LWT-FOOD SCIENCE AND TECHNOLOGY
·
2025
·
IF 6.6
Fusheng Sun,Chuanxin Pan,Xinru Zhang,Yuanman Liang,Weiyu Shen,Yantao Liu,Duoxia Xu,Nan Yang
In this work, Pickering emulsions, stabilized with carboxymethyl tamarind seed polysaccharide/chitosan (CMTSP/CS) complex microgels, were formulated with oil-phase ratios of 60 % and 80 % and encapsulating curcumin. The stability and in vitro digestive characteristics were systematically investigated. High internal phase emulsions (HIPEs) with 80 % oil phase demonstrated superior storage stability and improved oxidative stability. SAOS and LAOS analysis further revealed that the HIPEs stabilized by CMTSP/CS complex microgels at 1:1 ratio exhibited the highest viscoelastic property and greatest deformation resistance. Increasing the mass ratio of CMTSP to CS from 1:5 to 1:1 formed a more stable interfacial film of emulsion droplets with superior viscoelastic properties, resulting in higher centrifugal resistance and thermal stability. The Pickering emulsion (particularly HIPEs at 1:1) showed reduced curcumin degradation and higher retention rates. Lipid digestion kinetics revealed that the HIPEs at 1:1 achieved maximal free fatty acid release and the highest curcumin bioaccessibility. The system exhibited an increased electrostatic repulsion and highest viscoelastic film properties, which effectively mitigated oil droplet aggregation. It facilitated the release of free fatty acids and promoted the formation of additional mixed micelles, thereby improving the bioaccessibility of curcumin.
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FOOD CHEMISTRY
·
2025
·
IF 9.8
Chaoting Wen,Liyan Cao,Xin Xu,Li Liang,Xiaofang Liu,Jixian Zhang,Youdong Li,Guoyan Liu
In the present study, the differences among NLs prepared with soybean phospholipids (SPL), soybean phosphatidylcholine (PC), and sunflower seed phospholipids (SSPL) were investigated. The structural characteristics, physical stability, in vitro release, and bio-accessibility of NLs co-encapsulating curcumin (Cur) and oligomeric proanthocyanidins (OPC) were evaluated. Compared with PC and SSPL, SPL co-encapsulated Cur and OPC NLs (SPL-co-loaded-NLs) had a smaller particle size (147 nm), a more uniform shape (spherical bilayer structure), and better size homogeneity. In addition, SPL-co-loaded-NLs also possessed the highest stability, antioxidant capacity (DPPH· scavenging rate: 38.79 %, FRAP value: 0.17 mmol Fe 2+ /mL), and bio-accessibility (Cur: 93 %, OPC: 96 %). Furthermore, FT-IR and XRD confirmed that the higher stability of SPL-co-loaded-NLs compared with other NLs was due to their tighter lipid structure, tighter lipid aggregation, and stronger hydrophobic and hydrogen bonding interactions between active substances and phospholipids. This study was expected to provide a theoretical reference for developing functional foods with co-encapsulated active substances of different polarities.
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PubMed
高影响因子
eFood
·
2021
·Vol. 2
·期 2
·73-80
·
IF 0
Chengke Wang,Hanli Yang,Jiangyu Li
The combination of microwave irradiation, ultrasonication treatment, and enzyme-assisted extraction approach was applied to study the extraction efficiency and antioxidative activity of curcumin from turmeric ( Curcuma longa L.) using Response Surface Optimization (RSM). The effects of the power and treatment time of microwave irradiation and ultrasonication treatment, the types of enzymes, the amounts, and interaction time of pectinase on the extraction efficiency were studied. RSM was used to select the optimum extraction conditions by implementing Box–Behnken design. The extraction ratio and antioxidant activity of extracted species are 2.89% and 83.95% under the optimal conditions, respectively, which are close to the predicted values, and are much higher than the single extraction approach. Our results show that a versatile approach for biological compounds extraction from agricultural and natural products was successfully developed, and the bioactivity of extracted species could be kept well by using our proposed combination extraction methods.
