, H 2 O 2 , and glutathione (GSH), the lack of O 2 , and the relaxation of ferroptosis. To overcome these limitations, smart nanohybrid gels with excellent biocompatibility, stability and targeting function were prepared by using gold nanoclusters as cores and an in situ cross-linking composite gel of sodium alginate (SA)/hyaluronic acid (HA) as the shell. The obtained Au NCs-Cu 2+ @SA-HA core–shell nanohybrid gels possessed near-infrared light response synergistically benefitting photothermal imaging guided photothermal therapy (PTT) and photodynamic therapy (PDT). Meanwhile, the H + -triggered release of Cu 2+ ions from the nanohybrid gels not only induces cuproptosis to avoid the relaxation of ferroptosis, but also catalyzes H 2 O 2 in the TME to generate O 2 to simultaneously improve the hypoxic microenvironment and PDT effect. Furthermore, the released Cu 2+ ions could consume the excessive GSH to form Cu + ions effectively, which caused the formation of hydroxyl free radicals (·OH) to kill tumor cells, synergistically realizing GSH consumption-enhanced PDT and chemodynamic therapy (CDT). Hence, the novel design in our work provides another research avenue for cuproptosis-enhanced PTT/PDT/CDT via TME modulation.
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Food Packaging and Shelf Life
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2022
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IF 8.749
Shuo Shi,Xiaowei Xu,Jia Feng,Yanming Ren,Xue Bai,Xiufang Xia
The pH, ammonia, and H 2 S sensitivity of sodium alginate/black soybean seed coat anthocyanin (SA/BSSCA) films and their response mechanism were analyzed based on stability, intermolecular interactions, and microstructure. The results showed that the with the BSSCA content increased from 0.02% to 0.30%, SA/0.02–0.12BSSCA films had the highest color stability. The highest sensitivity to pH, ammonia, and H 2 S was observed for the SA/0.12–0.30BSSCA films, meanwhile, the SA/0.12BSSCA film had the highest sensitivity to meat unfreshness and spoilage. The incorporation of BSSCAs reduced the water solubility, water vapor absorption, and permeability of the films. With the BSSCA addition, the intermolecular interaction between BSSCAs and SA intensified, reducing the film roughness and number of aggregated particles, resulting in compact microstructures, which improved the film sensitivity. Thus, the SA/0.12BSSCA film was sensitive to pH, ammonia, and H 2 S and, therefore, meat spoilage, while having higher stability, moderate water barrier properties, and denser microstructure.
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高影响因子
CHEMOSPHERE
·
2023
·
IF 8.8
Xiangchu Zeng,Guanghua Zhang,Jia Wen,Xiuling Li,Junfeng Zhu,Zhe Wu
Heavy metals and azo dyes caused huge harm to the aqueous system and human health. A magnetic chitosan/polyethyleneimine embedded hydrophobic sodium alginate composite ( MCPS ) was designed and prepared to simultaneously remove aqueous same ionic type heavy metals and azo dyes. In mono-polluted system, the optimal pH for Cr(VI), MO (methyl orange), Cu(Ⅱ) and MB (methylene blue) were 3, 2, 6 and 12 with a saturated adsorption capacity of 87.53, 66.41, 351.03 and 286.54 mg/g, respectively. Pseudo-second-order was suitable to describe the adsorption kinetics of them and the adsorption isotherms were more consistent with the Langmuir isotherm model being a spontaneous, endothermic, and entropy-increasing process. In binary-polluted system, MCPS possessed simultaneous adsorption for Cr (Ⅵ)-MO and Cu(Ⅱ)-MB pollutants at their optimal pH, in addition, whether in anionic or cationic solution, the removal of heavy metals were promoted with the add of azo dyes but the removal of azo dyes were suppressed with the add of heavy metals. Both Cr (Ⅵ)-MO and Cu(Ⅱ)-MB pollutants could be effectively adsorbed and desorbed from MCPS by changing the pH of the aqueous solution to realize recyclability . Lastly, removal mechanism was revealed in detail by FT-IR, EDS and XPS .
