BIOMATERIALS
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2011
·
IF 7.883
Feihu Wang,Dianrui Zhang,Qiang Zhang,Yuxuan Chen,Dandan Zheng,Leilei Hao,Cunxian Duan,Lejiao Jia,Guangpu Liu,Yue Liu
Multidrug resistance (MDR) in tumor cells is a significant obstacle for successful cancer chemotherapy. Overexpression of drug efflux transporters such as P-glycoprotein (P-gp) is a key factor contributing to the development of tumor drug resistance. Verapamil (VRP), a P-gp inhibitor, has been reported to be able to reverse completely the resistance caused by P-gp. For optimal synergy, the drug and inhibitor combination may need to be temporally colocalized in the tumor cells. Herein, we investigated the effectiveness of simultaneous and targeted delivery of anticancer drug, paclitaxel (PTX), along with VRP, using DOMC-FA micelles to overcome tumor drug resistance. The floate-functionalized dual agent loaded micelles resulted in the similar cytotoxicity to PTX-loaded micelles/free VRP combination and co-administration of two single-agent loaded micelles, which was higher than that of PTX-loaded micelles. Enhanced therapeutic efficacy of dual agent micelles could be ascribe to increased accumulation of PTX in drug-resistant tumor cells. We suggest that the synergistic effect of folate receptor-mediated internalization and VRP-mediated overcoming MDR could be beneficial in treatment of MDR solid tumors by targeting delivery of micellar PTX into tumor cells. As a result, the difunctional micelle systems is a very promising approach to overcome tumor drug resistance.
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FOOD AND CHEMICAL TOXICOLOGY
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2020
·
IF 4.679
Congyong Sun,Wenjing Li,Ping Ma,Yang Li,Yuan Zhu,Huiyun Zhang,Michael Adu-Frimpong,Wenwen Deng,Jiangnan Yu,Ximing Xu
Syringic acid (SA), a natural polyphenol found in fruits and vegetables, is claimed to show notable hepatoprotection . Nevertheless, low solubility and bioavailability hamper the application of SA. This study aimed to investigate the potential of TPGS/F127/F68 mixed polymeric micelles as a sustained and liver-targeting nanocarrier for SA. Herein, the prepared SA-loaded TPGS/F127/F68 mixed polymeric micelles (SA-TPGS-Ms) were spherically-shaped and homogeneously-distributed nanoparticles with high entrapment efficiency (94.67 ± 2.05%) and sustained release. Besides, in-vitro cell culture studies revealed that SA-TPGS-Ms substantially promoted cellular uptake with excellent biocompatibility . After oral administration, SA-TPGS-Ms demonstrated an increased bioavailability (2.3-fold) and delayed in-vivo elimination compared with the free SA. Furthermore, the alleviation of oxidative stress and amelioration of hepatic injury in CCl 4 -induced hepatotoxicity mice further demonstrated the excellent hepatoprotection of SA-TPGS-Ms. Collectively, SA-TPGS-Ms could be a promising nanocarrier for the utilization of SA in functional foods, with enhanced bioavailability and hepatoprotection.
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Acta Biomaterialia
·
2022
·
IF 10.633
Rong Shi,Haisheng Li,Xin Jin,Xue Huang,Zelin Ou,Xuanfen Zhang,Gaoxing Luo,Jun Deng
Engineering smart nano-therapeutics for re-epithelialisation of chronic wounds facilitates the wound healing process. However, due to excessive oxidative stress damage and persistent inflammation in diabetic wound microenvironment, the migration of stimulating epidermal cells in diabetic wounds represents a significant challenge. Here we synthesised P311-loaded micelles by self-assembly of P311 peptides and diblock copolymer poly (ethylene glycol)-block-poly (propylene sulfide) (PEG-b-PPS, denoted as PEPS) that have unique ability to transform an oxidative wound microenvironment into a proregenerative one while also providing cues for epidermal cell migration. The [email protected] showed an accelerated migration of epidermal cells via activation of the Akt signalling pathway , simultaneously suppressing the unfavourable oxidative wound microenvironment by scavenging reactive oxygen species (ROS), ultimately leading to the induction of an environment conducive to cell migration. Furthermore, the micelles were able to bypass the inhibitory effect of ROS on the Akt signalling pathway, thereby promoting epidermal cell migration. Additionally, we observed that diabetic wounds treated with [email protected] showed accelerated chronic wound healing, granulation tissue formation, collagen deposition and re-epithelialisation, thereby suggesting the efficacy of [email protected] as a promising nanoplatform for the treatment of chronic wounds. Statement of significance Based on the unique conditions of the diabetic wound microenvironment, a smart drug delivery system with ROS-responsive nanomaterials has been widely investigated to enhance diabetic wound healing. In our previous studies, we observed that P311 promotes epidermal cell migration to induce wound re-epithelialisation. However, the application of P311 suffers from its instability. Herein, we developed a therapeutic platform with P311-loaded micelles ( [email protected] ), which were synthesized by the self-assembly of P311 peptides and diblock copolymer poly (ethylene glycol)-block-poly (propylene sulfide) (PEG-b-PPS, denoted as PEPS). These micelles provide continuous migration signals for epidermal cells by ROS-trigged P311 release. Additionally, [email protected] scavenges excess ROS and provides a microenvironment that reduces inflammation, which could protect P311 from enzymatic degradation and improve the bioavailability of P311.