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FOOD CHEMISTRY
·
2025
·
IF 9.8
Zhaohua Huang,Baozhong Guo,Junhui Pan,Deming Gong,Guowen Zhang
This research offers valuable understanding of the structural and functional attributes of water-in-oleogel emulsions (OGEs) containing proanthocyanidins and curcumin, highlighting the relationship between their rheological characteristics and gastrointestinal fate. By altering emulsifier types (PGPR, lecithin, zein, or none), OGEs demonstrate unique mechanical characteristics and digestion profiles. Microscopic observations confirmed emulsion formation, with polarized light microscopy revealing interfacial crystallization in OGE-zein. Interfacial tension analysis indicated synergistic interactions between carnauba wax and emulsifiers. Rheological analysis showed that PGPR and lecithin weakened the crystal network, while zein enhanced its density and stability. In vitro digestion revealed that the emulsions with PGPR and lecithin had lower bioaccessibility of proanthocyanidins and curcumin, whereas OGE-zein showed the highest free fatty acids release and bioaccessibility. Correlation analysis indicated that stronger oleogel matrices improve the bioaccessibility of co-encapsulated nutrients. These results provide insights for designing functional OGEs for low-fat foods and bioactive compound delivery systems.
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高影响因子
Biomedical Materials
·
2025
·Vol. 20
·期 3
·035013
·
IF 3.7
Meiting Lin,Kunyuan Tang,Wendi Zheng,Shijie Zheng,Ke Hu
Curcumin is a natural polyphenol extracted from plants that can interact with various molecular targets, including antioxidant, antibacterial, anticancer, and anti-aging activities. Due to its variety of pharmacological activities and large margin pf safety, curcumin has been used in the prevention and treatment of various diseases, such as Alzheimer's, heart, and rheumatic immune diseases. To develop curcumin eye drops that can be used as antioxidant and antibacterial agents after phacoemulsification, we have designed a nano-based drug delivery system to improve curcumin bioavailability and duration of action. We successfully prepared zeolitic imidazolate framework-8 (ZIF-8) coated with chitosan–liposome (Cur@ZIF-8/CS-Lip) for curcumin delivery. It can release curcumin for over 20 h in vitro and exhibits excellent biosafety, antioxidant, and antibacterial activities. Therefore, we hypothesized that Cur@ZIF-8/CS-Lip could reduce the incidence of oxidative stress and infection after cataract surgery.
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高影响因子
ACS Applied Materials & Interfaces
·
2025
·
IF 8.2
Yixun Zhang,Xin Zhou,Wenlian Zheng,Jianwei Chen,Qianfeng Xu,Zhenguo Liang,Hongli Zhang,Jundong Lin,Wenjie Xie,Yangjia Zhuo,Muqi Chen,Fen Zou,Biyan Wen,Zeheng Tan,Weide Zhong,Huikang Yang,Ronghua Yang
Melanoma is highly dependent on cellular metabolism, but current treatments show limited effectiveness. Despite the promising antitumor properties of curcumin, its clinical utility is limited by its poor bioavailability and potential systemic toxicity. To address these challenges, we formulated curcumin-loaded polyethylene glycol–polycaprolactone (PEG–PCL) nanoparticles, denoted as PEG–PCL@Cur. We employed omics technologies to investigate their impact on melanoma at the molecular level. In vitro studies revealed that PEG–PCL@Cur notably suppressed the growth, movement, and invasiveness of A375 melanoma cells in a dose-dependent manner. Untargeted metabolomics identified 347 metabolites that were significantly altered. A decrease in fumaric acid levels indicated the suppression of oxidative phosphorylation and a shift in metabolism. Proteomics further confirmed the downregulation of key mitochondrial proteins, such as SDHA, pointing to mitochondrial dysfunction. Mechanistically, PEG–PCL@Cur increased reactive oxygen species (ROS) production by raising NADH levels and inhibiting SDHA expression. This led to a reduction in the level of fumaric acid production and a disruption of the tricarboxylic acid (TCA) cycle. Additionally, PEG–PCL@Cur hindered the generation of inorganic phosphate (Pi), resulting in a decreased level of ATP production. These metabolic changes promoted apoptosis and enhanced melanoma cell death. In vivo, PEG–PCL@Cur significantly curtailed tumor growth in a melanoma xenograft model and displayed an enhanced biocompatibility. Histological analysis showed extensive tumor necrosis, diminished proliferation markers, and elevated levels of apoptosis indicators. Overall, our integrated metabolomic and proteomic approach highlights how PEG–PCL@Cur targets SDHA-mediated metabolic reprogramming and mitochondrial dysfunction. This discovery positions PEG–PCL@Cur as a promising nanoplatform for melanoma therapy and offers valuable insights into the development of targeted nanomedicines.
