CHEMICAL PHYSICS LETTERS
·
2022
·
IF 2.719
Weiqiu Huang,Bing Zhu,Jiahui Zhu,Xufei Li,Xinya Wang,Baoyou Yan,Fei Yi,Zhen Zhang
Novel AC (termed as A-AC/SiC) with high thermal conductivity was prepared by using emulsified asphalt as precursor and polycarbosilane (PCS) as thermal conductive addition by in-situ reaction. The specific surface area and total pore volume of sample A-AC/SiC-20 was up to 1346 m 2 ·g −1 and 0.89 cm 3 ·g −1 respectively. The SEM and FIIR showed that PCS had been successfully loaded into the A-AC and formed the uniform cross-linking structure, while its thermal conductivity increased by nearly 300 % than that of the parent A-AC. Moreover, it also exhibited high adsorption capacity up to 3.46 mmol·g −1 and excellent recyclability for n-hexane vapor.
✓ 已验证
产品关联
DOI
高影响因子
Journal of Physical Chemistry C
·
2023
·
IF 3.7
Hao Wu,Xiaoyu Cheng,Songjun Xie,Yan Huang,Raheel Ahmed Janjua,Xinzi Liu,Sailing He
Aluminum quantum dots (AlQDs) are an emerging class of optical material due to their unique photoluminescence in the ultraviolet waveband. Herein, a strategy is presented to control their photoluminescence emission. The synthesized AlQDs displayed photoluminescence from the UV-B region (<320 nm) to the near-ultraviolet region (∼425 nm) and high quantum yields. Our investigation revealed that surfactants and phosphonic acids (PAs) were competitively bound to the surface of AlQDs, and this was affected by the space volume of surfactants and charge of head groups. The steady-state and time-resolved spectroscopic data suggested the emission properties of AlQDs mainly originated from the surface-mediated states. The red-shifting of emission peak was a result of increased amount of PAs on the surface of AlQDs, which could be related to the surface oxygen presented in both ligands and surfactants. Overall, this study indicates a method to control the photoluminescence of AlQDs by changing the surfactants and surface ligands, which is fundamental to their applications in photonics and applications to energy and environment, in addition to biomedicine.
✓ 已验证
产品关联
DOI
高影响因子
INVESTIGATIONAL NEW DRUGS
·
2023
·Vol. 41
·期 1
·134-141
·
IF 3.4
Yan Gaobo,Zhang Hongyan,Li Yan,Miao Guoqiang,Liu Xiaolei,Lv Qifan
Lysine-specific demethylase 1 (LSD1) has been a promising target to treat prostate cancer, and discovery of novel LSD1 inhibitors would have great clinical significance. In this work, viscosalactone B was first identified as a novel LSD1 inhibitor. Viscosalactone B isolated from Withania Somnifera displayed antiproliferative activity against PC3, DU145, C42B, PC3/MDVR, DU145/MDVR, and C42B/MDVR cells with IC 50 values of 1.17, 0.72, 3.86, 2.06, 0.96 and 1.15 μM, respectively. In comparison, it was a selective LSD1 inhibitor with an IC 50 value of 970.27 nM and could induce a significant accumulation of LSD1 substrates H3K9me1, H3K9me2, and H3K4me1 in a concentration-dependent manner in DU145 cells. According to docking studies, it formed hydrogen bonds with the Thr11, Lys14, and Arg8 residues of LSD1. Importantly, while it displayed potent antitumor efficacy in vivo, it did not show obvious cytotoxicity on the major organs of nude mice. Therefore, viscosalactone B, as a novel LSD1 inhibitor, is a potential candidate that can be used for the treatment of prostate cancer in clinics.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2022
·
IF 5.518
Bin Sun,Fengfei Chen,Hualin Lin,Yuan Xue,Sheng Han
The poor cold flow properties (CFPs) are the main factors that hinder the utilization and popularization of diesel fuel. Cold flow improvers (CFIs) are usually add to diesel fuel to compensate for liquidity problems at low temperatures. In this study, monomers with different functional groups were used to synthesize methyl benzyl acrylate-co-hexadecene-maleic anhydride (MB-HD-MA) terpolymers with different mole ratios through free radical polymerization , and then the terpolymers were modified with tetradecanol to obtain comb type terpolymers (MB-HD-MA-C14). The structure of MB-HD-MA and MB-HD-MA-C14 were characterized by Fourier transform infrared spectroscopy (FTIR) and Nuclear Magnetic Resonance Hydrogen spectra (1 H NMR). Adding CFIs to diesel fuel effectively improved the CFPs, 1000 ppm MB-HD-MA-C14 (3:1:4) presented the best depression effects on cold filter plugging point (CFPP) and solid point (SP) by 12 °C and 21 °C, respectively. The results showed that the non-polar and polar components in CFIs exert synergistic effect at an optimal ratio to improve CFPs with greater efficiency. Moreover, rheology analysis and polarizing optical microscopy showed that MB-HD-MA-C14 (3:1:4) can improve the rheological properties by reducing dynamic viscosity and improve the crystallization behavior of wax crystals at low temperature by decreasing the size and modifying the morphology of the wax crystals.