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Polymer Chemistry
·
2014
·Vol. 6
·期 9
·1454-1464
·
IF 5.368
Qinglai Yang,Changyu He,Yuhong Xu,Bingya Liu,Zhifeng Shao,Zhenggang Zhu,Yongtai Hou,Bing Gong,Yu-Mei Shen
A folic acid (FA) conjugated chitosan oligosaccharide (CSO) polylactic acid (PLA) copolymer FA-CSO-PLA with double disulphide linkage in the backbone directed by H-bonding association duplex was synthesized, and its self-assembled micelles were evaluated as smart targeted drug delivery carriers. Both of the intermediates and the terminal copolymers were characterized by 1H-NMR and gel permeation chromatography (GPC). The critical micelle concentration (CMC) value is 0.045 mg mL−1 which suggests the micelles are highly stable in dilute solution. TEM and DLS further confirmed the successful formation of micelles with an average size of 61 and 100 nm, PDI of 0.209 and 0.230 for blank and DOX loaded micelles, respectively. The micelles were destructed under a reductive environment, leading to encapsulated drug release. Moreover, fluorescence microscopy demonstrated that the micelles exhibited both a passive and active targeting ability in HeLA cells due to an EPR effect and folate-mediated endocytosis. These results suggested the micelles would provide a favourable platform for constructing excellent drug delivery systems for cancer therapy.
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FOOD CHEMISTRY
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2021
·
IF 7.514
Chao Lin,Pengju Pan,Guorong Shan,Miao Du
Poly(ethylene glycol)- b -poly( ε -caprolactone) diblock copolymers ( PEG- b -PCL) with predesigned hydrophilic/hydrophobic block length ratios have been synthesized and self-assembled to form micelles, then used to emulsify medium-chain triglycerides with an aqueous phase. The morphologies and sizes of PEG- b -PCL copolymer micelles have been characterized by transmission electron microscopy and dynamic light scattering. Interfacial tension testing between micellar dispersions and oil, combined with water contact angle measurements, have been performed to assess the ability of these micelles to adjust interfacial tension and micellar hydrophobicity, respectively. Relationship between the wettability of PEG- b -PCL copolymer micelles and their emulsification properties has been proved through phase diagram, optical microscopic observation, droplet sizes evolution and phase separation behavior of Pickering emulsion samples. Results show that both oil-in-water and water-in-oil Pickering emulsions, as well as water-in-oil-in-water (W/O/W) double-Pickering emulsions, may be controllably prepared through one-step homogenization. Double microstructure of W/O/W Pickering emulsion has proved to be extremely stable during long-term storage.
