JOURNAL OF CHROMATOGRAPHY A
·
2019
·
IF 3.858
Rongguo Chen,Chenchen Lin,Haixia Lyu,Xucong Lin,Zenghong Xie
A facile strategy for highly efficient fabrication of chiral monolithic column was carried out by the simple “one-pot” hydroxymethyl polycondensation of native β-cyclodextrin (β-CD) and urea-formaldehyde (UF). In-situ rapid substitution of native β-CD and efficient polycondensation of β-CD products and UF oligomers was proposed and fulfilled in one pot. The feasibility, mechanism and key parameters of polycondensation reaction were discussed. The data on crosslinking polycondensation and reaction kinetics were further evaluated. Characteristics including the morphologies, permeability and structure stability of the resultant monolithic columns were also studied. Under the optimal conditions, the “one-pot” hydroxymethyl polycondensation was accomplished in an aqueous solution within only 10 mins. Satisfactory stability and repeatability were gained, and good enantioseparation of eight model enantiomers was successfully achieved with the resultant β-CD-based monolith. It was simple and highly efficient, and the organic solvents, special CD derivatives and tediously long-time polymerization reaction were successfully avoided, which might light a new access to rapid preparation of CD-chiral monolith for high-performance enantioseparation.
研究领域:
分析化学
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色谱技术
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DOI
高影响因子
ANALYTICA CHIMICA ACTA
·
2026
·
IF 6.1
Nanke Ma,Anqi Wei,Huiling Peng,Lixia Xie,Yuan Jin,Zhengzhi Yin,Guangli Li
Background Chirality plays a critical role in drug efficacy and environmental safety. The antibacterial activity of ofloxacin resides almost exclusively in its S-enantiomer (levofloxacin, LEV), while the R-enantiomer contributes little to therapeutic effects but may pose unnecessary risks. Rapid and reliable methods for enantioselective determination of ofloxacin enantiomers are therefore essential for pharmaceutical quality control, food safety monitoring, and environmental analysis. However, existing electrochemical sensors often suffer from limited enantioselectivity and insufficient sensitivity. To address this challenge, a novel enantioselective electrochemical platform is developed. Results A β-cyclodextrin/cerium-doped copper metal-organic framework/carboxylated multi-walled carbon nanotube composite (β-CD/Ce-doped Cu-MOF/MWCNTs-COOH) was fabricated on a glassy carbon electrode. The sensor achieves discrimination of ofloxacin enantiomers with an I L /I D ratio of 3.39. DFT calculations at pH 4.0 reveal that β-CD binds LEV with higher adsorption energy (−63.8 kJ/mol) than DEX (−58.3 kJ/mol), confirming the superior response for LEV originates from stereospecific inclusion. Quantitative analysis of LEV shows two linear ranges (0.03–1 μM and 1–10 μM) with a low detection limit of 0.01 μM. The sensor also enables accurate determination of LEV percentage in enantiomer mixtures across 0–100%. Excellent selectivity against common interferents, good reproducibility (RSD = 0.98%), repeatability (RSD = 1.26%), and long-term stability (95.2% retention after 21 days) are demonstrated. Practical applicability is validated by detecting LEV in commercial eye drops, honey, and tap water with satisfactory recoveries (96.0–108.0%). Significance and novelty This work presents the first application of Ce-doped Cu-MOF/β-CD/MWCNTs-COOH composites for the enantioselective electrochemical sensing of ofloxacin, a chiral fluoroquinolone antibiotic. The synergistic combination of high conductivity, abundant catalytic sites, and stereospecific host-guest recognition provides a generalizable strategy for high-performance enantioselective sensing, with promising applications in pharmaceutical, food, and environmental analysis.
