JOURNAL OF ALLOYS AND COMPOUNDS
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2026
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IF 6.7
Baolu Shi,Baosheng Xu,Xinqiao Wang,Zhiliang Zhou,Yan Zhang,Yuxuan Tian
SiO 2 -based ceramic aerogels have been extensively employed in thermal protection systems due to their lightweight and excellent thermal stability characteristics. However, their inherent brittleness and relatively high infrared transparency severely restrict their applications under extreme service conditions. In this study, the synergistic integration of anti-infrared property and 3D deformability was first achieved, and an anti-infrared ceramic aerogel composite metastructure (anti-infrared CAM) with an origami structure was designed and fabricated. To address the infrared transparency issue of SiO₂, potassium titanate whiskers (PTW) with high infrared reflective properties were introduced into the SiO₂ aerogel, while a TiO₂ coating was deposited on the fiber surfaces to construct a dual infrared barrier system. The results showed that the prepared anti-infrared CAM exhibited a high uniaxial tensile strain exceeding 80 % and excellent cyclic tensile fatigue resistance. Notably, the introduction of PTW enhanced the anti-infrared capability, making anti-infrared CAM possessed highly efficient high-temperature thermal insulation performance. Although the TiO 2 -coated fibers as the structural framework reduced the tensile strain, they improved the compressive strength. Therefore, the anti-infrared CAM broke through the limitations of brittleness and high infrared transparency in traditional SiO₂-based ceramic aerogels, significantly expanding the application in harsh and complex extreme environments.
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CARBOHYDRATE POLYMERS
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2026
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IF 13.2
Qianqian Ouyang,Hongjiao Qu,Weiyan Quan,Yongkai Tang,Xufeng Zhu,Luming Deng,Xian Xie,Kefeng Wu
Microneedle patches have emerged as promising tools for wound repair. However, their clinical utility is limited by poor adhesion and insufficient interfacial stability, which often lead to secondary wound separation and inefficient drug delivery. Here, we report a seaweed-derived bioadhesive microneedle patch that integrates robust tissue adhesion with sustained drug release for effective skin regeneration. The hydrogel patch, composed of chitosan and poly(vinylpyrrolidone) (PVP), absorbs wound exudates and forms mechanically stable adhesion on tissue surfaces. As such, it maintains long-term fixation and protects the wound site. The microneedle array, fabricated via electrostatic interactions between seaweed-derived polysaccharides (contained α -D-Glcp-1→, →4,6)- α -D-Glcp-(1→, and →4)- α -D-Glcp-(1 → units, with a molecular weight of 27,476 Da, named SFP) and chitosan, exhibits rigid, sharp conical tips that enable efficient skin penetration while ensuring strong interfacial adhesion through conformal contact and hydrogen bonding. This intimate microneedle–tissue integration facilitates localized, continuous release of the antibacterial polysaccharide at the wound interface, thereby ensuring sustained therapeutic efficacy. Furthermore, in vivo studies demonstrated accelerated wound closure, enhanced collagen deposition, promoted angiogenesis, and reduced inflammation. Together, these findings establish the seaweed-derived microneedle patch as a multifunctional platform that stabilizes the wound interface, enhances therapeutic delivery, and holds broad potential for diverse biomedical applications.
