ANALYTICA CHIMICA ACTA
·
2025
·
IF 6
Dan Li,Xiaolong Li,Zijia Huang,Tengteng Liu,Mao Li,Xiaoming Chen,Na Li,Yong Zhao
pH value plays a vital role in biochemical analysis. To achieve online analysis, a new type of fluorescent fiber sensor has been developed for real-time, wide-range pH monitoring in biological and environmental fluids. The fluorescent fiber pH sensor was facilely created by immobilizing orange-emitting silicon quantum dots onto a tapered fiber probe through a photoinduced hydrogel polymerization technique. The sensor displays a specific response to pH variations, covering an extensive dynamic range from pH 3.0 to 12.0 with a resolution of 0.06/pH. Additionally, the sensor exhibited remarkable stability, repeatability, robustness, and reversibility. Especially, its high stability to ion strength and temperature fluctuations ensures reliable performance across various physiological and physical conditions. Furthermore, successful implementations of this sensor in detecting pH levels in real serum, artificial sweat and seawater samples further validate its accuracy, practicality and versatility. Overall, this sensor offers a practical and versatile tool for sensitive, real-time pH sensing in complex fluid environments, with great potential across multiple fields.
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FISH & SHELLFISH IMMUNOLOGY
·
2025
·
IF 3.9
Xiaoman Huang,Zixuan E,Hao Yang,Guihong Lai,Shuang Liu,Shujia Liao,Jiaqi Lin,Siyi Liu,Chen Long,Haoran Lin,Danqi Lu,Shuisheng Li,Yong Zhang
Triploid fish are considered a promising candidate for aquaculture; however, their immunological properties remain incompletely characterized. In this study, we investigated the immunological differences between 10-month-old triploid and diploid grass carp. Triploids exhibited a higher head kidney index and obvious macrophage aggregation in the head kidney compared to diploids. Among the immune and antioxidant indices, serum IgM content, head kidney lysozyme and acid phosphatase activities, and catalase and total superoxide dismutase activities, were significantly elevated in the triploids. Transcriptomic analysis identified 610 differentially expressed genes (DEGs) in the head kidney between triploids and diploids. KEGG pathway enrichment analysis revealed that these DEGs were primarily associated with primary immunodeficiency and phagosome pathways. Notably, genes involved in antigen presentation, immunoregulation, phagocytosis, and inflammation were significantly down-regulated in triploids. In contrast, MYD88 , macrophage proliferation genes, and macrophage marker genes were up-regulated. Further investigation into macrophage function demonstrated that triploid macrophages exhibited reduced phagocytic capacity, but maintained respiratory burst activity comparable to that of diploids. This was accompanied by elevated expression of respiratory burst-related and lysosome-associated genes. Collectively, these findings suggest that although triploid grass carp exhibit diminished macrophage phagocytosis and inflammatory responses, compensatory immune regulatory mechanisms may be at play. This study provides a theoretical foundation for the application of triploid grass carp in aquaculture.
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SEPARATION SCIENCE AND TECHNOLOGY
·
2025
·
IF 2.3
Yongfei Zhu,Jiayi Li,Shujuan Yu
The oils and organic dyes in wastewater have caused serious damage to the environment, thus, it is very urgent to develop a multifunctional wastewater treatment material by a simple and environment-friendly method. Herein, a layer of polyvinyl alcohol (PVA)-Fe3+-citric acid (CA) crosslinked structure combined with β-FeOOH particles was firmly anchored on a cotton fabric (CF) through a simple dip-coating and in-situ mineralization method to obtain a robust multifunctional superhydrophilic/underwater superoleophobic CF (β-FeOOH/PVA/Fe-CA-CF). β-FeOOH/PVA/Fe-CA-CF could separate different immiscible oil/water mixtures with a separation efficiency of exceeding 98.26% and high flux of 25,347 L/m2·h only by gravity, especially, it also could separate oil-in-water emulsions with a separation efficiency up to 94.07%. Moreover, β-FeOOH/PVA/Fe-CA-CF displayed an outstanding photocatalytic degradation capacity to organic dyes and the removal efficiency of methylene blue (MB) could reach 98.5% in 20 min. Meanwhile, the modified CF exhibited satisfactory chemical stability, high temperature and abrasion resistance. More importantly, β-FeOOH/PVA/Fe-CA-CF possessed excellent reusability, whose separation efficiency for petroleum ether/water mixture could reach 96.5% after 20 cycles and removal efficiency of MB was still up to 89% after 12 cycles. Therefore, this work provides a facile strategy for the design of multifunctional biodegradable wastewater treatment materials with high durability.