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INTERNATIONAL JOURNAL OF PHARMACEUTICS
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2021
·
IF 5.875
Wei He,Yawei Du,Chuncao Li,Ji Wang,Yang Wang,Con Dogovski,Rui Hu,Zhiyong Tao,Chen Yao,Xinsong Li
Artesunate (ARS) is the only artemisinin-based intravenous drug approved for treatment of malaria in the clinic. ARS is rapidly metabolized in vivo to short lived (∼30–45 min) but fast acting, dihydroartemisinin (DHA). The short half-life of DHA necessitates multiple dose administration to circumvent the risk of recrudescence and development of artemisinin resistance. In this work, we report a stable, safe and potent alternative artemisinin-based injectable nanocomplex consisting of dimeric artesunate-choline conjugate (dACC) micelles coated with hyaluronic acid (HA). Firstly, dACC was synthesized by one-step esterification of two artesunate molecules with 3-(dimethylamino)-1,2-propanediol followed by quaternization. After that, dACC was self-assembled into cationic nanomicelles and further coated with anionic small molecular weight HA. The HA-coated dACC nanocomplex (dACC/HA nanocomplex) has a narrow size distribution of about 30 nm. Hemolytic toxicity and cytotoxicity studies revealed a favorable bio-safety profile. Finally, in vitro and in vivo studies showed the dACC/HA nanocomplex possess superior safety and antimalarial efficacy compared to ARS. Taken together, the dACC/HA nanocomplex is a promising injectable alternative to the traditional clinically used artesunate.
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ACS Sustainable Chemistry & Engineering
·
2022
·
IF 9.224
Yimin Hu,Jing Sun,Zixian Cai,Meiling Lei,Yu Chen,Shaoan Lei,Huijiao Cao,Xia Guo
The formation of long cylindrical wormlike micelles at low temperatures (near 0 °C) is relatively rare. In this work, the effect of different salts on the viscoelasticity of the formed wormlike micelles by the ionic liquid surfactant (1-octadecyl-3-nonyl imidazolium bromide, [C18imC9]Br) and glycerol/1,2-propanediol mixture at low temperature was studied. The rheological measurements revealed that only sodium salicylate (NaSal) can increase the viscoelasticity of [C18imC9]Br wormlike micelles by up to 15 times and the existence of temperature range. When the [C18imC9]Br concentration is fixed, the viscoelasticity of the [C18imC9]Br/NaSal wormlike micelles increases and then decreases with the increase of NaSal concentration. Tribological results show that the [C18imC9]Br/NaSal wormlike micelles have excellent friction reduction and antiwear properties for steel/steel contact at 6.00 °C. The friction coefficient and wear volume of [C18imC9]Br/NaSal wormlike micelles first decrease and then increase with the increase of the NaSal concentration. In addition, their tribological properties are significantly better than those of pure [C18imC9]Br wormlike micelles under the same conditions. The lubrication effect of [C18imC9]Br/NaSal wormlike micelles at low temperatures is improved due to the adhesion of [C18imC9]Br/NaSal wormlike micelles and the protective film formed by the tribochemical reaction.
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International Journal of Nanomedicine
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2017
·
IF 4.3
Jifu Hao,Tiantian Tong,Kai Jin,Qiannan Zhuang,Te Han,Yanping Bi,Jianzhu Wang,Xiaodan Wang
A folic acid (FA)-functionalized drug vehicle platform based on Pluronic 127 (P127)/D-α-tocopheryl polyethylene glycol 1000 succinate (TPGS) mixed micelles was orchestrated for an effective delivery of the model drug resveratrol in order to address the problem of poor water solubility and rapid metabolism of resveratrol and improve its targeted accumulation at tumor site. The FA-decorated mixed micelles were prepared using thin-film hydration method and optimized by central composite design approach. The micelles were also characterized in terms of size and morphology, drug entrapment efficiency and in vitro release profile. In addition, the cytotoxicity and cell uptake of the micelles were evaluated in folate receptor-overexpressing MCF-7 cell line. In vivo pharmacokinetic and biodistribution studies were also performed. The average size of the micelles was ~20 nm with a spherical shape and high encapsulation efficiency (99.67%). The results of fluorescence microscopy confirmed the targeting capability of FA-conjugated micelles in MCF-7 cells. FA-modified micelles exhibited superior pharmacokinetics in comparison with that of solution. Further, the low accumulation of resveratrol-loaded FA micelles formulation in the heart and kidney avoided toxicity of these vital organs. It could be concluded that folate-modified P127/TPGS mixed micelles might serve as a potential delivery platform for resveratrol.
