Polymers
·
2026
·Vol. 18
·期 13
·1647
·
IF 5.8
Zhongqiu Ge,Hengfeng Zhu,Yiyang Chen,Yihang Rong,Zhuqun Shi,Quanling Yang
Most adsorbent materials typically face difficulties such as poor blood compatibility, weak mechanical strength, and high cost. In this study, oxidized 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO) was used to obtain cellulose nanofiber (TOCN), and cellulose beads were prepared using a drop curing method. The structure, adsorption properties, and blood compatibility of the prepared beads were thoroughly investigated. The TOCN beads exhibit a uniform, nanometer-scale, three-dimensional porous structure. With increasing carboxyl content, after adsorption of TOCN beads, the bilirubin concentration in rabbit plasma decreased from 0.03 to 0.0089 mg mL−1within 90 min, which is significantly lower than the average bilirubin concentration in humans (about 0.01 mg mL−1), and the bilirubin concentration decreased by about 70%. The results illustrated the excellent blood compatibility, self-anticoagulant ability, and superior toxin removal capabilities of the TOCN beads, highlighting their potential as an ideal blood purification adsorbent.
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TALANTA
·
2026
·
IF 6.7
Xiao Ma,Junjie Wang,Xin Chen,Jingcheng Li,Jiaqi Xue,Yufan Hou,Shihao Zhao,Jingxiang Zhao,Xiaomi Meng,Huajun Chen,Fang Wang,Fangya Guo,Jian Sun,Dan Zhao
Oxidase-like nanozymes use dissolved O 2 as the terminal electron acceptor and do not require exogenous H 2 O 2 , offering methodological advantages; however, conventional “one-pot carbonization” often causes concurrent carbonization and active-site formation, making the coordination environment difficult to control. Here, a sequential “pre-coordinate-polymerize-pyrolyze” site-engineering route was developed. On carbon black, OPD-Fe 3+ pre-coordination and in situ oxidative polymerization were carried out, followed by thermal treatment and purification, by which Fe–N moieties were immobilized within the shell region of the material to afford highly dispersed Fe–N x moieties predominantly featuring Fe–N 4 -like coordination (Fe–N 4 @CB d ). Multiscale characterization (XRD/XPS/XANES/EXAFS) consistently showed that iron resided predominantly in a first coordination sphere dominated by Fe–N (coordination number CN ≈ 3.7; R ≈ 2.01 Å), with no resolvable Fe–Fe scattering and only minor, non-dominant Fe-containing phases. ROS-trapping and time-dependent EPR measurements further confirmed continuous O 2 activation with the generation of O 2 • - , •OH, and 1 O 2 in the Fe–N 4 @CB d /O 2 system. DFT calculations additionally supported Fe–N 4 -like Fe–N x sites as the most plausible dominant active structures for O 2 activation. Under a unified TMB/O 2 system, steady-state enzyme kinetics exhibited outstanding performance, with V max = 351 nmol L −1 s −1 and K m = 0.56 mM, which are competitive among reports using the same substrate/readout. An H 2 O 2 -free colorimetric platform for alkaline phosphatase (ALP) was constructed on this material, achieving a low limit of detection and good linearity; acceptable accuracy and precision were verified by standard additions in diluted serum. This sequential strategy predefines the Fe–N neighborhood and topology at the precursor stage, reduces uncertainty in site formation, and avoids metal-organic framework (MOF)/hard-template/ionic-liquid multi-step procedures, thereby providing a strong basis for reproducible Fe–N 4 -like/Fe–N x oxidase-like nanozyme preparation and streamlined, robust bioanalysis.