✓ 已验证
产品关联
DOI
高影响因子
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
·
2023
·
IF 3.4
Zhe Chen,Jia-Yu Zhang,Qian Jiang,Yang-Yang Bao,Zhi-Mei Li,Shui-Hong Zhou,Jiang-Tao Zhong,Zi-Ming Fu,Zai-Zai Cao,Jun Fan,Hong-Tian Yao
Objective To investigate the role of H + /K + ATPase in the proliferation of pepsin-induced vocal cord leukoplakia (VCL) cells. Study Design Translation research. Setting Affiliated Hospital of University. Methods Immunohistochemistry was used to detect pepsin, H + /K + ATPase (ATP4A and ATP4B subunits) in VCL cells with varying degrees of dysplasia. After primary cultures of VCL cells had been established, the effects of acidified pepsin on the proliferation, autophagy, and H + /K + -ATPase distribution of VCL cells were investigated. Results The levels of pepsin, ATP4A, and ATP4B were significantly higher in VCL tissue with moderate-to-severe dysplasia than in normal tissue ( p < .05); these levels gradually increased according to dysplasia severity. The expression levels of ATP4A and ATP4B were significantly correlated with the amount of pepsin in VCL cells ( p < .01). Acidified pepsin enhanced the levels of proliferation and autophagy in human VCL epithelial cells. The cloning- and autophagy-promoting effects of acidified pepsin on VCL cells were partially reversed by pantoprazole; these effects were completely blocked by the autophagy inhibitor chloroquine. Finally, acidified pepsin promoted the colocalization of H + /K + -ATPase and lysosomes in VCL cells; it also mediated lysosome acidification. Conclusion Pepsin and H + /K + -ATPase may contribute to the progression of VCL. Specifically, acidified pepsin may regulate lysosome acidification by promoting lysosomal localization of H + /K + -ATPase.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Polymer Materials
·
2023
·
IF 5
Longpeng Zhou,Jian Tang,Siwen Kuai,Yunqiang Li,Nana Chen,Xiao Xue,Hongtao Liu
Ice accumulation on the surface of outdoor equipment has adverse effects on normal operation. The superhydrophobic surface has attracted more attention because of its nonwettability and good ice-shedding potential. However, the poor stability seriously limits the application. Here, the robust superhydrophobic coating with excellent stability and ice-shedding performance was prepared by a facile spraying way. The combination of ethylene–propylene–diene terpolymer and γ-aminopropyl triethoxysilane could significantly enhance the robustness and stability. The coating can be directly sprayed on a variety of substrate surfaces to achieve large-scale production applications, and the bonding of internal particles and the adhesion of the coating to the substrate were strong. The coating showed a high contact angle and low rolling angle, exhibiting excellent self-cleaning ability, ice delay performance, low ice nucleation temperature, and low ice adhesion strength. Notably, the coating possessed excellent mechanical robustness, corrosion resistance, and temperature durability, maintaining superhydrophobic properties and low ice adhesion strength after 200 abrasion cycles, 60 tape-peeling cycles, 2 h water impacting, 30 min sand impacting, long time immersion (pH 1∼14), and 10 days at −40 °C/150 °C. This work provides a facile way to prepare robust superhydrophobic coating for ice shedding, which greatly improves the application in practical environments.