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JOURNAL OF THE EUROPEAN CERAMIC SOCIETY
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2019
·
IF 4.029
Hang Qin,Wenming Guo,Xin Huang,Pengzhao Gao,Hanning Xiao
8 mol% yttria-stabilized ZrO 2 (8YSZ) nanofiltration (NF) membranes were prepared from size-controlled spherical ZrO 2 nanoparticles with an average diameter of ˜10 nm and a particle roundness value greater than 0.90, and the nanoparticles were efficiently fabricated by a reverse micelles (RMs)-mediated sol-gel process. It was found that yttria doping not only suppressed the tetragonal to monoclinic (t-m) phase transition, ensuring the membranes integrity, but also decreased the tetragonal grain size, increased the specific surface area, narrowed the pore size distribution and thus optimized the NF performance. The as-prepared 8YSZ NF membranes with a thickness of ˜260 nm exhibited high NF performances, while the pure water permeability and molecular weight cut-off (MWCO) were 3.9-4.2 L m −2 h -1 bar -1 and 800 ± 50 Da respectively. In the treatment of pesticide wastewater, the removal rate of carbofuran by 8YSZ NF membranes was more than 82%, while the maximum removal rate could reach 89%. Furthermore, the contaminated membranes could be restored as ever after alkali wash and low-temperature calcination , implementing multiple reuses.
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Soft Matter
·
2015
·Vol. 11
·期 39
·7817-7826
·
IF 4.029
Caili Dai,Xuepeng Wu,Weitao Li,Qin You,Mingwei Zhao,Mingyong Du,Yifei Liu,Yuyang Li
To understand the role of electrostatic interactions and hydrogen bonds in the formation of wormlike micelles with the aid of sodium salicylate, two quaternary ammonium surfactants with the headgroup decorated by one hydroxyethyl group N-cetyl-N-(2-hydroxyethyl)dimethylammonium bromide and two hydroxyethyl groups N-cetyl-N,N-di(2-hydroxyethyl)methylammonium bromide, abbreviated as CHEMAB and CDHAB, respectively, were synthesized in this work. Single crystal X-ray diffraction was used to study the intermolecular interactions of surfactants, and 1H NMR and rheological measurements were employed to investigate the molecular arrangement and morphology of the wormlike micelles. The synergistic interactions of hydrogen bonding and more effective shielding of electrostatic repulsion contribute to the formation and viscoelastic behavior of wormlike micelles. The results also revealed the aggregation behavior of surfactants with hydroxyethyl headgroups in aqueous solutions.
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REACTIVE & FUNCTIONAL POLYMERS
·
2012
·
IF 2.479
Yu Wang,Haiqiang Wu,Jing Luo,Xiaoya Liu
We report on the fabrication of an amphiphilic random copolymer-based colorimetric and fluorescent chemosensor for Fe 3+ ions that was prepared by free radical polymerization of a novel rhodamine-based Fe 3+ -recognizing monomer , R6GEM, with N -vinylpyrrolidone (NVP). Because of its amphiphilic property, the copolymer P(NVP-co-R6GEM) can self-assemble into micelles , which allows it to be used as a chemosensor in aqueous solution. Upon addition of Fe 3+ ions to the micelle solution, visual color change and fluorescence enhancement were observed. Moreover, other metal ions did not induce obvious changes to the absorption and fluorescence spectra . The water dispersibility and biocompatibility of these polymer micelles could provide a new strategy for detecting analytes in environmental and biological systems.
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Acta Biomaterialia
·
2025
·
IF 9.6
Taotao Li,Mingzhen Cai,Qianqian Qiao,Wenjie Shi,Xin Guo,Shaoqun Tang,Xulin Jiang
Postoperative pain is a major clinic challenge and local anesthetics are preferred for use in postoperative pain management, but their short duration of analgesia limits their clinical use. Various drug carriers such as liposomes or nano/microparticles have been developed for prolonging the analgesic duration, yet how to achieve effective drug loading without using organic solvents and sustained-release local anesthetics remains a big challenge. Herein, we synthesized a pH-sensitive and biodegradable polymer to efficiently load ropivacaine (Rop-micelles) by pH-induced micellization method without using any organic solvent, avoiding the aggregation and precipitation of Rop under neutral conditions within 7 days. Subsequently, an injectable dispersion of Rop-micelles in hydroxypropyl chitin (Rop-micelles@HPCH) was developed for long-term local anesthesia. This system was prepared via a simple and solvent-free process that combined pH-sensitive micelles with thermosensitive HPCH, demonstrating proven biocompatibility and biodegradability. Importantly, the obtained Rop-micelles@HPCH composite hydrogel exhibited a much more sustained Rop release than that of drug loaded in micelles or hydrogel alone in vitro. The effective analgesic time of Rop-micelles@HPCH (20.3 h) or Rop-micelles@HPCH-Dex with only a small fraction (
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