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Foods
·
2025
·Vol. 14
·期 9
·1648
·
IF 5.1
Feng Yang,Xin Qi,Yan Chen,Kai Tang,Mengyang Fang,Yanwei Song,Jiufen Liu,Lianming Zhang
In this study, β-cyclodextrin (β-CD) functionalized graphene quantum dots (GQDs) was employed to augment the array of chiral recognition sites, thereby enhancing the affinity of GQDs/β-CD composite for imprinting molecules and realizing heightened chiral selectivity. The incorporation of GQDs/β-CD into the synthesis of molecularly imprinted polymers (MIPs), synergizing with the host-guest inclusion properties of β-CD and the abundant carboxyl groups of GQDs, enhanced the chiral recognition capacity of MIPs materials. Consequently, a novel MIPs/(GQDs/β-CD) sensor with chiral recognition capabilities tailored for D-carnitine was successfully fabricated. The binding mechanism between GQDs/β-CD and D-carnitine was elucidated via Ultraviolet-visible spectroscopy and Fourier transform infrared spectroscopy. The variation in the response signal (ΔI) of the probe molecule exhibited a linear correlation with the logarithm of D-carnitine concentration (lgC) in the range of 1.0 × 10−12mol/L to 1.0 × 10−9mol/L, and the detection limit (3δ/S) was calculated as 2.35 × 10−13mol/L. These results underscore a 7.15-fold enhancement in the selectivity of MIPs/(GQDs/β-CD) sensor for D-carnitine recognition. Moreover, the sensor presented commendable efficacy in real-world scenarios, yielding recovery rates ranging from 98.5% to 103.0% during the determination of D-carnitine content in real samples.
研究领域:
分析化学
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生物医学工程
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PubMed
高影响因子
CARBOHYDRATE RESEARCH
·
2025
·
IF 2.5
Chunlin Gou,Ziqing Weng,Xiaoshuang Dai,Jianpeng Liu,Ke Mei,Bin Sun,Neng Qiu
To address the ecological and health risks associated with residual tetracycline hydrochloride (TCH) in water, a green-synthesized adsorbent composed of β-cyclodextrin (β-CD), citric acid (CA), and polyethylene glycol (PEG) was developed for the effective removal of TCH from wastewater. The synthetic parameters were optimized, and the resulting PEG-CA-β-CD MOF was characterized by FT-IR, XRD, and SE. TGA analysis indicated an increase in the thermal stability. The maximum adsorption capacity of PEG-CA-β-CD MOF for TCH was 221.6 mg/g at pH = 4. Adsorption kinetics were well-described by the Elovich equation model, while the Freundlich isothermal model accurately described the equilibrium data adsorption Thermodynamic analysis revealed that the adsorption process was endothermic and spontaneous. Furthermore, the adsorbent maintained 84 % of its initial adsorption capacity after four reuse cycles. Analysis using zeta potential, FT-IR, and XPS confirmed that the possible adsorption mechanism of TCH mainly involves electrostatic interactions, hydrogen bonding, and cavity encapsulation. Finally, simulated wastewater experiments showed that PEG-CA-β-CD MOF was able to adsorb TCH efficiently even in the presence of other pollutants. Overall, due to its green synthesis process, low cost, ease of regeneration, and multi-mechanistic adsorption capability, the PEG-CA-β-CD MOF exhibits significant potential for TCH removal in wastewater treatment.
研究领域:
环境科学
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材料科学
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化学工程
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纳米技术
·
污染治理
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CHEMICAL ENGINEERING SCIENCE
·
2024
·
IF 4.1
Dan-Yang Liu,Guo-Peng Zhao,Yi-Di Wang,Jiang-Tao Hu,Xiao-Jing Guo,Xi Yan,Yan Chen,Xuan Zhang,Wan-Zhong Lang
A large amount of soluble beta-cyclodextrin (β-CD) was immobilized on polypropylene non-woven fabric (PP) by radiation and chemical grafting to obtain PP-g-MAH-β-CD, which can effectively adsorb bisphenol A (BPA) in water. A longer chemical chain was grafted by β-CD through the pre-modification, which effectively reduced the steric hindrance of further grafting reaction and made the grafting degree of β-CD on PP fabric higher. In addition, the adsorption mass transfer resistance of fabrics with different grafting degrees was calculated according to non-equilibrium thermodynamics to explore the effect of grafting degree on adsorption. The characterization results confirmed the successful preparation of PP-g-MAH-β-CD. The theoretical maximum saturated adsorption capacity of PP-g-MAH-β-CD was 146.55 mg/g. PP-g-MAH-β-CD was easy to recycle, and the adsorption capacity did not decrease significantly after 15 cycles of adsorption and desorption experiments.