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SEPARATION AND PURIFICATION TECHNOLOGY
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2026
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IF 9.1
Xiang Ni,Yihang Xu,Pengjun Duan,Mengcheng Zhang,Xiaozheng Han,Xinwen Zhang,Xinrui Geng,Qiaomei Sun,Jianzhong Zheng,Zhaoxiang Zhong
Covalent organic frameworks (COFs), characterized by tunable porous structures and functional surfaces, have emerged as promising adsorbents for efficient separation and enrichment of radioactive iodine. However, the constructing of two-dimensional (2D) COFs that expose a high density of adsorption sites to achieve both high adsorption capacity and rapid kinetics remains a significant challenge. In this work, hollow COF (H-COF) were synthesized using a dynamic micellar assembly strategy in an emulsion system, employing Pluronic F127/P123 dual surfactants as a soft template. The H-COF exhibited hollow features, enhanced pore size distribution, pore capacity, and pore connectivity, providing more accessible pathways for accelerating iodine molecule diffusion. Impressively, the H-COF demonstrated a superior iodine adsorption capacity of 9.25 g·g −1 . In addition, the K 80% adsorption rate of H-COF was 0.93 g·g −1 ·h −1 , which is 9.3 times higher than that of conventional C-COF (0.10 g·g −1 ·h −1 ), highlighting its significantly faster adsorption kinetics. Mechanism analysis and DFT calculations revealed that polyiodide anions (I 3 − and I 5 − ) form through electron transfer from the imine groups in H-COF to iodine molecules, with a strong adsorption affinity for the imine bonds. This study presents an efficient iodine capture material and the potential of COFs in waste management.
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INTERNATIONAL JOURNAL OF PHARMACEUTICS
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2026
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IF 6
Juan Tao,Yuning Wei,Mengyu Zhao,Zirong Dong,Zibo Wei,Shuyan Li,Jiaxin Zhao,Jinlong Yang,Jianping Qi
D100B is a first-in-class small-molecule activator of AMP-activated protein kinase (AMPK) that specifically targets the lysosomal pool, enabling precise metabolic regulation with lower systemic toxicity. Despite its favorable solubility and stability, D100B exhibits extremely poor oral bioavailability due to strong mucoadhesion and extensive retention within the intestinal mucus. Electrostatic and hydrophobic interactions between D100B and mucin were found to severely hinder its diffusion and epithelial absorption. To overcome this limitation, a PEGylated self-nanoemulsifying system (PSNE) was developed to reduce mucin binding and enhance mucus penetration. The optimized PSNE displayed uniform nanoscale droplets, sustained drug release, and significantly improved diffusion in simulated mucus. In Caco-2/HT29-MTX co-culture monolayers, PSNE significantly enhanced epithelial transport, while pharmacokinetic evaluation demonstrated a 2.66-fold increase in oral bioavailability compared with the unformulated drug. Overall, this study establishes a mucus-barrier-focused formulation strategy that may be applicable for improving the oral delivery of amphiphilic compounds whose absorption is compromised by mucus-mediated retention
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JOURNAL OF MEMBRANE SCIENCE
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2026
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IF 8.8
Guo Wang,Fan Yi,Zeyu Pei,Changting Hong,Li-Bo Huang,Zhongyi Jiang
Covalent organic framework membranes featuring uniform nanopores are ideal candidates for molecular sieving. However, the trade-off between permeability and selectivity should be appropriately solved. Herein, we propose a pore-environment engineering strategy by covalently anchoring histamines into the confined pores of COF-316. The introduced imidazoles function as hydrogen bond acceptors, forming dynamic hydrogen-bonding networks that facilitate selective water transport. Such modification significantly enhances the hydrophilicity of the pore interior and reduces the activation energy barrier for water permeation. As a result, the optimized COF-316H membrane achieves a remarkable water permeance of 319.2 L m −2 h −1 bar −1 , a nearly threefold enhancement over the pristine COF-316 membrane, while maintaining a dye rejection exceeding 99%. Furthermore, the membrane exhibits excellent long-term stability and reversible antifouling property. This work offers a promising avenue to overcoming the permeability-selectivity trade-off through precise engineering of confined pore environment in advanced separation membranes.