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NANO
·
2026
·
IF 1.3
Runcai Xu,Jiqing Dong,Xintao Gao,Xin Cheng,Xiangyan Chen,Yantao Li
Developing highly sensitive and stable nonenzymatic glucose sensors remains crucial for reliable glucose monitoring. Herein, we report an SMSI-driven Au/CeO 2 -BTC nanozyme derived from a Ce-BTC metal-organic frameworks (MOFs) for efficient electrochemical glucose detection. The Ce-trimesic acid (Ce-BTC) precursor was calcined to generate a porous CeO 2 -BTC framework with abundant oxygen vacancies, followed by the in situ deposition of Au nanoparticles. Structural analyses reveal the formation of Au-O-Ce interfacial sites, indicating pronounced trong metal-support interactions (SMSI) that induce electronic modulation, increase Ce 3+ concentration, and facilitate rapid charge transfer. Benefiting from these synergistic effects, the Au/CeO 2 -BTC-modified electrode exhibits excellent catalytic activity toward glucose oxidation, achieving a sensitivity of 41.3 µA cm -2 mM -1 and a detection limit of 4.75 µM, along with good reproducibility, stability, and selectivity. This work highlights the importance of SMSI engineering in MOF-derived nanozymes and provides an effective strategy for constructing high-performance electrochemical glucose sensors
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ELECTROANALYSIS
·
2026
·Vol. 38
·期 4
·e70149
·
IF 2.6
Haixu Wang,Xiaonan Qi,Shunli Zhou,Rongsong Cao,Xi Yang,Le Li,Zhen Sun
Gallic acid (GA) is a natural polyphenol known for its significant biological activity and widespread presence in food, medicine, and various other fields. The accurate and rapid detection of GA is crucial for ensuring food quality control and conducting pharmaceutical analyses. In this study, we successfully developed a novel electrochemical sensor based on a ZIF-67/pomelo carbon (ZIF-67/PC) composite through a simple and environmentally friendly synthetic route. The results indicated that the glassy carbon electrode (GCE) modified with ZIF-67/PC exhibited remarkable electrocatalytic activity towards GA oxidation. The pore-like structure of ZIF-67/PC accelerates the diffusion of GA, the carbon matrix enhances electron transfer, and the Co-N-C sites catalyze the oxidation of GA, thereby achieving excellent detection performance. Under optimal conditions, the sensor demonstrated an extensive linear response range of 8–1000 μM for GA, accompanied by a low detection limit of 0.25 μM (S/N = 3). Furthermore, this sensor displayed excellent selectivity as well as good stability-retaining 91.27% current after 15 days and satisfactory reproducibility with a relative standard deviation below 2%. When applied to detect GA in green tea samples, recovery rates ranged from 95.2% to 102.1%, underscoring its practical application potential. This work presents a viable strategy for developing low-cost yet high-performance electrochemical sensors by integrating metal–organic frameworks with biomass-derived carbon materials.
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ADVANCED FUNCTIONAL MATERIALS
·
2026
·
IF 19.9
Zhimei Mu,Changxiong Huang,Dan Wang,Minqiang Wang,Ke Shan,Yiming Liu,Xiu Liang,Xiao Cheng Zeng,Dangyuan Lei
Wearable electronic skins capable of overcoming sweat interference and leveraging sweat biomarkers are crucial for clinical-grade monitoring. Here, we report a holistic hydration-triggered whole-body E-Skin (HTWB-E-Skin) constructed from a biocompatible composite of nanofibrous silk fibroin and silver nanowires (Ag NWs). The elegance of this design lies in its structurally simple, multifunctional architecture, which leverages the hydration-triggered mechanism to synergistically enhance both biomechanical and biochemical sensing. On one hand, the design leverages silk's hydration-triggered conformational transition, as confirmed by theoretical and experimental studies, to achieve rapid sweat absorption (<10 s), exceptional water retention (>600% mass increase), and stable adhesion on wet skin. On the other hand, the embedded Ag NWs with silk fibroin concurrently enable motion-robust electrocardiogram (ECG) monitoring and generate plasmonic hotspots for surface-enhanced Raman spectroscopy (SERS). Through passive capillary action, trace sweat is autonomously channeled to sensing zones, enabling label-free, real-time continuous metabolic dynamics analysis of clinically relevant biomarkers (e.g., uric acid and urea) at ultralow concentrations, facilitating personalized nutritional oversight and health management. Integrated with a portable 12-lead Cloud-ECG module, the platform supports motion-adaptive ECG, speech recognition, and whole-body motion sensing, outperforming commercial electrodes, offering a practical methodology for long-term personalized health monitoring and point-of-care diagnostics.