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Materials Today Communications
·
2025
·
IF 4.5
Tianyi Hu,Qun Liu,Shoumei Wan,Liangting Deng,Xu Zeng,Wuyin Weng,Yucang Zhang
Real-time monitoring of food freshness is an efficient strategy to ensure food safety. In this work, a biomass-derived antibacterial and high-strength film featuring an intelligent freshness indication was developed, utilizing neutral red-bromothymol blue (NR-BTB) as a couple indicator, while high amylose corn starch-cinnamaldehyde (HACS-CIN) and bacterial cellulose nanofibers (BCNFs) as the film matrix. The FT-IR and encapsulation efficiency results demonstrated that the CIN was successfully encapsulated within the helical structure of the HACS via intermolecular interactions. The HACS-CIN/BCNFs films exhibit strong antibacterial activity against E. coli and S. aureus . After the incorporation of NR-BTB, the composite films exhibited a high mechanical strength of 27.05 ± 2.57 MPa and a responsive color change within a pH of 3 11. The multifunctional film maintained satisfactory color stability at both 4°C and 25°C at different humidity over 14 days. The cytotoxicity test indicated the composite films have good biocompatibility. As the freshness of the shrimp declined and the levels of TVB-N increased during storage, the color of the multifunctional film significantly changed from reddish-brown to yellowish-brown. This composite film exhibited sensitive pH responsiveness and no leakage in fat simulant. The results indicated that the composite film has the potential to be a real-time food freshness indicator.
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SCIENCE OF THE TOTAL ENVIRONMENT
·
2025
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IF 8
Xincong Su,Li Kai,Xiaowen Han,Rongzhi Wang,Xiao Yang,Xuedong Wang,Jin Yan,Qiuhui Qian,Zejun Wang,Huili Wang
Bisphenol S (BPS) and Bisphenol F (BPF), as alternatives to bisphenol A (BPA), are recognized for their endocrine-disrupting properties, but their combined immune toxicity mechanisms remain poorly understood. This study systematically evaluates the individual and joint immune toxicity effects of BPS and BPF through ADMET predictions, transgenic zebrafish models, and molecular docking analyses. The results indicate that equal effect concentration BPS and BPF act through distinct immune pathways: BPS primarily targets macrophages to mediate immune responses, while BPF significantly stimulates neutrophil proliferation and induces a stronger inflammatory response through chemokine signaling. Molecular docking studies show that BPF binds more stably to pro-apoptotic protein Mapk8 and oxidative stress-related protein Hsp90aa1, leading to significantly higher levels of apoptosis and reactive oxygen species (ROS) compared to BPS. The similarity of modes of action (MOA)between BPS and BPF based on relevant immune indicators calculated and experimentally is about 0.3; this quantitative result also proves that modes of action differ widely. Nonetheless, most of the indicators showed superimposed effects in the combined experiments, and it is noteworthy that the oxidative stress indicators (SOD, MDA) showed synergistic effects, suggesting that BPS and BPF, which have very different modes of action, are able to be risk assessed using an additive model with respect to immunity, but may exhibit synergistic risks with respect to oxidative stress. This research demonstrates that BPS and BPF induce immune toxicity via different molecular targets and pathways and highlights the need to account for their synergistic effects in risk assessments. These findings provide important insights into the immune toxicity mechanisms of BPA substitutes and the potential risks of combined exposures.
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COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
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2025
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IF 4.3
Yunshuo Chen,Yachan Gong,Dan Li,Weiwei Feng,Yao Chen,Ting Zhao,Liuqing Yang,Guanghua Mao,Xiangyang Wu
As a typical neonicotinoid insecticide, dinotefuran (DIN) has immunotoxicity, but its immunotoxicity effects on aquatic organisms and its molecular mechanisms are not known. In this study, zebrafish embryos were used as model to reveal its immunotoxicity and its mechanism from the perspective of inflammatory response. Zebrafish larvae were exposed to DIN at environmentally relevant concentrations (0, 2, 200, and 2000 mg/L) for 120 h, followed by comprehensive analyses of immune cell populations, immune marker activities, oxidative stress levels, and gene expression profiles. The results showed that the number of neutrophils and macrophages, two types of innate immune cells, was significantly reduced, and the activities of the immune markers, lysozyme (LYS), immunoglobulin M (IgM), and complement protein C3, were significantly inhibited. The level of oxidative stress in zebrafish larvae was significantly elevated and antioxidant enzyme activities were markedly inhibited in a dose-dependent manner after exposure to DIN. In this case, pro-inflammatory cytokines such as TNF-α, IL-6 and IL-1β were also abnormally expressed, and the expression levels of the genes related to the NF-κB pathway and the JNK-STAT pathway, tlr4a, myd88, nf-κb p65, jak1, jak2 , and stat3 , were elevated. The expression levels of genes related to the antioxidant signaling pathway Nrf2-keap1 signaling pathway were suppressed. Taken together, our results suggest that DIN exposure causes damage to the immune system of zebrafish embryos-larvae, generating oxidative stress and inflammatory responses that lead to immunotoxicity.