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FOOD CHEMISTRY
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2026
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IF 10.4
Jingbin Shi,Hongyuan Guo,Hao Wu,Xuedong Jia,Runying Chai,Yujue Feng,Suozhu Wu
Norfloxacin (NOR) is a fluoroquinolone antibiotic, and its long-term intake poses serious threats to human health. Therefore, sensitive determination of NOR is of great significance. This work develops a molecularly imprinted electrochemical sensor (MIES) for detecting NOR based on molecularly imprinted polypyrrole/carboxylated multi-walled carbon nanotubes-chitosan/glassy carbon electrode (MIP/cMWCNT-CS/GCE). The cMWCNT-CS serves as a conductive layer for signal amplification, while MIP acts as the recognition element for specific identification of NOR. NOR is indirectly detected by the reduction peak current of potassium ferricyanide probe . This MIES exhibits an ultra-wide linear range (1.00 × 10 −13 –1.00 × 10 −5 M) and an ultra-low detection limit (1.78 × 10 −14 M) with rapid response (adsorption time 4 min), high selectivity, and excellent reproducibility. Furthermore, the MIES is successfully applied to determine NOR in honey, milk, and tap water samples with satisfactory recoveries (87.30% ∼ 121.00%). This work provides a promising analytical avenue for rapid and ultrasensitive monitoring of NOR in food and environmental samples.
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Frontiers in Microbiology
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2026
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IF 5.8
Mengting Li,Shuiming Xiao,Yanli Wang,Tao Li,Qin Hu,Lijinchuan Dong,Yuxuan Guo,Zhe Shi,Qing Yang,Weiyan Cai,Qi Li,Bo Peng,Pengyue Li,Xiaogang Weng,Yajie Wang,Yujie Li,Yu Dong,Xiaoxin Zhu,Zipeng Gong,Ying Chen
Introduction Irritable bowel syndrome (IBS) is a typical disorder of gut-brain interaction (DGBI). The microbiota-gut-brain (MGB) axis is pivotal in preventing and treating IBS. Wuji Pill is a traditional Chinese medicine commonly used to treat IBS. This study aimed to investigate the mechanism by which Wuji Pill improves IBS via the MGB axis. Methods The visceral sensitivity and colonic motor function were evaluated using the abdominal wall withdrawal reflex test and the colonic motility curve. Depression-like behavior were evaluated using sucrose preference test, open field test, novelty-suppressed feeding test, and forced swimming tests. The intestinal mucus secretion and the activation status of microglia was detected using AB-PAS staining and immunofluorescence staining, respectively. The species composition and abundance of gut microbiota were detected through 16S rRNA sequencing and RT-qPCR. Targeted metabonomics and RT-qPCR were used for metabolites and metabolic enzymes analysis. Results In this study, Wuji Pill improved the symptoms of IBS rats and increased the relative abundance of Akkermansia muciniphila in feces. Additionally, antibiotics affected the repair of intestinal mucus secretion and significantly reduced the level of short-chain fatty acids. Subsequently, fecal microbiota transplantation and A. muciniphila transplantation can improve the symptoms of IBS rat by increasing intestinal mucus secretion, elevating the levels of acetic acid and butyric acid in feces. Additionally, the microglia in the cortex were suppressed, and the tryptophan-kynurenine pathway in the hippocampus was inhibited, leading to the conversion of tryptophan into 5-HT. Discussion This study highlights the Wuji Pill may alleviate IBS symptoms by modulating A. muciniphila and regulating the tryptophan metabolism pathway through MGB axis.