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ACS Applied Materials & Interfaces
·
2025
·
IF 8.2
Mohamed Bahri,Guoguang Rong,Xixi Song,Peiwu Qin,Mohamad Sawan
Signal amplification has become a paramount strategy in biosensing, offering substantial improvements in sensitivity and detection limits for analytical platforms. However, conventional methods often rely on separate amplification stages and intricate chemical functionalization, leading to inefficiencies and greater complexity in biosensing workflows. In this article, we introduce a novel dual-purpose application of AuNPs@CuMOF for both surface functionalization and signal amplification, enabling electrochemical biosensing of neuron-specific enolase (NSE), a key biological marker for neuronal disorders and small cell lung cancer. The proposed biosensing strategy implies immobilizing the biotinylated NSE antibody onto the AuNPs@CuMOF-functionalized surface of a screen-printed carbon electrode (SPCE), alongside a thiolated NSE aptamer conjugated to AuNPs@CuMOF for signal amplification. Following this approach, the proposed immunosensor showcased a detection limit (LOD) down to 0.02 pg/mL within the span of 0.1 pg/mL to 200 ng/mL, outperforming or matching previously reported NSE biosensors. Besides, the suggested NSE biosensor reliably identified NSE in spiked human serum samples, showing both strong selectivity and sensitivity, with performance metrics on par with those of standard ELISA tests, with the relative error ranging from 12.03% to 5.63%. By leveraging the combined advantages of CuMOF’s large surface area, versatility, and stability, the proposed method simplifies the biosensing workflow while enhancing sensitivity through intrinsic amplification, resulting in a robust and efficient platform for the detection of biomarkers. We highlight in this work the transformative potential of multifunctional nanomaterials in advancing electrochemical biosensing technologies, wihch represents a significant milestone in tumor diagnosis in clinical settings.
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JOURNAL OF ELECTROANALYTICAL CHEMISTRY
·
2026
·
IF 4.6
Liwen Qu,Hongying Liu,Jia Li,Yinghui Li,Xiangxiang Peng,Lihua Li,Lingao Yi
Ternary composite interface of gold nanoparticles, l -serine and molecularly imprinted polymer modified microelectrode was electrochemically fabricated. • A dual-template molecularly imprinted electrochemical sensor was constructed for the simultaneous detection of HQ and CC. • Molecular imprinting technology can achieve high selectivity for the analyte. • The platform shows potential application in pharmacology, diagnostics and electrophysiology, in-vivo and in-real. • This explore should open an access to integrate with Chinese acupuncture. Catechol (CC) and hydroquinone (HQ), typical toxic phenolic pollutants in industrial effluents, pose risks to ecosystems and human health, demanding rapid, accurate detection. Inspired by traditional Chinese acupuncture, This study developed a molecularly imprinted electrochemical sensor using acupuncture needle (ANE) as substrates. Gold nanoparticles (AuNPs) were electrodeposited on ANE for enhanced conductivity, l -Serine electropolymerized to strengthen recognition, and a melamine-based dual-template molecularly imprinted polymer (MIP) layer constructed as the sensing interface. The sensor was characterized via cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS), scanning electron microscopy (SEM), and elemental mapping techniques . It showed outstanding selectivity for HQ and CC, with a linear response of 0.1–1000 μM and detection limits of 0.021 μM (HQ) and 0.027 μM (CC), outperforming most reported sensors. In lake water analysis, it exhibited robust anti-interference, stability (RSD < 3.48%), and recoveries of 94.46%–105.6% (HQ) and 98.37%–106.08% (CC). This work integrates traditional Chinese acupuncture wisdom with modern molecular imprinting technology, providing an innovative, cost-effective strategy for on-site environmental monitoring of phenolic pollutants.