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Foods
·
2022
·Vol. 11
·期 10
·1394
·
IF 5.561
Wei Li,Wenxue Chen,Zhiyang Wang,Weijun Chen,Ming Zhang,Qiuping Zhong,Jianfei Pei,Haiming Chen
In this study, a system was designed that can encapsulate and deliver gallic acid (GA), which was composed of polysaccharide polymers based on sodium alginate (SA), carboxymethyl chitosan (CCT), and cellulose nanofibers (CN) and was assisted by porous starch. The compositions were characterized by rheology and zeta potentials, and the results showed that the materials used in this study could effectively guarantee the stability of the system. The morphology and chemical structure of the beads were characterized by SEM and FT-IR, the results indicated that the addition of CCT could effectively reduce the cracks and pores on the surface of the beads, which was beneficial to the encapsulation and delivery of GA. Moreover, the results of the swelling rate, release tests, and antioxidant tests also proved the effectiveness of the system. The pH response effect of SA/CN/CCT (SCC) beads and the protection of GA were superior, and the release rate of GA in simulated gastric fluid (SGF) was only 6.95%, while SA and SA/CN (SCN) beads reached 57.94% and 78.49%, respectively. In conclusion, the interpenetrating network polymers constructed by SA, CCT, and CN, which, combined with porous starch as a coating layer, can achieve the embedding and the delivery of GA.Keywords:porous starch;sodium alginate;cellulose nanofiber;carboxymethyl chitosan;gallic acid;small-intestine-targeted delivery
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2023
·
IF 8.2
Yadong Tan,Shijie Fan,Xiaoyu Wu,Menggege Liu,Ting Dai,Chun Liu,Su Ni,Jiafeng Wang,Xiuchen Yuan,Hongbin Zhao,Yiping Weng
Bone tissue engineering scaffolds have made significant progress in treating bone defects in recent decades. However, the lack of a vascular network within the scaffold limits bone formation after implantation in vivo . Recent research suggests that leonurine hydrochloride (LH) can promote healing in full-thickness cutaneous wounds by increasing vessel formation and collagen deposition. Gelatin and Sodium Alginate are both polymers. ATP is a magnesium silicate chain mineral. In this study, a Gelatin/Sodium Alginate/Nano-Attapulgite composite hydrogel was used as the base material first, and the Gelatin/Sodium Alginate/Nano-Attapulgite composite polymer scaffold loaded with LH was then created using 3D printing technology. Finally, LH was grafted onto the base material by an amide reaction to construct a scaffold loaded with LH to achieve long-term LH release. When compared to pure polymer scaffolds, in vitro results showed that LH-loaded scaffolds promoted the differentiation of BMSCs into osteoblasts, as evidenced by increased expression of osteogenic key genes. The results of in vivo tissue staining revealed that the drug-loaded scaffold promoted both angiogenesis and bone formation. Collectively, these findings suggest that LH-loaded Gelatin/Sodium Alginate/Nano-Attapulgite composite hydrogel scaffolds are a potential therapeutic strategy and can assist bone regeneration.
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FOOD CHEMISTRY
·
2023
·
IF 8.8
Yiqin Zhang,Yijing Pu,Haitao Jiang,Luyao Chen,Chaoyu Shen,Wanli Zhang,Jiankang Cao,Weibo Jiang
The insufficient water vapor barrier and mechanical capacity of sodium alginate (SA) film limited its application in fruit preservation. Herein, cellulose nanocrystals (CNCs) were used to stabilize Pickering emulsion. Then, we prepared SA composite films. Ginger essential oil (GEO) was loaded as antimicrobials and antioxidants. Finally, the application on mangos were investigated. Compared to coarse emulsion, Pickering emulsion and its film-formation-solution showed more stable system and larger droplet size. The emulsion significantly changed the properties of SA film. Specifically, CNCs improved the thermal, tensile, and barrier properties of the film and GEO enhanced the ultraviolet-visible light barrier capacity. Additionally, the SA/CNC film possessed a homogeneous micromorphology which had a sustained-release effect on GEO, thus maintaining high postharvest quality and long-term bioavailability for mangos. In conclusion, the film prepared via Pickering emulsion showed satisfactory properties which had great potential in fruit preservation.
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