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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2021
·
IF 5.279
Qiushuang Sun,Qun Niu,Yating Guo,Yu Zhuang,Xiaonan Li,Jia Liu,Ning Li,Zhiyu Li,Fang Huang,Zhixia Qiu
Upregulated de novo lipogenesis (DNL) plays a pivotal role in the progress of the nonalcoholic fatty liver disease (NAFLD). Cytoplasmic citrate flux, mediated by plasma membrane citrate transporter (SLC13A5), mitochondrial citrate carrier (SLC25A1), and ATP-dependent citrate lyase (ACLY), determines the central carbon source for acetyl-CoA required in DNL. Curcumin, a widely accepted dietary polyphenol, can attenuate lipid accumulation in NAFLD. Here, we first investigated the lipid-lowering effect of curcumin against NAFLD in oleic and palmitic acid (OPA)-induced primary mouse hepatocytes and high-fat plus high-fructose diet (HFHFD)-induced mice. Curcumin profoundly attenuated OPA- or HFHFD-induced hyperlipidemia and aberrant hepatic lipid deposition via modulating the expression and function of SLC13A5 and ACLY. The possible mechanism of curcumin on the citrate pathway was investigated using HepG2 cells, HEK293T cells transfected with human SLC13A5, and recombinant human ACLY. In OPA-stimulated HepG2 cells, curcumin rectified the dysregulated expression of SLC13A5/ACLY possibly via the AMPK–mTOR signaling pathway. Besides, curcumin also functionally inhibited both citrate transport and metabolism mediated by SLC13A5 and ACLY, respectively. These findings confirm that curcumin improves the lipid accumulation in the liver by blocking citrate disposition and hence may be used to prevent NAFLD.
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高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2019
·
IF 6.393
Jinyun Peng,Qing Huang,Yuxia Liu,Pingfeng Liu,Cuizhong Zhang
A novel efficient photoelectrochemical (PEC) sensor was assembled for curcumin (Cur) detection using 2-mercaptoacetic acid (TGA)-capped CdTe nanoparticles and nickel tetra-amined phthalocyanine-linked graphene oxide (TGA-CdTe@NiTAPc-Gr). The TGA-CdTe nanoparticles could be firmly immobilized on the thin film structure of NiTAPc-Gr in a hydrogen-bonded manner, thus producing the proposed PEC sensor with a high photoelectrochemical activity of TGA-CdTe nanoparticles and excellent stability of NiTAPc-Gr. The TGA-CdTe@NiTAPc-Gr thin film showed a stronger blue light absorption property than the individual precursors, and this resulted in the sensitive detection of Cur ranging from 0.25–100 μM with a detection limit of 12.50 nM. In addition, the PEC sensor exhibited a high sensitivity and selectivity and quite good reproducibility. Thus, it shows potential for Cur detection in real samples.
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JOURNAL OF FOOD ENGINEERING
·
2026
·
IF 5.8
Yan Li,Wanlinhao Wei,Yingying Sui,Olayemi Eyituoyo Dudu,Wentao Liu,Mingrui Zhang,Jinju Cheng,Yujun Jiang
s To investigate the effects of glycosylated covalent complexes and 12-hydroxystearic acid (12-HSA) on the properties of oleogel-structured high internal phase emulsions (OGHEs), this study prepared OGHEs with varying 12-HSA concentrations (0%, 1%, 3%, 5%, and 7%) using 1.5% sodium caseinate (SC) or conjugates of SC and carboxymethyl chitosan (SC-CMCS) as emulsifiers. A systematic evaluation was conducted on their droplet size, zeta potential, interfacial adsorbed protein content, rheological properties, stability, curcumin encapsulation efficiency, and in vitro digestion performance. Results showed that SC-CMCS-stabilized OGHEs exhibited significantly superior apparent viscosity and elastic modulus (with G' consistently greater than G'') compared to SC-stabilized OGHEs. The elastic modulus (G') reached its maximum at 7% 12-HSA, accompanied by a smaller initial droplet size (8.02 ± 0.17 μm) and more uniform distribution. Confocal laser scanning microscopy (CLSM) revealed a dual-stabilization structure consisting of oil droplets and a fibrous network, while differential scanning calorimetry (DSC) confirmed enhanced thermodynamic stability. Meanwhile, SC-CMCS-stabilized OGHEs with high 12-HSA concentrations demonstrated markedly improved thermal stability, freeze-thaw stability, and lipid oxidation stability. After 28 d of storage, their particle size increased only to 11.88 ± 0.79 μm, and the curcumin encapsulation efficiency significantly rose to 95.85 ± 0.31%, with a retention rate of 96.32 ± 0.38% after 12 d of storage. These results indicate that the synergistic interaction between SC-CMCS and 12-HSA comprehensively enhances the functionality of OGHEs, providing theoretical support for the development of carriers for active ingredients in functional foods.