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Journal of Cleaner Production
·
2023
·
IF 11.1
Shi Liu,Wen Cao,Fanrui Meng,Mingming Du,Wenwen Wei,Yunan Chen,Hui Jin,Liejin Guo
Supercritical water gasification (SCWG) of biomass waste as a new clean waste conversion technology is increasingly valued worldwide attributable to the unique properties of supercritical water (water: T > 374 °C, P > 22.1 MPa). However, the fate of conventionally contaminated elements such as nitrogen in this process still warrants further research to control potential contamination. In this work, uric acid was used as the model compound of nitrogenous components in chicken manure to investigate the transformation mechanism of nitrogen during the SCWG process. The effects of different temperatures (550–650 °C) and residence times (2–30 min) on the gasification characteristic of uric acid and the behaviour of nitrogen were experimentally explored. The results indicated that the higher temperatures and longer residence time significantly facilitated the uric acid gasification and nitrogen transformation. The maximum nitrogen conversion efficiency was 84.83%, and the maximum yield of NH 3 , H 2 , and CO 2 reached 20.20 mol/kg, 23.78 mol/kg, and 20.10 mol/kg at 650 °C and 30 min, respectively. Subsequently, the reaction pathways of nitrogen in uric acid were proposed in detail according to the product analysis. Finally, a kinetic model was developed to describe the SCWG process, especially the reaction kinetic of nitrogenous products. The results revealed that the hydrolysis reactions of uric acid led to a rapid increase in NH 3 yield in the initial stage of the SCWG process. As the process continued, the increase in NH 3 was mainly due to the deamidation reaction of small-molecule nitrogenous intermediates. Notably, NO x , NO 2 − , and NO 3 − were not detected in products, validating the inhibitory effects of the reducing environment of supercritical water on the generation of nitrogen oxides.
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MICROCHEMICAL JOURNAL
·
2023
·
IF 4.8
Yu Cui,Shiyue Zhang,Xiaoyu Zhou,Fei Yan,Wei Hu
The present work reports a rapid and convenient electrochemical method for highly sensitive detection of uric acid (UA) by integration of vertically-ordered mesoporous silica film bearing amino groups (NH 2 -VMSF) and three-dimensional graphene-carbon nanotubes (3DG@CNT) composite film. 3DG@CNT and NH 2 -VMSF are successively modified onto the glassy carbon electrode (GCE) surface through a rather simple two-step controllable electrochemical deposition method. Arising from the large specific surface area, excellent electrocatalytic activity, and favorable mass transfer, 3DG@CNT co-electrodeposited onto the GCE surface could not only significantly improve the electrode performance, but also provide oxygen-containing groups for further functionalization. NH 2 -VMSF prepared by co-condensation approach using electrochemically assisted self-assembly method, possesses uniform pore size (∼2 nm in diameter) and positively charged surface, showing pronounced anionic permselectivity. Thanks to the electroactive 3DG@CNT inner layer and electrostatically preconcentrated NH 2 -VMSF outer layer, the proposed NH 2 -VMSF/3DG@CNT/GCE displays outstanding analytical performance towards UA with a wide linear range (0.1∼50 μM), a high sensitivity (1.66 µA·μM −1 ) and a low limit of detection (6.8 nM). Furthermore, considering the inherent anti-fouling property of NH 2 -VMSF, direct analysis of UA in human serum and urine samples is achieved with satisfactory recoveries.