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SEPARATION SCIENCE AND TECHNOLOGY
·
2025
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IF 2.3
Hongjuan Bai,Dan Liu,Gang Wang,Yuanyuan Feng,Xuanyan Zhu,Huiling Lu,Pengzhan Guo,Yifei Ding,Shuai Yang,Junhang Chen
In this study, we synthesized a novel sulfonated polybenzothiazole (sPBT) which permitted the development of a sodium alginate-based composite (SA-sPBT), and this composite demonstrated promising potential as an adsorbent for the simultaneous removal of Malachite Green (MG) and Neutral Red (NR) from aqueous solutions. Experimental results revealed that SA-sPBT exhibited excellent adsorption performance for MG and NR in both single and binary dye systems. The adsorption isotherms of MG and NR in single-dye systems were well described by the Langmuir model. Kinetic studies showed that both MG and NR adsorption aligned with pseudo-second-order and pseudo-first-order models, respectively. Thermodynamic analyses indicated that the adsorption processes for both dyes were endothermic, spontaneous and feasible. The statistical physics model revealed distinct adsorption behaviors: in single-component systems, NR was adsorbed predominantly via pure non-parallel orientations, while MG exhibited no pure non-parallel orientation at a single adsorption site on SA-sPBT. In the binary dye system, competitive adsorption was observed, with NR showing higher adsorption energy compared to MG, leading to its preferential attachment to adsorption sites. Mechanistic insights were further explored using FT-IR, XPS and DFT calculations, confirming the efficacy of the SA-sPBT composite for organic dye removal from wastewater.
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WATER AIR AND SOIL POLLUTION
·
2024
·Vol. 235
·期 6
·1-12
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IF 3.8
Li Haiyang,Li Xiaran,Quan Fengyu,Chen Zhaojun,Xia Yanzhi,Xiong Zhong
Multifunctional adsorbents are significant for the treatment of water-soluble dyes in contaminated aquatic systems and oily dyes in colored organic effluents. However, the existing adsorbent for both water-soluble and oil-soluble dyes is rare and the cleanup effect is not ideal. In this study, alginic acid carbon aerogel (AACA) as an effective wide-spectrum adsorbent was prepared through wet-spinning, ion-exchanging, drying, and high-temperature carbonization. AACA obtained a specific surface area of 1046.0 m 2 g −1 and a mean pore size of 2.82 nm. The adsorption capacities of AACA for methylene blue (cationic dye), methyl orange (anion dye), and oil red O (oil-soluble dye) were 493.5, 389.5, and 244.2 mg g −1 , respectively, which were improved in comparison with those of previously reported calcium alginate and ferric alginate carbon aerogels. The adsorption kinetics of AACA for the three dyes were fit for the pseudo-second-order kinetic model and the adsorption isotherms could be explained by the Langmuir model. ACCA revealed good adsorption performance for other eleven different sorts of dyes and binary dye systems. The adsorption mechanism was mainly confirmed to be π–π interactions.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2025
·
IF 5.4
Xingdi Zhao,Pengfei Bian,Liu Wang,Xinyu Li,Jingxin Zhou,Yuqing Qiao,Mingli Wang,Tifeng Jiao
Cholesterol derivatives play a vital role in various fields, including medicine, biology, and smart materials. The Langmuir-Blodgett (LB) technology uses molecular self-assembly to create interfacially organized thin film materials with unique characteristics. This work primarily used two cholesterol derivatives (CCA and CCH) coupled with various dyes to create multilayer composite LB films. The SERS test determined the enhancement factor EF=1.07×10 5 for the CCA/ST composite film and EF=1.12×10 5 for the CCH/ST multilayer composite films, with relative standard deviation RSD=12.58% and 3.86%, respectively. The result demonstrates the superior signal responsiveness and uniformity of the resultant LB films, offering a novel option for active substrate materials in SERS detection of trace compounds. The photoelectric response signal of the CCA/dye and CCH/dye composite LB films was demonstrated to be sensitive by the photoelectric conversion test, and the films' superior reusability was demonstrated by the persistence of the same pattern over several recurring cycles. It offers a novel idea for investigating the use of cholesterol derivatives in optoelectronic devices in more detail.