研究领域:
材料科学
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环境科学
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化学工程
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高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
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2025
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IF 9
Song Xue,Yu Xu,Sihui Ding,Haoxiang Meng,Xiaodong Sun,Qi Zhang
Two hydrophobic (deep) eutectic solvents (H(D)ESs), menthol:octanoic acid (Men:OctA) and menthol:trioctylphosphine oxide (Men:TOPO), were prepared, characterized, and then employed for the first time in combination with sulfobutylether-β-cyclodextrin (SBE-β-CD) for chiral separations in capillary electrokinetic chromatography (EKC). The “H(D)ES + SBE-β-CD” dual pseudo-stationary phase (PSP) systems yielded not only enhanced enantioselectivities, but also accelerated migrations of primaquine and chlorpheniramine, two drugs that cannot be resolved using the single SBE-β-CD system. The enhancement originated from the combined effects of stereoselective complexation and hydrophobic partitioning involving the H(D)ES phase, which moved faster than the anionic CD phase under the separation conditions. The best results in terms of enantioresolution and migration time were obtained using a 20 mM phosphate buffer (pH 7.0) containing 2.0 % SBE-β-CD and 0.2 % Men:OctA at an applied voltage of 15 kV. We further compared the chiral EKC performance of the H(D)ESs with a series of conventional PSPs, including three micelles (Tween-20, Brij-35, SDS) and three ionic liquids (ILs). The results showed that none of these modifiers could achieve comparable EKC performance, suggesting that in certain cases, H(D)ESs could be a superior alternative to traditional modifiers for chiral EKC separations.
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DIAMOND AND RELATED MATERIALS
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2024
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IF 4.3
YuXuan Xiong,Dandan Luo,Guowen He,Saiwen Liu,Jin Zhang,Chao Chen
Baicalin is a principal component of traditional Chinese medicine and plays a crucial role in treating conditions such as arthritis, respiratory tract infections, chronic and acute hepatitis, and tumors. Graphene oxide is bonded to silicon dioxide (SiO 2 ) through covalent bonds or hydrogen bonds and then reduced to SiO 2 @rGO through hydrazine hydrate to solve the problem of easy accumulation of SiO 2 and improve the conductivity of the material. Next, β-cyclodextrin (β-CD) self-assembles on SiO 2 @rGO to form a stable inclusion complex. The hydrophobic inner cavity of β-CD can effectively accommodate various guest molecules to form inclusion complexes, enhancing molecular recognition and detection capabilities. Finally, β-CD/SiO 2 @rGO is bridged and surface-loaded between clay-like Ti 3 C 2 T x (MXenes) nanosheets through electrostatic interactions to form a stable three-dimensional composite material. It is precisely because of MXenes, due to their unique layered microstructure, excellent conductivity, and extensive hydrophilic surface area, that they are conducive to self-assembly or embedding nanoparticles in aqueous solution. The composite was characterized via X-ray diffraction, X-ray photoelectron spectroscopy, and scanning electron microscopy. Under optimized conditions, the electrochemical sensor constructed from this composite exhibited a broad detection range (0.008–10 μM) and a low detection limit (0.191 nM) for baicalin. In comparison to existing methods for detecting baicalin, this approach demonstrates strong anti-interference capabilities and stability. It can efficiently, sensitively, and accurately quantify baicalin in Chinese patent medicine samples, including Scutellaria baicalensis root, Shuanghuanglian oral liquid, and Bear Bile Scutellaria baicalensis eye drops, achieving a satisfactory recovery rate. This study introduces a novel approach for the electrochemical detection of baicalin.