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF ETHNOPHARMACOLOGY
·
2023
·
IF 5.4
Jiameng Zhang,Yanfang Wu,Chenyu Wang,Weidong Xu,Zichen Zhang,Suya Zhang,Xinyi Guan,Xinsheng Wang
Ethnopharmacological relevance Syringa Pubescens Turcz. (SP), a member of the Oleaceae family, is a species of plant known as Syringa . Flowers, as the medicinal part, are commonly used in the treatment of hepatitis and tonsillitis. Aim of the study: The research was the first to assess the antioxidant and anti-inflammatory potential of different parts of SP flowers (SPF) in vitro . The most promising fraction was ethyl acetate fraction of SP flower (SPFEA). The antioxidant, anti-inflammatory and analgesic activities of SPFEA were further studied, and the chemical components were identified. Methods HPLC was used to identify the major components in various fraction of SPF. DPPH and ABTS + radical scavenging assays as well as FRAP test and β-carotene bleaching test were employed to assess the antioxidant potential of SPF fraction in vitro . The inhibitory effect on NO production in LPS-treated RAW264.7 cells and heat-induced protein denaturation test were used to evaluate the anti-inflammatory potential of SPF fraction. Further analysis of the biological activity of SPFEA was performed. Acute toxicity test was conducted to assess the toxicity of SPFEA. The anti-inflammatory effect was assessed by utilizing xylene induced ear edema model, carrageenan-induced foot edema model and peritonitis model in vivo . The analgesic effect of SPFEA was evaluated using hot plate test, tail immersion test, formaldehyde test as well as acetic acid-induced abdominal writhing pain experiment in vivo . In carrageenan induced foot edema model, ELISA kits were employed to measure levels of inflammation factors (NO, TNF-α, IL-6, COX-2, IL-1β) in foot tissue as well as MDA, CAT, SOD, GSH-PX levels in liver tissue. Results HPLC results showed that there were significant differences in bioactive substances among different fractions of SPF, and SPFEA was rich in bioacitve components. Compared with other fractions of SPF, SPFEA exhibited better antioxidant and anti-inflammatory abilities. The 3000 mg/kg SPFEA group in mice had no obvious side effects. The xylene-induced ear edema model, carrageenan-induced foot edema and peritonitis models demonstrated that the SPFEA had significant anti-inflammatory effect. Moreover, inflammation factors including NO, TNF-α, IL-6, COX-2, IL-1β were significantly reduced in SPFEA groups in foot tissue induced by carrageenan. Additionally, SPFEA effectively decreased liver tissue oxidative stress levels (MDA, SOD, GSH-PX and CAT). The bioactivities of SPFEA demonstrated a clear dose-dependent relationship. The results of the hot plate test, tail immersion test, formaldehyde test and acetic acid-induced abdominal writhing pain experiments indicated the SPFEA possessed an excellent analgesic effect, and this effect was in dose-dependent manner. Conclusion The study provides a scientific foundation for understanding the pharmacological action of SPFEA. It has been indicated that SPFEA has excellent antioxidant, analgesic and anti-inflammatory effects.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2023
·
IF 9.5
Liang Pang,Peng Xiao,Zhuan Li,Heng Luo,Jinfei Zheng,Shaohua Jiang,Jinchao Tong,Yang Li
SiCxOy beaded carbon fibers were successfully fabricated for the first time using a facile and stable electrospinning and temperature process. The resulting fibers showcase a unique micro-nanocomposite structure, in which β-SiC beads with a silica-enriched surface are strung together with defect carbon fibers, as confirmed by XRD, XPS, and HRTEM investigation. The SiCxOy beaded carbon fibers display efficient microwave absorption performance, with a minimum reflection loss of −58.53 dB and an effective absorption bandwidth of 5.92 GHz. A modified Drude–Lorentz model was developed for SiCxOy beaded carbon fibers to reveal the double-peaked feature of the permittivity of these fibers, which is in good agreement with experimental measurements. Moreover, simulations were performed to extract polarized electric fields and microwave energy volume losses within a typical distribution of SiCxOy beaded carbon fibers. It is concluded that the dipole relaxation and hopping migration of localized electrons give a superior contribution to the overall decay of the microwave energy. This study indicates that SiCxOy beaded carbon fibers with a unique micro-nanocomposite structure hold great promise for microwave absorption applications. Additionally, this fabrication strategy offers a unique approach to producing micro-nanocomposite structures and highlights their potential applications.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
MOLECULES
·
2023
·Vol. 28
·期 13
·5077
·
IF 4.6
Zhenhao Yao,Yin Lu,Jianan Song,Kan Zhang
In this work, a novel bio-based high-performance bisbenzoxazine resin was synthesized from daidzein, 2-thiophenemethylamine and paraformaldehyde. The chemical structure was confirmed using nuclear magnetic resonance spectroscopy (NMR) and Fourier-transform infrared spectroscopy (FT-IR). The polymerization process was systematically studied using differential scanning calorimetry (DSC) and in situ FT-IR spectra. It can be polymerized through multiple polymerization behaviors under the synergistic reaction of thiophene rings with benzopyrone rather than a single polymerization mechanism of traditional benzoxazines, as reported. In addition, thermogravimetric analysis (TGA) and a microscale combustion calorimeter (MCC) were used to study the thermal stability and flame retardancy of the resulting polybenzoxazine. The thermosetting material showed a high carbon residue rate of 62.8% and a low heat release capacity (HRC) value of 33 J/gK without adding any flame retardants. Based on its outstanding capability of carbon formation, this newly obtained benzoxazine resin was carbonized and activated to obtain a porous carbon material doped with both sulfur and nitrogen. The CO2absorption of the carbon material at 0 °C and 25 °C at 1 bar was 3.64 mmol/g and 3.26 mmol/g, respectively. The above excellent comprehensive properties prove its potential applications in many advanced fields.Keywords:benzoxazine;daidzein;thiophene;CO2absorption;thermal stability
✓ 已验证
产品关联
DOI
PubMed
高影响因子
International Journal of Electrochemical Science
·
2023
·
IF 1.5
Tao Xu,Heqing Li,Jing Song,Guilian Wang,Seiji Samukawa,Xijiang Chang,Jingxia Yang
Silicone-modified epoxy coatings were prepared and treated under different plasma atmospheres in order to enhance their anticorrosion ability. The corrosion current density, corrosion potential and impedance of the modified coatings were measured by an electrochemical workstation. The results showed that the corrosion resistances of silicone-modified epoxy coatings were highly improved by surface-wave plasma treatment. Compared with the original coating, the corrosion current density of these coatings modified by plasma decreased from 0.5976 gA/cm 2 to the minimum of 0.0058 μA/cm 2 and the impedance increased from 1.925ȕ103 Q∙cm 2 to the maximum of 2.938× 106 Q∙cm 2 , in which Ar plasma showed the best significant effect.