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JOURNAL OF HAZARDOUS MATERIALS
·
2025
·
IF 11.3
Xinxin Tong,Zihan Li,Xiaoqing Li,Zongyang Tan,Xiaoyu Liu,Xujia Zhao,Mingyang Zhou,Yongqian Lei,Pengran Guo,Jian Liu,Shenghong Yang
The extensive utilization of nuclear energy exacerbated both the occurrence of accidental leakage incidents and the dispersion of uranium contamination, rendering the development of innovative analytical methods tailored for rapid on-site detection and long-term tracking of uranium increasingly critical. Herein, we report a solid-phase engineered strategy to synthesize red fluorescent carbon dots (NR-CDs) derived from neutral red dye. The NR-CDs exhibit enhanced optical stability, biocompatibility, and multi-mode detection capabilities for UO 2 2 + via absorption and fluorescent responses. The detection system achieves remarkable sensitivity with limits of detection of 20 nM (absorption) and 10 nM (fluorescence), surpassing the EPA’s safety threshold (30 ppb). A scanometric analysis mode utilizing grayscale change further enables rapid and high-throughput UO 2 2+ detection in real water and food samples. The NR-CDs also enable the visual tracking of UO 2 2+ in living cells and zebrafish, highlighting their versatility for environmental monitoring and biomedical imaging applications. Moreover, NR-CDs demonstrate pH-activated antibacterial efficacy against both Gram-positive/negative bacteria through a proton-enhanced bactericidal mechanism, achieving an intelligent closed-loop system with environment-sensing and precision bactericidal. This study expands the design principles and synthesis strategies of multifunctional CDs, establishing a scalable and sustainable platform to address critical challenges in environmental monitoring and public health.
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FISH & SHELLFISH IMMUNOLOGY
·
2025
·
IF 3.9
Hai-Chuan Yu,Meng-Yao Chen,Shuang-Ling Zhang,Fang-Chao Tong,Fan-Ping Wang,Lin Wang,Jia-Long Zhang,Jiao-Jie Guo,Bing-Yang Zhang,Jia-Qi Tian,Jiao Wu
Maintaining the hematopoietic balance between erythroid and myeloid lineages is crucial for immune function and oxygen transport. However, the mechanisms underlying the disruption of this balance during acute inflammation remain unclear. In this study, we investigated the effects of Lipopolysaccharide (LPS)-induced acute inflammation on erythroid-myeloid hematopoiesis in zebrafish (Danio rerio) and elucidated the key signaling pathways involved. LPS treatment significantly suppressed erythropoiesis, as evidenced by reduced expression of gata1a and hbae3 and decreased red blood cell production in the caudal hematopoietic tissue (CHT). Conversely, myelopoiesis was enhanced, with increased neutrophil and macrophage accumulation at inflammatory sites. Bioinformatics analysis revealed that LPS modulates hematopoietic differentiation via the Jak2/Stat3-Hif1a signaling axis. Experimental validation demonstrated that LPS activates Jak2/Stat3 signaling, leading to increased expression of hif1a in zebrafish and HIF1α in human hematopoietic cell lines (K562 and THP-1). Inhibition of Jak2 with Ruxolitinib or knockdown of hif1a reversed the LPS-induced suppression of erythropoiesis and expansion of myelopoiesis. Strikingly, acute hypoxia similarly disrupted the hematopoietic balance via the Jak2/Stat3-Hif1a pathway, suggesting a conserved, stress-responsive mechanism. Our findings highlight the critical role of Jak2/Stat3-Hif1a signaling in acute inflammation-induced hematopoietic lineage bias and propose potential therapeutic strategies for hematological disorders associated with acute infection or hypoxia.
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FOOD CHEMISTRY
·
2025
·
IF 9.8
Xiaoyu Yang,Shunbi Xie,Weifen Wu,Jingwen Liu,Manjun Liao,Runzi Zhang,Yao Liu,Mengjun Wang,Yi He
In SERS analysis, SERS substrates often suffer from uneven “hot spot” distribution, poor stability, and susceptibility to oxidation and aggregation, which limit detection precision and accuracy. To overcome these aggregation, this study presents a novel core-shell Au@Ag@hydrogen-bonded organic framework twin cone (Au@Ag@HOF TCs) as efficient SERS substrate. The HOF shell effectively protects Au and Ag from oxidation, thereby enhancing the long-term stability of the SERS substrate. It also prevents signal inhomogeneity caused by noble metal nanoparticle agglomeration and captures target molecules at “hotspots” for maximum Raman enhancement. Leveraging these features, the proposed Au@Ag@HOF TCs enable sensitive detection of bisphenol A, F, and S in food, with detection limits of 1.8033 × 10 −9 M, 4.2170 × 10 −9 M, and 2.0815 × 10 −10 M, respectively. Furthermore, this substrate was successfully applied to analyze real samples, including canned soup, beverages, and milk, demonstrating its potential for the detection of bisphenol compounds in food.
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