研究领域:
材料科学
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中药分析
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生物医学工程
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Analytical Methods
·
2024
·Vol. 16
·期 25
·4104-4115
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IF 2.7
Hong Cui,Qiuju Tian,Yunfeng Liu,Liangpo Liu,Xiangjun Li,Jisheng Nie,Ruiping Zhang
Fluoroquinolone (FQ) antibiotics, one of the leading environmental pollutants, have ecotoxic effects that can accumulate through ecosystems and harm human health. The determination of FQs is still difficult due to the complex matrix, many interfering factors, and low concentration. Hence, a magnetic microporous organic network (MON) composite denoted as Fe3O4@MON-NH2@CM-β-CD with excellent FQ adsorption performance was prepared by β-CD covalent modification of a MON. Based on the existence of π–π packing, hydrophobic interaction, and hydrogen bonding between Fe3O4@MON-NH2@CM-β-CD and FQs, a new magnetic solid phase extraction (MSPE) method for the enrichment of FQs was developed. Under optimized MSPE conditions, five FQs were detected by HPLC-UV with good linearity (R2 ≥ 0.9989) in the range of 0.02–1 μg mL−1, and detection limits (S/N = 3) in the range of 0.0014–0.0023 μg mL−1. The satisfactory recoveries ranged from 93.1 to 116.2% with RSDs lower than 8.39% when applied to actual environmental water samples. These results revealed that Fe3O4@MON-NH2@CM-β-CD as an adsorbent for MSPE had excellent performance for FQ extraction from real samples, and the MON material types were expanded through the functionalization of MONs, which would have great potential for further application in various analytical methods.
研究领域:
环境科学
·
分析化学
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高影响因子
DESALINATION
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2024
·
IF 8.3
Wubin Wang,Jin Wang,Yufei Yan
With the development of industry, the scarcity of lithium resources is becoming increasingly prominent. Therefore, the development of high-performance nanofiltration (NF) membranes for lithium extraction from salt lakes has become crucial. Herein, β-Cyclodextrin (β-CD) and amino-rich graphitic carbon nitride (g-C 3 N 5 ) sol were uniformly mixed to form β-CD@g-C 3 N 5 , which was then mixed with polyetherimide (PEI) monomer and subjected to interfacial polymerization (IP) reaction with trimesoyl chloride (TMC) on a 0.22 μm microfiltration (MF) membrane to prepare the PEI-(β-CD@g-C 3 N 5 )/TMC composite NF membrane. Through thin plate theory and gradient operation pressure filtration tests, it was found that the composite NF membrane prepared on the MF membrane substrate was not only defect-free but also exhibited superior compression resistance. In Li + /Mg 2+ filtration tests, the PEI-(β-CD@g-C 3 N 5 )/TMC membrane showed superior NF performance, with a Li + /Mg 2+ selectivity coefficient of 38.85 and a permeability of 8.91 L·m −2 ·h −1 ·bar −1 . This was attributed to the effect of β-CD@g-C 3 N 5 , which could thin the separation layer, slightly enlarge and more uniformly distribute the pores, increase hydrophilicity, and enhance positive charge; meanwhile, the cavity structure provided by β-CD helped to effectively separate Li + /Mg 2+ . Furthermore, under conditions of mixed salt solutions with different Mg 2+ /Li + mass ratios and 80 h of continuous filtration, the membrane exhibited excellent stability. This work introduces innovative membrane materials and design concepts to the field of lithium extraction via NF, potentially paving the way for the industrial application of NF technology.