✓ 已验证
产品关联
DOI
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2023
·
IF 8.6
Xincheng Jiang,Junyi Jiang,Guoyou Huo,Jiaxi Guo,Qiquan Zheng,Hong Li,Huaili Zheng
Effectively removing both soluble antibiotics and insoluble oils from wastewater is a significant challenge. To address both the problems, we synthesized a three-dimensional (3D) porous water treatment material. It can be converted from antibiotic removal mode to oil removal mode by simple surface performance regulation. This approach achieved a high removal rate for ciprofloxacin (CIP) and good separation efficiency for oil/water mixtures. Initially, Co 2 CO 3 (OH) 2 nano-needles were fixed on Ni foam to synthesize Co 2 CO 3 (OH) 2 @Ni foam-1, which had a high CIP removal rate (93.59 % at pH 7.0) and a certain anti-interference ability. To assess the CIP removal performance, the environmental impact, economic benefit and energy consumption (3E) triangle model was established and the optimal operating point was selected. Characterization experiments demonstrated that the removal of CIP was attributed to the mechanisms of surface complexation, electrostatic attraction, cation bridging, precipitation and flocculation . Subsequently, Co 2 CO 3 (OH) 2 @Ni foam-2 was obtained by hydrophobic modification, which exhibited separation efficiencies above 93.5 % for a series of different oil/water mixtures. Co 2 CO 3 (OH) 2 @Ni foam series materials are easy to prepare and possess effective pollutants treatment efficiency, thus providing a new strategy for developing multi-functional water treatment materials and a novel approach for the treatment of soluble antibiotics and insoluble oils in wastewater.
✓ 已验证
产品关联
DOI
高影响因子
IEEE TRANSACTIONS ON DIELECTRICS AND ELECTRICAL INSULATION
·
2023
·Vol. 30
·期 5
·2142-2149
·
IF 3.1
Wenjia Zhang,Shixun Hu,Yaru Zhang,Qi Zhang,Mingti Wang,Juan Li,Xinhua Dong,Xiyu Zhang,Shangshi Huang,Wei Wang,Qi Li,Jinliang He
Polypropylene (PP) is regarded as an environmentally friendly cable insulation material to replace cross-linked polyethylene (XLPE) owing to its thermoplastic nature, high-temperature resistance, and outstanding dielectric characteristics. Grafting modification was applied to satisfy the demand for a higher voltage power grid, and it was proved to be effective in enhancing the insulating performance of PP. The electrical tree is a common cause for cable insulation failure. This study examines the electrical tree initiation and growth characteristics of methyl methacrylate (MMA)-grafted PP under different temperatures. Our results indicate that high temperature can promote the electrical treeing process while grafting modification can hinder the process. The trap characteristics show that more deep traps are introduced in the grafted materials that can limit the motion of electrons and, thus, restrict the electrical tree initiation process. The crystallization morphology shows that the size of spherulites increases and the boundaries of the spherulites become blurry with higher MMA content. The compressed amorphous region and the tortuous boundaries of the crystalline can hinder the electrical treeing process. High temperature may improve charge carrier mobility and enhance the molecular chain relaxation, thus enlarging the free volume and finally accelerating the treeing process. The findings of this study would serve as a reference for designing grafted PP insulation for power cables.
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）