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ANALYTICAL AND BIOANALYTICAL CHEMISTRY
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2026
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IF 4.1
Yi Jintao,Fu Nani,Zhong Wenhui,Liu Xia,Zhou Anqi,Li Xun
Amoxicillin (AMO), a penicillin antibiotic, and ciprofloxacin (CIP), a quinolone antibiotic, are widely used to combat bacterial infections and are frequently co-administered to enhance therapeutic efficacy. However, improper use of AMO and CIP may lead to antibiotic residues in the environment, posing serious threats to human health. The visual detection of AMO and CIP remains significant challenges. Herein, the Eu-DPA@CQDs was used for the dual-mode detection of AMO and CIP, which was synthesized by CQDs doped in europium-DPA metal-organic framework. In the colorimetric mode, the catalase-mimicking Eu-DPA@CQDs oxidized TMB to blue oxTMB. Upon addition of AMO, the oxTMB was reduced, causing color fading. Subsequent introduction of CIP restored nanozyme activity, regenerating the blue signal and enabling dual-analyte antibiotic detection. In the fluorescence mode, the Eu-DPA@CQDs probe exhibited dual emission at 440 nm and 613 nm. Upon AMO addition, the fluorescence at both wavelengths was quenched, accompanied by a color change from red to purple. In the presence of CIP, the emission at 440 nm increased and redshifted to 490 nm, while the signal at 613 nm was quenched, resulting in a multicolor transition from red to cyan. The Eu-DPA@CQDs sensor enabled rapid and dual-mode detection of AMO and CIP. The colorimetric method exhibited wide linear ranges of 0.005–25 μM for AMO and 0.007–4.25 μM for CIP, with detection limits of 1.67 nM and 3.75 nM, respectively. A visible color transition from dark blue to colorless was observed with increasing AMO concentration, while the addition of CIP reversed the signal back to dark blue. Similarly, the fluorescence detection achieved wide linear ranges from 0.005 to 30 μM for AMO and 0.005 to 15 μM for CIP, with detection limits as low as 4.74 nM and 3.11 nM, respectively, also within only 1 min. As the concentration of AMO increased, the color shifted from red to purple. In contrast, increasing CIP concentration induced a color transition from red to cyan. These color transitions were both clearly visible to the naked eye. The sensor demonstrated excellent selectivity and anti-interference capability, providing a reliable platform for accurate, sensitive, and quantitative determination of both antibiotics in real samples. Graphical abstract
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APPLIED SURFACE SCIENCE
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2026
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IF 6.6
Hang Li,Muhammad Mubeen,Jingbao Wang,Salman Khalid,Jingmao Zhao,Baomin Fan,Yiqian Lv,Mohammad Tabish,Haiqing Liu
Zn-Al-Mg coated steel (ZM-steel) has emerged as a preferred material in automotive and infrastructure applications, yet its long-term durability remains challenged by localized corrosion in chloride-rich environments. Herein, a sustainable and scalable corrosion protection strategy based on the in-situ formation of layered double hydroxide (LDH) films intercalated with benzothiazole (BTZ) was reported. By exploiting the controlled corrosion of ZM-steel surface in BTZ-containing NaCl solution, compact LDH architectures spontaneously formed, incorporating BTZ molecules within their interlayers. The resulting hybrid coating integrated the physical barrier effect of LDH with the release of BTZ anions, enabling interfacial passivation and sustained corrosion inhibition. Comparative electrochemical tests revealed that BTZ-containing NaCl solution yielded markedly enhanced corrosion-resistance as compared to NaCl solution or bare BTZ solution, with charge transfer resistance increasing from 9.44 × 10 2 to 9.13 × 10 4 Ω·cm 2 . Moreover, epoxy-overcoating effectively suppressed filiform corrosion (FFC) of ZM-steel substrate for over 35 days. Unlike conventional hydrothermal or carbonate-assisted routes for LDH fabrication, this precursor-free strategy proceeds under ambient conditions without additional reagents, underscoring its simplicity, efficiency, and scalability. These findings demonstrate that the moderate corrosion is beneficial to the formation of LDH on ZM-steel surface.
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JOURNAL OF MEMBRANE SCIENCE
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2026
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IF 8.8
Wenji Zheng,Yuliang Tao,Fengting Yao,Zhixu Yun,Miao Yu,Xiaobin Jiang,Gaohong He
Metal organic frameworks (MOFs)-based mixed matrix membranes (MMMs) exhibit great prospect for He/CH 4 separation. However, it is still restricted by interfacial incompatibility-induced low filler loading and selectivity loss. This study proposed an interface fusion strategy by 6FDA-TFMB (PI) functionalized CF 3 -UiO-66 through NH 2 -UiO-66 bridging to achieve dual regulation of interface compatibility and molecular sieving. Crucially, this interface fusion strategy allowed a substantial increase in filler loading to 20 wt%, representing a 100% improvement over unfunctionalized CF 3 -UiO-66. The covalent bond formed between the amino group and the dianhydride improved the interfacial compatibility. The –CF 3 group on the UiO-66 reduced the pore size of UiO-66 and weaken the adsorption of CH 4 . The dual synergistic effect made the resultant MMMs exhibited excellent He permeability (165.2 Barrer) and He/CH 4 selectivity (394.1), representing improvements of 81.14% and 319.7%, respectively, compared with pristine 6FDA-TFMB membrane, approaching to the 2008 Robenson upper bound, surpassing most of the reported PI based membranes for He/CH 4 separation. This synergistic architecture not only validated the interface fusion engineering but also provided a foundation for designing efficient He/CH 4 separation materials with tailored microscopic properties.