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MICROCHIMICA ACTA
·
2023
·Vol. 190
·期 3
·1-12
·
IF 5.7
Chu Zhe,Gong Wenxue,Muhammad Yaseen,Shah Syed Jalil,Liu Qing,Xing Linguang,Zhou Xueyun,Liu Ying,Zhao Zhenxia,Zhao Zhongxing
A bimetallic polycrystalline sensor (Cr/Fe-SNCM) having nanosized and high dispersion was designed and used for the electrochemical simultaneous determination of dopamine (DA) and uric acid (UA). Catalytic nanosized Cr/Fe were highly anchored on N/S/O-contained porous carbon with high dispersion and polycrystalline Cr/Fe via energetic mechanochemical method and high-temperature carbonization. The obtained Cr/Fe-SNCM exhibited high graphitized carbon supporter and endowed high electron transport and signal output for the whole sensor. Moreover, highly dispersed Cr/Fe sites and the polycrystalline form (metal-N/S/O) efficiently enhanced the catalytic reaction, leading to a limits of detection (based on the 3σ/m criterion) of 25.8 and 22.5 nM for DA and UA, respectively. This is 1–2 orders of magnitude lower than many state-of-the-art reported sensors. The Cr/Fe-SNCM 1.0 sensor exhibited wide working range (0.1 to 10.0 μM), high recovery (96–103%) and low relative standard deviation (RSD = 3.2–4.7%) for DA and UA in real serum samples, possessing high significance for practical large-scale applications. Graphical abstract
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Brazilian Journal of Pharmaceutical Sciences
·
2023
·
IF 1.3
Zhao Li-Li,Ma Qingkun,Xu Chun-Yan,Zheng Guanghao,Han Yu,Qian Qing,Jin Wenlong,Min Jun Zhe
Serum uric acid (UA) is a traditional biomarker in the clinical diagnosis of gout and hyperuricemia. However, serum treatment and storage are cumbersome, and wounds are susceptible to infection. Therefore, in this study, a simple and noninvasive method was developed to detect the UA in human saliva to monitor the gout. An Inertsil ODS-3 column was used for the analysis under the condition of isocratic elution with the mixed solution phosphate buffer (74 mM, pH=2.2): Methanol=98:2 (v:v) and the UV detection at 284 nm. Using salivary UA data from healthy volunteers (HVs) (n=68) and gout patients (GPs) (n=14), we examined the salivary UA difference in their content. The intra-and inter-day accuracy and precision (RSD %) were less than 2.56%, the limit of detection (LOD) of UA was 5.0 ng/mL, the mean recoveries of the corresponding compounds were 102.48%. Saliva levels of UA in HVs and GPs were 35.26±14.06 µg/mL and 91.96±23.90 µg/mL, respectively. The concentrations of salivary UA in GPs were significantly higher than those in HVs ( p < 0.001). This method was also expected to monitor the hyperuricemia and other metabolic disorders in the future.
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MICROCHEMICAL JOURNAL
·
2023
·
IF 4.8
Li Huang,Shangying Qin,Yuanjin Xu,Shiqi Cheng,Jin Yang,Yilin Wang
MnO 2 nanosheets (MnO 2 NSs) were prepared and used as both oxidant of 3, 3′, 5, 5′- tetramethylbenzidine (TMB) and recognizer of UA, a simple colorimetric approach for sensitive detection of uric acid (UA) was established. In the medium of weak acid, MnO 2 NSs exhibited strong oxidation capacity and could oxidize colorless TMB to generate a blue oxidation product (oxTMB) with an absorbance signal. However, the introduction of UA could inhibit MnO 2 NSs - mediated TMB oxidation and reduce the formation of oxTMB, resulting in the blue fading and the absorbance weakening. Under the conditions of incubation time 20 min, pH 3.0, TMB 0.5 mM, and MnO 2 NSs 50 μM, the decrease in absorbance was linearly dependent on UA concentration in the range of 0.5–30.0 μM with a detection limit of 0.21 μM. Furthermore, the approach has been applied for determining UA in human urine samples with recoveries between 93.1 and 102.4 % and relative standard deviation less than 3.0 %.
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