研究领域:
材料科学
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环境工程
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化学工程
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Analytical Methods
·
2026
·
IF 3
Yao Tian,Mengsi Liang,Yongdong Wei,Yuxin Wang,Ning-Bo Li,Yaoyong Wang
Zearalenone (ZEN) is a carcinogenic mycotoxin commonly found in grains, cereals, and dairy products, posing cancer risks to humans and animals. Chronic high-dose ZEN exposure can cause liver disease, immunosuppression, kidney damage, and tumorigenesis. Sensitive and efficient ZEN detection is therefore essential for protecting human and animal health. To meet the need for sensitive, selective, and low-cost mycotoxin sensors in real food samples, we developed a novel ratiometric electrochemical aptamer sensor for ZEN detection. The sensor design utilizes β-cyclodextrin-functionalized graphene (CG) to effectively enhance electron transfer efficiency, combined with host–guest recognition between ferrocene (Fc) and β-cyclodextrin (β-CD), as well as Au-S covalent bonding. The 5′-SH and 3′-MB-modified dual-labeled ZEN aptamer (MB-Apt-SH) was immobilized via β-CD/Fc inclusion, with signal amplified by AuNPs binding to -SH. Without ZEN, the aptamer stays on the electrode, giving high IMB and low IFc. With ZEN, it binds the target, pulling it away. Adding Fc-COOH fills the β-CD cavities, increasing IFc and decreasing IMB, thus raising the IFc/IMB ratio proportionally to ZEN concentration. The sensor exhibits a wide linear range from 1 pg/mL to 1000 ng/mL, with a detection limit of 0.4344 pg/mL. Furthermore, the method was successfully applied to the determination of ZEN in wine samples, yielding recovery rates between 94.00% and 104.60%, demonstrating excellent accuracy and applicability. These results indicate that the MCH/AuNPs/SH-Apt-MB/CG/GCE platform is a highly sensitive and selective electrochemical sensor for ZEN detection.
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NANO
·
2020
·
IF 1.566
Junda Wu,Jia Gao,Zhiqing Hou,Wendong Xing,Jiangdong Dai,Yongsheng Yan,Yilin Wu
Enoxacin, as the broad-spectrum antibacterial activity antibiotics, has been widely used in treatment of bacterial diseases in animals and humans around the world. The extensive use of enoxacin in healthcare has also caused increasingly serious environmental risk as a matter of course. In this work, enoxacin imprinted poly (vinylidene fluoride) (PVDF) composite membranes (EIPCMs) were developed by strategy of surface grafting beta-cyclodextrin ( β -CD) for the improved hydrophilic and antifouling properties of the basal membrane. PVDF membrane was prepared by phase inversion method, and β -CD was grafted onto the surface after hydroxyl groups modification. The effects of adding amount of β -CD on performance of basal membranes were systematically examined. Further, the specific recognition sites were fabricated via sol–gel surface imprinting method using 3-aminopropyltriethoxysilane (APTES) and tetraethoxysilane (TEOS) as functional monomer and cross-linker, respectively. The specific adsorption and permeation experiments were investigated and explored the separation performance and mechanism of EIPCM. The results indicated that the as-prepared EIPCMs not only exhibited highly favorable features and high rebinding strength (31.25 mg g − 1 ) , but also possessed superior selective performance toward enoxacin (imprinted factor β is 3.15). Furthermore, in order to investigate the practical applications of EIPCMs, the adsorption experiments were carried out using environmental sewage. The work developed here shows great potential for further applications in selective recognition and separation antibiotics pollution from the environment.
研究领域:
环境科学
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材料科学
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化学工程
·
纳米技术
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高影响因子
JOURNAL OF HAZARDOUS MATERIALS
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2020
·
IF 9.038
Xiaojun Zhou,Lingshuai Kong,Zongyu Jing,Shuqing Wang,Yongchao Lai,Meng Xie,Long Ma,Zhenyu Feng,Jinhua Zhan
In this study, superparamagnetic β-CD-MnFe 2 O 4 with a large surface area was synthesized via a facile co-precipitation method, with β-cyclodextrin (β-CD) acting as a coating agent. The as-prepared β-CD-MnFe 2 O 4 exhibited better catalytic performance than bare MnFe 2 O 4 in terms of activating peroxymonosulfate (PMS) to degrade 2,4-dichlorophenol (2,4-DCP) over a broad pH range of 5–11. Electron spin resonance spectroscopy (ESR) and free radical quenching experiments indicate that various active species (SO 4 − / OH/O 2 − / 1 O 2 ) are generated in the β-CD-MnFe 2 O 4 /PMS system and that pollutants trapped in the cyclodextrin cavity are quickly degraded. Various reaction parameters of the β-CD-MnFe 2 O 4 /PMS system and the stability of β-CD-MnFe 2 O 4 were also investigated. The results indicate that β-CD-MnFe 2 O 4 is promising for use in water purification owing to its excellent magnetic separation and recovery properties and good resistance to humic acid (HA).
研究领域:
环境科学
·
材料科学
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PubMed
高影响因子
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