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ACS Food Science & Technology
·
2026
·
IF 3
Li Yang,Zheng Shijie,Zhang Xi,Sun Quancai,Peng Ye,Zhang Hui
Network structure plays a critical role in the performance
of oleogels
for delivering lipophilic bioactives. This study developed curcumin
(Cur)-loaded oleogels, comprising glycerol monolaurate (GML)-based
crystalline networks, whey protein isolate (WPI)-based polymeric networks,
and their hybrid crystalline-polymeric dual-network systems. The hybrid
oleogels showed up to a 90% reduction in creep compliance versus the
pure WPI oleogel, with Lissajous–Bowditch curves further confirming
their enhanced deformation resistance. The DSC melting temperature
increased from 44.5 ° C for the pure GML oleogel to a maximum
of 50.1 ° C for the hybrid oleogels. The oxidative stability index
of the hybrid oleogels reached a maximum of 70.40 h. The hybrid oleogels
prolonged curcumin release from 60 to 150 min in vitro intestinal digestion, with the polymeric network playing a dominant
role. This study showcases the hybrid oleogels as promising delivery
systems.
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MICROCHEMICAL JOURNAL
·
2026
·
IF 5.2
Wendi Xiao,Jiale Chen,Siting Peng,Dingfeng Wang,Junyuan Shi,Liwei Gao,Ting Zhang,Jiong Cheng,Da Chen
The widespread use of 4-nitrophenol (4-NP) and curcumin, although beneficial across numerous industries, poses potential risks to human health and the environment. Thus, creating a sensitive and straightforward detection strategy is crucial for the rapid monitoring of these pollutants. Herein, a nitrogen-doped carbon dots (N-CDs)-based dual-excitation ratiometric fluorescent probe is developed, capable of detecting 4-NP and curcumin. The N-CDs are prepared from tris (hydroxymethyl) aminomethane (Tris) and phloroglucinol via a facile hydrothermal method, exhibiting a strong cyan fluorescence centered at 497 nm under excitation at 399 nm and 469 nm. In the presence of 4-NP, the fluorescence excited at 399 nm is significantly quenched compared to that excited at 469 nm due to the inner filter effect (IFE) and static quenching, achieving a limit of detection (LOD) of 76 nM within a linear range of 0.076–110 μM. In contrast, curcumin induces nearly complete fluorescence quenching at both excitation wavelengths, resulting from the quenching mechanism of dominant IFE and partial fluorescence resonance energy transfer. This response allows for curcumin detection over a concentration range of 0.081–90 μM with a low LOD of 81 nM. Furthermore, a smartphone-assisted sensing platform is constructed for the visual detection of 4-NP and curcumin in actual samples, achieving LODs as low as 117 nM and 123 nM, respectively. Therefore, this work enhances the capability for multi-analyte monitoring in complex systems and provides a practical and instructive strategy for detecting 4-NP and curcumin.
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FOOD HYDROCOLLOIDS
·
2025
·
IF 12.4
Qi Wu,Xinna Hu,Shuyu Lu,Bo Xu,Chenyu Bai,Tao Ma,Yi Song
Compared with traditional single emulsions, the distinct three-phase and two-interface structures of double emulsions enable them to simultaneously encapsulate and deliver hydrophilic and lipophilic compounds, which significantly broadens their applications. Here, cellulose nanocrystal (CNC)/β-lactoglobulin (β-LG) complexes and polyglycerol polyricinoleate (PGPR) were used to fabricate water-in-oil-in-water (W/O/W) emulsions. We first examined the influence of different PGPR concentrations (1.0, 3.0, 5.0, and 7.0 wt%) and O:W 1 mass ratios (9:1, 8:2, 7:3, and 6:4) on the stability of the primary W 1 /O emulsions. Building on this, the influence of different W 1 /O:W 2 mass ratios (1:9, 2:8, 3:7, and 4:6) on W 1 /O/W 2 emulsions was studied. We then utilized laser confocal microscopy to explore the internal environment of the emulsions and employed urea and sodium dodecyl sulfate as interventions to analyze the interactions at their interfaces. Finally, curcumin and epigallocatechin gallate were selected as model hydrophobic and hydrophilic nutrients, respectively, to confirm the promising applications of the W 1 /O/W 2 emulsion. Their encapsulation efficiencies reached 95.7 % and 86.8 % when co-loading in the W 1 /O/W 2 emulsion. Additionally, in vitro simulated digestion revealed that nutrients remained protected throughout oral and gastric stages, with controlled release occurring upon intestinal arrival, and their bioaccessibility was enhanced to 65.1 % and 71.6 %, respectively. The W 1 /O/W 2 emulsions we prepared and the elucidation of their underlying mechanisms have presented new possibilities for developing food and delivery systems in the future.
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