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JOURNAL OF NANOBIOTECHNOLOGY
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2026
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IF 15
Xuehan Zhang,Qiuyun Shao,Mengjuan Yu,Yate Huang,Yuying Wang,Yangbing Wen,Kaihui Nan,Yangjun Chen
Glaucoma, characterized by elevated intraocular pressure (IOP), is the leading cause of irreversible vision loss worldwide. While topical eye drops remain the standard for IOP control, ocular surface dynamic and static barriers significantly limit intraocular drug bioavailability. Enhancing corneal retention and permeability is therefore crucial for effective glaucoma therapy. Here, we developed lignin-based nanoparticles coated with quaternary ammonium chitosan oligosaccharide (Lig-QCOS) for encapsulating and delivering the lipophilic drug latanoprost (Lat), a first-line hypotensive agent. The resulting Lat@Lig-QCOS nanoparticles exhibited a hydrodynamic size of ~ 225.6 nm, a low polydispersity index of 0.08, and a positive Zeta potential of + 21.5 mV. The positively charged surface enables prolonged ocular mucoadhesion and concurrently modulates corneal epithelial tight junctions, enhancing paracellular permeation. This dual mechanism increased corneal permeability by 2.2-fold within 6 h, thereby promoting transcorneal drug transport. In a dexamethasone-induced mouse glaucoma model, a single topical dose of Lat@Lig-QCOS nanoparticles achieved a superior IOP reduction compared to free Lat and anionic Lat@Lig nanoparticles. The formulation produced a maximum IOP reduction of 5.2 mmHg, outperforming the commercial Xalatan ® (4.1 mmHg), and sustained efficacy for up to 10 h. The area under the pharmacodynamic response curve (AUC) of Lat@Lig-QCOS was 3.1-fold greater than that of free latanoprost, indicating markedly improved therapeutic performance. Comprehensive in vitro and in vivo biocompatibility assessments confirmed the excellent safety profile of the Lig-QCOS nanocarrier. Collectively, these findings highlight the potential of natural biopolymer-based nanosystems as efficient eye drop formulations for glaucoma treatment.
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FOOD RESEARCH INTERNATIONAL
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2026
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IF 8.8
Jian Li,Yue-Wei Huang,Yi-Tong Li,Shi-Yin Luo,Wei-Yan Xiong,Jin-Hua Wang,Jun-Hu Cheng,Ting-Shi He,Xin-An Zeng
The impact of pulsed electric field (PEF) on the formation of acrylamide (AA) in air-fired French fries was investigated in this study. The results indicated that electric field intensity, pulse width, and cooking parameters significantly influence the formation of acrylamide in air-fried French fries. Compared with the traditional blanching treatment, PEF treatment more effectively inhibits AA formation and improves the cooking quality of French fries. Under optimal conditions, the AA content in the PEF-treated samples was reduced by 15.60% and 26.71% compared with that in the blanched and untreated groups, respectively. The significant suppression of AA formation may be closely associated with the ability of PEF to modify the microstructure of potato tissues and promote the leaching of AA precursors. PEF treatment did not induce significant gelatinization of potato starch. Instead, it caused electroporation of potato cells through polarization effects. This structural change enhanced heat and mass transfer efficiency during cooking, reduced processing time, and facilitated the continuous removal of key AA precursors, such as reducing sugars and asparagine. These structural and process modifications collectively suppress the Maillard reaction, thereby reducing AA generation. Furthermore, as a pretreatment method, PEF exhibits superior processing efficiency and lower energy consumption compared to blanching. In conclusion, PEF treatment can significantly decrease AA levels in air-fried French fries, showing great potential for producing healthier air-fried foods.
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